Cerebral Cortex (New York, NY)最新文献_第8页

Evidence for an Optimal Algorithm Underlying Signal Combination in Human Visual Cortex 人类视觉皮层信号组合的最优算法证据

Cerebral Cortex (New York, NY) Pub Date : 2016-12-27 DOI: 10.1093/cercor/bhw395

D. Baker, Alex R. Wade

引用次数: 22

The Influence of Alertness on the Spatial Deployment of Visual Attention is Mediated by the Excitability of the Posterior Parietal Cortices 警觉性对视觉注意空间分布的影响是由后顶叶皮层的兴奋性介导的

Cerebral Cortex (New York, NY) Pub Date : 2016-12-23 DOI: 10.1093/cercor/bhw390

R. Paladini, R. Müri, Jurka R. Meichtry, T. Nef, F. Mast, U. Mosimann, T. Nyffeler, D. Cazzoli

{"title":"The Influence of Alertness on the Spatial Deployment of Visual Attention is Mediated by the Excitability of the Posterior Parietal Cortices","authors":"R. Paladini, R. Müri, Jurka R. Meichtry, T. Nef, F. Mast, U. Mosimann, T. Nyffeler, D. Cazzoli","doi":"10.1093/cercor/bhw390","DOIUrl":"https://doi.org/10.1093/cercor/bhw390","url":null,"abstract":"Abstract With a reduced level of alertness, healthy individuals typically show a rightward shift when deploying visual attention in space. The impact of alertness on the neural networks governing visuospatial attention is, however, poorly understood. By using a transcranial magnetic stimulation twin‐coil approach, the present study aimed at investigating the effects of an alertness manipulation on the excitability of the left and the right posterior parietal cortices (PPCs), crucial nodes of the visuospatial attentional network. Participants’ visuospatial attentional deployment was assessed with a free visual exploration task and concurrent eye tracking. Their alertness level was manipulated through the time of the day, that is, by testing chronotypically defined evening types both during their circadian on‐ and off‐peak times. The results revealed an increased excitability of the left compared with the right PPC during low alertness. On the horizontal dimension, these results were accompanied by a significant rightward shift in the center and a bilateral narrowing in the periphery of the visual exploration field, as well as a central upward shift on the vertical dimension. The findings show that the manipulation of non‐spatial attentional aspects (i.e., alertness) can affect visuospatial attentional deployment and modulate the excitability of areas subtending spatial attentional control.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"27 4 1","pages":"233 - 243"},"PeriodicalIF":0.0,"publicationDate":"2016-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83120686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Parsing the Role of the Hippocampus in Approach–Avoidance Conflict 海马体在趋近-回避冲突中的作用分析

Cerebral Cortex (New York, NY) Pub Date : 2016-12-18 DOI: 10.1093/cercor/bhw378

Eleanor Loh, Z. Kurth-Nelson, D. Berron, P. Dayan, E. Duzel, R. Dolan, M. Guitart-Masip

{"title":"Parsing the Role of the Hippocampus in Approach–Avoidance Conflict","authors":"Eleanor Loh, Z. Kurth-Nelson, D. Berron, P. Dayan, E. Duzel, R. Dolan, M. Guitart-Masip","doi":"10.1093/cercor/bhw378","DOIUrl":"https://doi.org/10.1093/cercor/bhw378","url":null,"abstract":"Abstract The hippocampus plays a central role in the approach‐avoidance conflict that is central to the genesis of anxiety. However, its exact functional contribution has yet to be identified. We designed a novel gambling task that generated approach‐avoidance conflict while controlling for spatial processing. We fit subjects’ behavior using a model that quantified the subjective values of choice options, and recorded neural signals using functional magnetic resonance imaging (fMRI). Distinct functional signals were observed in anterior hippocampus, with inferior hippocampus selectively recruited when subjects rejected a gamble, to a degree that covaried with individual differences in anxiety. The superior anterior hippocampus, in contrast, uniquely demonstrated value signals that were potentiated in the context of approach‐avoidance conflict. These results implicate the anterior hippocampus in behavioral avoidance and choice monitoring, in a manner relevant to understanding its role in anxiety. Our findings highlight interactions between subregions of the hippocampus as an important focus for future study.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"15 1","pages":"201 - 215"},"PeriodicalIF":0.0,"publicationDate":"2016-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78367272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

