ACS Publications最新文献_第3页

Urinary Incontinence and Quality of Life: A Cross-Sectional Study. 尿失禁与生活质量：一项横断面研究

IF 16.4 4区医学

Otjr-Occupation Participation and Health Pub Date : 2025-01-01 Epub Date: 2024-06-08 DOI: 10.1177/15394492241256869

Tania L Shearon, Jeffrey L Alexander

引用次数: 0

Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review). 通过伴侣介导的自噬选择性降解蛋白质：对细胞稳态和疾病的影响（综述）。

IF 4.3 3区医学

Molecular medicine reports Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.3892/mmr.2024.13378

Jiahui Huang, Jiazhen Wang

{"title":"Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review).","authors":"Jiahui Huang, Jiazhen Wang","doi":"10.3892/mmr.2024.13378","DOIUrl":"10.3892/mmr.2024.13378","url":null,"abstract":"Cells rely on autophagy for the degradation and recycling of damaged proteins and organelles. Chaperone-mediated autophagy (CMA) is a selective process targeting proteins for degradation through the coordinated function of molecular chaperones and the lysosome‑associated membrane protein‑2A receptor (LAMP2A), pivotal in various cellular processes from signal transduction to the modulation of cellular responses under stress. In the present review, the intricate regulatory mechanisms of CMA were elucidated through multiple signaling pathways such as retinoic acid receptor (RAR)α, AMP‑activated protein kinase (AMPK), p38‑TEEB‑NLRP3, calcium signaling‑NFAT and PI3K/AKT, thereby expanding the current understanding of CMA regulation. A comprehensive exploration of CMA's versatile roles in cellular physiology were further provided, including its involvement in maintaining protein homeostasis, regulating ferroptosis, modulating metabolic diversity and influencing cell cycle and proliferation. Additionally, the impact of CMA on disease progression and therapeutic outcomes were highlighted, encompassing neurodegenerative disorders, cancer and various organ‑specific diseases. Therapeutic strategies targeting CMA, such as drug development and gene therapy were also proposed, providing valuable directions for future clinical research. By integrating recent research findings, the present review aimed to enhance the current understanding of cellular homeostasis processes and emphasize the potential of targeting CMA in therapeutic strategies for diseases marked by CMA dysfunction.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"31 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparison of Test-Retest Reliability and Practice Effects of Short Portable Mental State Questionnaire and Montreal Cognitive Assessment in Patients with Stroke. 脑卒中患者的便携式精神状态短问卷与蒙特利尔认知评估的测试-重测可靠性和实践效果比较。

IF 4.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-01-01 Epub Date: 2024-07-24 DOI: 10.1177/08919887241266793

Ta-Cheng Chen, Ya-Chen Lee, Yi-Ching Wang, Ton-Lin Hsieh, Mei-Hsiang Chen

{"title":"A Comparison of Test-Retest Reliability and Practice Effects of Short Portable Mental State Questionnaire and Montreal Cognitive Assessment in Patients with Stroke.","authors":"Ta-Cheng Chen, Ya-Chen Lee, Yi-Ching Wang, Ton-Lin Hsieh, Mei-Hsiang Chen","doi":"10.1177/08919887241266793","DOIUrl":"10.1177/08919887241266793","url":null,"abstract":"Objective: To compare the test-retest reliabilities and minimal detectable change (MDC) of the Short Portable Mental State Questionnaire (SPMSQ) and the Montreal Cognitive Assessment (MoCA) in patients with stroke.Methods: 63 patients were recruited from 1 medical center. The SPMSQ and MoCA were administered twice, 2 weeks apart.Results: Both measures showed high intraclass correlation coefficients (SPMSQ: 0.87; MoCA: 0.89) and acceptable MDC%s (SPMSQ: 14.8%; MoCA: 19.6%). A small correlation (r = 0.30) was found between the absolute difference and average in each pair of assessments in the SPMSQ, which was close to the criterion of heteroscedasticity. A small practice effect was observed in the MoCA (Cohen's d = 0.30).Conclusion: The SPMSQ demonstrated smaller random measurement error and an absence of practice effect. When comparing the psychometric properties of the SPMSQ and MoCA as outcome measures for assessing cognitive function in patients with stroke, the SPMSQ appears to be a more suitable choice than the MoCA.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"53-61"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parenting With and Beyond Cancer: A Photo-Elicitation Study. 与癌症为伴和超越癌症的父母：照片激发研究

IF 16.4 4区医学

Otjr-Occupation Participation and Health Pub Date : 2025-01-01 Epub Date: 2023-12-30 DOI: 10.1177/15394492231217746

Kara Glazer, Diya Wazirali, Laura Koszer, Benjamin Ezra Canter, Brianna Pinto, Laura Stursberg, Wendy J Coster, Robin Newman

引用次数: 0

Relatives' Unmet Needs in the Last Year of Life of Patients With Advanced Cancer: Results of a Dutch Prospective, Longitudinal Study (eQuiPe). 晚期癌症患者最后一年生活中亲属未满足的需求：荷兰前瞻性纵向研究（eQuiPe）的结果。

