ACS Publications最新文献

{"title":"Bone-Targeting Antibodies for Skeletal Precision Therapy","authors":"Boyang Zhou,&nbsp;Han Xiao","doi":"10.1021/acs.bioconjchem.6c00415","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.6c00415","url":null,"abstract":"<p>Therapeutic antibodies have transformed the treatment of cancer, inflammation, infection, and disorders of bone biology by recognizing disease-associated molecular targets with high specificity. However, achieving therapeutically effective antibody concentrations at the site of disease remains a major challenge, as systemic administration does not inherently result in efficient tissue-specific delivery. Bone is a particularly demanding destination because mineralized matrix, limited vascular access, marrow complexity, and active remodeling can restrict local antibody exposure. Recent advances in bone-targeting antibody design point to a powerful reframing in which antibodies can be engineered not only for antigen specificity but also for tissue specificity. By attaching hydroxyapatite-binding motifs such as bisphosphonates or acidic peptides, antibodies can be endowed with bone-homing capabilities. The efficacy of this strategy has now been validated across multiple preclinical disease models, including breast cancer bone metastasis and osteoporosis-related bone loss. The next challenge is to define how affinity, valency, conjugation site, circulation time, and release should be tuned for each skeletal disease.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":"37 10","pages":"1943–1948"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid−Liquid Phase Separation-Controlled Polymorphism and Stoichiomorphism in the Pterostilbene-(E)-1,2-bis(pyridin-4-yl)ethene Cocrystal","authors":"Mythili Aruchamy,&nbsp;Srivaishnavi Devi Beetukooru,&nbsp;Sunil Kumar Nechipadappu,&nbsp;Sridhar Balasubramanian","doi":"10.1021/acs.cgd.6c00366","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c00366","url":null,"abstract":"<p>Liquid−liquid phase separation (LLPS) can severely hinder controlled nucleation and crystal growth during cocrystallization, restricting access to phase-pure polymorphs and stoichiomorphs. During the cocrystallization of the Pterostilbene-(E)-1,2-bis(pyridin-4-yl)ethene (PTB-BPE) system, LLPS emerged as a major experimental barrier to crystal development. In situ microscopic observations revealed that strong PTB-solvent interactions under specific solvent environments promoted LLPS, thereby suppressing nucleation and crystal growth. This limitation was overcome through mechanochemical crystallization approaches combined with the ability of BPE to form stabilizing O−H···N hydrogen bond interactions with PTB. Systematic solvent modulation afforded four crystalline phases of PTB-BPE: Form I (plate, PTB/BPE = 1:0.5), Form II (needle, PTB/BPE = 1:0.5), and Form III (block, PTB/BPE = 2:1) as polymorphic forms, while Form IV (rod, PTB/BPE = 1:1.5) represents a distinct stoichiomorph. Mechanical pretreatment followed by slow evaporation enabled the formation of multiple solid forms; other mechanochemical routes predominantly yielded Form III, and slurry conversion selectively produced bulk Form IV. Single-crystal X-ray diffraction confirmed differences in packing, symmetry, and asymmetric unit composition among the forms. Lattice energy calculations and void analysis indicate comparable thermodynamic stability among the polymorphs, with Form III exhibiting strong intermolecular interactions and efficient packing within the PTB-BPE solid-form landscape.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8068–8085"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Molecule Multifunctional Additive Enables Coupled Solvation and Interphase Engineering for Highly Reversible Zinc Anodes","authors":"Bei Yan,&nbsp;Yue Fei,&nbsp;Xiaoyu Xia,&nbsp;Yue Li,&nbsp;Yuxuan Wu,&nbsp;Hao Zhang,&nbsp;Ge Li","doi":"10.1021/acsami.6c09786","DOIUrl":"10.1021/acsami.6c09786","url":null,"abstract":"<p>Dendritic formation and parasitic interfacial reactions occurring on the zinc anode remains a major obstacle to the commercialization of aqueous zinc-ion batteries. Rational electrolyte additive design offers an effective route to move beyond single-function regulation toward synergistic multimechanism control. Compared to multicomponent systems, single-molecule additives with multiple functional groups enable integrated control over solvation structure and interfacial chemistry while reducing complexity