IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-07 DOI: 10.1021/acsami.6c17670

Mengru Liu, Zhenlong Zhang, Huafang Zhang, Yuefeng Liu, Huiping Gao, Yanli Mao

{"title":"Constructing Molecular Bridging at the SnO2/Perovskite Interface for Efficient and Stable Perovskite Solar Cells","authors":"Mengru Liu, Zhenlong Zhang, Huafang Zhang, Yuefeng Liu, Huiping Gao, Yanli Mao","doi":"10.1021/acsami.6c17670","DOIUrl":"10.1021/acsami.6c17670","url":null,"abstract":"Interfacial quality at the SnO2 electron transport layer (ETL)/perovskite junction critically governs the electron collection and device performance in n-i-p type perovskite solar cells (PSCs). However, the defects within SnO2 and at the buried interface can impede electron extraction and promote charge recombination. Herein, cesium hexafluorophosphate (CsPF6) was introduced into the SnO2 precursor as an interfacial additive. Calculations and experimental measurements indicate that the F atoms of PF6– coordinate with undercoordinated Sn sites, whereas Cs participates in the formation of an FA-Cs alloyed layer at the buried perovskite surface. These interactions establish a molecular bridge across the SnO2/perovskite junction. The resulting bridge suppresses the interfacial defects, improves the energy-level alignment and physical contact, and regulates the perovskite crystallization. The devices incorporating CsPF6 deliver a champion power conversion efficiency (PCE) of 24.25%. They also show enhanced stability. The unencapsulated devices retain 90.05% of their initial PCE after 1000 h of aging in ambient air. These findings demonstrate that molecular bridging is an effective route to simultaneously improve the efficiency and stability of PSCs.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56246–56255"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria–Nanozyme Hybrid Therapeutic for Modulation of the Inflammatory Cascade in Psoriasis 线粒体-纳米酶混合治疗银屑病炎症级联的调节。

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-09 DOI: 10.1021/acsami.6c15258

Siyu Chen, Yanan Wei, Wei Huang, Ruonan Zhang, Honghong Yu, Ya Wen, Xingyu Li, Jingyin Bao, Dong Li

{"title":"Mitochondria–Nanozyme Hybrid Therapeutic for Modulation of the Inflammatory Cascade in Psoriasis","authors":"Siyu Chen, Yanan Wei, Wei Huang, Ruonan Zhang, Honghong Yu, Ya Wen, Xingyu Li, Jingyin Bao, Dong Li","doi":"10.1021/acsami.6c15258","DOIUrl":"10.1021/acsami.6c15258","url":null,"abstract":"The chronic recurrence of psoriasis is driven by a self-amplifying inflammatory cascade in which oxidative stress and mitochondrial metabolic dysfunction reinforce each other, and single-target conventional therapies often fail to break this cycle. Here, we present a micro–nano hybrid system, Mito-Ce, constructed by covalently immobilizing ceria nanozymes (CeNPs) onto the surface of isolated functional mitochondria through thiol–maleimide chemistry. This design endows the hybrid with dual functionalities, including mitochondrial bioactivity and durable ROS-scavenging capabilities of CeNPs. In H2O2-stimulated macrophages, upon internalization. Mito-Ce markedly reduced intracellular ROS and consequently suppressed the secretion of pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β). Topical application of Mito-Ce to an imiquimod-induced mouse model of psoriasis visibly resolved psoriatic plaques, reduced the PASI score, and reversed epidermal hyperplasia. Beyond local repair, Mito-Ce rebalanced systemic immunity, evidenced by a decline in splenic pathogenic Th17 cells and polarization toward anti-inflammatory M2 macrophages. Transcriptomic profiling further revealed that Mito-Ce broadly reversed the pathological gene expression program, downregulating stress-responsive and phagocytosis-related genes while upregulating genes associated with metabolism, epidermal proliferation, and tissue homeostatic remodeling. These coordinated networks ultimately re-established immune–barrier homeostasis at the molecular level. Collectively, by integrating nanozyme-mediated ROS scavenging with mitochondrial bioactivity, the Mito-Ce hybrid could treat psoriasis through coordinated disruption of the inflammatory cascade, potentially offering a highly effective platform for various chronic inflammatory disorders.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55976–55987"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trace Bifunctional Diboron Additive Enables Robust CEI/SEI Interphases for Long-Cycling 4.5 V Li||NCM811 Batteries 微量双功能双硼添加剂可为长循环4.5 V Li||NCM811电池提供稳健的CEI/SEI界面

