Chemical Physics Impact最新文献

{"title":"Novel low-temperature colorimetric indicator based on functional PDA/PVA","authors":"Sachin Goyal ,&nbsp;Deepika Sharma ,&nbsp;Amit L Sharma ,&nbsp;Kamlesh Kumar","doi":"10.1016/j.chphi.2024.100803","DOIUrl":"10.1016/j.chphi.2024.100803","url":null,"abstract":"<div><div>The conjugated polydiacetylene (PDA) polymers have garnered significant attention due to their potential use as a thermochromic indicator. The color transition at low-temperature ranges makes them suitable for monitoring frozen foods and medicinal products. This study presents the synthesis and characterization of a novel thermochromic molecule that experiences a low-temperature irreversible color transition. The synthesis of modified monomeric dye involves an esterification (Steglich) reaction between 10,12-Pentacosadiynoic acid (PCDA) and phenol. The formation of the ester moiety in the dye derivative was confirmed using FTIR and NMR spectroscopy. The composite film was fabricated by mixing modified monomer dye with the polymer polyvinyl alcohol (PVA), which, upon UV light exposure, undergoes topochemical polymerization, forming PDA via 1,4-addition reaction between the respective diacetylene monomeric units. Thermochromic studies of this dye showed a low-temperature irreversible color transition above 15 °C, contrasting the reversible color transition of pristine dye above 45 °C and characterized with absorption and Raman spectroscopy. Consequently, the results may uncover the potential applications of the conjugated PDA-based irreversible thermochromic dye as a warning indicator for frozen packaged food and pharmaceutical items.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100803"},"PeriodicalIF":3.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorptive removal of methylene blue dye by a ternary magnetic rGO/AK/Fe3O4 nanocomposite: Studying adsorption isotherms, kinetics, and thermodynamics","authors":"Hayat Mulaw Ahmed ,&nbsp;Worku Lakew Kebede ,&nbsp;Abrha Berhe Yaebyo ,&nbsp;Amogne Wendu Digisu ,&nbsp;Sleshi Fentie Tadesse","doi":"10.1016/j.chphi.2024.100800","DOIUrl":"10.1016/j.chphi.2024.100800","url":null,"abstract":"<div><div>Organic dyes have very toxic, mutagenic, and carcinogenic properties. Contamination of water by dyes can cause serious threats to aquatic systems and humankind. Therefore, water systems contaminated with organic dyes should be treated. A new cost-effective method for removing methylene blue (MB) dye using a reusable synthetic reduced graphene oxide/activated kaolin/magnetite (rGO/AK/Fe₃O₄) ternary nanocomposite was developed. The synthesis of reduced graphene oxide (rGO)-based magnetic activated kaolin nanomaterial was achieved through a simple, environmentally friendly, and single-step process. Fe₃O₄, rGO, and kaolin-based materials with distinct structures, high specific surface areas, and customizable functional groups show great potential as adsorbents. Magnetite nanoparticles (Fe₃O₄) were coated on reduced graphene oxide (rGO) nanosheets and AK surface by chemical co-precipitation method supported by ultrasonication. It is characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy to investigate the crystal structure, morphology, and functional groups present in rGO/AK/Fe₃O₄ composites, respectively. The adsorption of methylene blue dye onto the ternary nanocomposite was studied. The synthesized nanocomposite showed 66–98.2% removal of MB at pH 10, initial concentration of 15 ppm with the range of adsorbent dose 5 - 50 mg. To examine the interaction of dye molecules with the adsorbent, we employed four adsorption isotherm models: Freundlich, Langmuir, Temkin, and Dubinin-Radushkevich. The Langmuir model yielded the best fit with an R² value of 0.996 at pH 10 and 298 K. The kinetic data were analyzed with three different kinetic models at pH 10 and the linearized pseudo second-order kinetic model was found to be the best fit model for our adsorption experiment with an R² value of 0.998. Thermodynamic parameters were also evaluated. The negative values of, ΔH^o, ΔG^o and ΔS^o were calculated to be -54.8 kJ/mol, -9.91 kJmol^-1, and -150.65 J/molK at 298 K; revealing the exothermic, spontaneous, and less disordered (good adsorbent-dye affinity) process, respectively. The reusability test exhibited 98.1 % removal capacity even after the 5th cycle. Thus, the nanocomposite material showed excellent stability and reusability for removing MB dye.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100800"},"PeriodicalIF":3.