Advanced Chinese Medicine最新文献

{"title":"Expert consensus on quality control indicators of integrative medicine in primary Sjögren's syndrome (2023 version)","authors":"Qing-Wen Tao,&nbsp;Jing Luo,&nbsp;Tzu-Hua Wu,&nbsp;Jian-Ming Wang,&nbsp;Yuan Xu,&nbsp;Di-Er Jin","doi":"10.1002/acm4.21","DOIUrl":"https://doi.org/10.1002/acm4.21","url":null,"abstract":"<p>Treatment integrating traditional Chinese and Western medicine for primary Sjögren's syndrome (pSS) has yielded positive results and gained wide acceptance. However, the absence of standardized clinical management in certain regions has led to suboptimal outcomes in the diagnosis and treatment of pSS in China. In response, the Center for Traditional Chinese and Western Medicine at the China-Japan Friendship Hospital, in collaboration with the Beijing Association of Traditional Chinese and Western Medicine Rheumatology Professional Committee, initiated a project led by the Traditional Chinese Medicine Department of Rheumatism. The project (Beijing Association of the Integrating of Traditional and Western Medicine standardization expert consensus record number: 2021Z031A3) aims to develop a set of quality control indicators for the integrated treatment of pSS using traditional Chinese and Western medicine. Based on the 2021 version, the consensus revision incorporates seven new items, focusing on essential assessment areas for pSS patients, treatment response, and healthcare cost management. The 2023 expert consensus update seeks to enhance pSS diagnosis and treatment practices in China, offering a benchmark for medical quality control.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 2","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141624574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Qi-Shao-Tong-Mai-An-Shen herbal paste on coronary heart disease patients with depression and/or anxiety: Study protocol for a randomized controlled trial","authors":"Ying Chen,&nbsp;Xiang Xiao,&nbsp;Lin Li,&nbsp;Chao-Zeng Si,&nbsp;Hong Jiang,&nbsp;Ming-Jing Shao,&nbsp;Xiao-Yan Lu,&nbsp;Shu-Liang Zheng,&nbsp;Tian-Gu Dai,&nbsp;Qing He,&nbsp;Li Huang","doi":"10.1002/acm4.12","DOIUrl":"10.1002/acm4.12","url":null,"abstract":"<p>Coronary heart disease (CHD) poses a significant threat to human life and well-being. The presence of psycho-cardiology diseases not only exacerbates the progression of CHD but also imposes a substantial financial burden. Consequently, there is a pressing need to prioritize the prevention and management of psycho-cardiology conditions. Given the complex adverse effects associated with antidepressants, it is imperative to investigate alternative, safer, and more efficacious early interventions for psycho-cardiology diseases. The trial will randomly divide 99 patients who meet the inclusion criteria into two groups in a ratio of 1:2. Both groups will be administered standard western medicine treatment for CHD. The Qi-Shao-Tong-Mai-An-Shen (QSTMAS) group will be treated with an additional 30 mL QSTMAS herbal paste orally twice daily for up to 12 weeks. The primary endpoints are the changes of Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9 scores after the intervention for 12 weeks. The secondary endpoints include the scores of Traditional Chinese medicine syndromes, 6-min walking test, Insomnia severity index sleep scale, laboratory tests, and other examinations of both groups after the intervention for 12 weeks. The QSTMAS herbal paste exhibits potential and promise as a treatment modality for mild-to-moderate psychological disorders within the department of cardiology. The implementation of a rigorous trial design will facilitate an objective and scientific assessment of the clinical effectiveness and safety of combining QSTMAS herbal paste with standard western medicine for CHD patients with depression and/or anxiety. Trial Registration: China Clinical Trial Registry, ChiCTR2200065179. Registered 31 October 2022.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 2","pages":"96-104"},"PeriodicalIF":0.0,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140986978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the mechanism of Cutaneous and Respiratory Comorbidities with Chinese and Western medicine theories and research","authors":"Yi Liu,&nbsp;Wanmu Xie,&nbsp;Yue Yan,&nbsp;Baoyi Liu,&nbsp;Ang Li,&nbsp;Yue Yang,&nbsp;Xinzhu Zhou,&nbsp;Xianbo Zuo,&nbsp;Zhenguo Zhai,&nbsp;Yong Cui","doi":"10.1002/acm4.11","DOIUrl":"10.1002/acm4.11","url":null,"abstract":"<p>In the realms of traditional Chinese medicine and Western medicine research, the skin and lungs are recognized for their integral roles in both the physiological functions and pathological mechanisms affecting the human body. These organs are not only complementary and coordinated in their physiological functions but also interact pathologically, providing feedback and influencing each other. The etiology of immune-mediated skin diseases is multifaceted, involving numerous factors beyond mere skin characteristics, often including multisystem diseases. Cutaneous and Respiratory Comorbidities denote the concurrent presence of skin and lung diseases, sharing a common pathogenic mechanism. Although research on Cutaneous and Respiratory Comorbidities has received increasing attention, the foundational theories and the specifics of related diseases remain unclear. This paper aims to elucidate the theoretical basis of both traditional Chinese and Western medicine concerning immune-mediated Cutaneous and Respiratory Comorbidities, thereby laying a groundwork for the early detection and integrated treatment of these diseases.