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Quantifying the Heterointerface Contribution in a Cu7S4/CuCo2S4 Cathode with LiCl-All-Phenyl Complex Electrolyte for High-Performance Magnesium/Lithium Hybrid-Ion Batteries 高性能镁锂混合离子电池用LiCl-All-Phenyl络合电解质Cu7S4/CuCo2S4阴极异质界面贡献的定量研究
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-07 DOI: 10.1021/acsami.6c16394
Xuehui Wang, Guangwu Zhang, Kaifeng Huang, Xiang Fang, Cheng Wang, Haojun Xu, Chenchen Zhang, Xiaoya Wang, Qiye Zheng, Jinyun Liu
{"title":"Quantifying the Heterointerface Contribution in a Cu7S4/CuCo2S4 Cathode with LiCl-All-Phenyl Complex Electrolyte for High-Performance Magnesium/Lithium Hybrid-Ion Batteries","authors":"Xuehui Wang,&nbsp;Guangwu Zhang,&nbsp;Kaifeng Huang,&nbsp;Xiang Fang,&nbsp;Cheng Wang,&nbsp;Haojun Xu,&nbsp;Chenchen Zhang,&nbsp;Xiaoya Wang,&nbsp;Qiye Zheng,&nbsp;Jinyun Liu","doi":"10.1021/acsami.6c16394","DOIUrl":"10.1021/acsami.6c16394","url":null,"abstract":"<p>Heterostructured cathodes are widely credited with accelerating conversion kinetics in magnesium/lithium hybrid-ion batteries (MLHBs). Here, we construct a Cu<sub>7</sub>S<sub>4</sub>/CuCo<sub>2</sub>S<sub>4</sub> heterostructure in a single hydrothermal process, in which the two phases sharing a common Cu–S sublattice form a coherent interface within individual particles. By fixing the phase ratio independently through Rietveld refinement and benchmarking against both phase-pure constituents under identical conditions, we show that the composite exceeds the composition-weighted rule-of-mixtures prediction by a factor of 3.4 at 0.3 A g<sup>–1</sup>. Because the constituents exhibit closely comparable charge–discharge profiles, the redox chemistry itself is unchanged, and this strongly super-additive response can primarily originate from the interface rather than from composition. Elemental mapping and surface-sensitive XPS, together with the coexistence of Li<sub>2</sub>S and MgS in in situ XRD, further reveal that storage is spatially partitioned: Li<sup>+</sup> converts the particle interior while Mg<sup>2+</sup> reacts predominantly in the near-surface region, so that the two carriers occupy complementary regions of the same particle. Comparing APC-LiCl with APC-LiTFSI at matched salt concentration, and identical in every other respect, localizes the electrolyte effect to the electrode interface, where the chloride-containing system suppresses the progressive Mg-surface passivation that drives continuous overpotential growth in the TFSI<sup>–</sup> system. The resulting cell delivers 400 mAh g<sup>–1</sup> at 0.3 A g<sup>–1</sup> and retains 152.56 mAh g<sup>–1</sup> after 330 cycles at 1.0 A g<sup>–1</sup> at ∼100% Coulombic efficiency. DFT calculations indicate increased states near the Fermi level and a localized interfacial electrostatic gradient consistent with the measured kinetics.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56223–56235"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Near Infrared-Activatable Methylene Blue Polypeptide Codelivery of the NO Prodrug via π–π Stacking for Cascade Reactive Oxygen Species Amplification-Mediated Photodynamic Therapy” 修正“近红外活化亚甲基蓝多肽通过π-π堆叠协同递送NO前药用于级联活性氧扩增介导的光动力治疗”。
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-09 DOI: 10.1021/acsami.6c19623
Yu Zhang, Peng Zhao, Xiaoai Chen, Chang Xu, Jingzhe Guo, Xiongwei Qu, Xiuli Hu, Hui Gao, Pingsheng Huang, Jimin Zhang
{"title":"Correction to “Near Infrared-Activatable Methylene Blue Polypeptide Codelivery of the NO Prodrug via π–π Stacking for Cascade Reactive Oxygen Species Amplification-Mediated Photodynamic Therapy”","authors":"Yu Zhang,&nbsp;Peng Zhao,&nbsp;Xiaoai Chen,&nbsp;Chang Xu,&nbsp;Jingzhe Guo,&nbsp;Xiongwei Qu,&nbsp;Xiuli Hu,&nbsp;Hui Gao,&nbsp;Pingsheng Huang,&nbsp;Jimin Zhang","doi":"10.1021/acsami.6c19623","DOIUrl":"10.1021/acsami.6c19623","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56920–56924"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addition and Correction to “Polymer Brush-Assisted Fabrication of Layered Metal Oxide Heterostructures for Future Electronic Device Applications” 对“未来电子器件应用中层状金属氧化物异质结构的聚合物电刷辅助制造”的补充和修正。
