ACS Publications最新文献

{"title":"Correction to “Near Infrared-Activatable Methylene Blue Polypeptide Codelivery of the NO Prodrug via π–π Stacking for Cascade Reactive Oxygen Species Amplification-Mediated Photodynamic Therapy”","authors":"Yu Zhang, Peng Zhao, Xiaoai Chen, Chang Xu, Jingzhe Guo, Xiongwei Qu, Xiuli Hu, Hui Gao, Pingsheng Huang, Jimin Zhang","doi":"10.1021/acsami.6c19623","DOIUrl":"10.1021/acsami.6c19623","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56920–56924"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition and Correction to “Polymer Brush-Assisted Fabrication of Layered Metal Oxide Heterostructures for Future Electronic Device Applications”","authors":"Tandra Ghoshal, Sajan Singh, Hazel Neill, Farzan Gity, Joy Roy, Fernando Q. Borbon, Francisco Servando Aguirre-Tostado, Paul K. Hurley, Robert M. Wallace, Michael A. Morris","doi":"10.1021/acsami.6c19445","DOIUrl":"10.1021/acsami.6c19445","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56914–56915"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triaryl Imidazoles as a Hole-Transporting Interfacial Modifying Layer for Inverted Perovskite Solar Cells","authors":"Shakil N. Afraj,&nbsp;Xingnan Qi,&nbsp;Yu-Qi Li,&nbsp;Mohanapriya Subramani,&nbsp;Vishal Yeddu,&nbsp;Yameen Ahmed,&nbsp;Mohammed Misbah Uddin,&nbsp;Praveen B. Managutti,&nbsp;Bor Kae Chang,&nbsp;Ming-Chou Chen,&nbsp;Sergey Dayneko,&nbsp;Antoine Pavesic Junior,&nbsp;Makhsud I. Saidaminov,&nbsp;Ahmed L. Abdelhady","doi":"10.1021/acsami.6c17763","DOIUrl":"10.1021/acsami.6c17763","url":null,"abstract":"<p>The integration of hole-transporting organic interfacial modifying layers (OIMLs) into perovskite solar cells (PSCs) has attracted significant interest due to their ability to improve performance and stability. However, the development of cost-effective and straightforward methods for synthesizing OIMLs remains underexplored. In this work, we present the design and synthesis of two novel bromoaryl-substituted, imidazole-derived OIMLs: 2,4,5-tris(4-bromophenyl)-1<em>H</em>-imidazole (<strong>TPIM-Br</strong>) and 4,5-bis(4-bromophenyl)–2-(5-bromothiophen-2-yl)-1<em>H</em>-imidazole (<strong>DPIM-TBr</strong>). We investigated the thermal, optical, and electrochemical properties of the molecules, confirming their potential as OIMLs in PSCs. The computed energy levels and electrostatic surface potentials (ESPs) of these molecules were examined to elucidate the charge distribution and electron density within <strong>TPIM-Br</strong> and <strong>DPIM-TBr</strong>. Comprehensive characterization demonstrated that incorporation of the OIMLs enabled more efficient charge extraction and improved perovskite crystallinity. The champion device yielded <strong>25.85%</strong> power conversion efficiency for <strong>TPIM-Br</strong>, compared to the control's <strong>23.32%</strong>. This work presents a strategy to enhance the performance of inverted PSCs by incorporating OIMLs, offering a promising pathway for future developments in PSC technology.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56256–56265"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally Controllable Catalytic Environment Constructed by Lewis Acids Enables Highly Efficient and Stable Water Splitting","authors":"Yu Zhou,&nbsp;Min Ju,&nbsp;Kaining Shen,&nbsp;Chenxi Xu,&nbsp;Mei Hong,&nbsp;Shihe Yang","doi":"10.1021/acsami.6c16471","DOIUrl":"10.1021/acsami.6c16471","url":null,"abstract":"<p>Green hydrogen production from seawater electrolysis offers a promising route to harness intermittent renewable energy, particularly in resource-rich coastal regions. However, Cl^– in seawater triggers parasitic side reactions and corrosion, which degrade both the activity and durability of electrocatalysts and thus hinder the practical deployment of this technology. Here, a hard Lewis acid overlayer was constructed on the catalyst surface to promote water dissociation and accumulate in-situ generated OH^– in the vicinity of the active sites. Such locally generated alkalinity suppresses chlorine chemistry at the catalyst surface. Moreover, the strong affinity between the Lewis acid layer and OH^– limits the capture of hydroxide by Mg²⁺ and Ca²⁺ in bulk seawater, thereby alleviating precipitate formation. The Cr₂O₃(30)-NiMoO₄(10) catalyst exhibits exceptional hydrogen evolution reaction and oxygen evolution reaction activity, with overpotentials of 56 mV and 220 mV at 10 mA cm^–². The overall water splitting based on the catalysts for both electrodes reaches a low voltage of 1.72 [email protected] A cm^–².