An Examination of the Neural Unreliability Thesis of Autism 自闭症神经不可靠性理论的检验

Cerebral Cortex (New York, NY) Pub Date : 2016-12-06 DOI: 10.1093/cercor/bhw375

J. Butler, S. Molholm, G. Andrade, John J. Foxe

{"title":"An Examination of the Neural Unreliability Thesis of Autism","authors":"J. Butler, S. Molholm, G. Andrade, John J. Foxe","doi":"10.1093/cercor/bhw375","DOIUrl":"https://doi.org/10.1093/cercor/bhw375","url":null,"abstract":"Abstract An emerging neuropathological theory of Autism, referred to here as “the neural unreliability thesis,” proposes greater variability in moment‐to‐moment cortical representation of environmental events, such that the system shows general instability in its impulse response function. Leading evidence for this thesis derives from functional neuroimaging, a methodology ill‐suited for detailed assessment of sensory transmission dynamics occurring at the millisecond scale. Electrophysiological assessments of this thesis, however, are sparse and unconvincing. We conducted detailed examination of visual and somatosensory evoked activity using high‐density electrical mapping in individuals with autism (N = 20) and precisely matched neurotypical controls (N = 20), recording large numbers of trials that allowed for exhaustive time‐frequency analyses at the single‐trial level. Measures of intertrial coherence and event‐related spectral perturbation revealed no convincing evidence for an unreliability account of sensory responsivity in autism. Indeed, results point to robust, highly reproducible response functions marked for their exceedingly close correspondence to those in neurotypical controls","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"8 1","pages":"185 - 200"},"PeriodicalIF":0.0,"publicationDate":"2016-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84193153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Cortical Circuit for Binding Object Identity and Location During Multiple-Object Tracking 多目标跟踪中绑定目标识别和定位的皮质回路

Cerebral Cortex (New York, NY) Pub Date : 2016-12-02 DOI: 10.1093/cercor/bhw380

L. Nummenmaa, Lauri Oksama, E. Glerean, J. Hyönä

引用次数: 23

Extending the Cortical Grasping Network: Pre-supplementary Motor Neuron Activity During Vision and Grasping of Objects 扩展皮层抓取网络:视觉和抓取过程中的前补充运动神经元活动

Cerebral Cortex (New York, NY) Pub Date : 2016-12-01 DOI: 10.1093/cercor/bhw315

M. Lanzilotto, Alessandro Livi, M. Maranesi, M. Gerbella, F. Barz, P. Ruther, L. Fogassi, G. Rizzolatti, L. Bonini

引用次数: 34

The Organization of Mouse and Human Cortico-Hippocampal Networks Estimated by Intrinsic Functional Connectivity 通过内在功能连通性估计小鼠和人类皮质-海马体网络的组织

Cerebral Cortex (New York, NY) Pub Date : 2016-12-01 DOI: 10.1093/cercor/bhw327

Eyal Bergmann, Gil Zur, Guy Bershadsky, I. Kahn

{"title":"The Organization of Mouse and Human Cortico-Hippocampal Networks Estimated by Intrinsic Functional Connectivity","authors":"Eyal Bergmann, Gil Zur, Guy Bershadsky, I. Kahn","doi":"10.1093/cercor/bhw327","DOIUrl":"https://doi.org/10.1093/cercor/bhw327","url":null,"abstract":"While the hippocampal memory system has been relatively conserved across mammals, the cerebral cortex has undergone massive expansion. A central question in brain evolution is how cortical development affected the nature of cortical inputs to the hippocampus. To address this question, we compared cortico-hippocampal connectivity using intrinsic functional connectivity MRI (fcMRI) in awake mice and humans. We found that fcMRI recapitulates anatomical connectivity, demonstrating sensory mapping within the mouse parahippocampal region. Moreover, we identified a similar topographical modality-specific organization along the longitudinal axis of the mouse hippocampus, indicating that sensory information arriving at the hippocampus is only partly integrated. Finally, comparing cortico-hippocampal connectivity across species, we discovered preferential hippocampal connectivity of sensory cortical networks in mice compared with preferential connectivity of association cortical networks in humans. Supporting this observation in humans but not in mice, sensory and association cortical networks are connected to spatially distinct subregions within the parahippocampal region. Collectively, these findings indicate that sensory cortical networks are coupled to the mouse but not the human hippocampal memory system, suggesting that the emergence of expanded and new association areas in humans resulted in the rerouting of cortical information flow and dissociation of primary sensory cortices from the hippocampus.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"122 1","pages":"4497 - 4512"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83208473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 65

The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups 自由运动大鼠幼崽体感觉皮层伤害网络活动的发展