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-10 DOI: 10.1021/acsami.6c15184

Yahui Zhang, Detian Ma, Yebo Song, Yueyang Gao, Yunfei Bai, Dawei Yu, Jincai Wu, Xiaobo Pan

{"title":"Trace Bifunctional Diboron Additive Enables Robust CEI/SEI Interphases for Long-Cycling 4.5 V Li||NCM811 Batteries","authors":"Yahui Zhang, Detian Ma, Yebo Song, Yueyang Gao, Yunfei Bai, Dawei Yu, Jincai Wu, Xiaobo Pan","doi":"10.1021/acsami.6c15184","DOIUrl":"10.1021/acsami.6c15184","url":null,"abstract":"Developing efficient, low-cost, multifunctional additives that require small amounts and can simultaneously protect both the cathode and anode remains a major challenge for the practical application of lithium batteries. Herein, bis(2,4-dimethylpentane-2,4-glycolato)diboron (B2hmp2) was introduced to construct a greatly Li+-conductive cathode electrolyte interphases (CEIs) at the LiNi0.8Co0.1Mn0.1O2 (NCM811) surface together with robust solid electrolyte interphases (SEIs). Using a common electrolyte with 0.2 wt % B2hmp2, the Li||Li cells deliver markedly enhanced long-cycling stability, sustaining stable operation for 500 h at 0.5 mA cm–2. Furthermore, following 350 cycles at 0.5 C, the capacity retention of 4.5 V Li||NCM811 cells was elevated from 57.2 to 83.6%. Experimental results reveal that the thin, uniform, boron-rich CEI generated by B2hmp2 effectively mitigates particle microcracking and restrains the dissolution of transition metal ions. Interface analysis reveals that the modified SEI film enriched with B–O species and LiF facilitates uniform Li plating/stripping without dendrite formation and reduces the continuous parasitic decomposition of electrolyte solvents. This article highlights the value of trace diboron for forming desirable electrolyte interphases to obtain the wonderful long-term cycle performance and rate performance of Li||NCM811 cells.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56157–56168"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastable Cycling of Sodium Metal Battery at Rates Exceeding 20 C Achieved with a NaB3H8-SiO2 Composite Solid Electrolyte 使用NaB3H8-SiO2复合固体电解质实现钠金属电池在超过20℃下的超稳定循环

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c10920

Anqi Zhu, Pengtao Qiu, Yang Luo, Ning Feng, Guang-Jing Feng, Shujun Li, Liqing He, Yiying Wu, Xuenian Chen

{"title":"Ultrastable Cycling of Sodium Metal Battery at Rates Exceeding 20 C Achieved with a NaB3H8-SiO2 Composite Solid Electrolyte","authors":"Anqi Zhu, Pengtao Qiu, Yang Luo, Ning Feng, Guang-Jing Feng, Shujun Li, Liqing He, Yiying Wu, Xuenian Chen","doi":"10.1021/acsami.6c10920","DOIUrl":"10.1021/acsami.6c10920","url":null,"abstract":"Solid-state sodium metal batteries are promising candidates for grid-scale energy storage due to their inherent safety and low cost. However, the development of solid electrolytes that support high-rate (>20 C) cycling for fast-charging applications remains a major challenge. Herein, we explore how adding SiO2 affects the ionic conductivity and dendrite suppression of NaB3H8, to develop superior solid electrolytes for high-rate batteries. The composites featuring an amorphous passivating layer with B–O bonds were fabricated via ball milling. Among them, NaB3H8-40%SiO2 exhibits the best conductivity, reaching 0.62 mS cm–1 at 25 °C, 2 orders of magnitude higher than that of pristine NaB3H8. Crucially, by reducing electronic conductivity and enhancing mechanical strength, it possesses a high critical current density of up to 6.5 mA cm–2, significantly higher than that of other reported hydridoborates. The Na/NaB3H8-40%SiO2/TiS2 batteries exhibit superior rate capability (216.4 mAh g–1 at 1 C and 143.1 mAh g–1 at 20 C) and long-term cycling stability (nearly 100.0% capacity retention after 2000 cycles at 20 C) at 30 °C. This work offers a promising approach for the development of innovative solid electrolytes in fast-charging or high-power-density sodium metal batteries.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56048–56058"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VYQFF Peptide-Modified Brucine Liposomes: Antitumor Activity in Head and Neck Squamous Cell Carcinoma and Mechanistic Insights VYQFF肽修饰的马钱子碱脂质体：头颈部鳞状细胞癌的抗肿瘤活性及其机制见解