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-09 DOI: 10.1021/acsami.6c19445
Tandra Ghoshal, Sajan Singh, Hazel Neill, Farzan Gity, Joy Roy, Fernando Q. Borbon, Francisco Servando Aguirre-Tostado, Paul K. Hurley, Robert M. Wallace, Michael A. Morris
{"title":"Addition and Correction to “Polymer Brush-Assisted Fabrication of Layered Metal Oxide Heterostructures for Future Electronic Device Applications”","authors":"Tandra Ghoshal,&nbsp;Sajan Singh,&nbsp;Hazel Neill,&nbsp;Farzan Gity,&nbsp;Joy Roy,&nbsp;Fernando Q. Borbon,&nbsp;Francisco Servando Aguirre-Tostado,&nbsp;Paul K. Hurley,&nbsp;Robert M. Wallace,&nbsp;Michael A. Morris","doi":"10.1021/acsami.6c19445","DOIUrl":"10.1021/acsami.6c19445","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56914–56915"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triaryl Imidazoles as a Hole-Transporting Interfacial Modifying Layer for Inverted Perovskite Solar Cells 三芳基咪唑作为倒钙钛矿太阳能电池的空穴传递界面修饰层
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c17763
Shakil N. Afraj, Xingnan Qi, Yu-Qi Li, Mohanapriya Subramani, Vishal Yeddu, Yameen Ahmed, Mohammed Misbah Uddin, Praveen B. Managutti, Bor Kae Chang, Ming-Chou Chen, Sergey Dayneko, Antoine Pavesic Junior, Makhsud I. Saidaminov, Ahmed L. Abdelhady
{"title":"Triaryl Imidazoles as a Hole-Transporting Interfacial Modifying Layer for Inverted Perovskite Solar Cells","authors":"Shakil N. Afraj,&nbsp;Xingnan Qi,&nbsp;Yu-Qi Li,&nbsp;Mohanapriya Subramani,&nbsp;Vishal Yeddu,&nbsp;Yameen Ahmed,&nbsp;Mohammed Misbah Uddin,&nbsp;Praveen B. Managutti,&nbsp;Bor Kae Chang,&nbsp;Ming-Chou Chen,&nbsp;Sergey Dayneko,&nbsp;Antoine Pavesic Junior,&nbsp;Makhsud I. Saidaminov,&nbsp;Ahmed L. Abdelhady","doi":"10.1021/acsami.6c17763","DOIUrl":"10.1021/acsami.6c17763","url":null,"abstract":"<p>The integration of hole-transporting organic interfacial modifying layers (OIMLs) into perovskite solar cells (PSCs) has attracted significant interest due to their ability to improve performance and stability. However, the development of cost-effective and straightforward methods for synthesizing OIMLs remains underexplored. In this work, we present the design and synthesis of two novel bromoaryl-substituted, imidazole-derived OIMLs: 2,4,5-tris(4-bromophenyl)-1<em>H</em>-imidazole (<strong>TPIM-Br</strong>) and 4,5-bis(4-bromophenyl)–2-(5-bromothiophen-2-yl)-1<em>H</em>-imidazole (<strong>DPIM-TBr</strong>). We investigated the thermal, optical, and electrochemical properties of the molecules, confirming their potential as OIMLs in PSCs. The computed energy levels and electrostatic surface potentials (ESPs) of these molecules were examined to elucidate the charge distribution and electron density within <strong>TPIM-Br</strong> and <strong>DPIM-TBr</strong>. Comprehensive characterization demonstrated that incorporation of the OIMLs enabled more efficient charge extraction and improved perovskite crystallinity. The champion device yielded <strong>25.85%</strong> power conversion efficiency for <strong>TPIM-Br</strong>, compared to the control's <strong>23.32%</strong>. This work presents a strategy to enhance the performance of inverted PSCs by incorporating OIMLs, offering a promising pathway for future developments in PSC technology.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56256–56265"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Locally Controllable Catalytic Environment Constructed by Lewis Acids Enables Highly Efficient and Stable Water Splitting 路易斯酸构建的局部可控催化环境实现了高效稳定的水裂解
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-12 DOI: 10.1021/acsami.6c16471