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, antimicrobial evaluation, docking and dynamics investigation of novel stearoyl mannopyranosides","authors":"A.F.M. Sanaullah ,&nbsp;Md․Rubel Hossen ,&nbsp;Md Samiur Rahman ,&nbsp;Md․Hasinul Babu ,&nbsp;Sumaiya Chowdhury ,&nbsp;A․N․M․Shahriar Zawad ,&nbsp;Faisal Islam Chowdhury ,&nbsp;Zainul Abedin Siddique","doi":"10.1016/j.chphi.2024.100799","DOIUrl":"10.1016/j.chphi.2024.100799","url":null,"abstract":"<div><div>The exploration of acylated monosaccharide derivatives, particularly those derived from mannose, stands as a pivotal endeavor with multifaceted synthetic applications in both the realms of medicine and industry. Given the escalating challenges posed by drug resistance in antifungal and antibacterial treatments, the imperative for innovative therapeutic agents becomes increasingly pronounced. In response to this critical need, several novel mannopyranoside stearate esters have been synthesized. Direct unimolar stearoylation of methyl α-<span>d</span>-mannopyranoside (<strong>1</strong>) at room temperature showed selectivity at C-6 primary position and furnished 6-<em>O</em>-stearoyl-α-<span>d</span>-mannopyranoside <strong>2</strong> in 61 % yield. The newly synthesized stearoate <strong>2</strong> was further modified into several acyl esters for developing some novel biologically active mannopyranoside esters. Furthermore, the synthesized stearoyl esters were employed for prediction of activity spectra for substances (PASS) and <em>in vitro</em> antimicrobial assay. It was found that the experimental esters were more potent against fungal pathogens than that of bacterial organisms. Moreover, advocating for the antifungal efficacy, molecular docking investigations were conducted on the synthesized stearates, revealing enhanced binding affinities with lanosterol 14α-demethylase (3LD6) protein. Notably, stearates <strong>2</strong> (-7.7 kcal/mol) and <strong>3</strong> (-7.9 kcal/mol) demonstrated higher binding affinities with the model protein. Molecular dynamic simulation studies further revealed significant interactions for compounds <strong>2</strong> and <strong>3</strong>, suggesting strong potential for these synthesized stearates to be developed as non-azole-type biodegradable antifungal agents.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100799"},"PeriodicalIF":3.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the photocatalytic properties of nickel oxide nanoparticles via iron doping: Efficient degradation of eosin yellow dye","authors":"Burhan Uddin ,&nbsp;Md. Omor Farque ,&nbsp;Md. Moniruzzaman ,&nbsp;Md. Jasim Uddin ,&nbsp;Md. Kamrul Hossain ,&nbsp;Sayeda Halima Begum","doi":"10.1016/j.chphi.2024.100798","DOIUrl":"10.1016/j.chphi.2024.100798","url":null,"abstract":"<div><div>In this study, iron (Fe) doping was employed to enhance the photocatalytic performance of Nickel Oxide Nanoparticles (NiONPs), particularly in the degradation of Eosin Yellow, a representative organic dye. NiONPs were synthesized via a chemical precipitation method using nickel nitrate hexahydrate as the precursor, with iron (III) nitrate nonahydrate introduced as the dopant to achieve Fe concentrations of 2 %, 4 %, 6 %, and 8 % in the NiONPs. The resulting Fe-doped NiONPs were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). The photocatalytic performance was evaluated by monitoring the degradation of Eosin Yellow under visible light irradiation. The characterization studies confirmed successful Fe doping in the NiO lattice, resulting in structural and compositional changes. Photocatalytic testing revealed that Fe doping enhanced the degradation efficiency of NiONPs for Eosin Yellow. Among the tested samples, 4 % Fe-doped NiONPs showed an impressive increase of nearly 30 % in degradation efficiency compared to undoped NiONPs. This enhancement is attributed to improved charge separation and increased light absorption, driven by the Fe dopant's influence on the electronic structure of NiONPs. The improved photocatalytic performance of Fe-doped NiONPs can be explained by the reduction of electron-hole recombination, which enhances the generation of reactive species responsible for dye degradation. These findings highlight the potential of Fe-doped NiONPs for applications in environmental remediation, especially in wastewater treatment processes aimed at removing organic pollutants.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100798"},"PeriodicalIF":3.