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"52-65"},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New approach to heart failure: Integrated traditional Chinese with Western medicine","authors":"Qiao Wang,&nbsp;Hongshuai Cao,&nbsp;Peizhao Li,&nbsp;Chunyan Li,&nbsp;Zaixiang Shi,&nbsp;Jingyi Ren","doi":"10.1002/acm4.10","DOIUrl":"10.1002/acm4.10","url":null,"abstract":"<p>Heart failure (HF) is a major global healthcare problem leading to substantial deterioration of prognosis. The current clinical guidelines in HF have begun to emphasize the importance of traditional Chinese medicine (TCM). TCM has been utilized in clinical practice for over 2000 years and is capable of treating a variety of HF pathogenic issues. This review summarizes the classification, pathophysiology, and treatment of HF from three perspectives: Western medicine, TCM, and integrated traditional Chinese and Western medicine (ITCWM). Emphasizing the most recent evidence, this review consolidates knowledge on ITCWM treatments for HF pertaining to different TCM syndromes, including TCM decoctions, oral patent Chinese medicine, TCM injections, as well as therapies like acupuncture and moxibustion. Additionally, this review explores TCM approaches to HF prevention, such as tai chi, Baduanjin exercise, and <i>Sanfu</i> acupoint herbal patching. The findings of this study suggest that ITCWM holds promise for the treatment and rehabilitation of HF. However, further research is warranted to elucidate the underlying mechanisms.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"19-39"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140249103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guiding modern traditional Chinese medicine research using the theory of state-target differentiation and treatment—Maintaining the validity of traditional Chinese medicine and creating new medical science","authors":"Jiaran Lin,&nbsp;Jiaxing Tian,&nbsp;Xinyi Fang,&nbsp;Boxun Zhang,&nbsp;Yingying Yang,&nbsp;Yu Wei,&nbsp;Lisha He,&nbsp;Ye Lei,&nbsp;Bin Song,&nbsp;Linhua Zhao,&nbsp;Xiaolin Tong","doi":"10.1002/acm4.8","DOIUrl":"10.1002/acm4.8","url":null,"abstract":"<p>As an important part of Chinese civilization, traditional Chinese medicine (TCM) has a long history and broad social foundation. In the development of modern medicine, TCM bears the responsibility of inheriting Chinese culture, while integrating with modern science and technology to continuously promote medical progress. The theory of “state-target differentiation and treatment” is an innovative model combining Chinese and Western medicine that has provided a new mindset and method for modernizing TCM. This theory not only guides the reconstruction of modern TCM diagnosis and treatment systems, but also strongly promotes the reconstruction of the modern herbal system. As an emerging bioinformatics technology, phenomics research can reveal biological processes dynamically and quantitatively, which will help “open the black box” of TCM by providing technical methods to reveal the nature of “state” and the mechanism of “state modulation” in TCM. TCM can provide a valuable clinical reference from the perspective of disease cognition, sort out phenomics information parameters systematically and uniformly, and provide more accurate and meaningful data for phenomics research. The in-depth combination of TCM and phenomics from the concept and technology will vigorously promote the development of human precision medicine. Modern TCM research guided by the theory of state-target differentiation and treatment can effectively improve the scientific basis and targetability of clinical treatments and can also initiate a breakthrough in the integration of Chinese and Western medicine, further promoting the profound communication and cooperation between Chinese and Western medicine, so as to achieve better development of medicine in the future.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"3-12"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current traditional Chinese medicine treatments of psoriasis vulgaris","authors":"Ying Luo,&nbsp;Jiankun Song,&nbsp;Le Kuai,&nbsp;Qi Zheng,&nbsp;Mingxia Wang,&nbsp;Guoshu Deng,&nbsp;Ying Zhang,&nbsp;Xin Li,&nbsp;Ruiping Wang,&nbsp;Bin Li","doi":"10.1002/acm4.2","DOIUrl":"10.1002/acm4.2","url":null,"abstract":"<p>Psoriasis is a kind of immune-mediated chronic skin disease induced by combined genetic and environmental factors. The effective and safe treatment of psoriasis has always been a challenge in dermatology clinics. Traditional Chinese medicine (TCM), an important direction for the current treatment of psoriasis, is characterized by historical significance, unique characteristics, and rich experience. In recent years, the “hemo-modulating therapy” of TCM has reached a consensus with excellent progress in the treatment of psoriasis. This paper reviews the current TCM treatments of psoriasis and discusses the possibilities for psoriasis disease management.