IF 16.4 4区医学

Journal of Palliative Care Pub Date : 2025-01-01 Epub Date: 2024-03-22 DOI: 10.1177/08258597241239614

Laurien Ham, Heidi P Fransen, Alexander de Graeff, Mathijs P Hendriks, Wouter K de Jong, Jeroen Kloover, Evelien Kuip, Caroline Mandigers, Dirkje Sommeijer, Lonneke van de Poll, Natasja Raijmakers, Lia van Zuylen

{"title":"Relatives' Unmet Needs in the Last Year of Life of Patients With Advanced Cancer: Results of a Dutch Prospective, Longitudinal Study (eQuiPe).","authors":"Laurien Ham, Heidi P Fransen, Alexander de Graeff, Mathijs P Hendriks, Wouter K de Jong, Jeroen Kloover, Evelien Kuip, Caroline Mandigers, Dirkje Sommeijer, Lonneke van de Poll, Natasja Raijmakers, Lia van Zuylen","doi":"10.1177/08258597241239614","DOIUrl":"10.1177/08258597241239614","url":null,"abstract":"Objective(s): Unmet needs of relatives of patients with advanced cancer not only reduce their own health-related quality of life, but may also negatively affect patients' health outcomes. The aim of this study was to assess changes in relatives' unmet needs of patients with advanced cancer in the last year of life and to identify differences in unmet needs by gender and type of relationship. Methods: Relatives of patients with advanced cancer in the Netherlands were included in a prospective, longitudinal, observational study. Relatives' unmet needs were measured every 3 months with an adapted version of the Problems and Needs in Palliative Care (PNPC) questionnaire Caregiver form (44 items, 12 domains). Questionnaires completed in the patients' last year of life were analyzed. Change of unmet needs in the last year, and differences in unmet needs by gender and type of relationship were analyzed. Results: A total of 409 relatives were included with a median of 4 unmet needs in the patient's last year. Unmet needs were most prevalent at all time points during the last year in the domains \"caring for the patient\" (highest need = 35%) and \"psychological issues\" (highest need = 40%). The number of unmet needs of relatives did not change significantly during the last year of life (P=.807). There were no significant differences in the number of unmet needs between male and female partners and between partners and other relatives. Conclusion: The most unmet needs for relatives were in the domains \"caring for the patient\" and \"psychological issues.\" Professional support should focus on these items. Within these domains, it seems especially important that relatives get more knowledge and support about what scenarios to expect and how to deal with them.","PeriodicalId":51096,"journal":{"name":"Journal of Palliative Care","volume":" ","pages":"41-50"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Overlap and High Heterogeneity Across Common Measures of Eating Disorder Pathology: A Content Analysis. 饮食失调症病理的通用测量方法存在低重叠和高异质性：内容分析

IF 4.3 2区心理学

Assessment Pub Date : 2025-01-01 Epub Date: 2024-03-22 DOI: 10.1177/10731911241238084

Kara A Christensen Pacella, Lidia Wossen, Kelsey E Hagan

引用次数: 0

The Association Between Timely Documentation of Advance Care Planning, Hospital Care Consumption and Place of Death: A Retrospective Cohort Study. 及时记录预先护理计划、医院护理消耗和死亡地点之间的关系：回顾性队列研究

IF 16.4 4区医学

Journal of Palliative Care Pub Date : 2025-01-01 Epub Date: 2024-09-30 DOI: 10.1177/08258597241275355

Carolien Burghout, Lenny M W Nahar-van Venrooij, Carin C D van der Rijt, Sascha R Bolt, Tineke J Smilde, Eveline J M Wouters

{"title":"The Association Between Timely Documentation of Advance Care Planning, Hospital Care Consumption and Place of Death: A Retrospective Cohort Study.","authors":"Carolien Burghout, Lenny M W Nahar-van Venrooij, Carin C D van der Rijt, Sascha R Bolt, Tineke J Smilde, Eveline J M Wouters","doi":"10.1177/08258597241275355","DOIUrl":"10.1177/08258597241275355","url":null,"abstract":"Objectives: (1) To describe ACPT implementation frequency in practice. (2) To assess associations of ACPT documentation with a) hospital care consumption, including systemic anti-tumor treatment in the last month(s) of life, and b) match between preferred and actual place of death, among oncology patients. Methods: A retrospective cohort study was performed. Data concerning ACPT documentation, hospital care consumption, and preferred and actual place of death were extracted from electronic patient records. Patients with completely documented ACPT (cACPT) and no ACPT were compared using multivariable logistic regression analyses. Results: ACPT was implemented in 64.5% (n = 793) of all deceased patients (n = 1230). In 17.6% (n = 216), preferred place of care or death was documented at least three months before death (cACPT). A cACPT was not associated with systemic anti-tumor treatment (Adjusted OR (AOR): 0.976; 95% CI: 0.642-1.483), but patients with cACPT had fewer diagnostic tests (AOR: 0.518; CI: 0.298-0.903) and less contacts with hospital disciplines (AOR: 0.545; CI: 0.338-0.877). In patients with cACPT, a match between preferred and actual place of death was found for 83% of the patients for whom the relevant information was available (n = 117/n = 141). In patients without ACPT, this information was mostly missing. Conclusion: Although the ACPT was implemented in two thirds of patients, timely documentation of preferred place of care or death is often missing. Yet, timely documentation of these preferences may promote out-hospital-death and save hospital care consumption.","PeriodicalId":51096,"journal":{"name":"Journal of Palliative Care","volume":" ","pages":"79-88"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Corrigendum] Tripartite motif‑containing 11 regulates the proliferation and apoptosis of breast cancer cells. [更正] 含三方图案的 11 调节乳腺癌细胞的增殖和凋亡。

