Chemical & pharmaceutical bulletin最新文献

Experimental and DFT Studies of Intermolecular Interaction-Assisted Oxindole Cyclization Reaction of Di-t-butyl 2-Aminophenyl-2-methyl Malonate.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00663

Ryo Kakehi, Yu-Suke Yamai, Akio Tanaka, Kyoji Ishida, Shinichi Uesato, Yasuo Nagaoka, Takaaki Sumiyoshi

引用次数: 0

Foreword.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c25-ctf7303

Tetsuro Ito, Wei Li

引用次数: 0

Foreword.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c25-ctf7304

Yasuko Obata

引用次数: 0

Brominated 3-Acetyl-11-keto-β-boswellic Acid Derivative from Boswellia serrata Extract Characterized by Single-Crystal X-Ray Structure Analysis and Mass Spectroscopy.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00819

Masataka Ito, Keisuke Misao, Hironori Suzuki, Shuji Noguchi

引用次数: 0

Comparative Analysis of Needleless and Needle-Based Electrospinning Methods for Polyamide 6: A Technical Note. 聚酰胺 6 的无针和有针电纺方法比较分析：技术说明。

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00611

Arash Yavari, Takaaki Ito, Kouji Hara, Kohei Tahara

{"title":"Comparative Analysis of Needleless and Needle-Based Electrospinning Methods for Polyamide 6: A Technical Note.","authors":"Arash Yavari, Takaaki Ito, Kouji Hara, Kohei Tahara","doi":"10.1248/cpb.c24-00611","DOIUrl":"10.1248/cpb.c24-00611","url":null,"abstract":"This study investigates the influence of needleless versus needle-based electrospinning methods on the fiber diameter of polyamide 6 (PA6) nanofibers under comparable conditions, with an emphasis on potential pharmaceutical applications. Additionally, it examines how varying solvent systems impact fiber diameter specifically in needleless electrospinning. In this study, it was found that fibers produced by the needleless method were thicker compared to those produced by the needle-based method, a trend attributable to the specific solution characteristics and parameter settings unique to this study. Notably, a 2 : 1 acetic acid : formic acid solvent mixture yielded the largest fiber diameters among the solvent systems assessed for needleless electrospinning. These results underscore the potential of PA6 nanofibers in pharmaceutical applications, suggesting that further optimization of electrospinning conditions could enhance their suitability. The study also discusses the implications of scale-up production using needleless technology, highlighting its viability for industrial applications over single-needle electrospinning.","PeriodicalId":9773,"journal":{"name":"Chemical & pharmaceutical bulletin","volume":"73 1","pages":"18-24"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Vial-Inner-Surface Treatment Technology Improves Chemical Durability and Vial-Inner-Surface Uniformity to Reduce Drug Adsorption on the Vial.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00658

Norikazu Miyamoto, Kenta Ohsugi, Taishi Higashi, Keiichi Motoyama

引用次数: 0

Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00648

Fumihiko Ogata, Kazuya Ujita, Yugo Uematsu, Noriaki Nagai, Chalermpong Saenjum, Shigeharu Tanei, Naohito Kawasaki

{"title":"Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent.","authors":"Fumihiko Ogata, Kazuya Ujita, Yugo Uematsu, Noriaki Nagai, Chalermpong Saenjum, Shigeharu Tanei, Naohito Kawasaki","doi":"10.1248/cpb.c24-00648","DOIUrl":"10.1248/cpb.c24-00648","url":null,"abstract":"In the present study, magnetic-calcined bamboo composite adsorbents (MCBC200, MCBC400, MCBC600, MCBC800, and MCBC1000) were prepared, and their physicochemical characteristics (scanning electron microscope images, differential thermogravimetric analysis, Fourier transform-IR, specific surface area, surface functional groups, and point of zero charge [pHpzc]) were evaluated. Furthermore, the adsorption capacity of methylene blue (MB, cationic dye) using the prepared adsorbents was assessed. The value of pHpzc and the specific surface area of MCBC400 were 7.8 and 50.6 m2/g, respectively. The amounts of acidic or basic functional groups of MCBC400 were relatively greater than those of the other adsorbents. The amount of MB adsorbed onto MCBC400 (31.9 mg/g) was higher than that onto other adsorbents. The adsorption of MB using MCBC400 was evaluated in relation to various parameters, including coexistence, solution pH, adsorption temperature, and contact time. The results followed the Langmuir isotherm model and a pseudo-second-order model with correlation coefficients of 0.980-1.000 and 0.996, respectively. MB was selectively adsorbed by MCBC400 in a binary solution system containing anionic dyes. Finally, one of the adsorption mechanisms was determined by analyzing the elemental distribution and the binding energy before and after the adsorption of MB. The current findings provide important information for removing MB with MCBC400 from the aqueous phase.","PeriodicalId":9773,"journal":{"name":"Chemical & pharmaceutical bulletin","volume":"73 3","pages":"205-212"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Permeation of Model Chemicals through Medical Gowns Used in Anticancer Drug Preparation.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00838

Takuya Sotome, Takeshi Oshizaka, Tomoaki Toyama, Keiko Shinozaki, Satoru Usui, Kenji Mori, Kenji Sugibayashi

