{"title":"温阳生肌汤加黄连软膏治疗原发性皮肤 CD30 阳性无细胞大细胞淋巴瘤:病例报告","authors":"Kai Li, Tingting Bao, Ruonan Wei, Yingying Yang, Mengjiao Kang, Wei Zhang, Xianyu Zeng, Yiqun Duan, Liuqing Chen, Linhua Zhao","doi":"10.1002/acm4.27","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>Primary cutaneous CD30 positive anaplastic large cell lymphoma (PC-ALCL) is a rare non-Hodgkin's lymphoma. Combined chemotherapy regimens such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), or F-MACHOP (5-fluorouracil, methotrexate, cytosine-arabinoside, cyclophosphamide, doxorubicin, vincristine, and prednisone) are often used for its clinical treatment. In this study, we reported a new treatment method using a traditional Chinese therapy involving oral <i>Wenyang Shengji decoction</i> (WSD) combined with <i>Huanglian ointment</i> applied externally in a 32-year-old female patient with PC-ALCL. Introduction: A 32-year-old woman who complained of an ulcer on the forehead accompanied by significant pain. PC-ALCL was diagnosed by histopathological examination and immunohistochemical analysis. Treatment plan: WSD was prepared in 300 mL water and administered orally as a 150 mL decoction twice daily, and <i>Huanglian ointment</i> was applied to the ulcer three times daily. After 8 weeks of treatment with WSD combined with <i>Huanglian ointment</i>, the lesion healed completely. Immunohistochemical analysis revealed the presence of scattered CD3+++, CD4++, CD8++, CD20++, and CD30-positive cells. After 12 weeks of treatment, the ulcer healed completely, leaving only a marked pale red-pitted scar. The patient was followed up for 3 years without recurrence and no adverse events. Conclusion: oral WSD combined with <i>Huanglian ointment</i> applied to the ulcer for PC-ALCL can promote the healing of ulcers, reduce or alleviate the formation of scar, and eliminate CD30-positive cells. This case report provides a reference for the clinical treatment of PC-ALCL using traditional Chinese medicine.</p>\n </section>\n </div>","PeriodicalId":100029,"journal":{"name":"Advanced Chinese Medicine","volume":"1 3","pages":"172-178"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.27","citationCount":"0","resultStr":"{\"title\":\"Treatment of primary cutaneous CD30-positive anaplastic large cell lymphoma with Wenyang Shengji decoction and Huanglian ointment: A case report\",\"authors\":\"Kai Li, Tingting Bao, Ruonan Wei, Yingying Yang, Mengjiao Kang, Wei Zhang, Xianyu Zeng, Yiqun Duan, Liuqing Chen, Linhua Zhao\",\"doi\":\"10.1002/acm4.27\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <p>Primary cutaneous CD30 positive anaplastic large cell lymphoma (PC-ALCL) is a rare non-Hodgkin's lymphoma. Combined chemotherapy regimens such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), or F-MACHOP (5-fluorouracil, methotrexate, cytosine-arabinoside, cyclophosphamide, doxorubicin, vincristine, and prednisone) are often used for its clinical treatment. In this study, we reported a new treatment method using a traditional Chinese therapy involving oral <i>Wenyang Shengji decoction</i> (WSD) combined with <i>Huanglian ointment</i> applied externally in a 32-year-old female patient with PC-ALCL. Introduction: A 32-year-old woman who complained of an ulcer on the forehead accompanied by significant pain. PC-ALCL was diagnosed by histopathological examination and immunohistochemical analysis. Treatment plan: WSD was prepared in 300 mL water and administered orally as a 150 mL decoction twice daily, and <i>Huanglian ointment</i> was applied to the ulcer three times daily. After 8 weeks of treatment with WSD combined with <i>Huanglian ointment</i>, the lesion healed completely. Immunohistochemical analysis revealed the presence of scattered CD3+++, CD4++, CD8++, CD20++, and CD30-positive cells. After 12 weeks of treatment, the ulcer healed completely, leaving only a marked pale red-pitted scar. The patient was followed up for 3 years without recurrence and no adverse events. Conclusion: oral WSD combined with <i>Huanglian ointment</i> applied to the ulcer for PC-ALCL can promote the healing of ulcers, reduce or alleviate the formation of scar, and eliminate CD30-positive cells. This case report provides a reference for the clinical treatment of PC-ALCL using traditional Chinese medicine.</p>\\n </section>\\n </div>\",\"PeriodicalId\":100029,\"journal\":{\"name\":\"Advanced Chinese Medicine\",\"volume\":\"1 3\",\"pages\":\"172-178\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm4.27\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Chinese Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/acm4.27\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Chinese Medicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/acm4.27","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Treatment of primary cutaneous CD30-positive anaplastic large cell lymphoma with Wenyang Shengji decoction and Huanglian ointment: A case report
Primary cutaneous CD30 positive anaplastic large cell lymphoma (PC-ALCL) is a rare non-Hodgkin's lymphoma. Combined chemotherapy regimens such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), or F-MACHOP (5-fluorouracil, methotrexate, cytosine-arabinoside, cyclophosphamide, doxorubicin, vincristine, and prednisone) are often used for its clinical treatment. In this study, we reported a new treatment method using a traditional Chinese therapy involving oral Wenyang Shengji decoction (WSD) combined with Huanglian ointment applied externally in a 32-year-old female patient with PC-ALCL. Introduction: A 32-year-old woman who complained of an ulcer on the forehead accompanied by significant pain. PC-ALCL was diagnosed by histopathological examination and immunohistochemical analysis. Treatment plan: WSD was prepared in 300 mL water and administered orally as a 150 mL decoction twice daily, and Huanglian ointment was applied to the ulcer three times daily. After 8 weeks of treatment with WSD combined with Huanglian ointment, the lesion healed completely. Immunohistochemical analysis revealed the presence of scattered CD3+++, CD4++, CD8++, CD20++, and CD30-positive cells. After 12 weeks of treatment, the ulcer healed completely, leaving only a marked pale red-pitted scar. The patient was followed up for 3 years without recurrence and no adverse events. Conclusion: oral WSD combined with Huanglian ointment applied to the ulcer for PC-ALCL can promote the healing of ulcers, reduce or alleviate the formation of scar, and eliminate CD30-positive cells. This case report provides a reference for the clinical treatment of PC-ALCL using traditional Chinese medicine.