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China Journal of Chinese Matera Medica最新文献

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Antiproliferative effects mechanism of β-sitosterul in hepatoma HepG2 cells β-谷甾醇对肝癌HepG2细胞的抗增殖作用机制
China Journal of Chinese Matera Medica Pub Date : 2011-08-01 DOI: 10.4268/CJCMM20111529
Zhong-quan Zhang, Yujun Xing, Guo-qiang Hu, Songqiang Xie
{"title":"Antiproliferative effects mechanism of β-sitosterul in hepatoma HepG2 cells","authors":"Zhong-quan Zhang, Yujun Xing, Guo-qiang Hu, Songqiang Xie","doi":"10.4268/CJCMM20111529","DOIUrl":"https://doi.org/10.4268/CJCMM20111529","url":null,"abstract":"OBJECTIVE To study the antiproliferative effects of beta-sitosterul and its mechanism in hepatoma HepG2 cells. METHOD Cell proliferation was assessed by MTT assay. Cell cycle distribution, apoptosis and mitochondrial membrane potential were measured by high content screening (HCS). The protein expression of caspase-3, caspase-8, caspase-9, Bcl-2, Bax, tBid and cytochrome c in the HepG2 cells were evaluated by Western Blots. RESULT beta-Sitosterul exerted significant antiproliferative effects in HepG2 cells. Furthermore, beta-sitosterul also induced HepG2 cells apoptosis, lost mitochondrial membrane potential, activated caspase-3, caspase-8 and caspase-9, up-regulate Bax, tBid protein, down-regulation Bcl-2 protein. However, beta-sitosterul had hardly any effects on QSG7701 cells. CONCLUSION beta-Sitosterul exerted antiproliferative effects and induced HepG2 cells apoptosis via mitochondrial pathway and membrane death receptor pathway.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"24 1","pages":"2145"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83317746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Summary of revised contents of medical standards of preparation recorded in Chinese Pharmacopeia 中国药典制剂医学标准修订内容摘要
China Journal of Chinese Matera Medica Pub Date : 2011-07-15 DOI: 10.4268/CJCMM20111434
Bai Xiaoju
{"title":"Summary of revised contents of medical standards of preparation recorded in Chinese Pharmacopeia","authors":"Bai Xiaoju","doi":"10.4268/CJCMM20111434","DOIUrl":"https://doi.org/10.4268/CJCMM20111434","url":null,"abstract":"","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81044192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Advance of polysorbate 80 for injection accessories 注射配件用聚山梨酯80的研制进展
China Journal of Chinese Matera Medica Pub Date : 2011-07-01 DOI: 10.4268/CJCMM20111415
Zhang Meiyu
{"title":"Advance of polysorbate 80 for injection accessories","authors":"Zhang Meiyu","doi":"10.4268/CJCMM20111415","DOIUrl":"https://doi.org/10.4268/CJCMM20111415","url":null,"abstract":": Polysorbate 80 for injection accessories is one of the main reactions of clinical adverse to which may be leaded by a variety of traditional Chinese medicine injection. In this review, on the basis of literature research and experimental studies, polysorbate 80 are summarized in areas which conclude the chemical structure, basic nature,quality standards, pharmacological activity, safety evaluation and toxicity studies. The review aimed to provide theoretical basis for the rational selections of Chinese medicine, safe and efficient usages of injection accessories, and to promote healthy development of traditional Chinese medicine injections.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"24 1","pages":"1910"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81228792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Reseach on changes of varieties of ancient and modern Chinese herbs 古今中草药品种变化研究
China Journal of Chinese Matera Medica Pub Date : 2011-07-01 DOI: 10.4268/CJCMM20111328
Tang Decai
{"title":"Reseach on changes of varieties of ancient and modern Chinese herbs","authors":"Tang Decai","doi":"10.4268/CJCMM20111328","DOIUrl":"https://doi.org/10.4268/CJCMM20111328","url":null,"abstract":"Because of many reasons, big changes occur in the varieties of ancient and modern Chinese herbs. Besides a significant increase in the number, there are many other features, such as significant differences among mainstream varieties, partly resolving the chaotic situation of uncoincidence of different herb names, increasing proportion of plant herbs, and herbal multi-polarization, etc.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"5 1","pages":"1835"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72847874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of content changes of volatile oil and β-elemene in oil in Sarcandrae 菝葜属精油挥发油及β-榄香烯含量变化分析
China Journal of Chinese Matera Medica Pub Date : 2011-06-01 DOI: 10.4268/CJCMM20111221
Suxiang Wu, Shengna Zhang, Suhong Chen, Zhaohuan Lou, Guiyuan Lv
