Е. А. Kashirina, N. M. Yugay, O. B. Karabanova, L. V. Markina, E. Babenko, S. G. Zagidullina, O. A. Lomakina, N. Kolganova, A. Glazyrina, Y. Novikova, A. E. Andzhel, Y. Romanova, A. Y. Rtischev, D. Ovsyannikov, V. V. Gorev
{"title":"结合早期eb病毒感染,新冠肺炎相关儿童多系统炎症综合征诊断研究面临的挑战","authors":"Е. А. Kashirina, N. M. Yugay, O. B. Karabanova, L. V. Markina, E. Babenko, S. G. Zagidullina, O. A. Lomakina, N. Kolganova, A. Glazyrina, Y. Novikova, A. E. Andzhel, Y. Romanova, A. Y. Rtischev, D. Ovsyannikov, V. V. Gorev","doi":"10.22627/2072-8107-2022-21-2-51-56","DOIUrl":null,"url":null,"abstract":"Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare life-threatening immunopathological complication of COVID-19 that develops 1-6 weeks after the acute coronavirus infection. MIS-C is characterized by fever and multiorgan inflammation.We present a clinical case of a 10-year-old boy with skin lesions at the onset of MIS-C (erythematous malar rash, lacelike rash on the trunk and extremities and petechiae) with macrophage activation syndrome development and the early stage of primary Epstein-Barr virus infection (EBV infection) which required the exclusion of X-linked lymphoproliferative disease.This clinical case demonstrates the complexity of diagnosis in MIS-C with skin manifestations at the onset of the disease, especially with concurrent activation of other infections, particularly EBV infection.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Challenges in diagnostic research of multisystem inflammatory syndrome in children associated with COVID-19 in combination with the early stage of Epstein-Barr virus infection\",\"authors\":\"Е. А. Kashirina, N. M. Yugay, O. B. Karabanova, L. V. Markina, E. Babenko, S. G. Zagidullina, O. A. Lomakina, N. Kolganova, A. Glazyrina, Y. Novikova, A. E. Andzhel, Y. Romanova, A. Y. Rtischev, D. Ovsyannikov, V. V. Gorev\",\"doi\":\"10.22627/2072-8107-2022-21-2-51-56\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare life-threatening immunopathological complication of COVID-19 that develops 1-6 weeks after the acute coronavirus infection. MIS-C is characterized by fever and multiorgan inflammation.We present a clinical case of a 10-year-old boy with skin lesions at the onset of MIS-C (erythematous malar rash, lacelike rash on the trunk and extremities and petechiae) with macrophage activation syndrome development and the early stage of primary Epstein-Barr virus infection (EBV infection) which required the exclusion of X-linked lymphoproliferative disease.This clinical case demonstrates the complexity of diagnosis in MIS-C with skin manifestations at the onset of the disease, especially with concurrent activation of other infections, particularly EBV infection.\",\"PeriodicalId\":9855,\"journal\":{\"name\":\"CHILDREN INFECTIONS\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CHILDREN INFECTIONS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22627/2072-8107-2022-21-2-51-56\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CHILDREN INFECTIONS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22627/2072-8107-2022-21-2-51-56","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Challenges in diagnostic research of multisystem inflammatory syndrome in children associated with COVID-19 in combination with the early stage of Epstein-Barr virus infection
Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare life-threatening immunopathological complication of COVID-19 that develops 1-6 weeks after the acute coronavirus infection. MIS-C is characterized by fever and multiorgan inflammation.We present a clinical case of a 10-year-old boy with skin lesions at the onset of MIS-C (erythematous malar rash, lacelike rash on the trunk and extremities and petechiae) with macrophage activation syndrome development and the early stage of primary Epstein-Barr virus infection (EBV infection) which required the exclusion of X-linked lymphoproliferative disease.This clinical case demonstrates the complexity of diagnosis in MIS-C with skin manifestations at the onset of the disease, especially with concurrent activation of other infections, particularly EBV infection.