ACS Publications最新文献_第2页

Fentanyl Levels May Be Unchanged With Extracorporeal Membrane Oxygenation. 体外膜氧合可能不会改变芬太尼水平。

IF 4.6 4区医学

Annals of Pharmacotherapy Pub Date : 2025-01-01 Epub Date: 2024-05-20 DOI: 10.1177/10600280241249501

Jennifer W Chou, Matthew Mueller, Christopher Tainter, Travis Pollema, Cassia Yi, Mazen Odish, E Orestes O'Brien

引用次数: 0

Greater Apathy Associated With Selective Serotonin Reuptake Inhibitor Use in Parkinson's Disease. 帕金森病患者使用选择性羟色胺再摄取抑制剂会导致更严重的冷漠。

IF 4.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-01-01 Epub Date: 2024-05-23 DOI: 10.1177/08919887241254471

Rachel N Schade, Connor B Etheridge, Lauren E Kenney, Adrianna M Ratajska, Katie Rodriguez, Francesca V Lopez, Joshua Gertler, Alyssa Ray, Lauren Santos, Christopher Hess, Dawn Bowers

{"title":"Greater Apathy Associated With Selective Serotonin Reuptake Inhibitor Use in Parkinson's Disease.","authors":"Rachel N Schade, Connor B Etheridge, Lauren E Kenney, Adrianna M Ratajska, Katie Rodriguez, Francesca V Lopez, Joshua Gertler, Alyssa Ray, Lauren Santos, Christopher Hess, Dawn Bowers","doi":"10.1177/08919887241254471","DOIUrl":"10.1177/08919887241254471","url":null,"abstract":"Objective: Apathy, a motivational disorder, is common in Parkinson's disease (PD) and often misdiagnosed as depression. Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with increased apathy in adolescents and adults with depression. Based on observations that serotonin may downregulate dopaminergic systems, we examined the relationship between apathy and SSRI use in individuals with PD.Methods: Medications, mood/motivation scales, and clinical data were collected from a convenience sample of 400 individuals with PD. Depression and apathy were measured using the Beck Depression Inventory-II (BDI-Il) and the Apathy Scale (AS). Antidepressant medications were grouped by mechanism type.Results: Of the 400 PD patients, 26% were on SSRIs. On standard mood/motivation scales, 38% of the sample exceeded clinical cut-offs for apathy and 28% for depression. Results of hierarchical regression analyses revealed that SSRIs were the only antidepressant that were significantly associated with higher apathy scores (β = .1, P = .02). Less education (β = -.1, P = .01) worse cognition (β = -.1, P = .01), and greater depressive symptoms (β = .5, P < .001) were also significant predictors of apathy.Conclusion: These findings suggest that use of SSRIs, but not other antidepressants, is associated with greater apathy in PD. Given the interactive relationship between serotonin and dopamine, the current findings highlight the importance of considering apathy when determining which antidepressants to prescribe to individuals with PD. Similarly, switching a SSRI for an alternative antidepressant in individuals with PD who are apathetic may be a potential treatment for apathy that needs further study.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"13-22"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Instructions and Acoustic Feedback to Improve Staff Delivery of Behavior-Specific Praise in a Clinical Setting. 在临床环境中使用指令和声音反馈来改进员工对特定行为的表扬。

IF 4.6 3区心理学

Behavior Modification Pub Date : 2025-01-01 Epub Date: 2024-10-21 DOI: 10.1177/01454455241291472

Kwadwo Britwum, G David Smith, Michelle Britwum, Elizabeth Parthum, Eric Jacobs

{"title":"Using Instructions and Acoustic Feedback to Improve Staff Delivery of Behavior-Specific Praise in a Clinical Setting.","authors":"Kwadwo Britwum, G David Smith, Michelle Britwum, Elizabeth Parthum, Eric Jacobs","doi":"10.1177/01454455241291472","DOIUrl":"10.1177/01454455241291472","url":null,"abstract":"Past research has shown the effectiveness of contingent acoustic feedback (CAF) in various human performance settings, but its impact on staff performance in clinical settings remains unclear. The current study replicated and extended Herron et al. (2018) by using vocal instructions and CAF to teach staff to use behavior-specific praise (BSP) to reinforce designated client behavior in a clinical setting. Results from a multiple-baseline-across-staff design revealed that this intervention increased the rate at which staff used BSP to reinforce designated client behavior. Paired sample t-tests showed a significant increase in the rate of BSP for each participant from baseline to the intervention phase, and participants maintained increased rates of BSP during probes conducted 1 to 3 weeks after the intervention was complete. Additionally, paired sample t-tests showed statistically significant increases in the rates of designated behavior for each client. Participants also rated the instructions and CAF procedure as more worthwhile, helpful, relevant, pleasant, and less disruptive than feedback methods typically used in their agency.","PeriodicalId":48037,"journal":{"name":"Behavior Modification","volume":" ","pages":"3-48"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). 急性肺损伤/急性呼吸道疾病综合征中巨噬细胞驱动的发病机制：利用天然产品进行治疗干预（综述）。