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"At the beginning","authors":"Yong Cui,&nbsp;ACM Editors-in-Chief Team","doi":"10.1002/acm4.9","DOIUrl":"10.1002/acm4.9","url":null,"abstract":"<p>Traditional Chinese Medicine (TCM) is an esteemed medical system that originated in China and has safeguarded the survival and prosperity of the Chinese nation for over three millennia. TCM stands not only as a cherished national treasure but also as a shared heritage for people worldwide. After Western medicine was introduced into China over a century ago, it sparked a fervent clash with TCM due to the cultural disparities and fundamental theoretical differences between the two. Nevertheless, amidst the debates over right and wrong, and the quest for scientific superiority between Chinese and Western medicine, it is crucial to remember that the core purpose of medicine is to heal the ailing and preserve the living, with efficacy serving as the ultimate criterion for discerning truth. Consequently, following the founding of the People's Republic of China in 1949, the Chinese government formulated a fundamental health policy, advocating for the integration, communication, and cooperative advancement of Chinese and Western medicine. Guided by this approach, China's medical and health endeavors have flourished, epitomized by their resounding triumph in combatting the COVID-19 pandemic.</p><p>In recent years, the rapid advancements of science and technology have contributed significantly to the development of modern medicine. However, despite these remarkable achievements, the current medical system still faces numerous challenges due to the complexity of human diseases. Malignant tumors, immunological disorders, rapid outbreaks of novel infectious diseases, cardiovascular diseases, and other complex conditions still pose severe challenges to human health. In light of this, TCM, though an ancient medical system, offers distinctive insights into human physiology, pathology, and natural medicine pharmacology, which hold tremendous potential for catalyzing the growth and advancement of human medicine.</p><p>As our understanding of diseases and health improves, modern medicine has gradually shifted from a micro perspective to a macro one, as exemplified by the emergence of concepts such as phenomics and integrative medicine. TCM too, evolves in tandem with current science and technology, such as with the rise of microcosmic syndrome differentiation, the combination of disease and syndrome, as well as state-targeted differentiation and treatment. Consequently, the future trajectory of human medicine lies in the development of a new medical system that integrates both macro and micro approaches.</p><p>Against this background, the National Medical Center of Integrated Chinese and Western Medicine of China-Japan Friendship Hospital and the Higher Education Press are proud to jointly announce the publication of <i>Advanced Chinese Medicine</i> (ACM). ACM aims to present the theoretical descriptions and research products within the framework of integrated Chinese and Western medicine to the global community. ACM aspires to serve as a platform for communicat","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140428987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of Baduanjin on metabolic syndrome: An overview of systematic reviews and meta-analyses","authors":"JingYi Zhao,&nbsp;Min Li,&nbsp;KaiLe Ma,&nbsp;Rui Hao,&nbsp;LiJuan Zhou","doi":"10.1002/acm4.3","DOIUrl":"10.1002/acm4.3","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This meta-analysis evaluated the effects of Baduanjin on the metabolic status of individuals with metabolic syndrome (MetS). The aim was to identify effective interventions for MetS prevention and treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a comprehensive search of English (PubMed, Embase, Web of Science, and Cochrane Library) and Chinese (CNKI, Wanfang, Chinese Biomedical Database, VIP) databases till August 19, 2022. Randomized controlled trials (RCTs) focusing on Baduanjin for MetS patients were included. Data were pooled and assessed using the Cochrane risk-of-bias tool. The Grades of Recommendation, Assessment, Development, and Evaluation for Systematic Reviews was used to evaluate literature quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight RCTs involving 435 participants were included. Baduanjin showed significant improvements in fasting blood glucose (mean difference [MD] = −0.41, 95% confidence interval [CI] [−0.22, −0.61], <i>p</i> &lt; 0.0001) and glycated hemoglobin levels (MD = −0.99, 95% CI [−0.38, −1.60], <i>p</i> &lt; 0.00001). Waist-to-hip ratio (MD = −0.04, 95% CI [−0.03, −0.06], <i>p</i> = 0.002), body