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[Drug consumption of certain pharmacotherapeutic groups in relation to age and sex. Psychopharmacueticals]. [若干药物治疗组别的药物消耗量与年龄及性别的关系。]Psychopharmacueticals]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
M Kotoucková, J Kadlcková, V Springer
{"title":"[Drug consumption of certain pharmacotherapeutic groups in relation to age and sex. Psychopharmacueticals].","authors":"M Kotoucková,&nbsp;J Kadlcková,&nbsp;V Springer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper presents data on the consumption of psycho-active drugs in the urban population, which are expressed by the number of packages and costs. The consumption of the group of agents under study represents 6.2% of total costs of drugs within the framework of out-patient care. The results of a one-year survey have revealed that the curve of the consumption of psycho-active drugs for the whole population after calculation per one person possesses the shape of a 2nd degree parabola. Consumption of psycho-active drugs per one person is significantly higher in women than in man and it consistently grows with the age.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"155-7"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12622112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anti-inflammatory and antipyretic activity of aqua-dihydroxybenzoate copper complexes]. [水-二羟基苯甲酸铜配合物的抗炎和解热活性]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
J Sokolík, I Tumová, LucanskáB, Z Hecková, J Krätsmár-Smogrovic, P Svec
{"title":"[Anti-inflammatory and antipyretic activity of aqua-dihydroxybenzoate copper complexes].","authors":"J Sokolík,&nbsp;I Tumová,&nbsp;LucanskáB,&nbsp;Z Hecková,&nbsp;J Krätsmár-Smogrovic,&nbsp;P Svec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using screening methods, the anti-inflammatory and antipyretic activities of mononuclear otahedral complexes [composition:Cu(2,YDHB)2.H2O;dihydroxybenzoate ion - DHB; Y(n)-4(8).5(4) and 6(8)] and the corresponding carboxylic acids were studied. On paw dextran edema (rats, an effective dose of 10 mg/kg), a higher efficacy of the complexes was found as compared with the acids. All compounds significantly reduced the endotoxin pyretic reaction (rabbits, in a single dose of 20 mg/kg; in the case of the first two complexes half-dose was administered). Marked toxic effects were determined for Cu(II) salts when they were administered i.p. The observed biological activities of complexes are discussed in relation to their proposed structures.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"127-9"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12621555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Substitutional relations in the expression of drug consumption]. [药物消费表达中的替代关系]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
V Springer, J Majtás, M Kotoucková
{"title":"[Substitutional relations in the expression of drug consumption].","authors":"V Springer,&nbsp;J Majtás,&nbsp;M Kotoucková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper analyzes the formal equivalence of expressing the consumption of medicines in financial and physical units. The study was carried out on a representative sample of population; for the sake of the need of analytical expression also the factor of the age in the consumption of drugs measured per 1 inhabitant was taken into consideration. A highly close relationship between the two specific variables is observed. On this basis the postulate of the validity of equivalence is formulated. The paper points to the stability of this formal equivalence also in the conditions of the action of the seasonal component and the pragmatic significance of the obtained results for pharmaco-epidemiological studies is stressed.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"152-4"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12622111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in the relative levels of fatty acids in blood and myocardium in the Prague breed of rats with hereditary hypercholesteremia after administration of slow calcium channel blockers]. [慢性钙通道阻滞剂对遗传性高胆固醇血症大鼠血液和心肌中脂肪酸相对水平的影响]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
S Edelsteinová, A Bukovská, P Svec, I Vozár, M Kuzelová
{"title":"[Changes in the relative levels of fatty acids in blood and myocardium in the Prague breed of rats with hereditary hypercholesteremia after administration of slow calcium channel blockers].","authors":"S Edelsteinová,&nbsp;A Bukovská,&nbsp;P Svec,&nbsp;I Vozár,&nbsp;M Kuzelová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper describes the effect of six-week oral administration of verapamil and diltiazem (1 mg.kg-1 of weight two times daily in 12 hour intervals) on the content of fatty acids of the serum and myocardium of PHHC rats. A cholesterol diet changes the content of fatty acids of the serum and myocardium of PHHC rats in comparison with control rats without the cholesterol diet. A significant decrease in the content of palmitic acid, a decrease in the content of stearic acid, linoleic acid and arachidonic acid and a significant increase in the content of oleic acid were observed in the serum. Long-term administration of the slow calcium channel blockers produces another decrease in the content of the bound form of arachidonic acid. Changes in the representation of other fatty acids are not marked. Long-term administration of a cholesterol diet produces an increase in the content of palmitic acid and stearic acid and a decrease in the content of oleic acid, linoleic acid and arachidonic acid in the myocardium. Administration of verapamil results in a modification of the above-mentioned changes in all parameters excepting the content of arachidonic acid, the content of which was decreased in an even more marked manner. Administration of diltiazem produced an accumulation of both saturated and mono-unsaturated fatty acids (palmitic, stearic and oleic acids) and produced a significant decrease in the content of linoleic acid and mainly the bound form of arachidonic acid.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"144-7"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12621556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibiotic consumption in relation to sex and age]. [抗生素用量与性别和年龄的关系]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