IF 4.3 3区医学

Oncology reports Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.3892/or.2024.8838

Xianping Dai, Feng Geng, Mengshun Li, Ming Liu

{"title":"[Corrigendum] Tripartite motif‑containing 11 regulates the proliferation and apoptosis of breast cancer cells.","authors":"Xianping Dai, Feng Geng, Mengshun Li, Ming Liu","doi":"10.3892/or.2024.8838","DOIUrl":"10.3892/or.2024.8838","url":null,"abstract":"Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerning the flow cytometric plots shown in Fig. 5A and B on p. 2572, each figure part contained a pair of duplicated data panels; specifically, the panels depicting the 'NC/5‑FU' and the 'shTRIM11/Gemcitabine' experiments in Fig 5A (MCF‑7 cells), and the 'NC/Paclitaxel' and 'shTRIM11/Adriamycin' experi-ments in Fig. 5B (MDA‑MB‑231 cells), were apparently identical. The authors were able to re‑examine their original data files, and realize that this figure was inadverently assembled incorrectly. The revised version of Fig. 5, now showing the correct data for the 'shTRIM11/Gemcitabine' experiment in Fig 5A and the 'NC/Paclitaxel' experiment in Fig. 5B, is shown on the next page. Note that the revisions made to this figure do not affect the overall conclusions reported in the paper. The authors are grateful to the Editor of Oncology Reports for allowing them the opportunity to publish this Corrigendum, and apologize to the readership for any inconvenience caused. [Oncology Reports 41: 2567‑2574, 2019; DOI: 10.3892/or.2019.7015].","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"53 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Angioedema to Oral Doxycycline and Cross-Reactivity to Minocycline. 一例口服强力霉素引起的血管性水肿和米诺环素的交叉反应。

IF 4.6 4区医学

Annals of Pharmacotherapy Pub Date : 2025-01-01 Epub Date: 2024-05-14 DOI: 10.1177/10600280241252542

Jieun Yu, Da Woon Sim

引用次数: 0

The Impact of Palliative Care Consultation on Aggressive Medical Interventions in End-of-life Among Patients with Metastatic Breast Cancer: Insights from the U.S. National Patient Sample. 姑息治疗咨询对转移性乳腺癌患者临终前积极医疗干预的影响：来自美国全国患者样本的启示。

IF 16.4 4区医学

Journal of Palliative Care Pub Date : 2025-01-01 Epub Date: 2024-05-15 DOI: 10.1177/08258597241253933

Zidong Zhang, Alexandria Lovell, Divya S Subramaniam, Leslie Hinyard

{"title":"The Impact of Palliative Care Consultation on Aggressive Medical Interventions in End-of-life Among Patients with Metastatic Breast Cancer: Insights from the U.S. National Patient Sample.","authors":"Zidong Zhang, Alexandria Lovell, Divya S Subramaniam, Leslie Hinyard","doi":"10.1177/08258597241253933","DOIUrl":"10.1177/08258597241253933","url":null,"abstract":"Background: Advancement in treatment has led to prolonged survival and a rising number of women living with metastatic breast cancer (MBC) in the United States. Due to its high symptom burden, it is recommended that palliative care be integrated into the standard care to help improve quality of life. However, little is known about the use of palliative care among MBC patients in the nation.Objectives: To determine utilization of palliative care consult (PCC) after metastasis and the influence of PCC on healthcare utilization in the end of life among women living with MBC in the US.Methods: This retrospective cohort study examined a national electronic health record database to quantify the PCC use after metastasis diagnosis until death and the associations of PCC with Emergency Department (ED), Intensive Care Unit (ICU), and chemotherapies in the end-of-life women (age ≥ 18 years) living with MBC.Results: From a cohort of 2615 deceased MBC patients, 37% received PCC in the last 6 months of life. Patients who had received PCC in the end-of-life were more likely to be hospitalized, admitted to ED and ICU, and receive chemotherapies in the last 60 days before death. However, patients who had received end-of-life PCC had less hospital and ED visits and received less chemotherapies after PCC initiated.Conclusion: While PCC can reduce end-of-life aggressive interventions, it was underutilized among patients with MBC in the end-of-life. A myriad of clinical and patient factors may still challenge timely consultation. We urge for future endeavors in developing strategies to remove barriers in the implementation, especially earlier in the disease course, to assure timely PC treatments and reduce discomfort amid aggressive interventions for MBC.","PeriodicalId":51096,"journal":{"name":"Journal of Palliative Care","volume":" ","pages":"8-17"},"PeriodicalIF":16.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0