Photochemical & Photobiological Sciences最新文献_第8页

Role of Histidine 310 in Amydetes vivianii firefly luciferase pH and metal sensitivities and improvement of its color tuning properties 组氨酸 310 在 Amydetes vivianii 萤火虫荧光素酶 pH 值和金属敏感性中的作用及其颜色调节特性的改进

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-05-01 DOI: 10.1007/s43630-024-00570-1

Gabriel F. Pelentir, Atílio Tomazini, Vanessa R. Bevilaqua, Vadim R. Viviani

{"title":"Role of Histidine 310 in Amydetes vivianii firefly luciferase pH and metal sensitivities and improvement of its color tuning properties","authors":"Gabriel F. Pelentir, Atílio Tomazini, Vanessa R. Bevilaqua, Vadim R. Viviani","doi":"10.1007/s43630-024-00570-1","DOIUrl":"https://doi.org/10.1007/s43630-024-00570-1","url":null,"abstract":"Firefly luciferases emit yellow-green light and are pH-sensitive, changing the bioluminescence color to red in the presence of heavy metals, acidic pH and high temperatures. These pH and metal-sensitivities have been recently harnessed for intracellular pH indication and toxic metal biosensing. However, whereas the structure of the pH sensor and the metal binding site, which consists mainly of two salt bridges that close the active site (E311/R337 and H310/E354), has been identified, the specific role of residue H310 in pH and metal sensing is still under debate. The Amydetes vivianii firefly luciferase has one of the lowest pH sensitivities among the group of pH-sensitive firefly luciferases, displaying high bioluminescent activity and special spectral selectivity for cadmium and mercury, which makes it a promising analytical reagent. Using site-directed mutagenesis, we have investigated in detail the role of residue H310 on pH and metal sensitivity in this luciferase. Negatively charged residues at position 310 increase the pH sensitivity and metal sensitivity; H310G considerably increases the size of the cavity, severely impacting the activity, H310R closes the cavity, and H310F considerably decreases both pH and metal sensitivities. However, no substitution completely abolished pH and metal sensitivities. The results indicate that the presence of negatively charged and basic side chains at position 310 is important for pH sensitivity and metals coordination, but not essential, indicating that the remaining side chains of E311 and E354 may still coordinate some metals in this site. Furthermore, a metal binding site search predicted that H310 mutations decrease the affinity mainly for Zn, Ni and Hg but less for Cd, and revealed the possible existence of additional binding sites for Zn, Ni and Hg.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140839478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectral changes of light-harvesting complex 2 lacking B800 bacteriochlorophyll a under neutral pH conditions. 在中性 pH 值条件下，缺乏 B800 细菌叶绿素 a 的采光复合物 2 的光谱变化。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-05-01 Epub Date: 2024-04-02 DOI: 10.1007/s43630-024-00560-3

Shota Kawato, Shinichi Sato, Hirotaka Kitoh-Nishioka, Yoshitaka Saga

{"title":"Spectral changes of light-harvesting complex 2 lacking B800 bacteriochlorophyll a under neutral pH conditions.","authors":"Shota Kawato, Shinichi Sato, Hirotaka Kitoh-Nishioka, Yoshitaka Saga","doi":"10.1007/s43630-024-00560-3","DOIUrl":"10.1007/s43630-024-00560-3","url":null,"abstract":"Exchange of B800 bacteriochlorophyll (BChl) a in light-harvesting complex 2 (LH2) is promising for a better understanding of the mechanism on intracomplex excitation energy transfer of this protein. Structural and spectroscopic properties of LH2 lacking B800 BChl a (B800-depleted LH2), which is an important intermediate protein in the B800 exchange, will be useful to tackle the energy transfer mechanism in LH2 by the B800 exchange strategy. In this study, we report a unique spectral change of B800-depleted LH2, in which the Qy absorption band of B800 BChl a is automatically recovered under neutral pH conditions. This spectral change was facilitated by factors for destabilization of LH2, namely, a detergent, lauryl dimethylamine N-oxide, and an increase in temperature. Spectral analyses in the preparation of an LH2 variant denoted as B800-recovered LH2 indicated that most BChl a that was released by decomposition of part of B800-depleted LH2 was a source of the production of B800-recovered LH2. Characterization of purified B800-recovered LH2 demonstrated that its spectroscopic and structural features was quite similar to those of native LH2. The current results indicate that the recovery of the B800 Qy band of B800-depleted LH2 originates from the combination of decomposition of part of B800-depleted LH2 and in situ reconstitution of BChl a into the B800 binding pockets of residual B800-depleted LH2, resulting in the formation of stable B800-recovered LH2.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140333965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fagopyrin F fraction from Fagopyrum tataricum demonstrates photodynamic inactivation of skin infecting bacterium and squamous cell carcinoma (A431) cells. 从鞑靼法葛中提取的法葛素 F 部分对皮肤感染细菌和鳞状细胞癌（A431）细胞具有光动力灭活作用。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-05-01 Epub Date: 2024-05-16 DOI: 10.1007/s43630-024-00571-0