{"title":"Permeation of Model Chemicals through Medical Gowns Used in Anticancer Drug Preparation.","authors":"Takuya Sotome, Takeshi Oshizaka, Tomoaki Toyama, Keiko Shinozaki, Satoru Usui, Kenji Mori, Kenji Sugibayashi","doi":"10.1248/cpb.c24-00838","DOIUrl":"https://doi.org/10.1248/cpb.c24-00838","url":null,"abstract":"The wearing of medical gowns during anticancer drug preparation is recommended for the prevention of drug exposure. Non-breathable and breathable gowns (gown- and gown+, respectively) are both available. However, anticancer drugs may permeate \"gown+.\" In the present study, water, hydrophilic and lipophilic dyes, and aqueous solutions of several model chemicals with different physical properties (pyridoxine, antipyrine, ethyl p-hydroxybenzoate, and butyl p-hydroxybenzoate) were applied to four types of gowns and their chemical permeabilities were measured. The permeability of gowns to vaporized ethanol was also investigated because several volatile anticancer drugs are currently used in the treatment of cancer. The results obtained showed that the hydrophilic chemical, pyridoxine, did not permeate any of the gowns tested. Furthermore, gowns became more permeable as the lipophilicity of chemicals increased. No significant changes were observed in the chemical permeability between \"gown-\" and \"gown+,\" suggesting that the protective efficacy of the gowns against permeation by anticancer drugs was similar regardless of breathability. On the contrary, \"gown + \" was permeable to vaporized ethanol, whereas \"gown-\" was not. The present study demonstrates the need for safety measures in lipophilic or volatile anticancer drug handling and the importance of developing medical gowns that are highly resistant to chemical permeation.","PeriodicalId":9773,"journal":{"name":"Chemical & pharmaceutical bulletin","volume":"73 3","pages":"227-233"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00732

Tomoki Takayama, Shun Kaneko, Vasanthi Palanisamy, Makoto Ono, Varin Titapiwatanakun, Kenjirou Higashi, Toshiro Fukami

{"title":"Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous.","authors":"Tomoki Takayama, Shun Kaneko, Vasanthi Palanisamy, Makoto Ono, Varin Titapiwatanakun, Kenjirou Higashi, Toshiro Fukami","doi":"10.1248/cpb.c24-00732","DOIUrl":"10.1248/cpb.c24-00732","url":null,"abstract":"Co-amorphous materials have gained special attention in the pharmaceutical field due to their high potential to enhance the oral bioavailability of poorly aqueous soluble drugs. In co-amorphous studies, few reports have examined the physical properties and molecular states of different active pharmaceutical ingredients (APIs) : co-amorphous former (CF) molar ratios and preparation methods. Therefore, we investigated the effect of molar ratio and preparation method on the physical properties of a novel co-amorphous system consisting of cilostazol and l-tryptophan, which we identified through screening. Co-amorphous consisting of molar ratios of 1 : 1 (co-milling (CM) 1 : 1), 1 : 1.5 (CM 1 : 1.5), and 1 : 2 (CM 1 : 2) were prepared by the CM method, while samples with a molar ratio of 1 : 1 (spray drying (SD) 1 : 1) were prepared by the spray drying method. CM 1 : 1.5 and CM 1 : 2 showed the highest solubility. Storage stability was excellent for CM 1:1.5, CM 1 : 2, and SD 1 : 1, whereas physical properties were improved by co-amorphization. To investigate the factors responsible for the improved physical properties, the molecular state of the co-amorphous system was evaluated, and it was inferred that hydrogen bonds were formed between cilostazol and l-tryptophan. Solid-state 13C-NMR showed several new peaks specific to the solid state in the co-milled sample compared to SD 1 : 1 and cilostazol amorphous, suggesting that the molecular state may differ depending on the preparation method. As described above, different physical properties and molecular states were observed in the novel co-amorphous system consisting of cilostazol and l-tryptophan when the molar ratio of APIs and CF, and the preparation method differed.","PeriodicalId":9773,"journal":{"name":"Chemical & pharmaceutical bulletin","volume":"73 4","pages":"318-326"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unconventional Synthetic Approaches to Unusual Peptide Derivatives.

IF 1.5 4区医学

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/cpb.c24-00752

Takeshi Nanjo

{"title":"Unconventional Synthetic Approaches to Unusual Peptide Derivatives.","authors":"Takeshi Nanjo","doi":"10.1248/cpb.c24-00752","DOIUrl":"10.1248/cpb.c24-00752","url":null,"abstract":"Peptides that contain unusual motifs, such as non-proteinogenic amino acids (AAs) and/or macrocyclic substructures, have recently attracted great attention as a new modality in medium-sized-molecule drug discovery. Therefore, it is highly important to develop methods for the chemical synthesis of a wide variety of such unusual peptide derivatives, which are often difficult to prepare via conventional synthetic approaches. In this review, the development of unconventional approaches for the synthesis of unusual peptide derivatives is discussed. Specifically, a novel external-oxidant-mediated decarboxylative condensation of α-ketoacids that can be applied to the synthesis of a wide variety of unusual peptide derivatives is reported. Moreover, an organocatalytic asymmetric Mannich-type addition is discussed that provides chiral β-amino-α-ketoacids, which are required as starting materials for the decarboxylative condensation. In this reaction, the adducts corresponding to various unusual AA side chains are obtained in high yield and excellent stereoselectivity. Furthermore, the \"N-chloropeptide strategy\" is proposed as a new method for the chemical modification of peptides without the need for a reactive AA residue.","PeriodicalId":9773,"journal":{"name":"Chemical & pharmaceutical bulletin","volume":"73 4","pages":"268-282"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0