Chemical Research in Chinese Universities最新文献_第8页

Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle. 揭示单个狂犬病毒颗粒进入细胞的动力学机制

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2022-01-01 Epub Date: 2022-05-02 DOI: 10.1007/s40242-022-2069-y

Siying Li, Yangang Pan, Honggang Teng, Yuping Shan, Guocheng Yang, Hongda Wang

{"title":"Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle.","authors":"Siying Li, Yangang Pan, Honggang Teng, Yuping Shan, Guocheng Yang, Hongda Wang","doi":"10.1007/s40242-022-2069-y","DOIUrl":"10.1007/s40242-022-2069-y","url":null,"abstract":"The rabies virus is a neurotropic virus that causes fatal diseases in humans and animals. Although studying the interactions between a single rabies virus and the cell membrane is necessary for understanding the pathogenesis, the internalization dynamic mechanism of single rabies virus in living cells remains largely elusive. Here, we utilized a novel force tracing technique based on atomic force microscopy(AFM) to record the process of single viral entry into host cell. We revealed that the force of the rabies virus internalization distributed at (65±25) pN, and the time was identified by two peaks with spacings of (237.2±59.1) and (790.3±134.4) ms with the corresponding speed of 0.12 and 0.04 µm/s, respectively. Our results provide insight into the effects of viral shape during the endocytosis process. This report will be meaningful for understanding the dynamic mechanism of rabies virus early infection.Electronic supplementary material: Supplementary material is available in the online version of this article at 10.1007/s40242-022-2069-y.","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"38 1","pages":"838-842"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42144515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation. 基于适配体的生物分子识别与生物过程调控研究进展

4区化学

Chemical Research in Chinese Universities Pub Date : 2022-01-01 Epub Date: 2022-05-07 DOI: 10.1007/s40242-022-2087-9

Sisi Chen, Lei Zhang, Quan Yuan, Jie Tan

{"title":"Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation.","authors":"Sisi Chen, Lei Zhang, Quan Yuan, Jie Tan","doi":"10.1007/s40242-022-2087-9","DOIUrl":"10.1007/s40242-022-2087-9","url":null,"abstract":"The interaction between biomolecules with their target ligands plays a great role in regulating biological functions. Aptamers are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological functions. In the past ten years, aptamers have made great progress in target biomolecule recognition, becoming a powerful tool to regulate biological functions. At present, there are many reviews on aptamers applied in biomolecular recognition, but few reviews pay attention to aptamer-based regulation of biological functions. Here, we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity, cellular immunity and cellular behaviors. Furthermore, this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation, aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"38 1","pages":"847-855"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45845518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors. 基于高选择性和高灵敏度电化学适体的传感器的最新进展。

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2022-01-01 Epub Date: 2022-05-05 DOI: 10.1007/s40242-022-2084-z

Tianwei Tang, Yinghuan Liu, Ying Jiang

引用次数: 0

Antipsychotics With Different Chemical Structures Cause Different Degrees of Functional Impairments in the Primary Visual Cortex in a Murine Model: A Pilot Study. 在小鼠模型中，不同化学结构的抗精神病药物会对初级视觉皮层造成不同程度的功能损害：一项试验性研究

IF 0.7 4区化学

Chemical Research in Chinese Universities Pub Date : 2021-12-01 DOI: 10.5152/pcp.2021.20022

Si Gao, Xiaoyan Ma, Feng Ji, Ce Chen, Deguo Jiang, Yong Xu, Xueqin Song, Wenqiang Wang, Xiaodong Lin, Hongjun Tian, Chuanjun Zhuo, Xinwu Ye, Haiping Yu

{"title":"Antipsychotics With Different Chemical Structures Cause Different Degrees of Functional Impairments in the Primary Visual Cortex in a Murine Model: A Pilot Study.","authors":"Si Gao, Xiaoyan Ma, Feng Ji, Ce Chen, Deguo Jiang, Yong Xu, Xueqin Song, Wenqiang Wang, Xiaodong Lin, Hongjun Tian, Chuanjun Zhuo, Xinwu Ye, Haiping Yu","doi":"10.5152/pcp.2021.20022","DOIUrl":"10.5152/pcp.2021.20022","url":null,"abstract":"Background: Antipsychotic medications can impair vision in patients with schizophrenia. However, little is known regarding the pharmacodynamics of antipsychotics in the primary visual cortex. We aimed to study the pharmacodynamics of antipsychotics in the visual cortex in a murine model.Methods: We used an adapted 2-photon imaging technique to observe changes in calcium dynamics induced by 4 antipsychotics (olanzapine, risperidone, aripiprazole, and amisulpride) in the primary visual cortex of healthy and schizophrenic C57BL/6 mice. Visual function was further assessed by using a novel object recognition test.Results: All 4 antipsychotics decreased calcium activity in the primary visual cortex and reduced visual recognition test scores in healthy and schizophrenic mice. The most potent drug was olanzapine, followed by risperidone, aripiprazole, and amisulpride. All drugs showed significant differences between groups.Conclusion: Our pilot study demonstrated that antipsychotics impair visual cortical function. This finding underscores the importance of monitoring for visual adverse events in patients receiving antipsychotic medications to treat schizophrenia.","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"34 1","pages":"364-369"},"PeriodicalIF":0.7,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74448003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube. 一罐合成双层抗凝水凝胶管。

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2021-01-01 Epub Date: 2021-09-04 DOI: 10.1007/s40242-021-1267-3