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c15023

Rixin Su, Runjing Li, Xiaorui Wu, Jie Xiong, Jia Jin, Xueling Zhang, Banglong Song, Yu Zhang, Ping Li

{"title":"VYQFF Peptide-Modified Brucine Liposomes: Antitumor Activity in Head and Neck Squamous Cell Carcinoma and Mechanistic Insights","authors":"Rixin Su, Runjing Li, Xiaorui Wu, Jie Xiong, Jia Jin, Xueling Zhang, Banglong Song, Yu Zhang, Ping Li","doi":"10.1021/acsami.6c15023","DOIUrl":"10.1021/acsami.6c15023","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat, and conventional chemotherapy has limited efficacy and substantial toxicity. We developed a VYQFF peptide-modified brucine liposome (Bru-VYQFF-Lip) and characterized its particle size, zeta potential, polydispersity, encapsulation efficiency, and drug loading. Bru-VYQFF-Lip showed greater uptake in Trop2-high HSC3 cells than in HOK cells and inhibited HNSCC-cell proliferation, migration, and invasion while promoting apoptosis. After intratumoral administration, the VYQFF-modified formulation showed greater local fluorescence retention than the NHS-bearing, non-peptide comparator; this experiment does not establish systemic tumor targeting or direct Trop2-specific recognition. Bru-VYQFF-Lip also suppressed tumor growth in a nude-mouse xenograft model. Terminal serum chemistry and organ histology did not reveal overt hepatorenal or histopathological injury, although the safety assessment was limited by the absence of complete longitudinal and hematological evaluation. Bioinformatic and experimental analyses identified INHBA as a candidate mediator associated with poor prognosis. Mechanistic experiments were consistent with suppression of the INHBA/TGF-β/Smad axis and epithelial-mesenchymal transition. These findings support further evaluation of VYQFF-functionalized brucine liposomes, including physicochemically matched controls, receptor-blocking studies, systemic biodistribution experiments, and comprehensive toxicology.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55946–55961"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Molecule Multifunctional Additive Enables Coupled Solvation and Interphase Engineering for Highly Reversible Zinc Anodes 单分子多功能添加剂实现了高可逆锌阳极的耦合溶剂化和界面工程。

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-08 DOI: 10.1021/acsami.6c09786