{"title":"Analysis of content changes of volatile oil and β-elemene in oil in Sarcandrae","authors":"Suxiang Wu, Shengna Zhang, Suhong Chen, Zhaohuan Lou, Guiyuan Lv","doi":"10.4268/CJCMM20111221","DOIUrl":"https://doi.org/10.4268/CJCMM20111221","url":null,"abstract":"OBJECTIVE To reveal the factors that affect the contents of volatile oil and beta-elemene in oil in Sarcandrae and to provide scientific basis for Sarcandrae's reasonable exploitation and quality assessment. METHOD A GC method was established and the contents of volatile oil and beta-elemene were determined in Sarcandrae from different length of time to grow, different medicament portions, different collection periods and different length of time to dry. RESULT The length of time to grow had no significant effect and the collection periods had effect on the volatile oil yield and content of beta-elemene. The volatile oil yield and content of beta-elemene were the highest in Sarcandrae harvested in December. The yield of volatile oil in different medicament portions descended in an order of roots, leaves and stems. The content of beta-elemene was the highest in leaves and the lowest in stems. With the increasing of the length of time to dry, the volatile oil yield and content of beta-elemene decreased calculated on an anhydrous basis. CONCLUSION The established method is simple, accurate and repeatable. It can be used for the quality control of beta-elemene in Sarcandrae. The study provides a valuable basis for the quality assessment, the development and utilization of Sarcandrae.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"48 1","pages":"1637"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84792545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Treatment of premenstrual syndrome with Chinese medicine formula, baixiangdan capsule: implications for neuron viability and GABA(A) receptor modulation in rat cortex]. [中药方剂、白香丹胶囊治疗经前期综合征:对大鼠皮层神经元活力及GABA受体调节的影响]。
China Journal of Chinese Matera Medica Pub Date : 2011-06-01 DOI: 10.4268/CJCMM20111122
Sun Shiguang
{"title":"[Treatment of premenstrual syndrome with Chinese medicine formula, baixiangdan capsule: implications for neuron viability and GABA(A) receptor modulation in rat cortex].","authors":"Sun Shiguang","doi":"10.4268/CJCMM20111122","DOIUrl":"https://doi.org/10.4268/CJCMM20111122","url":null,"abstract":"OBJECTIVE: To explore the effects of Baixiangdan capsule (BXD), a Chinese medicinal formula, on the premenstrual syndrome (PMS) rats with Liver-qi invasion and the possible underlying micro-mechanisms. METHOD: Wistar rats were randomly assigned to two groups, nomal group and BXD group After evaluated by macro-behavior observation and open-field test, MTT assay and the whole-cell patch clamp recording were performed respectively to evaluate the effects of serum from BXD capsule-treated rats on the viability and GABA(A) R-induced currents of cortical neurons in vitro. RESULT: In the open-field test, the crossing score, rearing score and total score of BXD rats decreased significantly (P < 0.05), compared by the normal rats. Compared with cells exposed to serum of normal rats, the viability values of those incubated with serum of BXD group for 24 h and 48 h significantly increased (P < 0.05), measured by MTT assay. The results of whole-cell patch clamp recording showed that concentration-response relationship curves revealed an EC50 value of (29.0 +/- 4.4) micromol x L(-1) and a Hill coefficient of 1.07 for normal-exposed cultures, (63.5 +/- 8.2) micromol x L(-1), 1.04 for BXD-exposed cultures after incubation for 24 h. Furthermore, the difference in EC50 values was statistically significant (P < 0.01), that in the Hill coefficient was not obvious. CONCLUSION: BXD capsule could significantly decrease crossing score and total score of open-field test and effectively enhance the neuron viability and GABA(A) receptor activity in rat cortex. Paeonimetabolins I and paeonol may play a significant role in treating PMS model rats with Liver-qi invasion by BXD capsule, and paeonol may target at GABA(A) receptor, especially.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"27 1","pages":"1508"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82216061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Study on chemical constituents from branches and leaves of Polyalthia nemoralis 毛茛枝叶化学成分的研究
China Journal of Chinese Matera Medica Pub Date : 2011-04-01 DOI: 10.4268/CJCMM20110817
Lu Ziming
