CHILDREN INFECTIONS最新文献_第9页

Challenges in diagnostic research of multisystem inflammatory syndrome in children associated with COVID-19 in combination with the early stage of Epstein-Barr virus infection 结合早期eb病毒感染，新冠肺炎相关儿童多系统炎症综合征诊断研究面临的挑战

CHILDREN INFECTIONS Pub Date : 2022-07-20 DOI: 10.22627/2072-8107-2022-21-2-51-56

Е. А. Kashirina, N. M. Yugay, O. B. Karabanova, L. V. Markina, E. Babenko, S. G. Zagidullina, O. A. Lomakina, N. Kolganova, A. Glazyrina, Y. Novikova, A. E. Andzhel, Y. Romanova, A. Y. Rtischev, D. Ovsyannikov, V. V. Gorev

引用次数: 0

Clinical and immunological characteristics of opportunistic infections in children with the natural course of HIV infection, taking into account the route of infection 机会性感染儿童的临床和免疫学特点与HIV感染的自然过程，同时考虑到感染途径

CHILDREN INFECTIONS Pub Date : 2022-07-20 DOI: 10.22627/2072-8107-2022-21-2-16-22

V. Denisenko, E. M. Simovanyan

{"title":"Clinical and immunological characteristics of opportunistic infections in children with the natural course of HIV infection, taking into account the route of infection","authors":"V. Denisenko, E. M. Simovanyan","doi":"10.22627/2072-8107-2022-21-2-16-22","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-16-22","url":null,"abstract":"The purpose of the study is to improve the diagnosis and prognosis of opportunistic infections in children infected with HIV by vertical and parenteral routes, taking into account the dynamics of clinical and immunological parameters.Research methods. Clinical and laboratory examinations were carried out in 192 children infected with HIV by the vertical route (91; group I), parenteral route in infancy (44; group II) and over the age of one year (57; group III).Research results. In group I, a rapid development of immunosuppression was observed: mild immunodeficiency was diagnosed at the age of Me 4 (IQI 2—10) months, advanced immunodeficiency — Me 11 ( IQI 6—24.5) months, severe immunodeficiency — Me 23 ( IQI 11— 56) months. Clinical manifestation of opportunistic infections occurred in the first three years of life with a relatively high content of CD4-lymphocytes. Localized bacterial infections (Me 27,5; IQI 21,9–34,1/100 MYO), candidiasis (Me 14,1; IQI 10,2—18,9 / 100 MYO) and generalized infections (Me 5,2; IQI 2,9—8,5 / 100 MYO) had the highest relative incidence rate. In group II, there was a slower progression of immunosuppression (within one to seven years), the addition of opportunistic infections with a lower content of CD4-lymphocytes, in terms of one to nine years, a high relative incidence of herpes simplex infection (Me 12,9; IQI 7,8—14,9 / 100 MYO), herpes zoster (Me 3; IQI 1,5—5,4 / 100 MYO) and pneumocystosis (Me 3,8; IQI 2,1—6,4 / 100 MYO). In group III, there was a slow progression of immunosuppression (within one to eight years), the development of opportunistic infections with a low content of CD4-lymphocytes, in terms of two to ten years, a rarer manifestation of most diseases.Conclusion. These patterns should be taken into account when planning diagnostic, therapeutic and preventive measures in children with HIV infection, taking into account the path and age at the time of infection.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81233456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the influence of the etiological spectrum herpesviruses into systemic and local immune response in encephalitis in children 评估疱疹病毒病原谱对儿童脑炎全身和局部免疫反应的影响

CHILDREN INFECTIONS Pub Date : 2022-07-20 DOI: 10.22627/2072-8107-2022-21-2-11-15

E. Skripchenko, G. F. Zheleznikova, N. Skripchenko, E. Gorelik, N. F. Pullman, A. Vilnits, A. Astapova, V. Lobzin

{"title":"Evaluation of the influence of the etiological spectrum herpesviruses into systemic and local immune response in encephalitis in children","authors":"E. Skripchenko, G. F. Zheleznikova, N. Skripchenko, E. Gorelik, N. F. Pullman, A. Vilnits, A. Astapova, V. Lobzin","doi":"10.22627/2072-8107-2022-21-2-11-15","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-11-15","url":null,"abstract":"Herpesviruses are the most common etiological agents of encephalitis in children. The most pathogenic properties for humans are: Herpes Simplex virus type 1, type 2, Varicella Zoster virus, Human Herpes virus type 6 and Epstein-Barr virus, combined infection with which, along with the individual characteristics of the patient's immune status, can lead to a severe course and unpredictable outcome encephalitis.Materials and methods. Clinical and neurological monitoring, etiological verification of infectious agents in the blood and cerebrospinal fluid by PCR and ELISA methods were carried out in 85 children with encephalitis at the age of 10—18 years. In patients suffering from herpesvirus encephalitis, the levels of pro-inflammatory cytokines, interleukins, chemokines were determined in the blood during the acute period of the disease and after 10—14 days.Results. A decrease in the production of IFN-α and IFN-γ was revealed, which is an unfavorable factor prolonging the course of an active herpes virus infection. Conclusions. Cytokines should be considered as one of the prognostic factors for the course and outcomes of encephalitis in children, which will allow timely correction of patient management tactics in each specific case and improve the outcome of the disease.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86628832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphofunctional state of the gastric mucosa in children with chronic gastritis and the persistence of Epstein-Barr virus 慢性胃炎患儿胃黏膜形态功能状态与eb病毒持续存在的关系