Yu Zhou, Min Ju, Kaining Shen, Chenxi Xu, Mei Hong, Shihe Yang
{"title":"Locally Controllable Catalytic Environment Constructed by Lewis Acids Enables Highly Efficient and Stable Water Splitting","authors":"Yu Zhou,&nbsp;Min Ju,&nbsp;Kaining Shen,&nbsp;Chenxi Xu,&nbsp;Mei Hong,&nbsp;Shihe Yang","doi":"10.1021/acsami.6c16471","DOIUrl":"10.1021/acsami.6c16471","url":null,"abstract":"<p>Green hydrogen production from seawater electrolysis offers a promising route to harness intermittent renewable energy, particularly in resource-rich coastal regions. However, Cl<sup>–</sup> in seawater triggers parasitic side reactions and corrosion, which degrade both the activity and durability of electrocatalysts and thus hinder the practical deployment of this technology. Here, a hard Lewis acid overlayer was constructed on the catalyst surface to promote water dissociation and accumulate in-situ generated OH<sup>–</sup> in the vicinity of the active sites. Such locally generated alkalinity suppresses chlorine chemistry at the catalyst surface. Moreover, the strong affinity between the Lewis acid layer and OH<sup>–</sup> limits the capture of hydroxide by Mg<sup>2+</sup> and Ca<sup>2+</sup> in bulk seawater, thereby alleviating precipitate formation. The Cr<sub>2</sub>O<sub>3</sub>(30)-NiMoO<sub>4</sub>(10) catalyst exhibits exceptional hydrogen evolution reaction and oxygen evolution reaction activity, with overpotentials of 56 mV and 220 mV at 10 mA cm<sup>–</sup><sup>2</sup>. The overall water splitting based on the catalysts for both electrodes reaches a low voltage of 1.72 [email protected] A cm<sup>–</sup><sup>2</sup>.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56236–56245"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recyclable Poly(urethane-urea) Covalent Adaptable Network Foams via Catalyst-, Isocyanate-, and Additive-Free Synthesis 通过催化剂,异氰酸酯和无添加剂合成可回收的聚(聚氨酯-尿素)共价自适应网络泡沫。
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-01 DOI: 10.1021/acsami.6c12906
Jihong Lyu, Chanyeong Jeong, Jun Young Jo, Nam Jung Heo, Young Il Park, Hyocheol Jung, Hyoung Eun Bae, Hiep Dinh Le, Young-Jae Jin, Ji-Eun Jeong, Jin Chul Kim
{"title":"Recyclable Poly(urethane-urea) Covalent Adaptable Network Foams via Catalyst-, Isocyanate-, and Additive-Free Synthesis","authors":"Jihong Lyu,&nbsp;Chanyeong Jeong,&nbsp;Jun Young Jo,&nbsp;Nam Jung Heo,&nbsp;Young Il Park,&nbsp;Hyocheol Jung,&nbsp;Hyoung Eun Bae,&nbsp;Hiep Dinh Le,&nbsp;Young-Jae Jin,&nbsp;Ji-Eun Jeong,&nbsp;Jin Chul Kim","doi":"10.1021/acsami.6c12906","DOIUrl":"10.1021/acsami.6c12906","url":null,"abstract":"<p>For decades, poly(urethane-urea) (PUU) foam production has relied on hazardous isocyanates and a complex array of external catalysts and blowing agents, resulting in chemically persistent materials that defy recycling. Herein, we break this convention by reporting the first-ever synthesis of high-performance PUU foams through an entirely autonomous, isocyanate-free, and additive-free pathway. By leveraging the ring-opening of thiazolidin-2-one with multifunctional amines, we establish a streamlined reaction that simultaneously constructs a covalent adaptable network (CAN) and triggers <em>in situ</em> CO<sub>2</sub> evolution. This chemistry bypasses traditional reagents; instead, internal thiol groups react with ethylene carbonate to drive foaming under entirely catalyst-free conditions. By precisely tuning the tris(2-aminoethyl)amine ratio, we synchronize gas expansion with matrix vitrification, overcoming the structural collapse typical of nontraditional systems. The resulting foams feature hindered urea linkages that impart dissociative CAN behavior, enabling full chemical reprocessability and structural recovery over multiple cycles without compromising mechanical integrity. With an open-cell architecture and acoustic performance comparable to those of the tested commercial reference materials under the present measurement conditions, this work provides a promising strategy for designing circular cellular materials that contribute to a zero-waste chemical economy.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56092–56104"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Core-Shell Microneedle Patches Co-Loaded with Gymnema Sylvestre Extract and IL-4 Accelerate Diabetic Wound Repair via Inflammatory Microenvironment Remodeling 木藤提取物和IL-4共同负载的核壳微针贴片通过炎症微环境重塑加速糖尿病伤口修复。