Cerebral Cortex (New York, NY) Pub Date : 2016-12-01 DOI: 10.1093/cercor/bhw330

P. Chang, L. Fabrizi, S. Olhede, M. Fitzgerald

{"title":"The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups","authors":"P. Chang, L. Fabrizi, S. Olhede, M. Fitzgerald","doi":"10.1093/cercor/bhw330","DOIUrl":"https://doi.org/10.1093/cercor/bhw330","url":null,"abstract":"Cortical perception of noxious stimulation is an essential component of pain experience but it is not known how cortical nociceptive activity emerges during brain development. Here we use continuous telemetric electrocorticogram (ECoG) recording from the primary somatosensory cortex (S1) of awake active rat pups to map functional nociceptive processing in the developing brain over the first 4 weeks of life. Cross-sectional and longitudinal recordings show that baseline S1 ECoG energy increases steadily with age, with a distinctive beta component replaced by a distinctive theta component in week 3. Event-related potentials were evoked by brief noxious hindpaw skin stimulation at all ages tested, confirming the presence of functional nociceptive spinothalamic inputs in S1. However, hindpaw incision, which increases pain sensitivity at all ages, did not increase S1 ECoG energy until week 3. A significant increase in gamma (20–50 Hz) energy occurred in the presence of skin incision at week 3 accompanied by a longer-lasting increase in theta (4–8 Hz) energy at week 4. Continuous ECoG recording demonstrates specific postnatal functional stages in the maturation of S1 cortical nociception. Somatosensory cortical coding of an ongoing pain “state” in awake rat pups becomes apparent between 2 and 4 weeks of age.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"42 1","pages":"4513 - 4523"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81773513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

An Electrophysiological Index of Perceptual Goodness 感知良善的电生理指标

Cerebral Cortex (New York, NY) Pub Date : 2016-12-01 DOI: 10.1093/cercor/bhw255

A. Makin, Damien Wright, Giulia Rampone, L. Palumbo, M. Guest, Rhiannon Sheehan, Helen Cleaver, Marco Bertamini

{"title":"An Electrophysiological Index of Perceptual Goodness","authors":"A. Makin, Damien Wright, Giulia Rampone, L. Palumbo, M. Guest, Rhiannon Sheehan, Helen Cleaver, Marco Bertamini","doi":"10.1093/cercor/bhw255","DOIUrl":"https://doi.org/10.1093/cercor/bhw255","url":null,"abstract":"A traditional line of work starting with the Gestalt school has shown that patterns vary in strength and salience; a difference in “Perceptual goodness.” The Holographic weight of evidence model quantifies goodness of visual regularities. The key formula states that W = E/N, where E is number of holographic identities in a pattern and N is number of elements. We tested whether W predicts the amplitude of the neural response to regularity in an extrastriate symmetry-sensitive network. We recorded an Event Related Potential (ERP) generated by symmetry called the Sustained Posterior Negativity (SPN). First, we reanalyzed the published work and found that W explained most variance in SPN amplitude. Then in four new studies, we confirmed specific predictions of the holographic model regarding 1) the differential effects of numerosity on reflection and repetition, 2) the similarity between reflection and Glass patterns, 3) multiple symmetries, and 4) symmetry and anti-symmetry. In all cases, the holographic approach predicted SPN amplitude remarkably well; particularly in an early window around 300–400 ms post stimulus onset. Although the holographic model was not conceived as a model of neural processing, it captures many details of the brain response to symmetry.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"146 1","pages":"4416 - 4434"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80541673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways 突触磷脂信号通过谷氨酸依赖的Ca2+介导的分子途径调节轴突的生长

Cerebral Cortex (New York, NY) Pub Date : 2016-12-01 DOI: 10.1093/cercor/bhw370

J. Vogt, S. Kirischuk, P. Unichenko, Leslie Schlüter, Assunta Pelosi, Heiko Endle, Jenq-Wei Yang, Nikolai Schmarowski, Jin Cheng, Carine Thalman, U. Strauss, A. Prokudin, Suman B. Bharati, J. Aoki, J. Chun, B. Lutz, H. Luhmann, R. Nitsch

{"title":"Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways","authors":"J. Vogt, S. Kirischuk, P. Unichenko, Leslie Schlüter, Assunta Pelosi, Heiko Endle, Jenq-Wei Yang, Nikolai Schmarowski, Jin Cheng, Carine Thalman, U. Strauss, A. Prokudin, Suman B. Bharati, J. Aoki, J. Chun, B. Lutz, H. Luhmann, R. Nitsch","doi":"10.1093/cercor/bhw370","DOIUrl":"https://doi.org/10.1093/cercor/bhw370","url":null,"abstract":"Abstract Altered synaptic bioactive lipid signaling has been recently shown to augment neuronal excitation in the hippocampus of adult animals by activation of presynaptic LPA2‐receptors leading to increased presynaptic glutamate release. Here, we show that this results in higher postsynaptic Ca2+ levels and in premature onset of spontaneous neuronal activity in the developing entorhinal cortex. Interestingly, increased synchronized neuronal activity led to reduced axon growth velocity of entorhinal neurons which project via the perforant path to the hippocampus. This was due to Ca2+‐dependent molecular signaling to the axon affecting stabilization of the actin cytoskeleton. The spontaneous activity affected the entire entorhinal cortical network and thus led to reduced overall axon fiber numbers in the mature perforant path that is known to be important for specific memory functions. Our data show that precise regulation of early cortical activity by bioactive lipids is of critical importance for proper circuit formation.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"3 1","pages":"131 - 145"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82400449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11