and cost. Herein, the natural amino acid hydroxyproline (hyp) is introduced as a multifunctional electrolyte additive for simultaneous regulation of the Zn²⁺ solvation and interfacial chemistry. The −COOH and −OH groups reconstruct the solvation sheath and hydrogen-bond network, while the −NH− group promotes interfacial adsorption and induces a compact, N-rich interphase that homogenizes Zn²⁺ flux and suppresses dendrite growth. Benefiting from this cooperative solvation−interphase regulation, stable Zn plating/stripping is achieved for over 2000 h in Zn//Zn cells, an average coulombic efficiency of 99.79% is maintained over 1500 cycles in Zn//Cu cells, and Zn//LiFePO₄ full cells deliver a capacity of 154 mAh g⁻¹ over 500 cycles at 0.2 A g⁻¹. This work highlights single-molecule, multifunctional electrolyte additive engineering as a rational, scalable strategy for durable, safe aqueous zinc batteries.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56038–56047"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton-Exchange Surface Engineering Enables Air-Stable Sodium Layered Oxide Cathodes for Carbon-Neutral Energy Storage","authors":"Lin Huangfu,&nbsp;Le Tong,&nbsp;Yiming Zhang,&nbsp;Xing Shen,&nbsp;Xiaoping Jiang,&nbsp;Baihua Qu,&nbsp;Chaohe Xu,&nbsp;Jingfeng Wang","doi":"10.1021/acsami.6c16266","DOIUrl":"10.1021/acsami.6c16266","url":null,"abstract":"<p>O3-type layered oxides have emerged as one of the most promising cathode candidates for sodium-ion batteries, which are widely regarded as a key enabling technology for carbon-neutral grid-scale energy storage. However, their practical application is hindered by surface degradation upon air exposure and structural distortion from Mn³⁺. Herein, we develop a two-step surface engineering protocol that combines proton-exchange washing with a short postcalcination to treat O3-type cathodes. Proton-exchange treatment removes surface carbonates and oxidizes Mn³⁺ to widen the interlayers for enhanced Na⁺ diffusion and Jahn–Teller suppression, while the subsequent short calcination heals residual defects and locks in the refined structure. The optimally treated Na_0.82Cu_0.19Fe_0.39Mn_0.42O₂ cathode delivers a reversible capacity of 110.2 mAh g^–1 at 0.2 C with 92.3% retention after 100 cycles (substantially outperforming the pristine sample at 48.6%), while retaining its superior performance even after one month of air exposure. This cost‑effective and scalable surface engineering approach thus removes a critical industrial bottleneck for sodium‑ion batteries, marking a tangible step toward sustainable storage technologies for the zero‑carbon transition.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56192–56202"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149133988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy","authors":"Fei Xie,&nbsp;Lulu Feng,&nbsp;Yuting Wang,&nbsp;Chaofan Huang,&nbsp;Chenlong Wang,&nbsp;Chao Luo,&nbsp;Li Zhang,&nbsp;Congyong Sun,&nbsp;Qilong Wang","doi":"10.1021/acsami.6c14588","DOIUrl":"10.1021/acsami.6c14588","url":null,"abstract":"<p>Combining chemotherapy and immunotherapy shows great promise for treating esophageal squamous cell carcinoma (ESCC), but its effectiveness is hindered by the immunosuppressive tumor environment and challenges in drug delivery. Recent research has focused on cell membrane-coated nanoparticles for targeted drug delivery, leveraging their ability to evade the immune system while selectively targeting tumor cells. In this study, we developed a biomimetic hybrid nanoplatform based on cell membranes to combine molecular chemotherapy and improve the effectiveness of immunochemotherapy in treating ESCC. The nanoplatform is coated with a membrane fusion of activated neutrophils and ESCC cells and loaded with paclitaxel (PTX) and small interfering RNA targeting EFNA1 (siEFNA1), a molecule linked to ESCC metastasis. By exploiting the homologous targeting properties of ESCC cell membranes and the tumor-homing ability of neutrophil membranes, the platform effectively targets ESCC tissues and delivers siEFNA1 and PTX. This allows for a synergistic treatment approach, combining EFNA1 gene silencing with PTX-induced cytotoxicity to target ESCC more effectively. Crucially, the nanoplatform reprograms tumor-associated macrophages from the pro-tumor M2 phenotype to the anti-tumor M1 phenotype while boosting T cell-mediated cytotoxicity and remodeling the immunosuppressive tumor microenvironment. Overall, this strategy presents a promising approach for the targeted treatment of ESCC.