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-08 DOI: 10.1021/acsami.6c14857
Jingye Yao, Qingrong Zhang, Mengnan Zhang, Zhao Zhou, Shentian Zou, Shixuan Chen, Yuhui Cai, Yi Zhang
{"title":"Core-Shell Microneedle Patches Co-Loaded with Gymnema Sylvestre Extract and IL-4 Accelerate Diabetic Wound Repair via Inflammatory Microenvironment Remodeling","authors":"Jingye Yao,&nbsp;Qingrong Zhang,&nbsp;Mengnan Zhang,&nbsp;Zhao Zhou,&nbsp;Shentian Zou,&nbsp;Shixuan Chen,&nbsp;Yuhui Cai,&nbsp;Yi Zhang","doi":"10.1021/acsami.6c14857","DOIUrl":"10.1021/acsami.6c14857","url":null,"abstract":"<p>Chronic wound healing remains a persistent challenge clinically, particularly in diabetic wounds, where hyperglycemia drives sustained activation of the AGE–RAGE-associated signaling within the wound bed, precipitating excessive ROS generation and persistent inflammation that together stall tissue repair and erode quality of life. To address this, we developed a core–shell microneedle (GS + IL-4@MN) patch loading Gymnema sylvestre (GS) extract and interleukin-4 (IL-4) as a promising therapeutic strategy. The patch comprised a 10 × 10 array of conical needles and the optimized shell-loading concentration of GS was determined to be 1.0 mg/mL. The GS-loaded outer shell can suppress the release of pro-inflammatory mediators, scavenge ROS, and strengthen antioxidant defenses, thereby attenuating local inflammation; the IL-4-encapsulated core induces macrophage polarization toward the M2 phenotype, mitigates the pro-inflammatory microenvironment, and modulates T-cell immunity, while enhancing cellular proliferation and migration to support tissue regeneration. In diabetic wound models, GS + IL-4@MN achieved wound-closure rates of 64.72 ± 6.3% at day 3 and 85.80 ± 3.6% at day 7, and re-epithelialization reached 91.52 ± 2.1% by day 14. Moreover, collagen deposition increased to 79.38 ± 4.3%, CD31-positive neovascularization reached 70.50 ± 3.7%, and the M1/M2 ratio decreased to 0.3, indicating marked inflammatory resolution and regenerative activation. In summary, this core–shell MN system achieves multidimensional regulation of the pathological microenvironment of diabetic wounds through a dual mechanism: outer-layer inflammatory suppression and inner-layer microenvironment reset, and offers a new avenue for promoting diabetic wound healing.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55930–55945"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BODIPY-Based Fluorescent Probes for Selected Hazardous Chemicals: Multilevel Regulation of Sensing Performance 基于bodipy的荧光探针用于选定的危险化学品:传感性能的多级调节
IF 7.8 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2026-10-21 Epub Date: 2026-10-10 DOI: 10.1021/acsami.6c17906
Gege Wang, Min Qiao, Yujia Li, Yuyang Chen, Deqing Baima, Qi Zhang, Liping Ding, Xiaolin Zhu, Yu Fang
{"title":"BODIPY-Based Fluorescent Probes for Selected Hazardous Chemicals: Multilevel Regulation of Sensing Performance","authors":"Gege Wang,&nbsp;Min Qiao,&nbsp;Yujia Li,&nbsp;Yuyang Chen,&nbsp;Deqing Baima,&nbsp;Qi Zhang,&nbsp;Liping Ding,&nbsp;Xiaolin Zhu,&nbsp;Yu Fang","doi":"10.1021/acsami.6c17906","DOIUrl":"10.1021/acsami.6c17906","url":null,"abstract":"<p>The rapid and reliable detection of hazardous chemicals in complex environments remains an important challenge in fluorescence sensing. BODIPY dyes and related boron-difluoride fluorophores have attracted considerable attention because