</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56236–56245"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable CVD Synthesis and Sulfur-Vacancy-Mediated Phase Transition of SnS2 and Sn2S3 Nanostructures","authors":"Ting Shu,&nbsp;Huafeng Wang,&nbsp;Juan Zhou,&nbsp;Xiongxiong Xue,&nbsp;Guolin Hao","doi":"10.1021/acs.cgd.6c01021","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c01021","url":null,"abstract":"<p>Tin-based sulfides have attracted considerable interest because of their distinctive electronic structures and promising optoelectronic, photovoltaic, electrochemical, and photocatalytic properties. However, the phase-controlled synthesis of tin sulfides remains challenging because competing Sn−S phases can readily form during growth. In addition, the thermodynamic and kinetic factors governing phase evolution among tin sulfides are still not fully understood, which limits rational phase engineering and device-oriented optimization. Here, we report a facile chemical vapor deposition strategy using fluorine-doped tin oxide as an in situ tin source for the controllable growth of large-area SnS₂ nanosheet arrays and Sn₂S₃ nanostructures. By tuning the growth temperature, sulfur precursor dosage, and reaction duration, SnS₂ nanosheets can be transformed into Sn₂S₃ under sulfur-deficient, high-temperature conditions. The optimized window for pure Sn₂S₃ formation is 525 °C, 50 mg sulfur precursor, and 10 min growth duration, under sulfur-deficient Ar/H₂ atmosphere. Comprehensive structural and chemical characterizations, together with Gibbs free-energy analysis and density functional theory calculations, suggest that sulfur vacancies play a key role in weakening Sn−S bonding and promoting lattice reconstruction. These results provide an experimentally accessible route for the phase-controlled synthesis of tin sulfides and offer mechanistic insight into vacancy-mediated phase transformation in two-dimensional metal chalcogenides.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8454–8463"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Flexible HOF with Reversible Structural Transformation for Selective Separation of Chlorobenzene from Chlorocyclohexane","authors":"Baiyang Fan,&nbsp;Quanhao Wei,&nbsp;He Zhao,&nbsp;Guiyan Liu,&nbsp;Pengchong Xue","doi":"10.1021/acs.cgd.6c00762","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c00762","url":null,"abstract":"<p>The separation of chlorobenzene (ClBz) and chlorocyclohexane (ClCy) represents a critical industrial challenge owing to their similar boiling points and polarities, which renders traditional distillation energy-intensive and inefficient. Herein, we report a novel flexible hydrogen-bonded organic framework (HOF), X−HOF−12, assembled from a non-planar tetracyano-functionalized 1,4-dihydropyrrolo[3,2-<em>b</em>]pyrrole building block (DPTCN). Single-crystal X-ray diffraction demonstrates that X−HOF−12 adopts a three-dimensional hydrogen-bonded network with penetrating channels, where guest ClBz molecules are stabilized by multiple C<span></span>N···Cl and C−H···π interactions. Upon thermal removal of ClBz, X−HOF−12 undergoes a reversible structural transformation to a dense, nonporous phase (X−HOF−12a). X−HOF−12a displays exceptional selective adsorption of ClBz over ClCy through a guest-responsive “open-gate” adsorption mechanism, and the purity of ClBz released from the HOF reaches 94.81%. Furthermore, the material preserves high selectivity and structural integrity over multiple adsorption−desorption cycles. This work not only offers a high-performance flexible HOF adsorbent for energy-efficient ClBz/ClCy separation but also provides a design principle for constructing guest-responsive porous materials for precise molecular separations.