K Merin Rinky, D Gayathri Devi, V K Priya

{"title":"Fagopyrin F fraction from Fagopyrum tataricum demonstrates photodynamic inactivation of skin infecting bacterium and squamous cell carcinoma (A431) cells.","authors":"K Merin Rinky, D Gayathri Devi, V K Priya","doi":"10.1007/s43630-024-00571-0","DOIUrl":"10.1007/s43630-024-00571-0","url":null,"abstract":"Photodynamic therapy (PDT) stands out as a noteworthy development as an alternative targeted treatment against skin ailments. While PDT has advanced significantly, research into photo-activatable \"Green drugs\" derived from plants which are less toxic than the synthetic drugs has not kept pace. This study investigates the potential of Fagopyrin F Containing Fraction (FCF) derived from Fagopyrum tataricum in mediating PDT against Staphylococcus aureus and skin cancer cells (A431). FCF was isolated from the plant extract using thin-layer chromatography, followed by identification of the compound through high-performance liquid chromatography and high-resolution liquid chromatography-mass spectrometry. FCF was tested to determine its antibacterial and anticancer efficacy. Results revealed that FCF-mediated PDT exhibited potent action against S. aureus, significantly reducing bacterial viability (MIC 19.5 μg/100 μL). Moreover, FCF-mediated PDT showed good efficacy against A431 cells, resulting in a notable reduction in cell viability (IC50 29.08 μg/mL). Given the known association between S. aureus and squamous cell carcinoma (SCC), FCF shows the potential to effectively target and eradicate both SCC and the related S. aureus present within the lesions. In silico study reveals that Fagopyrin F effectively binds with the epidermal growth factor (EGFR), one among the highly expressed proteins in the A431 cells, with a binding energy of - 9.6 kcal/mol. The affinity of Fagopyrin F for EGFR on A431 cancer cells along with its cytotoxicity against skin cancer cells while safeguarding the normal cells (L929) plays a major part in the way it targets cancer cells. However, its safety, efficacy, and long-term advantages in treating skin conditions require more investigation, including in vivo investigations and clinical trials.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT 下调 SMAD4 可通过激活 EMT 保护 HaCaT 细胞免受 UVB 诱导的损伤和氧化应激的影响

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-29 DOI: 10.1007/s43630-024-00574-x

Xiangzhi Li, Yimeng Wang, Xian Wang, Yi Shen, Yawen Yuan, Qingquan He, Shuyi Mao, Cailian Wu, Meijuan Zhou

{"title":"Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT","authors":"Xiangzhi Li, Yimeng Wang, Xian Wang, Yi Shen, Yawen Yuan, Qingquan He, Shuyi Mao, Cailian Wu, Meijuan Zhou","doi":"10.1007/s43630-024-00574-x","DOIUrl":"https://doi.org/10.1007/s43630-024-00574-x","url":null,"abstract":"As a member of the SMAD family, SMAD4 plays a crucial role in several cellular biological processes. However, its function in UVB radiation-induced keratinocyte damage is not yet clarified. Our study aims to provide mechanistic insight for the development of future UVB protective therapies and therapeutics involving SMAD4. HaCaT cells were treated with UVB, and the dose dependence and time dependence of UVB were measured. The cell function of UVB-treated HaCaT cells and the activity of epithelial-mesenchymal transition (EMT) after overexpression or silencing of SMAD4 was observed by flow cytometry, quantitative reverse transcription PCR (qRT-PCR) and Western Blots (WB). We found that a significant decrease in SMAD4 was observed in HaCaT cells induced by UVB. Our data confirm SMAD4 as a direct downstream target of miR-664. The down-regulation of SMAD4 preserved the viability of the UVB-treated HaCaT cells by inhibiting autophagy or apoptosis. Furthermore, the silencing of SMAD4 activated the EMT process in UVB-treated HaCaT cells. Down-regulation of SMAD4 plays a protective role in UVB-treated HaCaT cells via the activation of EMT.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140839510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence enhancement of benzimidazolium derivative on clay nanosheets by surface-fixation induced emission (S-FIE) 通过表面固定诱导发射（S-FIE）提高粘土纳米片上苯并咪唑衍生物的荧光强度

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-28 DOI: 10.1007/s43630-024-00576-9

Hakan Mori, Ryosuke Nakazato, Hiroshi Tachibana, Tetsuya Shimada, Tamao Ishida, Miyajima Ryo, Eietsu Hasegawa, Shinsuke Takagi