N Luknárová, M Slezáková, A Blahútová
{"title":"[Antibiotic consumption in relation to sex and age].","authors":"N Luknárová,&nbsp;M Slezáková,&nbsp;A Blahútová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper aims at an analysis of the consumption of antibiotics in relation to age, sex and diagnosis in the district of Bratislava-vidiek. The prescription of 17 primary out-patient care physicians was evaluated. The set under study included 17,771 inhabitants divided into 10 age categories. Drug consumption was expressed by the number of packages per 1000 inhabitants and a month. The processed data were statistically evaluated. The results of the paper showed a higher consumption in women. Within the framework of the age categories under study, the consumption of antibiotics does not increase with age. The highest consumption of antibiotics, 70.45%, was found in the diseases of the respiratory system, the consumption in acute diseases being 60.46%. Tetracycline and penicillin antibiotics are the most frequently used preparations in the population under study.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"162-5"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12622114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Phytochemical overview of the components of Calendula officinalis L. and their therapeutic evaluation]. 金盏菊成分的植物化学综述及其疗效评价
Ceskoslovenska farmacie Pub Date : 1992-07-01
I Masterová, Z Grancaiová
{"title":"[Phytochemical overview of the components of Calendula officinalis L. and their therapeutic evaluation].","authors":"I Masterová,&nbsp;Z Grancaiová","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"173-6"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12622115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A new system of additional education in the pharmacy professions]. [对药学专业的一种新的额外教育体系]。
Ceskoslovenska farmacie Pub Date : 1992-06-01
P Komárek
{"title":"[A new system of additional education in the pharmacy professions].","authors":"P Komárek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 3","pages":"85-8"},"PeriodicalIF":0.0,"publicationDate":"1992-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12695074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Detection of antibiotics in biological materials for purposes of toxicologic analysis. II. Detection of tetracyclines in biological materials]. 生物材料中抗生素的毒理学分析检测。2生物材料中四环素类药物的检测[j]。
Ceskoslovenska farmacie Pub Date : 1992-06-01
E Nováková
{"title":"[Detection of antibiotics in biological materials for purposes of toxicologic analysis. II. Detection of tetracyclines in biological materials].","authors":"E Nováková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A method of demonstration of tetracycline antibiotics elaborated as a model was used in toxicological practice. Urines of patients were analyzed after therapeutic doses and after large doses taken with suicidal intentions. At the same time, also excretion of these antibiotics from the organism was investigated. All antibiotics under study were found in the original form; in tetracycline other substances, identified as 4-epitetracycline and 4-epianhydrotetracycline, regularly appeared. A question is discussed whether these substances can be considered to be real metabolites or only products of epimerization. The importance of 4-epianhydrotetracycline for analytical purpose and interpretation of the finding is pointed out.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 3","pages":"105-7"},"PeriodicalIF":0.0,"publicationDate":"1992-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12695072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological effects of anthraquinones. II. Mutagenic, cancerogenic and antineoplastic effects. Effect on the immune system]. [蒽醌类生物效应。2致突变、致癌和抗肿瘤作用。对免疫系统的影响]。
Ceskoslovenska farmacie Pub Date : 1992-06-01
I Hrones
{"title":"[Biological effects of anthraquinones. II. Mutagenic, cancerogenic and antineoplastic effects. Effect on the immune system].","authors":"I Hrones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 3","pages":"108-11"},"PeriodicalIF":0.0,"publicationDate":"1992-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12695073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antimicrobial activity of selected aqua-carboxyl-cupric complexes]. [选定的水-羧基-铜配合物的抗菌活性]。
Ceskoslovenska farmacie Pub Date : 1992-03-01
J Sokolík, M Blahová, B Lucanská, D Mlynarcík, A Valent, L Andrezälová, O Svajlenová, M Zemlicka
{"title":"[Antimicrobial activity of selected aqua-carboxyl-cupric complexes].","authors":"J Sokolík,&nbsp;M Blahová,&nbsp;B Lucanská,&nbsp;D Mlynarcík,&nbsp;A Valent,&nbsp;L Andrezälová,&nbsp;O Svajlenová,&nbsp;M Zemlicka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activity of compounds of different structural types of aqua-complexes of the composition Cu(R-COO)2.nH2O-methoxybenzoatocupric complexes, R = 2-, 3- and 4-methoxyphenyl (n = 1, 1 and 3); aryloxyacetatocupric complexes, R = phenoxymethyl (n = 3), 2-, 3- and 4-chlorophenoxymethyl (n = 4, 2 and 2) and 1-naphthoxymethyl (n = 4), and furthermore isomeric furanecarboxylato-(R = 2- or 3-furyl, n = 3, or 1) and thiophencarboxylatocupric complexes (R = 2- or 3-thienyl, n = 1 and 1), was examined by the methods of the 1st screening on selected anthropo- and phytopathogenic microorganisms. The effects of all aqua-complexes (suspension dosage form) on the representatives of bacteria and yeasts are minimal. On the other hand, the effect of these substances on the causative agents of dermatomycoses (Trichophyton terrestre, Microsporum gypseum) in the case of methoxybenzoato- and furoatocupric complexes achieves a MIC value of 500 micrograms/cm3 and lower. The activity against phytopathogenic fungi (both in vitro and in vivo experiments) is generally relatively low at 0.05% concentration of active ingredients (dispersible powders). At the same time the antimicrobial activity of the pertinent free carboxylic acids was investigated in relation to the cupric salts being formed. They are able to form the required pharmacoactive form prevalently as late as they are in the form of aqua-carboxylatocupric complexes.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 2","pages":"40-6"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12566938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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