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical and photoluminescence characteristics of Pr3+-doped P2O5 +BaO+La2O3 glasses","authors":"C.R. Kesavulu ,&nbsp;Ch. Basavapoornima ,&nbsp;Pikkili Ramprasad ,&nbsp;C.J. Deviprasad ,&nbsp;Shobha Rani Depuru ,&nbsp;C.K. Jayasankar","doi":"10.1016/j.chphi.2024.100797","DOIUrl":"10.1016/j.chphi.2024.100797","url":null,"abstract":"<div><div>This paper focusses on the spectral analysis of glasses composed of Pr³⁺:barium phosphate (PBaLaPr), which are employed in visible lasers and optical amplifiers. FTIR analysis of the vibrational modes of Pr³⁺:barium phosphate glasses has been studied. Using the absorption spectra, the three Judd-Ofelt (JO) parameters (Ω_2,4,6) were calculated. The resultant JO values (× 10^–20 cm²) were estimated to be Ω₂ = 3.49, Ω₄ = 22.06, and Ω₆ = 20.48. The radiative probabilities for the fluorescence states of Pr³⁺ were determined. The luminescence spectra show the emission bands in the visible range of 480–750 nm, and when the concentration of Pr³⁺ ions increased, decrease in emission intensities is observed due to concentration quenching. A luminescence peak at 600 nm was used as a monitoring level, and a 445 nm excitation was used to assess the decay curves. The decay rates exhibit a bi-exponential pattern, meaning that as the concentration of Pr³⁺ ions increase, the lifetimes become shorter. The near infrared luminescence characteristics were studied (λ_exe = 488 nm), and the resultant spectrum contains three emission bands, ranging from 800 to 1600 nm. The results of the investigation showed that the titled PBaLaPr glasses have potentiality for the development of VIS-NIR optical amplifiers and optical display devices.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100797"},"PeriodicalIF":3.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the comment by P. E. Tomaszewski","authors":"Debasish Panda,&nbsp;Sudhansu Sekhar Hota,&nbsp;Ram Naresh Prasad Choudhary","doi":"10.1016/j.chphi.2024.100795","DOIUrl":"10.1016/j.chphi.2024.100795","url":null,"abstract":"<div><div>This Reply mainly deals with the scientific description of the comments on the structure of the published ceramic KBiMn₂O₅. The developed material was prepared using a standard ceramic technology (high-temperature solid-state reaction technique). The high-purity ingredients (K₂CO₃, Bi₂O₃, and Mn₂O₃) were taken stoichiometrically to create a single-phase compound. The prominent X-ray diffraction pattern also matched with Bi₁₂MnO₂₀ (JCPDS 01-082-1024) and K₂Mn₄O₈ (JCPDS 00-016-0205) phases. The presence of dual phases is already written in the published article. In this Reply, we reanalyze this information. We do not agree with the statements made in the Comment.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100795"},"PeriodicalIF":3.8,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments to paper by D. Panda et al. on KBiMn2O5","authors":"Paweł E. Tomaszewski","doi":"10.1016/j.chphi.2024.100794","DOIUrl":"10.1016/j.chphi.2024.100794","url":null,"abstract":"<div><div>The ‘novel’ complex material KBiMn₂O₅ described in the paper “Structural, morphological, dielectric, and electrical characteristics of a brownmillerite material for electronic devices: KBiMn₂O₅” written by Debasish Panda, Sudhansu Sekhar Hota &amp; R. N. P. Choudhary (Chemical Physics Impact 8 (2024) 100540), does not exist at all. The studied sample was mainly the sillenite Bi₂₄Mn₂O₄₀ instead of brownmillerite KBiMn₂O₅. The comments present the erroneous approach to the processing of diffraction data. Thus, the data from subsequent experiments are without scientific value as measured on a mixture of at least two phases.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100794"},"PeriodicalIF":3.8,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential inhibitors of Ubiquitin carboxyl-terminal hydrolase 21 from repurposed drugs: Implications in anticancer therapeutics","authors":"Anas Shamsi ,&nbsp;Nojood Altwaijry ,&nbsp;Moyad Shahwan ,&nbsp;Akram Ashames ,&nbsp;Dharmendra Kumar Yadav ,&nbsp;Mohammad Furkan ,&nbsp;Rizwan Hasan Khan","doi":"10.1016/j.chphi.2024.100792","DOIUrl":"10.1016/j.chphi.2024.100792","url":null,"abstract":"<div><div>Ubiquitin carboxyl-terminal hydrolase 21 (USP21) is involved in the regulation of multiple cellular processes and participates in tumorigenesis. Due to its importance in the onset and progression of cancer, USP21 has become an appealing target in anticancer drug discovery. Therefore, this study aimed to screen a collection of repurposed drugs from the DrugBank 6.0 database for possible USP21 inhibitors. At the beginning of the selection process, the library was filtered by the binding efficiency to USP21, which identified a few drug molecules with appreciable binding affinity towards the USP21 binding pocket. These shortlisted molecules were then scrutinized based on their drug profiles and biological activities, with reference to their anticancer potential. Among them, Nilotinib and Radotinib were identified as the top candidates, with higher Pa values for anticancer activity. The interaction analysis and molecular