发布求助
文献互助 智能选刊 最新文献

Ceskoslovenska farmacie最新文献

筛选
英文 中文
[Densitometric determination of piroxicam in plasma]. 血浆中吡罗昔康的密度测定。
Ceskoslovenska farmacie Pub Date : 1991-03-01
M Peterková, O Matousová, V Rejholec
{"title":"[Densitometric determination of piroxicam in plasma].","authors":"M Peterková,&nbsp;O Matousová,&nbsp;V Rejholec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Piroxicam was extracted from acid medium into chloroform and isolated on a thin layer of silica gel with the use of the system chloroform - absolute ethanol - benzene - aqueous ammonia (20:15:15:0.5). The intensity of fluorescence of stains was measured densitometrically (an Hg lamp, a filter FL - 39, 330 nm). The limit of detection of the stain is 0.020 microgram/ml of plasma.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"40 1","pages":"40-1"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13038892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of piperidinoethylesters of n-alkoxyphenyl-carbamic acids on bacterial cells]. [正烷氧基苯基氨基甲酸酯对细菌细胞的影响]。
Ceskoslovenska farmacie Pub Date : 1991-03-01
D Mlynarcík, J Bittererová, J Ciźmárik, L Masárová
{"title":"[The effect of piperidinoethylesters of n-alkoxyphenyl-carbamic acids on bacterial cells].","authors":"D Mlynarcík,&nbsp;J Bittererová,&nbsp;J Ciźmárik,&nbsp;L Masárová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The inhibitory effect of local anaesthetic agents of this type on the bacteria Escherichia coli were evaluated. The dependence between antimicrobial activity and structure (log 1/MIC = f/m) was studied with the use of a bilinear model. In the positional paraisomers a lower effect of spherical and electron effects than in the case of ortho- and meta-isomers is assumed. The efficacy of these agents depends on their lipophilicity. Membrane activity of these agents was confirmed. In subinhibitory concentrations they cause leakage of cytoplasmic material lysis of spheroplasts, they increase the permeability of the membrane for protons and inhibit dehydrogenase activity of cells. The mode of action of heptacainium chloride and its positional isomers on cells is identical and is similar as in organic ammonium salts and amine oxides.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"40 1","pages":"25-8"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13039006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reform of pharmacy education in Hungary]. [匈牙利药学教育改革]
Ceskoslovenska farmacie Pub Date : 1990-12-01
K Zalai
{"title":"[Reform of pharmacy education in Hungary].","authors":"K Zalai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 10","pages":"463-6"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13245854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of cofactors on microsomal S-oxygenation of oxyprothepine]. [辅助因子对氧原素微粒体s -氧合的影响]。
Ceskoslovenska farmacie Pub Date : 1990-12-01
I Pauliková, O Helia
{"title":"[The effect of cofactors on microsomal S-oxygenation of oxyprothepine].","authors":"I Pauliková,&nbsp;O Helia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oxyprothepine in the medium of the microsomal fraction of the rat liver is biotransformed to the corresponding metabolites originating by oxidation of both sulfur atoms. The formation of S-oxygenation products is bound to the presence of NADPH, with a marked synergism with NADH. Induction with phenobarbital increases the formation of the individual metabolites.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 10","pages":"456-7"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13140407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Disposition of [3H]flobufen and its active metabolite in rats]. [3H]氟布芬及其活性代谢物在大鼠体内的分布]。
Ceskoslovenska farmacie Pub Date : 1990-12-01
R Lapka, A Brejcha, S Smolík, Z Franc
{"title":"[Disposition of [3H]flobufen and its active metabolite in rats].","authors":"R Lapka,&nbsp;A Brejcha,&nbsp;S Smolík,&nbsp;Z Franc","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present authors investigated the excretion, distribution and pharmacokinetics of the novel potential antirheumatic agent flobufen and its active metabolite after p.o. and i.v. doses of 2, 10 and 50 mg/kg administered to rats. The drug is resorbed well from the digestive tract and mostly it is metabolized to the principal metabolite M, which is only slowly excreted from the organism mainly by renal clearance. Within the whole dose range the kinetics of the drug is linear. Binding of flobufen and M to proteins is high (95-99%). The highest concentrations of radioactive metabolites (mostly M) were found in the plasma, liver, lungs, kidneys, connective tissue and inflammatory foci. The penetration of metabolites through the placenta and excretion in human milk are relatively important.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 10","pages":"443-7"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13245792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Requirements for standards for monoclonal anti-A and anti-B antibodies]. 【单克隆抗a、抗b抗体标准品要求】。
Ceskoslovenska farmacie Pub Date : 1990-11-01
A Májský
{"title":"[Requirements for standards for monoclonal anti-A and anti-B antibodies].","authors":"A Májský","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>On the model of the Soviet monoclonal anti-A and anti-B antibody--erythrocytes of the groups A1, A2, A1B and A2B the conditions for the elaboration of the branch standard for anti-A and anti-B monoclonal antibodies were worked out. In comparison with the standard for human sera determining the ABO groups, the requirement for avidity can be increased, furthermore it seems necessary to determine the percentage of non-A blood cells in the A2B group, which should not exceed 30%, and the percentage of non-B blood cells in A1B erythrocytes, which should not exceed 10%.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 9","pages":"409-11"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13251207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Derivatives of para-hydroxyacetophenone and para-hydroxypropiophenone as a potential new beta-adrenolytic agent]. [对羟基苯乙酮和对羟基丙烯酮的衍生物作为一种潜在的新型β -肾上腺溶解剂]。