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55910–55929"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Cofactor Recycling Electroenzymatic Platform for Endergonic CO2 Reduction","authors":"J. Shanthi Sravan,&nbsp;Hyeryeong Lee,&nbsp;Yuna Bang,&nbsp;Celine Imanuel Hermanto,&nbsp;In Seop Chang","doi":"10.1021/acsami.6c12368","DOIUrl":"10.1021/acsami.6c12368","url":null,"abstract":"<p>To overcome the thermodynamic barrier of “<em>NADH-dependent CO</em>_<em>2</em> <em>reduction</em>”, we developed a bioelectrosynthesis platform via the co-immobilization of CO₂ reductase (CR) and diaphorase (DP) on a graphite electrode. A strategic protein engineering approach, utilizing carbon-specific solid-binding peptides (SBPs), enabled oriented enzyme assembly to facilitate efficient interfacial electron transfer. Among the variants, the dual-functionalized system—comprising C-terminal SBP-fused CR and N-terminal ferredoxin (Fd)/SBP-fused DP3—exhibited superior bioelectrocatalytic synergy, achieving a current density of –193.35 µA cm^–2. At –0.5 V (vs Ag/AgCl), this integrated interface effectively drove the endergonic reduction process, maintaining continuous cofactor regeneration with an electron transfer efficiency of 39.2%.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56070–56080"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Polyacrylamide-Conjugated Boronic Acid Probes for Glycocalyx Labeling","authors":"Alexander B. Tuzikov,&nbsp;Eugenia M. Rapoport,&nbsp;Anna I. Astakhova,&nbsp;Ivan M. Ryzhov,&nbsp;Aleksey A. Moskovtsev,&nbsp;Nicolai V. Bovin","doi":"10.1021/acs.bioconjchem.6c00395","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.6c00395","url":null,"abstract":"<p>A polyacrylamide derivative of boric acid has been proposed for staining the cellular glycocalyx. Probes differing in their boric acid residue content and type of fluorescent label were obtained by conjugating fully activated polyacrylic acid with aminophenylboronic acid and amino derivatives of dyes. Maximal glycocalyx staining and, at the same time, minimal penetration inside the living cell were observed with a ∼20 kDa probe containing fluorescein and phenylboronic acid residues at a loading of 30 mol %. The patch-like staining reaches its maximum within a few minutes, is irreversible (the probe does not wash out of the glycocalyx), and partly differs from lectin staining.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":"37 10","pages":"2054–2061"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Driven Multiscale Design of Protein-Based Materials","authors":"Xinzhi Zhou,&nbsp;Chen Zhao,&nbsp;Qiang Zhang,&nbsp;Yuan Yao","doi":"10.1021/acs.bioconjchem.6c00309","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.6c00309","url":null,"abstract":"<p>Protein filaments, including silk, collagen, and amyloids, are natural building blocks whose hierarchical self-assembly produces adaptive mechanics and diverse functions. Conventional protein engineering has had limited success in resolving sequence-structure-function relationships across length scales. Recent advances in artificial intelligence (AI) now provide a framework for physics-informed multiscale design, from molecular motifs to functional macroscopic architectures. Machine-learning models can encode biophysical principles and guide the generation of protein-based materials. When combined with high-throughput experimentation, generative AI can integrate sequence design, structure prediction, and functional validation into closed-loop workflows. These workflows can accelerate the development of programmable biomaterials. This review summarizes AI-driven advances in protein-based materials and emerging links with autonomous robotics.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":"37 10","pages":"1917–1929"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Synergistic Approach Using a ROS-Responsive Lipid-Based Prodrug for Liposomal Delivery of Doxorubicin","authors":"Brooke E. Smith,&nbsp;Jinchao Lou,&nbsp;Miranda A. Phillips,&nbsp;Ruhani Sagar,&nbsp;Megan Qualls,&nbsp;Dillon P. McBee,&nbsp;Robert F. Turner,&nbsp;Mahbub Ullah,&nbsp;Joshua A. Baccile,&nbsp;Michael D. Best","doi":"10.1021/acs.bioconjchem.6c00165","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.6c00165","url":null,"abstract":"<p>Many clinically used chemotherapeutics, including doxorubicin, suffer from dose-limiting toxicities, poor biodistribution, and