CHILDREN INFECTIONS Pub Date : 2022-07-20 DOI: 10.22627/2072-8107-2022-21-2-34-37

E. P. Sitnikova, E. Spivak, O. M. Manyakina

{"title":"Morphofunctional state of the gastric mucosa in children with chronic gastritis and the persistence of Epstein-Barr virus","authors":"E. P. Sitnikova, E. Spivak, O. M. Manyakina","doi":"10.22627/2072-8107-2022-21-2-34-37","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-34-37","url":null,"abstract":"The aim is to establish the effect of the persistence of the Epstein-Barr virus on the morphofunctional state of the gastric mucosa in chronic gastritis in children. Methods. 324 children aged 6—16 years with chronic gastritis were examined. We analyzed clinical and anamnestic data, the results of esophagogastroduodenoscopy with biopsy, genetic typing of Hp with the identification of pathogenicity genes VacA, CagA, IceA, BabA. The persistence of the Epstein-Barr virus was determined by the detection of its DNA in the materials of gastrobiopsy. The titer of class G antibodies to gastric parietal cells was studied in 110 patients.The results of the study. In children with chronic gastritis, Epstein-Barr virus was detected in the gastric mucosa in 49.1% of cases. In these patients, its colonization by highly pathogenic Hp strains was detected 1.8 times more often than in patients who had no infection with this virus. The persistence of the Epstein-Barr virus contributed to an increase in the severity of inflammation, the appearance of signs of indefinite atrophy of the mucous membrane and in the absolute majority of children was not accompanied by an increase in the titer of antibodies to the parietal cells of the stomach.Conclusion. The persistence of Epstein-Barr virus in the gastric mucosa in chronic Hp-associated gastritis contributes to its infection with highly pathogenic Hp strains and severe inflammation. No data have been obtained indicating the role of Epstein-Barr virus in the formation of atrophic or autoimmune gastritis in childhood.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86583572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and laboratory features of acute respiratory viral infections in hospitalized children 住院儿童急性呼吸道病毒感染的临床和实验室特征

CHILDREN INFECTIONS Pub Date : 2022-07-20 DOI: 10.22627/2072-8107-2022-21-2-5-10

E. V. Sharipova, E. Orlova, I. Babachenko, E. Kozyrev, N. S. Tyan

{"title":"Clinical and laboratory features of acute respiratory viral infections in hospitalized children","authors":"E. V. Sharipova, E. Orlova, I. Babachenko, E. Kozyrev, N. S. Tyan","doi":"10.22627/2072-8107-2022-21-2-5-10","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-5-10","url":null,"abstract":"The aim of the study was to study the clinical and laboratory features of acute respiratory viral infections in hospitalized children.The analysis of medical records of 623 patients admitted to the clinic, aged from 1 month to 16 years 11 months 29 days, was carried out. All patients were diagnosed with ARVI on the basis of clinical symptoms with laboratory confirmation in the study of naso- or oropharyngeal smears by PCR.Three groups of children were identified: with respiratory syncytial (RSV) — 384 children (61,6%), metapneumovirus — 142 (22,8%) and bocavirus — 97 (15,6%) infections. It has been established that in the general structure of acute respiratory viral infections in hospitalized children, RSV and rhinovirus are the leading pathogens — 28,8—48,6% and 22,1—41,3%, respectively, depending on the calendar year. The main clinical form was acute bronchitis in 80,5% of cases of confirmed infection, with RS-viral etiology in 79,5% (n = 287) of cases, with metapneumo- and bocavirus infections in 85,6% (n = 95) and 77,8% (n = 56) of children, respectively. Bronchiolitis was characteristic of RSV infection in 10,5% of cases (n = 38). From 10 to 19,4% of cases, the course of these viral infections was complicated by the development of pneumonia.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77885872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of SARS-CoV-2-infection in a child with chronic kidney disease 慢性肾病患儿sars - cov -2感染1例