{"title":"Study on chemical constituents from branches and leaves of Polyalthia nemoralis","authors":"Lu Ziming","doi":"10.4268/CJCMM20110817","DOIUrl":"https://doi.org/10.4268/CJCMM20110817","url":null,"abstract":"OBJECTIVE To investigate the chemical constituents of the branches and leaves of Polyalthia nemoralis. METHOD The compounds were isolated and purified by silica gel, macroporous adsorption resin and Sephadex LH-20 column chromatographic methods. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data. RESULT Fourteen compounds were isolated and identified as syringic acid (1), 3-methoxy-4-hydroxycinnamic acid (2), vanillic acid (3), 4-hydroxybenzoic acid (4), mauritianin (5), (+)-xylopinidine (6), (+)-oblongine(7), (+)-tembetarine (8), eythritol (9), D-mannitol (10), ethyl-beta-D-glucopyranoside (11), (+)-magnoflorine (12), stepharanine (13), (2S, 4R)-4-hydroxy-2-piperidine-carboxylic acid (14), respectively. CONCLUSION All the compounds were isolated from the genus Polyalthia for the first time; compounds 6 and 13 showed inhibitation activities against multi tumor cell lines.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"140 1","pages":"1024"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80548257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Composition and thermal stability of traditional Tibetan mineral medicine Nanhanshuishi 藏药南寒水石的组成及热稳定性研究
China Journal of Chinese Matera Medica Pub Date : 2011-03-01 DOI: 10.4268/CJCMM20110607
Quan Zhengxiang
{"title":"Composition and thermal stability of traditional Tibetan mineral medicine Nanhanshuishi","authors":"Quan Zhengxiang","doi":"10.4268/CJCMM20110607","DOIUrl":"https://doi.org/10.4268/CJCMM20110607","url":null,"abstract":"OBJECTIVE: To determine the composition, structure, trace elements and thermal stability of Tibetan medicine Nanhanshuishi. METHOD: The trace elements, the structure, and the thermal stability of Nanhanshuishi were assayed and calculated by X-ray fluorescence spectrometry (XRF), inductively coupled plasma optical emission spectrometer (ICP-OES), atomic fluorescence spectrometry (AFS), inductively coupled plasma mass spectrometry (ICP-MS), X-ray power diffraction (XRD), TG-DTA. RESULT: The results indicated that the phase is mainly made up of CaCO3 (Rhombohedral, R-3c) in Nanhanshuishi. The analysis of elements show that Nanhanshuishi is rich in Ca and O, and contains other more than 20 minor elements, such as Si, Mg, Fe, Al, Na, K, Zn, Mn, Pb, As, Hg etc. The result of TG-DTA show that the weight of Nanhanshuishi starts to decline from near 700 degrees C and get steady above 850 degrees C. CONCLUSION: The study provided scientific data for the establishment of quality standards of Tibetan medicine Nanhanshuishi.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"296 1","pages":"691"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77759173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of soil water content on seedlings growth and active ingredients of Salvia miltiorrhiza 土壤含水量对丹参幼苗生长及有效成分的影响
China Journal of Chinese Matera Medica Pub Date : 2011-02-01 DOI: 10.4268/CJCMM20110320
Liu Dahui
{"title":"Effects of soil water content on seedlings growth and active ingredients of Salvia miltiorrhiza","authors":"Liu Dahui","doi":"10.4268/CJCMM20110320","DOIUrl":"https://doi.org/10.4268/CJCMM20110320","url":null,"abstract":"OBJECTIVE: In order to provide a scientific water management for the standardized cultivation, the effects of soil water content on the seedlings growth and active ingredients of S. miltiorrhiza were studied. METHOD: A water stress experiment with pot culture was applied to study the effects of different soil water content on the seedlings growth, biomass and the accumulation of tanshinone, salvianolic acid B and mineral nutrition of S. miltiorrhiza. RESULT: Soil water content had serious influence on the growth, yield, outer appearance and inner quality of S. miltiorrhiza when the soil was under severe drought or with too much water. But the shoot and root biomass of S. miltiorrhiza was increased significantly under mild drought. As well as the content and cumulant of dihydrotanshinone I , cryptotanshinone, tanshinone I , tanshinone IIA and salvianolic acid B in root of mild drought were increased. It also enhanced the P, K, Ca, Mg, Mn, Zn, Cu and Fe contents of S. miltiorrhiza under mild drought. CONCLUSION: The overall results from the experiment suggest that the appropriate soil water content is 55% to 60% in seedling stage of S. miltiorrhiza. And it will be strongly recommended that the ridge culture and suitable soil moisture management must be carry out in production of S. miltiorrhiza in order to improve the yield and quality of medicinal materials.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"46 1","pages":"321"},"PeriodicalIF":0.0,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89208992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Study on 11 mental element contents in Dendrobium officinale 铁皮石斛中11种金属元素含量的研究
China Journal of Chinese Matera Medica Pub Date : 2011-02-01 DOI: 10.4268/CJCMM20110128
Zhu Yan
{"title":"Study on 11 mental element contents in Dendrobium officinale","authors":"Zhu Yan","doi":"10.4268/CJCMM20110128","DOIUrl":"https://doi.org/10.4268/CJCMM20110128","url":null,"abstract":"","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84285070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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