IF 4.3 3区医学

Molecular medicine reports Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.3892/mmr.2024.13381

Jincun Li, Wenyu Ma, Zilei Tang, Yingming Li, Ruiyu Zheng, Yuhuan Xie, Gang Li

{"title":"Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review).","authors":"Jincun Li, Wenyu Ma, Zilei Tang, Yingming Li, Ruiyu Zheng, Yuhuan Xie, Gang Li","doi":"10.3892/mmr.2024.13381","DOIUrl":"10.3892/mmr.2024.13381","url":null,"abstract":"Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a common respiratory disease characterized by hypoxemia and respiratory distress. It is associated with high morbidity and mortality. Due to the complex pathogenesis of ALI, the clinical management of patients with ALI/ARDS is challenging, resulting in numerous post‑treatment sequelae and compromising the quality of life of patients. Macrophages, as a class of innate immune cells, play an important role in ALI/ARDS. In recent years, the functions and phenotypes of macrophages have been better understood due to the development of flow cytometry, immunofluorescence, single‑cell sequencing and spatial genomics. However, no macrophage‑targeted drugs for the treatment of ALI/ARDS currently exist in clinical practice. Natural products are important for drug development, and it has been shown that numerous natural compounds from herbal medicine can alleviate ALI/ARDS caused by various factors by modulating macrophage abnormalities. In the present review, the natural products from herbal medicine that can modulate macrophage abnormalities in ALI/ARDS to treat ALI/ARDS are introduced, and their mechanisms of action, discovered in the previous five years (2019‑2024), are presented. This will provide novel ideas and directions for further research, to develop new drugs for the treatment of ALI/ARDS.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"31 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melittin promotes the proliferation of Schwann cells in hyperglycemic environment by up‑regulating the Crabp2/Wnt/β‑catenin signaling pathway. Melittin 通过上调 Crabp2/Wnt/β-catenin 信号通路，促进高血糖环境下许旺细胞的增殖。

IF 4.3 3区医学

Molecular medicine reports Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.3892/mmr.2024.13371

Qiuyi Zhang, Yuxia Chen, Wei Huang, Jiaqian Zhou, Dawei Yang

{"title":"Melittin promotes the proliferation of Schwann cells in hyperglycemic environment by up‑regulating the Crabp2/Wnt/β‑catenin signaling pathway.","authors":"Qiuyi Zhang, Yuxia Chen, Wei Huang, Jiaqian Zhou, Dawei Yang","doi":"10.3892/mmr.2024.13371","DOIUrl":"10.3892/mmr.2024.13371","url":null,"abstract":"The present study aimed to explore the effect of melittin (MLT) on the growth of Schwann cells (SCs) in high glucose conditions and to understand the mechanisms involved. The goal was to provide a theoretical basis for using MLT in the treatment of diabetic peripheral neuropathy (DPN). The CCK‑8 assay was used to measure cell activity at different concentrations of glucose and MLT. Flow cytometry was employed to analyze the effect of MLT on cell cycle phases and apoptosis in SCs under high glucose conditions. To identify differentially expressed proteins, 4D label‑free quantitative proteomics with liquid chromatography‑mass spectrometry was used, followed by biological analysis to explore potential mechanisms. PCR, western blotting and immunofluorescence were conducted to confirm these mechanisms. Melittin (0.2 µg/ml) increased the proliferation of SCs in a high glucose environment. Flow cytometry showed that after MLT treatment, the proportion of cells in the G2/M+S phase increased and the combined ratio of early and late apoptosis decreased under high glucose conditions. Proteomics identified 1,784 proteins with significant changes in expression; 725 were upregulated, and 1,059 were downregulated. Kyoto Encyclopedia of Genes and Genomes analysis indicated that the differentially expressed proteins were mainly involved in metabolic pathways and neurodegenerative disease pathways. PCR, western blotting and immunofluorescence confirmed the increase in Crabp2, Wnt3a, C‑Jun, CDK4, CyclinD1 and proliferating cell nuclear antigen. In high glucose conditions, MLT protects SCs from glucose toxicity by upregulating the Crabp2/Wnt/β‑catenin signaling pathway, potentially providing a new treatment for DPN.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"31 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative Care Consultation in the Intensive Care Unit Reduces Hospital Costs: A Cost-Analysis. 重症监护室的姑息治疗咨询降低了医院成本：成本分析。