Bei Yan, Yue Fei, Xiaoyu Xia, Yue Li, Yuxuan Wu, Hao Zhang, Ge Li

{"title":"Single-Molecule Multifunctional Additive Enables Coupled Solvation and Interphase Engineering for Highly Reversible Zinc Anodes","authors":"Bei Yan, Yue Fei, Xiaoyu Xia, Yue Li, Yuxuan Wu, Hao Zhang, Ge Li","doi":"10.1021/acsami.6c09786","DOIUrl":"10.1021/acsami.6c09786","url":null,"abstract":"Dendritic formation and parasitic interfacial reactions occurring on the zinc anode remains a major obstacle to the commercialization of aqueous zinc-ion batteries. Rational electrolyte additive design offers an effective route to move beyond single-function regulation toward synergistic multimechanism control. Compared to multicomponent systems, single-molecule additives with multiple functional groups enable integrated control over solvation structure and interfacial chemistry while reducing complexity and cost. Herein, the natural amino acid hydroxyproline (hyp) is introduced as a multifunctional electrolyte additive for simultaneous regulation of the Zn2+ solvation and interfacial chemistry. The −COOH and −OH groups reconstruct the solvation sheath and hydrogen-bond network, while the −NH− group promotes interfacial adsorption and induces a compact, N-rich interphase that homogenizes Zn2+ flux and suppresses dendrite growth. Benefiting from this cooperative solvation−interphase regulation, stable Zn plating/stripping is achieved for over 2000 h in Zn//Zn cells, an average coulombic efficiency of 99.79% is maintained over 1500 cycles in Zn//Cu cells, and Zn//LiFePO4 full cells deliver a capacity of 154 mAh g−1 over 500 cycles at 0.2 A g−1. This work highlights single-molecule, multifunctional electrolyte additive engineering as a rational, scalable strategy for durable, safe aqueous zinc batteries.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56038–56047"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton-Exchange Surface Engineering Enables Air-Stable Sodium Layered Oxide Cathodes for Carbon-Neutral Energy Storage 质子交换表面工程使空气稳定的钠层状氧化物阴极用于碳中性储能。

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-08 DOI: 10.1021/acsami.6c16266

Lin Huangfu, Le Tong, Yiming Zhang, Xing Shen, Xiaoping Jiang, Baihua Qu, Chaohe Xu, Jingfeng Wang

{"title":"Proton-Exchange Surface Engineering Enables Air-Stable Sodium Layered Oxide Cathodes for Carbon-Neutral Energy Storage","authors":"Lin Huangfu, Le Tong, Yiming Zhang, Xing Shen, Xiaoping Jiang, Baihua Qu, Chaohe Xu, Jingfeng Wang","doi":"10.1021/acsami.6c16266","DOIUrl":"10.1021/acsami.6c16266","url":null,"abstract":"O3-type layered oxides have emerged as one of the most promising cathode candidates for sodium-ion batteries, which are widely regarded as a key enabling technology for carbon-neutral grid-scale energy storage. However, their practical application is hindered by surface degradation upon air exposure and structural distortion from Mn3+. Herein, we develop a two-step surface engineering protocol that combines proton-exchange washing with a short postcalcination to treat O3-type cathodes. Proton-exchange treatment removes surface carbonates and oxidizes Mn3+ to widen the interlayers for enhanced Na+ diffusion and Jahn–Teller suppression, while the subsequent short calcination heals residual defects and locks in the refined structure. The optimally treated Na0.82Cu0.19Fe0.39Mn0.42O2 cathode delivers a reversible capacity of 110.2 mAh g–1 at 0.2 C with 92.3% retention after 100 cycles (substantially outperforming the pristine sample at 48.6%), while retaining its superior performance even after one month of air exposure. This cost‑effective and scalable surface engineering approach thus removes a critical industrial bottleneck for sodium‑ion batteries, marking a tangible step toward sustainable storage technologies for the zero‑carbon transition.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56192–56202"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149133988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy 生物工程杂交纳米囊泡通过靶向药物递送调节免疫微环境用于食管鳞状细胞癌治疗

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-10 DOI: 10.1021/acsami.6c14588

Fei Xie, Lulu Feng, Yuting Wang, Chaofan Huang, Chenlong Wang, Chao Luo, Li Zhang, Congyong Sun, Qilong Wang