dynamics (MD) simulation study further confirmed that both Nilotinib and Radotinib bind to the important and common residues of the USP21 binding site, which may inhibit the aberrant activity of USP21 in pathological conditions. The 500 ns MD simulations showed that both drugs are capable of binding to USP21 without any significant structural changes, which justifies their likelihood of being used as repurposed agents for cancer treatment. The RMSD, <em>R</em>g, and hydrogen bond analyses showed minimal fluctuations, indicating high conformational stability. Additionally, free energy landscape (FEL) analysis supported the stability of the complexes. These results suggest that Nilotinib and Radotinib could serve as promising repurposed agents for USP21 inhibition in cancer treatment after required validation. In conclusion, the combination of docking and MD simulations highlights their potential therapeutic relevance, laying the groundwork for further development of USP21 inhibitors as anticancer drugs.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100792"},"PeriodicalIF":3.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting PI3K/AKT/mTOR signalling pathway in non-small-cell lung carcinoma: Exploring promising bioactive natural compounds as anti-cancer agents","authors":"Anam N. Khan ,&nbsp;Rahul D. Jawarkar ,&nbsp;Magdi E.A. Zaki ,&nbsp;Aamal A. Al Mutairi ,&nbsp;Suraj N. Mali","doi":"10.1016/j.chphi.2024.100793","DOIUrl":"10.1016/j.chphi.2024.100793","url":null,"abstract":"<div><div>Lung cancer has become the most common solid tumor and the leading cause of cancer-related deaths worldwide. It is estimated that the annual mortality rate for lung cancer is 1.8 million out of which 85 % are non-small-cell lung cancer (NSCLC) cases. PI3K/Akt/mTOR signalling pathways play a critical role in both pathological and physiological situations, influencing different aspects of cell survival and proliferation in lung cancer. Despite the use of several therapies, lung cancer treatment has been found to be insufficient, leading to unsatisfactory patient outcomes. There has been a growing interest in natural compounds derived from plants, due to their easy availability, low toxicity, cost-effectiveness, and ability to regulate various biological pathways. Therefore, in the current investigation, we studied various natural compounds having an inhibitory action on PI3K/Akt/mTOR signalling pathways in lung cancer by inducing apoptosis. Further, natural compounds like vitexin, betalain, morusin, bromophenol erianin, peruvoside, and resveratrol were found to decrease Bcl-2 and Bcl-xl expression, whereas elevated BAX, caspase-3, caspase-7, and caspase-9 expression leading to apoptosis and downregulation of p-PI3K/p-Akt/p-mTOR expression in NSCLC.The ultimate goal is to create new and safe treatments for the prevention and treatment of lung cancer.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100793"},"PeriodicalIF":3.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of preparation atmospheres on the structural and luminescent properties of Tb-doped CaF2 thin films","authors":"M.Y.A. Yagoub,&nbsp;H.C. Swart,&nbsp;E. Coetsee","doi":"10.1016/j.chphi.2024.100791","DOIUrl":"10.1016/j.chphi.2024.100791","url":null,"abstract":"<div><div>The effect of preparation conditions, Ar/H₂ and air atmospheres, on structural and luminescent properties of CaF₂:Tb thin films was investigated. The structure of the CaF₂:Tb thin films was confirmed by X-ray powder diffraction. Cracks and big grain sizes on the thin film's surface, prepared in air atmosphere, were observed in the scanning electron microscopy images. Atomic force microscopy images for the film prepared under air atmosphere showed big particle sizes with some cracks on the surface, while a dense and smaller particle size was formed for the film prepared under Ar/H₂ atmosphere. The measured transmittance showed that the thin film prepared under Ar/H₂ exhibited slightly higher transmittance in the visible to near infrared regions. Weak emission intensity from the Tb³⁺ ion with a decrease in lifetime was observed from the film prepared under air. Whereas the film prepared under an Ar/H₂ atmosphere showed a homogenous surface morphology with intense luminescence intensity from the Tb³⁺ ion. The variation in the Tb³⁺:⁵D₄ lifetime was analysed using rate equation analysis. The presence of Tb⁴⁺ ions in the thin films was confirmed by X-ray photoelectron spectroscopy. This work highlighted the importance of the preparation atmosphere on the photoluminescence properties of CaF₂:Tb³⁺ thin films.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100791"},"PeriodicalIF":3.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}