Martin Hébert, Gabriel Bellavance and Louis Barriault*,
{"title":"","authors":"Martin Hébert, Gabriel Bellavance and Louis Barriault*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 26","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c01012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kanga Marius N'Gatta, Edja Florentin Assanvo, Joelle El Hayek, Nathalie Masquelez, Pelagie Kamgang Syapnjeu, Stefano Deabate, Valérie Bonniol, Laurence Soussan, Camilo Zamora-Ledezma, Jeevithan Elango, Valérie Flaud, David Boa, Chrystelle Salameh
{"title":"3D-Printed Polycaprolactone Scaffolds Reinforced with Cellulose Nanocrystals and Silver Nanoparticles for Bone Tissue Engineering.","authors":"Kanga Marius N'Gatta, Edja Florentin Assanvo, Joelle El Hayek, Nathalie Masquelez, Pelagie Kamgang Syapnjeu, Stefano Deabate, Valérie Bonniol, Laurence Soussan, Camilo Zamora-Ledezma, Jeevithan Elango, Valérie Flaud, David Boa, Chrystelle Salameh","doi":"10.1021/acsami.5c06504","DOIUrl":"https://doi.org/10.1021/acsami.5c06504","url":null,"abstract":"<p><p>Cellulose nanocrystals (CNC) have garnered significant attention in pharmaceutical and medical applications due to their biocompatibility, biodegradability, renewability, and strong surface reactivity. In this study, we designed 3D-printed bioactive composite scaffolds via fused deposition modeling (FDM), incorporating polycaprolactone (PCL), CNC derived from Ficus thonningii bark, and silver nanoparticles (AgNps) synthesized through <i>in situ</i> reduction of silver nitrate AgNO<sub>3</sub>. Energy-dispersive X-ray spectroscopy (EDX) confirmed AgNps incorporation, while scanning electron microscopy (SEM) revealed a highly porous, interconnected structure. The inclusion of CNC and AgNps enhanced PCL's biodegradability, hydrophilicity, and hydroxyapatite nucleation, all crucial for osteoconductivity. The scaffolds demonstrated mechanical properties suitable for bone regeneration, effective antibacterial activity against <i>Escherichia coli</i>, and cytocompatibility with Mesenchymal Stem Cells (MSCs). These findings highlight the potential of PCL/CNCx/AgNps scaffolds as advanced biomaterials for bone tissue engineering, since they offer enhanced resorbability, antibacterial protection, and structural adaptability.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi-Tzai Chen, Rui Qi, Ang Cai, Bongsup P Cho, Deyu Li
{"title":"Conformation-Dependent Lesion Bypass and Mutagenicity of Bulky 2-Acetylaminofluorene-Guanine DNA Adduct in Epigenetically Relevant Sequence Contexts.","authors":"Yi-Tzai Chen, Rui Qi, Ang Cai, Bongsup P Cho, Deyu Li","doi":"10.1021/acs.chemrestox.5c00055","DOIUrl":"https://doi.org/10.1021/acs.chemrestox.5c00055","url":null,"abstract":"<p><p>DNA base cytosine can be modified epigenetically by adding a methyl group to form 5-methylcytosine (5mC). 5mC in DNA CpG islands plays a crucial role in mammalian cell development and epigenetic regulation. While 5mC does not block DNA replication and is not mutagenic, the biological consequences of 5mC affecting the flanking guanine with a bulky modification during DNA replication are not well understood. This paper examined the lesion bypass and mutagenicity of the 2-acetylaminofluorene-modified guanine DNA adduct (dG-AAF) in epigenetically relevant sequence contexts in <i>Escherichia coli</i>. The C/5mC context exhibited significantly different bypass and mutagenicity profiles for dG-AAF. The biological outcomes also varied depending on the nature of the 3' flanking base and the lesion bulkiness. In addition, we extensively observed a unique type of -1 G deletion when the lesion was flanked by 3' purines, possibly due to the formation of a stacked slipped mutagenic intermediate. However, there was no such deletion with 3' pyrimidines. Our findings provide a new perspective on the role of epigenetic markers in DNA replication and could help to develop methods to identify mutation patterns associated with specific mutational signatures or spectra in cancer.</p>","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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