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[Study of molecular mechanism of anti-Parkinson's disease traditional Chinese medicine using model of Caenorhabditis elegans]. [利用秀丽隐杆线虫模型研究中药抗帕金森病的分子机制]。

China Journal of Chinese Matera Medica Pub Date : 2010-03-01 DOI: 10.4268/cjcmm20100527

Wang Xiangming, W. Xiaoyan, Gao Huili, W. Danqiao

{"title":"[Study of molecular mechanism of anti-Parkinson's disease traditional Chinese medicine using model of Caenorhabditis elegans].","authors":"Wang Xiangming, W. Xiaoyan, Gao Huili, W. Danqiao","doi":"10.4268/cjcmm20100527","DOIUrl":"https://doi.org/10.4268/cjcmm20100527","url":null,"abstract":"Parkinson′s disease(PD) is a neurodegenerative disorder with a complex,multifactorial aetiology.The brains of patients affected with PD are characterized by a loss of neurons in dopamine neurons in the substantia nigra,decreasing of dopamine secretion,and the deposition of Lewy bodies(LBs) in the cytoplasm of remaining neurons.In China the data show that the incidence of Parkinson′s disease increases at least 20 times in recent 20 years,and it makes things worse for the aging society.Developing good anti-PD drugs to improve the patient′s quality of life is particularly important.The treatment of PD using traditional Chinese medicine(TCM) has made remarkable effect,while the the molecular mechanisms of it is still not known,while elucidating the molecular mechanismof TCM is the base of better understanding its function.Using genetically modified PD model of Caenorhabditis elegans,which is suitable for molecular mechanism study,to explore the interference mechanism of TCM to PD might be an effective way.This review briefly introduces the research progress on molecular mechanism of PD,and then discusses the idea of using C.elegans to study molecular mechanism of TCM intervention to PD.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79900678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Ginkgo biloba extract on glucose uptake of diaphragm in diabetic rats 银杏叶提取物对糖尿病大鼠膈肌葡萄糖摄取的影响

China Journal of Chinese Matera Medica Pub Date : 2010-02-01 DOI: 10.4268/CJCMM20100322

Li Xusheng

{"title":"Effect of Ginkgo biloba extract on glucose uptake of diaphragm in diabetic rats","authors":"Li Xusheng","doi":"10.4268/CJCMM20100322","DOIUrl":"https://doi.org/10.4268/CJCMM20100322","url":null,"abstract":"OBJECTIVE To investigate the effects of Ginkgo biloba extract (GbE) on the glucose uptake rate and gene expression of glucose transporter 4 (GLUT4) in diaphragm of diabetic rats. METHOD Forty SD male rats were randomly divided into normal control group (n=10) and model group (n=30). Diabetic models were induced by feeding with high-sucrose-high-fat diet and intraperitoneal injecting 25 mg X kg(-1) streptozotocin. 20 successful models were rearranged to two groups: diabetic group and GbE treatment group, 10 rats in each. Then the saline and 8 mg X kg(-1) x d(-1) of GbE were respectively intraperitoneal injected, once a day continuously for 8 weeks. The contents of fasting blood glucose (FBG), fasting insulin (FINS) were detected, respectively. The glucose uptake rate and gene expression of GLUT4 in diaphragm were determinated and the varieties of diaphragm ultrastructure were observed. RESULT Compared with control group, levels of FBG and FINS obviously increased in diabetic rats (P < 0.01), but the glucose uptake rate and expression of GLUT4 mRNA in diaphragm decreased significantly (P < 0.05, P < 0.01). The ultrastructure in diabetic group under electron microscope indicated that diaphragm mitochondrion swelled and degenerated. The above changes were inhibited by GbE. CONCLUSION GbE can improve the glucose metabolism in diabetic rats and reduce the diabetes-induced diaphragm damage. The action mechanism of the drug may be related to promote the mRNA expression of GLUT4 in diaphragm and improve the uptake and metabolism of blood glucose.","PeriodicalId":9835,"journal":{"name":"China Journal of Chinese Matera Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91323069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Effects of space flight on protein content and electrophoresis in Glycyrrhiza uralensis 太空飞行对乌拉尔甘草蛋白质含量和电泳的影响

China Journal of Chinese Matera Medica Pub Date : 2010-01-01 DOI: 10.4268/CJCMM20100201

Gao Wenyuan

引用次数: 0

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