Ceskoslovenska farmacie Pub Date : 1990-11-01
R Cizmáriková, A Dingová, J Kozlovský, O Greksáková
{"title":"[Derivatives of para-hydroxyacetophenone and para-hydroxypropiophenone as a potential new beta-adrenolytic agent].","authors":"R Cizmáriková,&nbsp;A Dingová,&nbsp;J Kozlovský,&nbsp;O Greksáková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Within the framework of the study of the structure-effect relationship, a series of novel potential beta-adrenolytic agents derived from p-hydroxyacetophenone and p-hydroxypropiophenone with an alyloxymethyl and a cycloalkyloxymethyl group in the lipophilic part of the molecule and an isopropyl and a tert-butyl group in the hydrophilic part on the basic nitrogen were prepared by means of a well-tried method. The structure of the prepared drugs was confirmed on the basis of interpretation of the IR, UV, 1H-NMR and mass spectra. The results of pharmacological evaluation of selected drugs show that the agents poses beta-adrenolytic and antiarrhythmic activity. From the viewpoint of comparison of the individual drugs subjected to testing the presence of an alyl seems more advantageous than that of a cyclohexyl. The characteristic of the prepared drugs was supplemented by the determination of their partition coefficients, surface tension and acute toxicity.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 9","pages":"403-8"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13141668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The importance of studying lipid peroxidation in testing new drugs]. [研究脂质过氧化在新药测试中的重要性]。
Ceskoslovenska farmacie Pub Date : 1990-11-01
B Binková, R J Srám
{"title":"[The importance of studying lipid peroxidation in testing new drugs].","authors":"B Binková,&nbsp;R J Srám","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The drugs which are foreign to the organism can increase the production of free oxygen radicals either spontaneously or by means of metabolic activation, or they can act as inhibitors of protective enzymic systems. They can thus activate the process of peroxidation of lipids (LPO) causing gradual structural degradation of biomembranes, thus negatively affecting the course of both pathological and physiological processes in the organism. Investigation of the inductive or inhibitory effect of newly developed drugs on LPO should become a part of their preclinical and clinical testing. The present paper proposes and recommends on the basis of the present authors' results the methodical approaches to the investigation of LPO processes.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 9","pages":"415-7"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13251069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Unscheduled DNA synthesis and evaluation of the effects of drugs]. [计划外的DNA合成和药物作用的评价]。
Ceskoslovenska farmacie Pub Date : 1990-11-01
J Topinka, R J Srám
{"title":"[Unscheduled DNA synthesis and evaluation of the effects of drugs].","authors":"J Topinka,&nbsp;R J Srám","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Unplanned DNA synthesis (UDS) represents one of the methods for the evaluation of genetic risk due to the action of xenobiotics in the organism. UDS is a parameter enabling quantification of the process of excisional repair of DNA, which results in the regeneration of the integrity of the genetic information (i. e,. correct sequence of nucleotides in DNA) after interaction with a mutagen. If the activity of the repair enzymic systems is not sufficient, the gene expression is affected, disorders in the functions of the damaged cells and tissues occur, or the cells die. The most important result is, however, the initiation of the process of carcinogenesis. A study of UDS within the framework of testing of novel drugs would markedly contribute to reveal possible negative as well as positive effects of the drugs tested both in vitro and in vivo tests. The present paper thus discusses possible uses of UDS study within preclinical and clinical testing of novel drugs.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 9","pages":"412-4"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13251068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of naphthidrofuryl and naphthidrofurylic acid in human plasma using RP-HPLC and fluorimetric detection]. [RP-HPLC和荧光法测定人血浆中萘酰和萘酰呋喃]。
Ceskoslovenska farmacie Pub Date : 1990-11-01
P Stehlík, H Houbová
{"title":"[Determination of naphthidrofuryl and naphthidrofurylic acid in human plasma using RP-HPLC and fluorimetric detection].","authors":"P Stehlík,&nbsp;H Houbová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An analytical method was developed for the determination of naphthidrofuryl and its principle metabolite--naphthidrofurylic acid in human plasma by the RP-HPLC method with fluorimetric detection. The analytical method is based on a single extraction with a 5 ml mixture ether: hexane (1:1 by volume), with salting out by means of potassium chloride after which the organic phase after centrifugation, evaporation and reconstitution is sprayed on the reverse phase of HPLC and the separated substances are determined fluorimetrically (excitation 271 nm, emission 240 nm). Lonazolac served as the internal standard. The mobile phase consisted of 72% methanol, 1% triethylamine, 0.6% phosphoric acid. Optimization of the composition of the mobile phase from the aspect of the amino base, dependence of the percent content of methanol in the mobile phase and dependence of the recovery of substances on the composition of the extracting reagent are presented. The limit of detection was 4 ng/ml of plasma for naphthidrofuryl. The stability of compounds (a minimum of 2 months) and interference of some other drugs are shown.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"39 9","pages":"394-9"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13251206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信