mass index (MD = −1.60, 95% CI [−0.10, −3.10], <i>p</i> = 0.04), fasting insulin (MD = −4.82, 95% CI [−0.15, −8.59], <i>p</i> = 0.01), systolic blood pressure (MD = −7.16, 95% CI [−5.16, −9.17], <i>p</i> &lt; 0.00001), diastolic blood pressure (MD = −3.43, 95% CI [−0.62, −6.24], <i>p</i> = 0.02), total cholesterol (MD = −0.48, 95% CI [−0.10, −0.85], <i>p</i> = 0.01), triglycerides (MD = −0.39, 95% CI [−0.14, −0.64], <i>p</i> = 0.003), and low-density lipoprotein cholesterol (MD = −0.52, 95% CI [−0.10, −0.94], <i>p</i> = 0.01) also significantly improved. No adverse events were reported. Literature quality ranged from very low to moderate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Baduanjin effectively improves metabolic status in individuals with MetS, including blood glucose, lipid profile, obesity-related indicators, insulin levels, and blood pressure. However, the overall literature quality is moderate to low. Further rigorous RCTs are needed to explore Baduanjin's effects on MetS, considering intervention methods, content, and research methodologies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"66-78"},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139802928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of Baduanjin on metabolic syndrome: An overview of systematic reviews and meta‐analyses","authors":"J. Zhao, Min Li, Kaile Ma, Rui Hao, Lijuan Zhou","doi":"10.1002/acm4.3","DOIUrl":"https://doi.org/10.1002/acm4.3","url":null,"abstract":"This meta‐analysis evaluated the effects of Baduanjin on the metabolic status of individuals with metabolic syndrome (MetS). The aim was to identify effective interventions for MetS prevention and treatment.We conducted a comprehensive search of English (PubMed, Embase, Web of Science, and Cochrane Library) and Chinese (CNKI, Wanfang, Chinese Biomedical Database, VIP) databases till August 19, 2022. Randomized controlled trials (RCTs) focusing on Baduanjin for MetS patients were included. Data were pooled and assessed using the Cochrane risk‐of‐bias tool. The Grades of Recommendation, Assessment, Development, and Evaluation for Systematic Reviews was used to evaluate literature quality.Eight RCTs involving 435 participants were included. Baduanjin showed significant improvements in fasting blood glucose (mean difference [MD] = −0.41, 95% confidence interval [CI] [−0.22, −0.61], p < 0.0001) and glycated hemoglobin levels (MD = −0.99, 95% CI [−0.38, −1.60], p < 0.00001). Waist‐to‐hip ratio (MD = −0.04, 95% CI [−0.03, −0.06], p = 0.002), body mass index (MD = −1.60, 95% CI [−0.10, −3.10], p = 0.04), fasting insulin (MD = −4.82, 95% CI [−0.15, −8.59], p = 0.01), systolic blood pressure (MD = −7.16, 95% CI [−5.16, −9.17], p < 0.00001), diastolic blood pressure (MD = −3.43, 95% CI [−0.62, −6.24], p = 0.02), total cholesterol (MD = −0.48, 95% CI [−0.10, −0.85], p = 0.01), triglycerides (MD = −0.39, 95% CI [−0.14, −0.64], p = 0.003), and low‐density lipoprotein cholesterol (MD = −0.52, 95% CI [−0.10, −0.94], p = 0.01) also significantly improved. No adverse events were reported. Literature quality ranged from very low to moderate.Baduanjin effectively improves metabolic status in individuals with MetS, including blood glucose, lipid profile, obesity‐related indicators, insulin levels, and blood pressure. However, the overall literature quality is moderate to low. Further rigorous RCTs are needed to explore Baduanjin's effects on MetS, considering intervention methods, content, and research methodologies.","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"187 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To explore the pathogenesis and scientific connotation of non-alcoholic fatty liver based on the theory of turbid toxin of traditional Chinese medicine","authors":"Guanjun Kou,&nbsp;Hongwei Luo,&nbsp;Xing Huang,&nbsp;Mingxue Bai,&nbsp;Ke Cao,&nbsp;Hongyu Ma,&nbsp;Xiang Lv","doi":"10.1002/acm4.1","DOIUrl":"10.1002/acm4.1","url":null,"abstract":"<p>Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease characterized by the accumulation of excessive liver lipids without alcohol-induced damage. It has emerged as a significant global health issue. A recent research has indicated that dysregulation of lipid decomposition, uptake, production, oxidation, and secretion causes alterations in various types of lipids, leading to organelle dysfunction and metabolic signaling pathway impairment. Scholars propose that turbid toxin is crucial in the pathogenesis of NAFLD. This article elucidates the meaning of turbid toxin in conjunction with the current literature and analyzes the modern pathophysiological mechanism underlying the development of NAFLD, including turbid toxic substance production, related organelle involvement, biological processes, and pathways, ultimately leading to disease outcomes. The relationship between traditional Chinese medicine and the turbid toxin is also explored to establish a foundation for further mechanistic research on NAFLD.</p>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 1","pages":"40-51"},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}