Ceskoslovenska farmacie最新文献_第7页

[Biological effects of anthraglycosides. I. Laxatives]. 蒽糖苷的生物学效应。即泻药)。

Ceskoslovenska farmacie Pub Date : 1992-03-01

I Hrones, J Sícha

引用次数: 0

[Effectiveness of phosphonoformic acid in herpes infections]. 膦甲酸对疱疹感染的疗效。

Ceskoslovenska farmacie Pub Date : 1992-02-01

F Smejkal, B Otová, V Zikán, F Roubínek

引用次数: 0

[Problems in laboratory decontamination and destruction of antineoplastic agents in routine clinical practice]. 【临床常规抗肿瘤药物实验室净化与破坏的问题】。

Ceskoslovenska farmacie Pub Date : 1992-02-01

M Matrka

引用次数: 0

[The effect of additives on the availability of atropine in transdermal therapeutic systems]. [添加剂对阿托品在透皮治疗系统中可用性的影响]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

M Rehula

引用次数: 0

[Preparation of a prekallikrein concentrate and determination of its activator in blood derivatives]. [prekallikrein浓缩物的制备及其在血液衍生物中激活剂的测定]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

E Simonianová

{"title":"[Preparation of a prekallikrein concentrate and determination of its activator in blood derivatives].","authors":"E Simonianová","doi":"","DOIUrl":"","url":null,"abstract":"The determination of an increased level of a fragment of the Hageman's factor (HFf) in preparations prepared from blood plasma can be an index of their potential reactivity in clinical application. The demonstration of the presence of HFf is based on the fact that the preparation containing this factor is able to activate the prekallikrein substrate. When the concentration of prekallikrein is sufficient, the amount of the developed active enzyme kallikrein is proportional to the amount of HFf. The amount of kallikrein is determined by cleaving the specific chromogenic substrate NO-Pro-Phe-Arg-pNA. The presence of salts negatively influences the rate of the activating stage of the reaction. The described preparation of the prekallikrein concentrate from the human blood plasma is a modification of the method of Levy and Sober) for the separation of the human immunoglobulin fraction. The blood plasma with an addition of hexadimethrinebromide is sorbed on DEAE Sephadex equilibrated with 0.0175 mol/l phosphate buffer pH 6.3 with hexadimethrinebromide in a vessel with an intact surface. Prekallikrein together with IgG are not sorbed on the anion exchanger under the above-mentioned conditions. The obtained supernatant can be employed as the prekallikrein substrate to determine the HFf activity in blood derivatives.","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 1","pages":"8-9"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12753919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Fundamentals in making projections for new drugs]. [预测新药的基本原理]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

M Remko

引用次数: 0

[The effect of ionizing radiation on enzymes. VI. The effect of gamma irradiation on the proteolytic activity of pepsin derived from porcine gastric mucosa]. 电离辐射对酶的影响。γ辐照对猪胃黏膜胃蛋白酶蛋白水解活性的影响[j]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

A Libický, J Pipota, J Fidlerová

{"title":"[The effect of ionizing radiation on enzymes. VI. The effect of gamma irradiation on the proteolytic activity of pepsin derived from porcine gastric mucosa].","authors":"A Libický, J Pipota, J Fidlerová","doi":"","DOIUrl":"","url":null,"abstract":"The present paper examines the effect of gamma radiation on the proteolytic effectiveness of pepsin of an activity of 6640, 8940 and 11,333 units in 1 g, expressed according to the Czechoslovak Pharmacopoeia. The samples were irradiated with graded doses from 5.2 to 128.7 kGy so that the course of inactivation could be determined. Effectiveness was determined six times in each sample and parallel experiments were statistically evaluated. The results are shown in Tables 1 to 3. The relative width of the interval of reliability only exceptionally exceeds 5%. A decrease in effectiveness shown in Fig. 1 shows that the course of the decrease in effectiveness did not depend in the interval used on the initial activity of the enzyme. In the semilogarithmic arrangement in Fig. 2, the dependence of the decrease in effectiveness on the dose possesses a linear course. The decrease in effectiveness in dependence on the dose of radiation can be approximately read in the graph in Fig. 3. The Czechoslovak Pharmacopoeia prescribes a dose of 24 kGy to achieve sterility by means of ionizing radiation. When microbiological indefectibility is the case, a smaller dose suffices, depending on the level of the initial contamination and the resistance of the present microorganisms. It usually does not exceed 10 kGy, in our case even 5 kGy. Nevertheless, there occurs a loss of effectivity, in the extreme case 10-13%. The largest dose used in the present paper decreased effectiveness by 60%. If ionizing radiation is to be used to decontaminate pepsin, a certain decrease in activity must be taken into account. In addition, a toxicological evaluation must be recommended.","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 1","pages":"10-3"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12753917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Precursor drugs 1980-1990]. [1980-1990年的前体药物]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

V Opletalová, K Palát, H Kavánková

引用次数: 0

[Determination of serum calcitonin using a non-commercial RIA method]. [非商业RIA法测定血清降钙素]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

R Bílek, M Soutorová, J Bednár, M Pechová, M Neradilová, J Nĕmec, J Havelka

引用次数: 0

[Hospital pharmacy service and its role in health care]. [医院药房服务及其在卫生保健中的作用]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

J Solich

引用次数: 0