Di Sun, Wenqing Gao, Peng Wu, Jie Liu, Shengmei Li, Shilin Li, Meili Yu, Meng Ning, Ru Bai, Tong Li, Ying Liu, Chunying Chen

{"title":"A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube.","authors":"Di Sun, Wenqing Gao, Peng Wu, Jie Liu, Shengmei Li, Shilin Li, Meili Yu, Meng Ning, Ru Bai, Tong Li, Ying Liu, Chunying Chen","doi":"10.1007/s40242-021-1267-3","DOIUrl":"https://doi.org/10.1007/s40242-021-1267-3","url":null,"abstract":"Extracorporeal membrane oxygenation(ECMO) has emerged as a viable treatment in severe cases of acute respiratory distress syndrome, acute respiratory failure, and adult respiratory distress syndrome. However, thromboembolic events stemming from the use of ECMO devices results in significant morbidity and mortality rates; the inner surface of the ECMO tubing comes into contact with the blood and can readily initiate coagulation. In addition, the tubing needs to be continually replaced due to thromboses on the inner tube wall, which not only increases the risk of infection but also the economic burden. Despite considerable effort, a surface modification strategy that effectively addresses these challenges has not yet been realized. In this study, we developed an integrated hollow core-shell-shell hydrogel tube of gelatin/alginate/acrylamide-bacterial nanocellulose(GAA) that meets the anticoagulant requirements for the inner tubing layer as well as the highly elastic soft material needed for the outer layer. Using static blood from healthy volunteers, we confirmed that the platelets or coagulation is not stimulated by the GAA tubing. Importantly, experiments with dynamic blood also demonstrated that the inner layer of the tubing does not elicit blood clotting. The one-pot-synthesized process may provide guidance for the design of anticoagulation tubes used clinically.Electronic supplementary material: Supplementary material is available in the online version of this article at 10.1007/s40242-021-1267-3.","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"37 5","pages":"1085-1091"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39408162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Dip-Pen Nanolithography(DPN): from Micro/Nano-patterns to Biosensing. 浸笔纳米光刻(DPN):从微/纳米模式到生物传感。

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2021-01-01 Epub Date: 2021-07-05 DOI: 10.1007/s40242-021-1197-0

Haonan Li, Zhao Wang, Fengwei Huo, Shutao Wang

引用次数: 5

Graphdiyne: from Preparation to Biomedical Applications. 石墨炔:从制备到生物医学应用。

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2021-01-01 Epub Date: 2021-10-23 DOI: 10.1007/s40242-021-1343-8

Xiaodan Li, Mengyu Guo, Chunying Chen

引用次数: 7

Electrospun Aspirin/Eudragit/Lipid Hybrid Nanofibers for Colon-targeted Delivery Using an Energy-saving Process. 采用节能工艺电纺阿司匹林/桉叶油/脂质混合纳米纤维用于结肠靶向给药

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2021-01-01 Epub Date: 2021-03-31 DOI: 10.1007/s40242-021-1006-9

Yibin Wang, Liang Tian, Tianhao Zhu, Jing Mei, Zezhong Chen, Deng-Guang Yu

{"title":"Electrospun Aspirin/Eudragit/Lipid Hybrid Nanofibers for Colon-targeted Delivery Using an Energy-saving Process.","authors":"Yibin Wang, Liang Tian, Tianhao Zhu, Jing Mei, Zezhong Chen, Deng-Guang Yu","doi":"10.1007/s40242-021-1006-9","DOIUrl":"10.1007/s40242-021-1006-9","url":null,"abstract":"Both electrospinning apparatus and their commercial products are extending their applications in a wide variety of fields. However, very limited reports can be found about how to implement an energy-saving process and in turn to reduce the production cost. In this paper, a brand-new type of coaxial spinneret with a solid core and its electrospinning methods are developed. A novel sort of medicated Eudragit/lipid hybrid nanofibers are generated for providing a colon-targeted sustained release of aspirin. A series of characterizations demonstrates that the as-prepared hybrid nanofibers have a fine linear morphology with the aspirin/lipid separated from the matrix Eudragit to form many tiny islands. In vitro dissolution tests exhibit that the hybrid nanofibers are able to effectively prevent the release of aspirin under an acid condition (8.7%±3.4% for the first two hours), whereas prolong the drug release time period under a neutral condition(99.7±4.2% at the seventh hour). The energy-saving mechanism is discussed in detail. The prepared aspirin-loaded hybrid nanofibers can be further transferred into an oral dosage form for potential application in countering COVID-19 in the future.","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"37 3","pages":"443-449"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25557617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami. 通过DNA折纸揭示抗体-抗原相互作用的动力学。

IF 3.1 4区化学

Chemical Research in Chinese Universities Pub Date : 2020-01-01 Epub Date: 2020-08-18 DOI: 10.1007/s40242-020-0252-6

Zhou Nie

引用次数: 0

Enantioselective Resolution of (±)-1-Phenylethyl Acetate by Using the Whole Cells of Deep-sea Bacterium Bacillus sp. DL-2 深海芽孢杆菌DL-2全细胞对（±）-1-苯乙酸乙酯的拆分

4区化学

Chemical Research in Chinese Universities Pub Date : 2019-08-21 DOI: 10.1007/s40242-019-9126-1

Lu Dong, Yongkai Xu, Yun Zhang, Aijun Sun, Yunfeng Hu

引用次数: 1