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[Histologic evaluation of potential new beta-adrenolytics]. [潜在的新β -肾上腺溶解药物的组织学评估]。
Ceskoslovenska farmacie Pub Date : 1992-10-01
R Cizmáriková, E Pazin, Hricková
{"title":"[Histologic evaluation of potential new beta-adrenolytics].","authors":"R Cizmáriková,&nbsp;E Pazin,&nbsp;Hricková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper investigated histological changes in the myocardium in two potential beta-adrenolytic agents, 4-[3-isopropylamino-2-hydroxypropoxy]-3-[propoxymethyl]acetophenone and 4-[3-isopropylamino-hydroxypropoxy]-3-[pentyloxymethyl]acetophenon e after intravenous administration in doses of 8 mg/kg and 24 mg/kg. It results from the found data that in both agents in the doses used there are no necrotic changes in the myocardium and the values of the impairment range within the 1st degree of Zbinden's classification, comparable to the standard metipranolol.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 7-8","pages":"264-5"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12534976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antioxidative properties of the kampo drugs TJ-9, TJ-15, TJ-23, TJ-96 and TJ-114]. [汉布药TJ-9、TJ-15、TJ-23、TJ-96和TJ-114的抗氧化性能]。
Ceskoslovenska farmacie Pub Date : 1992-10-01
K Ondrias, S Biskupic, M Hromadová, L Benes
{"title":"[Antioxidative properties of the kampo drugs TJ-9, TJ-15, TJ-23, TJ-96 and TJ-114].","authors":"K Ondrias,&nbsp;S Biskupic,&nbsp;M Hromadová,&nbsp;L Benes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plant extracts from Kampo medicines TJ-9 (A), TJ-15 (B), TJ-23 (C), TJ-114 (D) and TJ-96 (E) inhibited peroxidation of low-density lipoprotein (LDL) in vitro and peroxidation of multilamellar liposomes formed by total lipids isolated fro the rat brain. The order of relative efficacy of the extracts in both experiments was as follows: C < D equal to or greater than A < B. Using EPR spectroscopy, the Kampo extracts were found to be oxidated by means of PbO2 and to become relatively stable radicals, which shows that they possess electro-donor properties. A relationship between their ability to inhibit peroxidation of LDL and liposomes and their ability to become a radical was found. The Kampo medicines which produced more radicals inhibited peroxidation of LDL and liposomes more effectively. By means of EPR spectroscopy, Kampo B was found to reduce the vitamin E radical. The results contribute to the understanding of the positive effects of Kampo extracts in the diseases in which a negative influence of free radicals is assumed.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 7-8","pages":"253-7"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12659697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological effects of anthraquinones. IV. General toxicity, other effects]. [蒽醌类生物效应。IV.一般毒性，其他影响]。
Ceskoslovenska farmacie Pub Date : 1992-10-01
I Hrones
{"title":"[Biological effects of anthraquinones. IV. General toxicity, other effects].","authors":"I Hrones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 7-8","pages":"266-9"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12659699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic]. [二硫腺氧化物的药理学特征，一种潜在的非镇静h1抗组胺药]。
Ceskoslovenska farmacie Pub Date : 1992-09-01
H Blehová, J Metys
{"title":"[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].","authors":"H Blehová,&nbsp;J Metys","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dithiadenoxide, a product of metabolic S-oxidation of the H1-antihistaminic agent dithiaden (bisulepin, Dithiaden), is also an effective histaminic H1-antagonist in pharmacological experiments in in vivo conditions. In contrast to dithiaden, dithiadenoxide exerts a demonstrable inhibitory action as much as the subtoxic or sublethal dosage in experiments in mice and rats. Its acute toxicity in mice and guinea-pigs substantially decreases; acute toxicological findings in rats are not unambiguous. Other experimental findings demonstrate higher selectivity of pharmacological effects of dithiadenoxide.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 6","pages":"185-90"},"PeriodicalIF":0.0,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12536207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological effects of anthraquinones. III. Effect on microorganisms and as a repellent]. [蒽醌类生物效应。3对微生物的作用和作为驱虫剂]。
Ceskoslovenska farmacie Pub Date : 1992-09-01
I Hrones
{"title":"[Biological effects of anthraquinones. III. Effect on microorganisms and as a repellent].","authors":"I Hrones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 6","pages":"217-9"},"PeriodicalIF":0.0,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12465649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of potential beta-adrenolytic agents on oxidation and phosphorylation processes in myocardial muscle mitochondria in vitro]. [潜在的-肾上腺素溶解剂对体外心肌线粒体氧化和磷酸化过程的影响]。
Ceskoslovenska farmacie Pub Date : 1992-09-01
R Cizmáriková, A Gvozdjaková, J Kucharská