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8188–8194"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Pressure Regulation of Defect-Mediated Transport in Si-Doped β-Ga2O3 Homoepitaxial Films","authors":"Shujun Zhu,&nbsp;Dongyang Han,&nbsp;Shulin Hu,&nbsp;Fengquan Qiu,&nbsp;Ning Xia,&nbsp;Shen Hu,&nbsp;Li Ji,&nbsp;Tao Wu,&nbsp;Jichun Ye,&nbsp;Wenrui Zhang","doi":"10.1021/acs.cgd.6c00978","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c00978","url":null,"abstract":"<p>The electrical properties of Si-doped β-Ga₂O₃ homoepitaxial films are governed by the interaction between Si donor activation and native point defects formed during metal−organic chemical vapor deposition (MOCVD) growth. Although growth pressure directly affects precursor transport, boundary-layer evolution, gas-phase reactions, and surface kinetics, its role in regulating defect-mediated carrier transport remains insufficiently understood. Here, we systematically investigate the effect of the growth pressure on the structural, electrical, and defect properties of MOCVD-grown Si-doped β-Ga₂O₃ (100) homoepitaxial films. The film grown at 40 mbar exhibits a carrier concentration of 4.7 × 10¹⁷ cm⁻³ and a Hall mobility of 120.0 cm²/(V·s). As the growth pressure increases from 50 mbar to 80 mbar, the β-Ga₂O₃ films show a much lower dopant activation efficiency and lower Hall mobility. Combined temperature-dependent Hall, cathodoluminescence, and X-ray photoelectron spectroscopy analyses indicate that elevated pressure reduces the concentration of electrically active Si_Ga(I) donors, which dominates the decrease in carrier concentration, while increasing vacancy-related defects, including gallium-oxygen divacancy (V_Ga-V_O) complexes and oxygen vacancy (V_O)-related oxygen-deficient environments, which act as scattering centers and lower the mobility. Lateral MOSFETs fabricated on the film grown at 40 mbar achieve a drain on/off ratio above 10⁹, a specific on-resistance of 169.8 mΩ·cm², and a breakdown voltage exceeding 3 kV. This work reveals how growth pressure modulates the formation of native defects and defect-mediated carrier transport in Si-doped β-Ga₂O₃ homoepitaxy, providing mechanistic insight into developing high-mobility channel layers for β-Ga₂O₃ power devices.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8385–8392"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystal Structures of 1,3-Bis[thioxo-thiazolinyl]-/1,3-[oxo/thioxo-thiazolinyl] Aromatic Atropisomers with Two C(Aryl)−N(Heterocycle) Chiral Axes: An X-ray and DFT Analysis of Dispersion and Weak Chalcogen Interactions Governing Supramolecular Ordering","authors":"Marcel Mirel Popa,&nbsp;Andrei-Alunel Pătraşcu,&nbsp;Petru Filip,&nbsp;Anca Hîrtopeanu,&nbsp;Isabela-Costinela Man","doi":"10.1021/acs.cgd.6c00558","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c00558","url":null,"abstract":"<p>The crystal packing of five atropisomers with two C(aryl)-N(heterocyle) chiral axes, namely, four 1,3-bis[thioxo-thiazolinyl]- and one 1,3-[oxo/thioxo-thiazolinyl] aromatic compounds, was investigated by single-crystal X-ray diffraction. The aim is to establish the relevance of S···S/S···O chalcogen interactions and S···H weak hydrogen bonds in the crystalline network. The high number of alkyl substituents, together with hindered rotation about the C−N bonds, suggests that dispersion is the primary contributor to crystal cohesion. However, even weak, highly directional contacts such as C−H···S and S···S could be emphasized as significant forces in the crystalline supramolecular network. Chalcogen S···S/O<span></span>C synthon was identified as a pattern along the series of compounds, and replacing S···S<span></span>C with S···O<span></span>C confirmed the propensity of these chalcogen interactions, C<span></span>O being a stronger nucleophile. DFT, NBO, and QTAIM methods were used to define the type and features of the S···S/S···O interactions even at distances 10% beyond the sum of the Bondi van der Waals radii (ΣvdW). SAPT analysis revealed dispersion-driven interactions even when σ-hole interactions were geometrically within the chalcogen bond definition.