IF 16.4 4区医学

Journal of Palliative Care Pub Date : 2025-01-01 Epub Date: 2022-04-26 DOI: 10.1177/08258597221095986

Tong Han Chung, Linh K Nguyen, Lincy S Lal, J Michael Swint, Yen-Chi L Le, Kathleen R Hanley, Efrain Siller, Cheryl M Chanaud

{"title":"Palliative Care Consultation in the Intensive Care Unit Reduces Hospital Costs: A Cost-Analysis.","authors":"Tong Han Chung, Linh K Nguyen, Lincy S Lal, J Michael Swint, Yen-Chi L Le, Kathleen R Hanley, Efrain Siller, Cheryl M Chanaud","doi":"10.1177/08258597221095986","DOIUrl":"10.1177/08258597221095986","url":null,"abstract":"Background: Palliative care aims to improve or maintain quality of life for patients with life-limiting or life-threatening diseases. Limited research shows that palliative care is associated with reduced intensive care unit length of stay and use of high-cost resources.Methods: This was an observational, non-experimental comparison group study on all patients 18 years or older admitted to any intensive care unit (ICU) at Memorial Hermann - Texas Medical Center for 7 to 30 days from August 2013 to December 2015. Length of stay (LOS) and hospital costs were compared between the treatment group of patients with palliative care in the ICU and the control group of patients with usual care in the ICU. To adjust for confounding of the palliative care consultation on LOS and hospital cost, an inverse probability of treatment weighted method was conducted. Generalized linear models using gamma distribution and log link were estimated. All costs were converted to 2015 US dollars.Results: Mean LOS was 13 days and mean total hospital costs were USD 58,378. In adjusted and weighted analysis, LOS for the treatment group was 8% longer compared to the control group. The mean total hospital cost was estimated to decrease by 21% for the treatment group versus the control group. We found a reduction of USD 33,783 in hospital costs per patient who died in the hospital and reduction of USD 9113 per patient discharged alive.Conclusion: Palliative care consultation was associated with a reduction in the total cost of hospital care for patients with life-limiting or life-threatening diseases.","PeriodicalId":51096,"journal":{"name":"Journal of Palliative Care","volume":"1 1","pages":"3-7"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45777617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review. 全球姑息镇静临床实践指南：系统回顾。

IF 16.4 4区医学

Journal of Palliative Care Pub Date : 2025-01-01 Epub Date: 2022-11-28 DOI: 10.1177/08258597221138674

Martyna Tomczyk, Cécile Jaques, Ralf J Jox

{"title":"Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review.","authors":"Martyna Tomczyk, Cécile Jaques, Ralf J Jox","doi":"10.1177/08258597221138674","DOIUrl":"10.1177/08258597221138674","url":null,"abstract":"Objective: The principal aim of this study was to identify, systematically and transparently, clinical practice guidelines (CPGs) on palliative sedation from around the world. Methods: A systematic search was performed using 5 databases, grey literature search tools, citation tracking, and contact with palliative care experts across the world. Current CPGs accredited by an international, national, or regional authority, published in English, German, French, or Italian, were subjected to content analysis. Results: In total, 35 CPGs from 14 countries and 1 international CPG were included in the analysis. The CPGs had diverse formal characteristics. Their thematic scope was difficult to analyze and compare because of differences in the terms and definitions of palliative sedation in those texts. We identified 3 main situations: (1) CPGs with a fully explicit thematic scope; (2) CPGs with a partially explicit thematic scope; and (3) CPGs without an explicit thematic scope. Several CPGs explicitly stated what forms of sedation were excluded from the text. However, this presentation was often confusing. Conclusion: Our review provides several pieces of information that could guide international reflections in this field, and be used to develop or update CPGs at all levels. Efforts should be made to clarify the thematic scope of each CPG on palliative sedation, in order to generate an understanding of the forms of this therapy addressed in the text.","PeriodicalId":51096,"journal":{"name":"Journal of Palliative Care","volume":" ","pages":"58-71"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10332571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practitioner Perspectives on Occupation-Based Practice Across Varied Settings. 从业者对不同环境下基于职业的实践的看法。

