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Microglia go beyond surveillance to fuel neuronal protein synthesis on demand 小胶质细胞超越了监视，可以根据需要为神经元蛋白质合成提供燃料
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.05.013
Stefano Pluchino,Evridiki Asimakidou
{"title":"Microglia go beyond surveillance to fuel neuronal protein synthesis on demand","authors":"Stefano Pluchino,Evridiki Asimakidou","doi":"10.1016/j.cmet.2026.05.013","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.05.013","url":null,"abstract":"In this issue of Cell Metabolism, Adler et al.11.Adler, D. ∙ Martín-Ávila, A. ∙ Cheng, E. ...Activity-dependent protein synthesis in neurons requires microglia-metabolic couplingCell Metab. 2026; 38:1650-1667.e10Full TextFull Text (PDF)Scopus (0)Google Scholar demonstrate that microglia coordinate multicellular metabolic interactions within the neurovascular niche. They identify microglia-derived cysteine-rich angiogenic inducer 61 (CYR61) as a mediator promoting cerebral glucose uptake and neuronal protein synthesis, thereby highlighting a role for microglia in supporting neuronal adaptation on demand.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"39 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methionine tuning for health without frailty 蛋氨酸调谐为健康而无虚弱
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.013
Amanda Garrido,Nathan L. Price,Rafael de Cabo
{"title":"Methionine tuning for health without frailty","authors":"Amanda Garrido,Nathan L. Price,Rafael de Cabo","doi":"10.1016/j.cmet.2026.06.013","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.013","url":null,"abstract":"Dietary protein quality, not merely quantity, shapes metabolic health and aging trajectories. Fanti et al. show that moderate methionine supplementation to a low-protein, Mediterranean-inspired diet activates a GH-GLP-1-FGF21 axis that reduces adiposity and frailty without caloric restriction; their findings provide a mechanism for why traditional plant-rich diets may promote longevity while sometimes compromising physical robustness.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"26 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer’s disease 乳酸说话时：阿尔茨海默病中星形细胞-神经元代谢的重新布线
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.05.007
Jessica Furtado,Marc Schneeberger
{"title":"When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer’s disease","authors":"Jessica Furtado,Marc Schneeberger","doi":"10.1016/j.cmet.2026.05.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.05.007","url":null,"abstract":"Metabolic dysfunction is a defining but poorly understood feature of Alzheimer’s disease. Du et al. show that a brain-penetrant GLP-1 receptor agonist rewires astrocyte-neuron metabolic coupling through lactate-driven histone lactylation, linking astrocytic glycolysis to neuronal lipid homeostasis and positioning metabolite signaling as a therapeutic axis in neurodegeneration.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"37 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight-loss-independent actions of GLP-1 medicines GLP-1药物的非减肥作用
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.07.006
Maria J. Gonzalez-Rellan,Daniel J. Drucker
{"title":"Weight-loss-independent actions of GLP-1 medicines","authors":"Maria J. Gonzalez-Rellan,Daniel J. Drucker","doi":"10.1016/j.cmet.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.006","url":null,"abstract":"The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to improve cardiovascular, renal, hepatic, musculoskeletal, and organismal health. Defining dose-response relationships for weight-loss-independent mechanisms will facilitate optimization of the therapeutic potential of GLP-1 medicines.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"4 2 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding neural signals to build metabolic therapies 解码神经信号来建立代谢疗法
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.010
Tune H. Pers,Amber L. Alhadeff,Martin G. Myers Jr.,Alice E. Adriaenssens,Henning Fenselau,Sarah A. Stanley,Virginie Mansuy-Aubert,Ana I. Domingos,Alejandro Caicedo,Beste Mutlu
{"title":"Decoding neural signals to build metabolic therapies","authors":"Tune H. Pers,Amber L. Alhadeff,Martin G. Myers Jr.,Alice E. Adriaenssens,Henning Fenselau,Sarah A. Stanley,Virginie Mansuy-Aubert,Ana I. Domingos,Alejandro Caicedo,Beste Mutlu","doi":"10.1016/j.cmet.2026.06.010","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.010","url":null,"abstract":"Ongoing research points to neural circuits as the major targets for the incretin-mimetic drugs that are transforming obesity treatment. In this Voices piece, we asked researchers to discuss their work on how central and peripheral pathways influence energy balance and metabolism, and what next steps are needed to therapeutically target these pathways.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"23 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hormone Cell Atlas decodes the human endocrine system, one cell at a time 激素细胞图谱解码人类内分泌系统，一次一个细胞