{"title":"[The effect of potential beta-adrenolytic agents on oxidation and phosphorylation processes in myocardial muscle mitochondria in vitro].","authors":"R Cizmáriková,&nbsp;A Gvozdjaková,&nbsp;J Kucharská","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Concentrations ranging from 1-9 x 10(-7) mol.dm-3 were employed for in vitro studies. Under the selected experimental conditions, both agents markedly decreased the stimulated consumption of oxygen by the cardiac muscle mitochondria in the condition S3, the rate of the formation of energy by mitochondria as well as the respiratory control index. The coefficient of oxidative phosphorylation was not markedly changed due to the effect of the added agents. The results of the present paper suggest possible integration of the cardiac muscle mitochondria in the oxidative metabolism of the potential beta-adrenolytic agents FA33 and FP33, which requires further in vivo studies.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 6","pages":"191-3"},"PeriodicalIF":0.0,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12465647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological activity of salicylanilides]. [水杨酸苯胺类化合物的生物活性]。
Ceskoslovenska farmacie Pub Date : 1992-09-01
L Kubicová, K Waisser
{"title":"[Biological activity of salicylanilides].","authors":"L Kubicová,&nbsp;K Waisser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 6","pages":"208-16"},"PeriodicalIF":0.0,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12465648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prescriptions for individually prepared dermatologic agents. I]. [单独配制皮肤药物的处方。我]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
A Fekárová, Z Gruntová, M Hornácková
{"title":"[Prescriptions for individually prepared dermatologic agents. I].","authors":"A Fekárová,&nbsp;Z Gruntová,&nbsp;M Hornácková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper reports the results of a survey of contemporary medical prescriptions of solutions, suspensions and emulsions used in dermatological practice. The obtained results were compared with the district prescription lists from Slovakia. The analysis of contemporary prescription was carried out in 27 districts in the years 1987 and 1989. The results show that 112 drugs are prescribed in the preparation of solutions. Most solutions are composite and 90% of solutions are hydrophilic. An analysis of suspensions revealed that in hydrophilic suspensions the liquid media water-glycerol or spirit-water prevail, and in hydrophobic suspensions nearly always plant oils are used. Emulsions are represented in topical extemporaneous preparations in a smaller amount than solutions and suspensions; it is 0.7% in the set under study.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"158-61"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12622113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An overview of the development of pharmacy education in Slovakia]. [斯洛伐克药学教育发展概况]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
M Kucerová
{"title":"[An overview of the development of pharmacy education in Slovakia].","authors":"M Kucerová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Before 1777, the pharmacist in Slovakia gained their professional qualification by practising in a pharmacy. From the establishment of the University of Trnava to 1777, they attended lectures and took examinations at its Faculty of Medicine, then from 1784 onwards in Budapest. After the establishment of Czechoslovakia, the candidates of pharmacy studied in Prague, and after the closing of Czech universities (1939) in Bratislava. Between 1940 and 1948 there existed a three-year course, and later a four-year course at the Faculty of Medicine, the contents of which were close to the level of the development of sciences and the requirements of pharmaceutical practice. A logical completion of the development of the course of studies was the establishment of independent Faculties of Pharmacy in Bratislava and Brno and the prolongation of the course to five years. Commencing with the academic year 1977/78, the course of studies was divided into three specializations, General Pharmacy, Clinical Pharmacy and Technological Pharmacy. Since the academic year 1990/91 the course is uniform again, with possible differentiations in the profile of the graduate during the course according to the interests and options of the student.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"123-6"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12621554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An anniversary of the Comenius University Pharmacy School in Bratislava]. [布拉迪斯拉发夸美纽斯大学药学院的周年纪念]。
Ceskoslovenska farmacie Pub Date : 1992-07-01
M Chalabala, P Kovács, V Svec
{"title":"[An anniversary of the Comenius University Pharmacy School in Bratislava].","authors":"M Chalabala,&nbsp;P Kovács,&nbsp;V Svec","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"41 4-5","pages":"121-2"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12621553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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