CHILDREN INFECTIONS Pub Date : 2022-07-20 DOI: 10.22627/2072-8107-2022-21-2-67-72

O. Kovaleva, L. A. Lityaeva, O. Kaykova

引用次数: 1

On the diagnosis of intrauterine listeriosis 论宫内李斯特菌病的诊断

CHILDREN INFECTIONS Pub Date : 2022-03-22 DOI: 10.22627/2072-8107-2022-21-1-66-69

A. A. Nafeev, V. I. Modnikova, V. Popov, N. P. Gorbikova, F. A. Sayfutdinova, O. A. Fakhrutdinova, A. A. Nafeevа

引用次数: 0

Resolution of the XX Anniversary Congress of Children's Infectious Diseases Doctors of Russia with international participation «Topical issues of infectious pathology and vaccine prevention» 国际参与的俄罗斯儿童传染病医生二十周年大会决议“传染病病理学和疫苗预防的专题问题”

CHILDREN INFECTIONS Pub Date : 2022-03-22 DOI: 10.22627/2072-8107-2022-21-1-70-72

A. Editorial

引用次数: 0

Epidemiology and clinic of microbial-inflammatory nephropathy in children living in an ecologically unfavorable region 生态不利地区儿童微生物性炎症性肾病的流行病学及临床研究

CHILDREN INFECTIONS Pub Date : 2022-03-21 DOI: 10.22627/2072-8107-2022-21-1-29-32

E. P. Sitnikova, T. G. Pukhova, E. Spivak

{"title":"Epidemiology and clinic of microbial-inflammatory nephropathy in children living in an ecologically unfavorable region","authors":"E. P. Sitnikova, T. G. Pukhova, E. Spivak","doi":"10.22627/2072-8107-2022-21-1-29-32","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-1-29-32","url":null,"abstract":"The aim is to establish the epidemiology and features of the clinic of microbial inflammatory nephropathy in children living in an ecologically unfavorable area.Research methods. The prevalence of microbial-inflammatory nephropathies and their incidence in the urban children's population, as well as in areas with favorable and unfavorable environmental situation were analyzed. A clinical and laboratory examination of patients was carried out with an assessment of the features of the manifestations of the disease in children living in an area with environmental pollution.The results of the study. Over the past two decades, there has been a decrease in the incidence of microbial inflammatory nephropathies and their general prevalence in the urban children's population. However, in an urban area with an unfavorable environmental situation, a significant increase in these epidemiological indicators has been recorded over a ten-year period. The peculiarities of microbial-inflammatory nephropathies in children living in an area with significant air and soil pollution are their occurrence against the background of congenital anomalies or malformations of the kidneys and urinary tract, frequent relapses, the presence of complications. They are characterized by a frequent combination of kidney and bladder lesions, higher activity of the inflammatory process with impaired renal function, slow reverse dynamics of symptoms during treatment.Conclusion. Microbial-inflammatory nephropathies in children living in ecologically unfavorable areas of the city have features of epidemiology and clinical manifestations, which must be taken into account when carrying out medical support for this category of patients.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82579969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and laboratory differences between primary acute and reactivation of chronic Epstein-Barr viral infection in children (systematic review and meta-analysis) 儿童原发性急性和再激活慢性eb病毒感染的临床和实验室差异(系统回顾和荟萃分析)

CHILDREN INFECTIONS Pub Date : 2022-03-21 DOI: 10.22627/2072-8107-2022-21-1-49-55

M. M. Kulikova, T. V. Solomay, T. Semenenko

{"title":"Clinical and laboratory differences between primary acute and reactivation of chronic Epstein-Barr viral infection in children (systematic review and meta-analysis)","authors":"M. M. Kulikova, T. V. Solomay, T. Semenenko","doi":"10.22627/2072-8107-2022-21-1-49-55","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-1-49-55","url":null,"abstract":"At the moment, the clinical differences between primary acute and reactivation of chronic infection caused by Epstein-Barr virus (EBV) have not been fully studied.The aim is to identify clinical and laboratory differences between primary acute and reactivation of chronic EBV infection in children aged 0—17 years.Materials and methods. A systematic review and meta-analysis of publications was carried out, which were searched through the bibliographic databases PubMed, Cyberleninka, eLibrary, as well as using the Researchgate scientific network. The total number of keyword search results was 1,830 publications, of which 26 were included in the study according to the results of the selection. 1318 cases of active EB infection were subjected to meta-analysis, including 917 cases of acute primary and 401 cases of reactivation.Results. Distinctive signs of primary acute EBV infection are fever, generalized lymphadenopathy, enlargement of cervical lymph nodes, acute tonsillitis, exanthema, excess of ALT reference values, leukocytosis, the presence of atypical mononuclears. With the reactivation of chronic EBV infection, the clinical manifestations are less pronounced, but in 24% of cases the disease is accompanied by the development of interstitial pneumonia. Characteristic signs are hypertrophy of the lymphoepithelial pharyngeal ring and thymomegaly, not described in primary acute infection.Conclusion. The revealed clinical and laboratory differences between primary acute and reactivation of chronic EBV infection in children aged 0—17 years can be used for differential diagnosis of these conditions.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85177354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3