{"title":"Fluorescence enhancement of benzimidazolium derivative on clay nanosheets by surface-fixation induced emission (S-FIE)","authors":"Hakan Mori, Ryosuke Nakazato, Hiroshi Tachibana, Tetsuya Shimada, Tamao Ishida, Miyajima Ryo, Eietsu Hasegawa, Shinsuke Takagi","doi":"10.1007/s43630-024-00576-9","DOIUrl":"https://doi.org/10.1007/s43630-024-00576-9","url":null,"abstract":"The photophysical behaviors of benzimidazolium derivative [4-(1,3-dimethylbenzimidazol-3-imu-2-yl)-N, N-diphenylaniline (2-(4-(diphenylamino)phenyl)-1,3-dimethyl-1H-benzo[d]imidazol-3-ium)] (BID) in water, organic solvents and on synthetic saponite were investigated. The fluorescence quantum yield (Φf) of BID was 0.91 on the saponite surface under the optimal condition, while that in water was 0.010. Such fluorescence enhancement on the inorganic surface is called “surface-fixation induced emission (S-FIE)”. This fluorescence enhancement ratio for BID is significantly high compared to that of conventional S-FIE active dyes. From the values of Φf and the excited lifetime, the non-radiative deactivation rate constant (knr) and radiative deactivation rate constant (kf) of BID on the saponite surface and in water were determined. Results showed that the factors for fluorescence enhancement were both the increase of kf and the decrease of knr on the saponite surface; especially, knr decreased by more than two orders due to the effect of nanosheets.<h3 data-test=\"abstract-sub-heading\">Graphic abstract</h3>The fluorescence quantum yield increased approximately 90 times by the addition of clay.\u0000","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140810052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different wavelengths of LED irradiation promote secondary metabolite production in Pycnoporus sanguineus for antioxidant and immunomodulatory applications 不同波长的 LED 照射可促进 Pycnoporus sanguineus 产生次生代谢物，从而实现抗氧化和免疫调节应用

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-25 DOI: 10.1007/s43630-024-00569-8

Chui Li Lim, Chao-Hsun Yang, Xin-Yu Pan, Hsiao-Yun Tsai, Cheng-Yu Chen, Wei-Lin Chen

{"title":"Different wavelengths of LED irradiation promote secondary metabolite production in Pycnoporus sanguineus for antioxidant and immunomodulatory applications","authors":"Chui Li Lim, Chao-Hsun Yang, Xin-Yu Pan, Hsiao-Yun Tsai, Cheng-Yu Chen, Wei-Lin Chen","doi":"10.1007/s43630-024-00569-8","DOIUrl":"https://doi.org/10.1007/s43630-024-00569-8","url":null,"abstract":"Pycnoporus sanguineus is a fungus of the phylum Basidiomycota that has many applications in traditional medicine, modern pharmaceuticals, and agricultural industries. Light plays an essential role in the metabolism, growth, and development of fungi. This study evaluated the mycelial growth and antioxidant and anti-inflammatory activities in P. sanguineus fermentation broth (PFB) cultured under different wavelengths of LED irradiation or in the dark. Compared to the dark cultures, the dry weight of mycelia in red- and yellow-light cultures decreased by 37 and 35% and the yields of pigments increased by 30.92 ± 2.18 mg and 31.75 ± 3.06 mg, respectively. Compared with the dark culture, the DPPH free radical scavenging ability, ABTS+ free radical scavenging capacity, and reducing power of yellow-light cultures increased significantly, and their total phenolic content peaked at 180.0 ± 8.34 μg/mL. However, the reducing power in blue-light cultures was significantly reduced, though the total phenol content did not vary with that of dark cultures. In LPS- and IFN-γ-stimulated RAW 264.7 cells, nitrite release was significantly reduced in the red and yellow light-irradiated PFB compared with the dark culture. In the dark, yellow-, and green-light cultures, TNF-α production in the inflamed RAW 264.7 cells was inhibited by 62, 46, and 14%, respectively. With red-, blue-, and white-light irradiation, TNF-α production was significantly enhanced. Based on these results, we propose that by adjusting the wavelength of the light source during culture, one can effectively modulate the growth, development, and metabolism of P. sanguineus.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemistry and light: an adventure into probing, understanding and controlling events at the molecular scale 化学与光：探究、理解和控制分子尺度事件的探险之旅

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-24 DOI: 10.1007/s43630-024-00572-z

Céline Frochot, Martinus H. V. Werts, René M. Williams

引用次数: 0

Development of dye-sensitized solar cells using pigment extracts produced by Talaromyces atroroseus GH2 利用 Talaromyces atroroseus GH2 产生的色素提取物开发染料敏化太阳能电池

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-21 DOI: 10.1007/s43630-024-00566-x