of their excellent photophysical properties and highly tunable molecular structures. However, sensing performance depends not only on analyte recognition but also on excited-state processes, intermolecular interactions, aggregation behavior, analyte transport, and practical signal readout. This review examines BODIPY-based fluorescent sensing of selected hazardous chemicals at the molecular level, supramolecular and aggregated-state level, and sensing material and device level, focusing on how regulation at different levels addresses different performance limitations. At the molecular level, recognition unit design, conformational regulation, and boron-center transformation regulate analyte recognition and signal transduction. At the supramolecular and aggregated-state level, noncovalent interactions, aggregation-state regulation, and molecular packing influence emission behavior and signal stability. At the sensing material and device level, interfacial and transport regulation, sensing material construction, and device integration and signal readout improve analyte accessibility and practical detection performance. This review provides a systematic framework for understanding the factors that govern BODIPY-based fluorescence sensing. This multilevel classification facilitates the identification of major factors limiting sensing performance and the corresponding regulation strategies, thereby providing guidance for the rational design and optimization of BODIPY-based fluorescent sensing systems.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55735–55752"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serotonin Neurobiology and Artificial Intelligence-Driven Biomarker Detection in Affective Disorders: A Comprehensive Review 情感障碍中血清素神经生物学和人工智能驱动的生物标志物检测:综合综述
IF 4.5 3区 医学
ACS Chemical Neuroscience Pub Date : 2026-10-21 Epub Date: 2026-09-09 DOI: 10.1021/acschemneuro.6c00406
Madiha Farooqui, Minha Fatima, Sameer Khan, Saumitra Singh, Furqan Choudhary, Tabinda Farooq, Anish Murtaja Alam Khan, Maryam Sarwat, Humaira Farooqi
{"title":"Serotonin Neurobiology and Artificial Intelligence-Driven Biomarker Detection in Affective Disorders: A Comprehensive Review","authors":"Madiha Farooqui,&nbsp;Minha Fatima,&nbsp;Sameer Khan,&nbsp;Saumitra Singh,&nbsp;Furqan Choudhary,&nbsp;Tabinda Farooq,&nbsp;Anish Murtaja Alam Khan,&nbsp;Maryam Sarwat,&nbsp;Humaira Farooqi","doi":"10.1021/acschemneuro.6c00406","DOIUrl":"https://doi.org/10.1021/acschemneuro.6c00406","url":null,"abstract":"<p>Affective disorders, including major depressive disorder(MDD)and generalized anxiety disorder (GAD), impose a major global healthburden because of their high prevalence, early onset, disability,and substantial social and economic impacts. Diagnosis remains challengingbecause it relies largely on subjective clinical assessment and symptom-basedcriteria, which often delay recognition and contribute to heterogeneoustreatment response. Serotonin (5-hydroxytryptamine, 5-HT) has longbeen central to the understanding of these disorders, but the classicalserotonin hypothesis has evolved into a broader systems-level frameworkin which serotonergic dysfunction is linked with neurotransmission,receptor signaling, transporter regulation, neuroplasticity, endocrinebalance, immune modulation, circadian rhythm control, and gut-braincommunication. Serotonin biosynthesis, metabolism, and compartmentalizationare tightly regulated, and variation in the serotonin transporterand related pathways influences vulnerability to disease, symptomexpression, and response to therapy. Although serotonin-targeted pharmacotherapyremains foundational, its delayed and variable clinical effects highlightthe need for objective biomarkers and more-precise monitoring strategies.This Review gives a comprehensive overview of serotonin neurobiologyin affective disorders and the therapeutic implications of