Ceskoslovenska farmacie最新文献_第8页

[Utilization of drugs in the Czech Republic 1991-2000]. [1991-2000年捷克共和国药物使用情况]。

Ceskoslovenska farmacie Pub Date : 1992-02-01

J Solich

引用次数: 0

[The European Pharmacopoeia]. [欧洲药典]。

Ceskoslovenska farmacie Pub Date : 1991-12-01

M Trávnícková, J Portych, H Drahotová

引用次数: 0

[Metabolic N- and S-oxygenation of dokloxytepin in vitro]. [dokloxytepin体外代谢N-和s -氧合]。

Ceskoslovenska farmacie Pub Date : 1991-12-01

O Helia, I Pauliková

引用次数: 0

[The origins of the Brno School of Pharmacy and the development of pharmaceutical chemistry as an important discipline]. [布尔诺药学院的起源和药物化学作为一门重要学科的发展]。

Ceskoslovenska farmacie Pub Date : 1991-12-01

L Novácek

引用次数: 0

[Binding of phenytoin to serum albumin in vitro and in vivo]. [体内外苯妥英与血清白蛋白的结合]。

Ceskoslovenska farmacie Pub Date : 1991-12-01

J Pospísil, F Perlík, V Kordac, M Kolínová

{"title":"[Binding of phenytoin to serum albumin in vitro and in vivo].","authors":"J Pospísil, F Perlík, V Kordac, M Kolínová","doi":"","DOIUrl":"","url":null,"abstract":"The present paper describes an ultrafiltration method of determination of the concentration of free phenytoin (DPH) in serum and its use for the study of the binding equilibrium phenytoin--albumin. The procedure was employed to determine the binding affinity of serum albumin (a) in a group of healthy volunteers (n = 8) in in vitro conditions, (b) in a group of healthy volunteers (a mixed serum, n = 6) and (c) in a group of patients suffering from epilepsy with fits of the generalized type grand mal (n = 15) in in vivo conditions. The calculation of binding parameters was carried out by the method of nonlinear regression analysis with the use of the one-parameter Scatchard's model of the bond. Binding activity of serum albumin in the volunteers of group (a) was N.Ka = 17,500 l/mol, group (b) N.Ka = 18,700 l/mol, and in patients with epilepsy n.Ka = 19,200 l/mol. The results of covariational analysis demonstrated good agreement in the binding parameters of all three groups under study. The paper also discusses the suitability of the binding model used and the mathematical processing and possible use of the binding parameters measured in in vitro conditions for the estimation of the value of the free fraction of the drug in patients with epilepsy.","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"40 6-7","pages":"200-2"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The founding of the Association of Pharmacists 1783 to 1784]. [1783年至1784年药剂师协会的成立]。

Ceskoslovenska farmacie Pub Date : 1991-12-01

Z Hanzlícek

{"title":"[The founding of the Association of Pharmacists 1783 to 1784].","authors":"Z Hanzlícek","doi":"","DOIUrl":"","url":null,"abstract":"The Czech Association of Pharmacists was established as a state-constituted professional organization by the decree of the Czech Government dated 11 March 1784, the initiator of the decree being Josef Gottfried Mikan (1742-1818), the then Dean of the Faculty of Medicine and Professor of Botany and Chemistry at Charles University. His correspondence with the government between 10 February and 16 May 1784, preserved in the State Central Archives, Prague, clearly demonstrates Mikan's main contribution to the issue of the decree. In his letter of 10 February 1784, he asked the government to order the establishment of a compulsory nation-wide association of pharmacists. Their meetings were to be presided by dean of the faculty in order to prevent disorders which he did not specify and evaluate at all. The pharmacists of Prague were acquainted with the governmental decree of 23 February, 1784, at the Carolinum Hall on 6 March, 1784. The decree included Mikan's requirements and the introduction of tests for pharmacists' apprentices (tirones) prior to the journeyman's examination and compulsory registration of employed pharmacists (subjecti) at the Faculty of Medicine. These supplements to education were added by the government. The Prague pharmacist Ignác Broz, the owner of the Golden Bear pharmacy since 1763, was appointed chairman of the Association. The governmental decree of 11 March 1784, including the above-mentioned regulations, was sent to all districts of Bohemia. The emperor was informed about the decision of the government by a letter dated as late as 17 June 1784.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"40 6-7","pages":"217-20"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Organic ammonium salts. XLI. Preparation, aggregation properties and antimicrobial activity of N-[2-(10-undecenoyloxy)ethyl]-N,N,N-alkyldimethylammonium bromides]. 有机铵盐。XLI。N-[2-(10-十一烯氧基)乙基]-N,N,N-烷基二甲基溴化铵的制备、聚合性能及抗菌活性

Ceskoslovenska farmacie Pub Date : 1991-11-01

I Csiba, F Devínsky, L Masárová, I Lacko

{"title":"[Organic ammonium salts. XLI. Preparation, aggregation properties and antimicrobial activity of N-[2-(10-undecenoyloxy)ethyl]-N,N,N-alkyldimethylammonium bromides].","authors":"I Csiba, F Devínsky, L Masárová, I Lacko","doi":"","DOIUrl":"","url":null,"abstract":"The paper describes the preparation of 7 novel organic ammonium salts of N-[2-(10-undecenoyloxy)ethyl]-N,N,N-alkyl-dimethylammonium bromides, in which the alkyl chain was gradually lengthened from ethyl to tetradecyl, constantly keeping the other groups (10-undecenoyloxyethyl and methyl) bound to the ammonium nitrogen. In the paper the antimicrobial effect of the prepared ammonium salts and the aggregative properties of their aqueous solutions were studied. The aggregative properties are expressed by the values of the critical concentration of the micelles formation, which were determined tensiometrically and conductometrically. The antimicrobial activity expressed by the minimal inhibition concentration in dependence on the prolongation of the alkyl chain was determined by the dilution test on the strains Staphylococcus aureus, Escherichia coli and Candida albicans. As follows from the table, all ammonium salts prepared were active in this respect, the most effective ones possessing 6, 8 and 10 carbon atoms in the alkyl chain. They were more effective than the standard Ajatin to all strains of the microorganisms tested. The antimicrobial effect decreased with the increasing length of the alkyl chain. Also the structure--activity relationship was quantified by the QSAR analysis methods using two procedures: the dependence log ck vs. m was linear and the dependence log (1/MIC) vs. m and log (1/MIC) vs. log ck were nonlinear. The calculated coefficients of regression equations and statistical evaluation of dependences are shown in Table 4.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"40 4-5","pages":"148-51"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12982638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Synthesis and antibacterial activity of thiosemicarbazones of 3-acylquinolones]. [3-酰基喹诺酮类硫代氨基脲的合成及抗菌活性研究]。

Ceskoslovenska farmacie Pub Date : 1991-11-01

S Rádl, M Bartonová, L Kovárová

引用次数: 0

[Prognostic study of utilization of infusion preparations]. 输液制剂使用的预后研究。

Ceskoslovenska farmacie Pub Date : 1991-11-01

V Klemerová, M Espandrová, J Solich

引用次数: 0

[Detection of antibiotics in biological materials for purposes of toxicological analysis. I. Methodologic study for the detection of tetracycline]. 生物材料中抗生素的毒理学检测。1 .检测四环素的方法学研究[j]。

Ceskoslovenska farmacie Pub Date : 1991-11-01

E Nováková

引用次数: 0