Alessia Tropea, Donatella Spadaro, Stefano Trocino, Daniele Giuffrida, Tania Maria Grazia Salerno, Juan Pablo Ruiz-Sanchez, Julio Montañez, Lourdes Morales-Oyervides, Laurent Dufossé, Luigi Mondello, Giuseppe Calogero

{"title":"Development of dye-sensitized solar cells using pigment extracts produced by Talaromyces atroroseus GH2","authors":"Alessia Tropea, Donatella Spadaro, Stefano Trocino, Daniele Giuffrida, Tania Maria Grazia Salerno, Juan Pablo Ruiz-Sanchez, Julio Montañez, Lourdes Morales-Oyervides, Laurent Dufossé, Luigi Mondello, Giuseppe Calogero","doi":"10.1007/s43630-024-00566-x","DOIUrl":"https://doi.org/10.1007/s43630-024-00566-x","url":null,"abstract":"The identification of more efficient, clean, secure, and competitive energy supply is necessary to align with the needs of sustainable devices. For this reason, a study for developing innovative dye-sensitized solar cells (DSSCs) based on microbial pigments is reported starting from Talaromyces atroroseus GH2. The fungus was cultivated by fermentation and the extracellular pigment extract was characterized by HPLC-DAD-ESI-MS analyses. The most abundant compound among the 22 azaphilone-type pigments identified was represented by PP-O. The device’s behavior was investigated in relation to electrolyte and pH for verifying the stability on time and the photovoltaic performance. Devices obtained were characterized by UV–vis measurements to verify the absorbance intensity and transmittance percentage. Moreover, photovoltaic parameters through photo-electrochemical measurements (I–V curves) and impedance characteristics by Electrochemical Impedance Spectroscopy (EIS) were determined. The best microbial device showed a short-circuit current density (Jsc) of 0.69 mA/cm2, an open-circuit photo-voltage (Voc) of 0.27 V and a Fill Factor (FF) of 0.60. Furthermore, the power conversion efficiency (PCE) of the device was 0.11%. Thus, the present study demonstrated the potential of microbial origin pigments for developing DSSCs.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-emitting plants development by inoculating of Vibrio campbellii RMT1 on the rhizospheric zone of Aglaonema cochinchinense 通过将 Campbelli弧菌 RMT1 接种到 Aglaonema cochinchinense 的根瘤区来培育发光植物

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-16 DOI: 10.1007/s43630-024-00568-9

Chutipa Kanjanapokin, Paitip Thiravetyan, Nattida Chonjoho, Rujira Dolphen, Chairat Treesubsuntorn

{"title":"Light-emitting plants development by inoculating of Vibrio campbellii RMT1 on the rhizospheric zone of Aglaonema cochinchinense","authors":"Chutipa Kanjanapokin, Paitip Thiravetyan, Nattida Chonjoho, Rujira Dolphen, Chairat Treesubsuntorn","doi":"10.1007/s43630-024-00568-9","DOIUrl":"https://doi.org/10.1007/s43630-024-00568-9","url":null,"abstract":"The concept of utilizing light-emitting plants (LEPs) as an alternative to traditional electricity-based lighting has garnered interest. However, challenges persist due to the need for genetic modification or chemical infusion in current LEPs. To address this, researchers have investigated the interaction between plants and luminous bacteria, specifically Vibrio campbellii, which can efficiently be translocated into Aglaonema cochinchinense tissues through the roots to produce LEPs. This study concentrated on examining light intensity and enhancing luminescence by growing plants and spraying them with various media substances. The results indicated that V. campbellii successfully translocated into the plant tissue via the root system and accumulated a high number of bacteria in the stems, approximately 8.46 × 104 CFU/g, resulting in a light-emitting intensity increase of 12.13-fold at 48 h, and then decreased after 30 h. Interestingly, luminescence stimulation by spraying the growth medium managed to induce the highest light emission, reaching 14.84-fold at 48 h, though it had some negative effects on the plant. Conversely, spraying plants with CaCl2 on the leaves prolonged light emission for a longer duration (42 h after spraying) and had a positive effect on plant health, it maintained ion homeostasis and reduced-MDA content. This study highlights the potential of using V. campbellii and CaCl2 spraying for the future development of practical light-emitting plants.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contradictory role of febuxostat in ABCG2 expression and potentiating hypericin-mediated photodynamic therapy in colorectal cancers 非布索坦在结直肠癌 ABCG2 表达和增效金丝桃素介导的光动力疗法中的矛盾作用

IF 3.1 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-04-16 DOI: 10.1007/s43630-024-00575-w

Aaron King, Thomas Maisey, Erica L. Harris, James A. Poulter, David G. Jayne, M. Ibrahim Khot

引用次数: 0