serotonergicdysregulation. It discusses the current understanding of serotoninsynthesis, receptor heterogeneity, transporter function, and broadersystem interactions that shape mood, stress responsivity, and treatmentoutcomes. The Review also examines the growing role of artificialintelligence in psychiatric biomarker discovery, including machinelearning and deep learning approaches applied to neuroimaging, electrophysiology,physiological signals, and language-based data for improved diagnosisand prediction of antidepressant responses. In addition, emergingserotonin-specific biosensors are discussed as promising tools forreal-time, noninvasive neurochemical monitoring. By integrating mechanisticinsights into serotonin biology with AI-based analytics and biosensingtechnologies, this Review highlights a pathway toward more objective,personalized, and effective management of affective disorders.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"17 20","pages":"3388–3407"},"PeriodicalIF":4.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Robust Co(II)-Based MOF for Highly Selective and Efficient Adsorption of Congo Red Dye 高选择性高效吸附刚果红染料的Co(II)基MOF
IF 3.6 2区 化学
Crystal Growth & Design Pub Date : 2026-10-21 Epub Date: 2026-10-05 DOI: 10.1021/acs.cgd.6c00282
Huan Wu, Yinna Xu, Aparna Kushwaha, Jinmei Wang, Jun Wang, Shreya Srivastava, Mohd. Muddassir, Jiefeng Huang, Ying Pan, Abhinav Kumar
{"title":"A Robust Co(II)-Based MOF for Highly Selective and Efficient Adsorption of Congo Red Dye","authors":"Huan Wu,&nbsp;Yinna Xu,&nbsp;Aparna Kushwaha,&nbsp;Jinmei Wang,&nbsp;Jun Wang,&nbsp;Shreya Srivastava,&nbsp;Mohd. Muddassir,&nbsp;Jiefeng Huang,&nbsp;Ying Pan,&nbsp;Abhinav Kumar","doi":"10.1021/acs.cgd.6c00282","DOIUrl":"https://doi.org/10.1021/acs.cgd.6c00282","url":null,"abstract":"<p>A new heteroleptic Co(II)-based metal−organic framework (MOF), {[Co<sub>2</sub>(L)(bib)<sub>1.5</sub>(H<sub>2</sub>O)]·2H<sub>2</sub>O}<sub><em>n</em></sub> (<strong>1</strong>), is synthesized using 5,5′-(1,3-phenylenebis(methyleneoxy)diisophthalate) (H<sub>4</sub>L) and 4,4′-bis(imidazolyl)biphenyl (bib) as structurally complementary linkers and characterized. The structural analysis reveals that <strong>1</strong> adopts a robust 2-fold interpenetrated 3D framework with a (4,6)-connected fsc topology, whose highly interlocked architecture contributes to structural stability in aqueous media. The flexible <em>V</em>-shaped polycarboxylate ligand promotes extended connectivity, while the rigid nitrogen-rich biphenyl-imidazole linker enhances framework stability <em>via</em> strong coordination and π···π stacking interactions. Adsorption studies demonstrate that MOF <strong>1</strong> exhibits remarkable selectivity and efficiency toward the anionic dye Congo Red (CR), achieving 99.55% removal and a maximum adsorption capacity (<em>q</em><sub>max</sub>) of 5529 mg·g<sup>−1</sup> at 20 °C under mild conditions. Dosage optimization identifies 9 mg of MOF <strong>1</strong> as optimal, providing 98.94% removal and 5496 mg·g<sup>−1</sup> capacity under near-ambient conditions. pH-dependent studies show maximum uptake at pH 6, where electrostatic attraction, hydrogen bonding, and framework integrity act synergistically. Furthermore, MOF <strong>1</strong> maintains a high recovery efficiency of 87.50% over multiple cycles. The material retains an appreciable adsorption performance over repeated cycles, although some loss in capacity occurs during successive adsorption−desorption treatments. The combination of high adsorption capacity, rapid dye removal, and structural stability positions MOF <strong>1</strong> as a promising candidate for sustainable wastewater dye remediation.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"26 20","pages":"8043–8057"},"PeriodicalIF":3.6,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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