IF 16.4 4区医学

Otjr-Occupation Participation and Health Pub Date : 2025-01-01 Epub Date: 2024-02-09 DOI: 10.1177/15394492241226876

Ben D Lee, Nancy Bagatell, Monica K Ridlehoover, Jennifer Womack

引用次数: 0

Assessing Between- and Within-Person Reliabilities of Items and Scale for Daily Procrastination: A Multilevel and Dynamic Approach. 评估日常拖延症的项目和量表在人与人之间和人与人之间的可靠性：多层次动态方法。

IF 4.3 2区心理学

Assessment Pub Date : 2025-01-01 Epub Date: 2024-03-18 DOI: 10.1177/10731911241235467

Xiaohui Luo, Yueqin Hu, Hongyun Liu

{"title":"Assessing Between- and Within-Person Reliabilities of Items and Scale for Daily Procrastination: A Multilevel and Dynamic Approach.","authors":"Xiaohui Luo, Yueqin Hu, Hongyun Liu","doi":"10.1177/10731911241235467","DOIUrl":"10.1177/10731911241235467","url":null,"abstract":"Intensive longitudinal data (ILD) has been collected to capture the dynamic fluctuations of procrastination; however, researchers have typically measured daily procrastination by modifying trait measures (e.g., adding a time reference \"today\") without adequately testing their reliabilities. The main purpose of this study was to use an advanced approach, dynamic structural equation modeling, to assess the between- and within-person reliabilities of a widely used six-item measure of daily procrastination. A total of 252 participants completed retrospective measures of various types of trait procrastination and daily measures of procrastination over 34 consecutive days. The results showed that the entire scale for daily procrastination and five of its six items had high between- and within-person reliabilities, but one item had much lower reliabilities, suggesting that this item may be inappropriate in everyday contexts. Furthermore, we found moderate to strong associations between the latent trait factor of procrastination and trait measures of procrastination. In addition, we identified substantial between-person variation in person-specific reliabilities and explored its relevant factors. Overall, this study assessed the reliabilities of a daily measure of procrastination, which facilitated future studies to obtain more reliable and consistent results and to better estimate the reliability of ILD.","PeriodicalId":8577,"journal":{"name":"Assessment","volume":" ","pages":"61-76"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating the Sex Gap in Depression-Free Life Expectancy Among Widowed Americans Aged 50 and Older: An Application Using the Interpolated Markov Chain Approach. 估算 50 岁及以上丧偶美国人无抑郁症预期寿命的性别差距：使用插值马尔可夫链方法的应用。

IF 4.6 3区医学

Journal of Aging and Health Pub Date : 2025-01-01 Epub Date: 2024-02-21 DOI: 10.1177/08982643241233029

Alessandro Feraldi, Cristina Giudici, Nicolas Brouard

{"title":"Estimating the Sex Gap in Depression-Free Life Expectancy Among Widowed Americans Aged 50 and Older: An Application Using the Interpolated Markov Chain Approach.","authors":"Alessandro Feraldi, Cristina Giudici, Nicolas Brouard","doi":"10.1177/08982643241233029","DOIUrl":"10.1177/08982643241233029","url":null,"abstract":"Objectives: Using Interpolated Markov Chain software, we compare the length of life with and without depression among married individuals and widowers, and the related sex differences.Methods: We applied a multi-state life table approach to estimate depression-free life expectancy among recent cohorts of older married and widowed women and men in the United States, using data from the Health and Retirement Study over a 7-year period (2012-2018).Results: The study revealed that the difference in life expectancy between sexes widens in the context of widowhood. At age 50, the sex gap in depression-free life expectancy is 0.8 years among married people, whereas the gap almost doubles to 1.7 years among widowed people.Discussion: By quantifying disparities in the duration of life affected by depression between married and widowed women and men, policymakers could properly allocate resources specifically to address the mental health needs of these groups.","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":" ","pages":"117-130"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0