Development of Cell-Penetrating Peptides and Their Application to DDS.

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c25-00272

Makoto Oba

引用次数: 0

Abstract

Cell-penetrating peptides (CPPs) hold great potential as tools for drug delivery systems (DDSs). Numerous research groups have developed novel CPPs with enhanced functionality and safety. This review highlights recent advancements in CPP research by my research group and our collaborators. We have designed novel CPPs incorporating unnatural amino acids, explored their applications in DDSs, and elucidated their functional mechanisms.

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细胞穿透肽的研究进展及其在DDS中的应用。

细胞穿透肽（CPPs）作为药物传递系统（dds）的工具具有巨大的潜力。许多研究小组已经开发出具有增强功能和安全性的新型CPPs。这篇综述重点介绍了我的研究小组和我们的合作者在CPP研究方面的最新进展。我们设计了含有非天然氨基酸的新型CPPs，探索了它们在dds中的应用，并阐明了它们的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.