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8086–8104"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CIRP: New Horizons for CNS Injury Biomarkers and Therapy","authors":"Na Lv,&nbsp;Hao Tian,&nbsp;Qiuyan Hao,&nbsp;Fengtang Yang,&nbsp;Hui Zhen,&nbsp;Zhonghong Cao","doi":"10.1021/acschemneuro.6c00414","DOIUrl":"https://doi.org/10.1021/acschemneuro.6c00414","url":null,"abstract":"<p>Cold-inducibleRNA-binding protein (CIRP) is a stress-responseprotein that protects cells under conditions of low temperature andother stresses. The expression of CIRP is induced by various stressors.CIRP regulates gene expression through complex, multi-layered mechanismsand plays a central role in physiological and pathological processes,including cell proliferation, apoptosis, inflammatory responses, andcircadian rhythms. In central nervous system (CNS) injuries, CIRPexhibits a dual role. Intracellular CIRP has a neuroprotective function.In contrast, when released into the extracellular space as eCIRP,it acts as a damage-associated molecular pattern (DAMP) that exacerbatesneuroinflammation. Serum levels of eCIRP are significantly elevatedin patients with CNS injuries, such as acute ischemic stroke and intracerebralhemorrhage, suggesting its potential as a biomarker for diagnosisand prognosis. Furthermore, targeting the eCIRP signaling pathwayhas shown significant therapeutic effects in various models of neurologicalinjury. Strategies include using inhibitory peptides like C23 andM3, as well as microRNA-based approaches. Here, we systematicallyreview the molecular characteristics, expression regulation, and biologicalfunctions of CIRP, with a focus on its neuroprotective role, biomarkerpotential, and therapeutic targeting in CNS injuries.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"17 20","pages":"3408–3420"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of NanoBRET Cellular Target Engagement Assays in Primary Neurons for Activating Mutants of p21-Activated Kinase 1","authors":"Jacob L. Capener,&nbsp;Abdiel Badillo-Martinez,&nbsp;Bassel Awada,&nbsp;Zachary W. Davis-Gilbert,&nbsp;Thomas W. Kramer,&nbsp;Cameron S. Blair,&nbsp;Frances M. Bashore,&nbsp;Hassan Al-Ali,&nbsp;Alison D. Axtman","doi":"10.1021/acschemneuro.6c00326","DOIUrl":"https://doi.org/10.1021/acschemneuro.6c00326","url":null,"abstract":"<p>The p21-activatedkinases (PAKs) are a group of serine-threoninekinases central to multiple signaling pathways that govern cell survivaland proliferation. Aberrant activity of PAK1, the most well characterizedmember of the PAK family, drives progression of several malignanciesand brain disorders, including Alzheimer’s disease and neurodevelopmentaldisorders. Despite growing interest in PAK1 as a drug target for thesediseases, there is no assay to evaluate the intracellular target engagementof PAK1 inhibitors. To address this need, we developed first-in-classNanoBRET assays for wild-type PAK1 and a neurodevelopmental disorder-causinggain-of-function PAK1 mutant. Furthermore, we executed our novel PAK1NanoBRET assay to evaluate target engagement of PAK1 inhibitors inprimary hippocampal neurons. To the best of our knowledge, this isthe first demonstration of a NanoBRET cellular target engagement assayin primary neurons, thereby increasing the relevance of our work byconfirming PAK1 inhibitor binding to the aberrant form of the proteinin cerebral cells.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"17 20","pages":"3441–3452"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}