limited control over intracellular activation. To mitigate these challenges, two primary delivery strategies have been widely explored: prodrug design and liposomal encapsulation. Prodrugs can improve solubility, pharmacokinetics, and site-selective activation, while liposomes enhance circulation time and reduce off-target exposure. However, each approach presents limitations when employed independently. Prodrugs may introduce stability or solubility concerns and can undergo premature activation, whereas liposomal formulations often rely on passive release mechanisms and may exhibit incomplete or non-specific cargo leakage. In the current work, we sought to develop a synergistic delivery approach that integrates a chemically responsive prodrug directly within the liposomal membrane that responds to reactive oxygen species (ROS) highly upregulated within diseased cells. We report a ROS-responsive doxorubicin lipid prodrug conjugate, <strong>ROSDoxL</strong>, which is incorporated within the liposomal bilayer, enabling membrane-embedded therapeutic loading rather than aqueous core encapsulation. The prodrug design features a boronate caging group that undergoes oxidation in the presence of elevated reactive oxygen species, triggering a self-immolative release of doxorubicin. A non-responsive control doxorubicin lipid, <strong>DoxL</strong>, lacking the boronate moiety, was used to evaluate the specific ROS-mediated uncaging mechanism. ESI-HRMS studies confirmed ROS-dependent cleavage of <strong>ROSDoxL</strong>, while liposomal characterization and cellular studies demonstrated functional delivery and concentration-dependent cytotoxicity in A375 melanoma cells comparable to free doxorubicin. Our membrane-integrated liposomal prodrug approach provides a modular strategy for coupling disease-associated biochemical signals to controlled drug activation, advancing liposomal systems beyond passive carriers towards stimulus-responsive therapeutic delivery.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":"37 10","pages":"1975–1986"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligand-Induced Polyoxometalate Supramolecular Hybrids for Efficient Tetracycline Photodegradation","authors":"Ning Li,&nbsp;Xue-Yi Wang,&nbsp;Yu-Heng Liu,&nbsp;Dong-Dong Yang,&nbsp;Jin Zhang,&nbsp;Tai-Ran Wang,&nbsp;Yong-Xin Gu,&nbsp;Qiu-Yu Bao,&nbsp;Su-Fang Zhang","doi":"10.1021/acs.cgd.6c00719","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c00719","url":null,"abstract":"<p>The construction of efficient and durable photocatalysts for antibiotic elimination remains a formidable challenge. Herein, two novel polyoxometalate-based metal−organic complexes, [Zn₄(Hppb)₆(ppb)₂(H₂O)₂][PW₁₂O₄₀]₂·H₂O (<strong>1</strong>) and [Ni(Hppb)₂(H₂O)₂]₂[PW₁₂O₄₀]·COOH·4H₂O (<strong>2</strong>), were successfully synthesized via a hydrothermal method by incorporating Keggin-type [PW₁₂O₄₀]^3- polyanions and transition metal ions (Zn²⁺/Ni²⁺) with a rigid π-conjugated Hppb ligand (where Hppb = 2-(3-(pyridin-2-yl)-1<em>H</em>-pyrazol-1-yl)benzoate). Both compounds feature stable three-dimensional supramolecular architectures constructed through coordination bonds, C−H···O hydrogen bonds, and π−π interactions, which bridge the metal−organic units and polyoxoanions. The π-conjugated Hppb ligand facilitates light harvesting and charge transfer, while the synergistic cooperation between the metal−organic matrix and POM units endows the hybrids with excellent photocatalytic activity for tetracycline degradation under both visible and UV light. Under optimized visible light, <strong>1</strong> and <strong>2</strong> achieved high degradation efficiencies of 92.7% and 90.6% within 110 and 140 min, respectively; under UV light, the degradation proceeded more rapidly, with <strong>1</strong> and <strong>2</strong> attaining 93.8% and 89.7% degradation within just 80 and 100 min, respectively. Structure−activity and photoelectrochemical analyses reveal that <strong>1</strong> outperforms <strong>2</strong> due to its more favorable structural features and charge separation efficiency. EPR results, together with radical trapping experiments, identified ^•O₂⁻ as the dominant reactive species. Both catalysts exhibited good recyclability. This work provides a viable strategy for designing robust POM-based photocatalysts for antibiotic-contaminated water remediation.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8161–8172"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}