{"title":"Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy","authors":"Fei Xie, Lulu Feng, Yuting Wang, Chaofan Huang, Chenlong Wang, Chao Luo, Li Zhang, Congyong Sun, Qilong Wang","doi":"10.1021/acsami.6c14588","DOIUrl":"10.1021/acsami.6c14588","url":null,"abstract":"Combining chemotherapy and immunotherapy shows great promise for treating esophageal squamous cell carcinoma (ESCC), but its effectiveness is hindered by the immunosuppressive tumor environment and challenges in drug delivery. Recent research has focused on cell membrane-coated nanoparticles for targeted drug delivery, leveraging their ability to evade the immune system while selectively targeting tumor cells. In this study, we developed a biomimetic hybrid nanoplatform based on cell membranes to combine molecular chemotherapy and improve the effectiveness of immunochemotherapy in treating ESCC. The nanoplatform is coated with a membrane fusion of activated neutrophils and ESCC cells and loaded with paclitaxel (PTX) and small interfering RNA targeting EFNA1 (siEFNA1), a molecule linked to ESCC metastasis. By exploiting the homologous targeting properties of ESCC cell membranes and the tumor-homing ability of neutrophil membranes, the platform effectively targets ESCC tissues and delivers siEFNA1 and PTX. This allows for a synergistic treatment approach, combining EFNA1 gene silencing with PTX-induced cytotoxicity to target ESCC more effectively. Crucially, the nanoplatform reprograms tumor-associated macrophages from the pro-tumor M2 phenotype to the anti-tumor M1 phenotype while boosting T cell-mediated cytotoxicity and remodeling the immunosuppressive tumor microenvironment. Overall, this strategy presents a promising approach for the targeted treatment of ESCC.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55910–55929"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacial Cofactor Recycling Electroenzymatic Platform for Endergonic CO2 Reduction 界面辅因子回收电酶平台的吸氧CO2还原

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c12368

J. Shanthi Sravan, Hyeryeong Lee, Yuna Bang, Celine Imanuel Hermanto, In Seop Chang

引用次数: 0

Gastrointestinal-Responsive Jelly Fig–Alginate Microgels for Restoring Intestinal Barrier Homeostasis through Microbiota–Metabolite Remodeling 通过微生物代谢物重塑恢复肠道屏障稳态的胃肠道反应性果冻无花果海藻酸盐微凝胶

IF 7.8 2区材料科学

ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-07 DOI: 10.1021/acsami.6c13475

Yifan Wang, Jiyue Hu, Bowen Li, Sean Xu, Xiangming He

{"title":"Gastrointestinal-Responsive Jelly Fig–Alginate Microgels for Restoring Intestinal Barrier Homeostasis through Microbiota–Metabolite Remodeling","authors":"Yifan Wang, Jiyue Hu, Bowen Li, Sean Xu, Xiangming He","doi":"10.1021/acsami.6c13475","DOIUrl":"10.1021/acsami.6c13475","url":null,"abstract":"Oral biomaterials capable of protecting natural bioactives during gastrointestinal transit while restoring intestinal barrier function offer a promising strategy for inflammatory bowel disease intervention. Here, we developed edible Jelly Fig (Ficus awkeotsang Makino, JF) pectin–alginate composite microgels (Mgel) through Ca2+-mediated ionic crosslinking as a gastrointestinal-responsive oral biomaterial. The resulting microgels exhibited uniform spherical morphology, enhanced mechanical robustness, gastric stability, and intestinal responsiveness, thereby improving the delivery performance of JF-derived bioactive components. Phytochemical and HPLC analyses showed that the ethanol-soluble fraction of JF was enriched in phenolic constituents and displayed potent antioxidant, anti-inflammatory, and epithelial barrier-protective effects in macrophage and intestinal epithelial cell models. In dextran sulfate sodium-induced colitis mice, orally administered Mgel showed superior protective efficacy compared with unformulated JF hydrogel at an equivalent dose, as evidenced by reduced body weight loss, disease activity, colon shortening, histological injury, inflammatory cytokine production, oxidative stress, and intestinal permeability. Mgel further restored mucus and tight junction barrier markers, promoted epithelial regeneration, and improved mucosal healing. Moreover, 16S rRNA sequencing combined with targeted metabolite profiling revealed that Mgel remodeled the gut microbiota, enriched beneficial taxa such as Lactobacillus and Akkermansia, and restored short-chain fatty acid and secondary bile acid metabolism. These findings demonstrate that Jelly Fig–alginate microgels serve as a food-grade, gastrointestinal-responsive oral biomaterial platform for coordinated restoration of epithelial barrier integrity and microbiota–metabolite homeostasis in colitis.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55891–55909"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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