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.019
Dominique Langin,André C. Carpentier
{"title":"The Hormone Cell Atlas decodes the human endocrine system, one cell at a time","authors":"Dominique Langin,André C. Carpentier","doi":"10.1016/j.cmet.2026.06.019","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.019","url":null,"abstract":"Farooqi, Teichmann, and collaborators developed the Hormone Cell Atlas, a 14-million-cell dataset mapping hormone production and sensitivity across 47 human tissues. Their findings expand knowledge on sites of production and receiver cells, opening new avenues in endocrinology and metabolism.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"15 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mitochondrial antioxidant axis fuels iron addiction in colorectal cancer 线粒体抗氧化轴促进结直肠癌的铁依赖
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.011
Le Jin Sun,Gina M. DeNicola
{"title":"A mitochondrial antioxidant axis fuels iron addiction in colorectal cancer","authors":"Le Jin Sun,Gina M. DeNicola","doi":"10.1016/j.cmet.2026.06.011","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.011","url":null,"abstract":"Colorectal cancer (CRC) cells accumulate iron to fuel proliferation yet paradoxically resist its toxicity. Jain et al. reveal that heme stabilizes succinate dehydrogenase subunit C, sustaining complex II-dependent coenzyme Q reduction and its redistribution to the plasma membrane, enabling CRC cells to buffer oxidative stress and iron-induced cell death.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"55 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulsatile FXR activation for liver diseases 脉冲FXR激活治疗肝病
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.07.005
Pingxin Sun,Ke Feng,Wenlin Li
{"title":"Pulsatile FXR activation for liver diseases","authors":"Pingxin Sun,Ke Feng,Wenlin Li","doi":"10.1016/j.cmet.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.005","url":null,"abstract":"Sustained receptor activation is often prioritized in drug development. Zang and colleagues challenge this paradigm with linafexor, a rapidly cleared farnesoid X receptor agonist that produces pulsatile activation, preserves receptor responsiveness, reduces broad transcriptional disruption, and improves efficacy and safety, highlighting temporal alignment as a design principle for metabolic therapeutics.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"295 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control 高迁移率组盒1对线粒体质量控制至关重要
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-07-18 DOI: 10.1016/j.cmet.2026.07.009
Daolin Tang, Rui Kang, Kristen M. Livesey, Guido Kroemer, Timothy R. Billiar, Bennett Van Houten, Herbert J. Zeh III, Michael T. Lotze
{"title":"High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control","authors":"Daolin Tang, Rui Kang, Kristen M. Livesey, Guido Kroemer, Timothy R. Billiar, Bennett Van Houten, Herbert J. Zeh III, Michael T. Lotze","doi":"10.1016/j.cmet.2026.07.009","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.009","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"241 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance FGF21与瘦素协同作用，通过逆转肝脏瘦素抵抗来对抗肥胖相关的代谢合并症
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-07-16 DOI: 10.1016/j.cmet.2026.06.021
Qing Shen, Hailan Zou, Leigang Jin, Jiaxin Liu, Shixiang Wang, Na Li, Runhong Zhou, Ming Yue, Baile Wang, Ranyao Yang, Erfei Song, Yifen Lin, Songyan Liao, Zhiwei Chen, Yang Xiao, Yun-Shen Chan, Hung-Fat Tse, Aimin Xu
{"title":"FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance","authors":"Qing Shen, Hailan Zou, Leigang Jin, Jiaxin Liu, Shixiang Wang, Na Li, Runhong Zhou, Ming Yue, Baile Wang, Ranyao Yang, Erfei Song, Yifen Lin, Songyan Liao, Zhiwei Chen, Yang Xiao, Yun-Shen Chan, Hung-Fat Tse, Aimin Xu","doi":"10.1016/j.cmet.2026.06.021","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.021","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"43 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148461663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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