Central European Journal of Urology最新文献

{"title":"Artificial intelligence in robotic urologic surgery: bridging augmented reality and surgical autonomy.","authors":"Rafał B Drobot","doi":"10.5173/ceju.2025.0341","DOIUrl":"10.5173/ceju.2025.0341","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 2","pages":"202-205"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to use a handheld pressure meter for safer intravesical pressure control during morcellation.","authors":"Mohamed Omar, Bhaskar K Somani","doi":"10.5173/ceju.2025.0301","DOIUrl":"https://doi.org/10.5173/ceju.2025.0301","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 1","pages":"52"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enfortumab vedotin demonstrates consistent efficacy in platinum- and ICI-refractory metastatic urothelial carcinoma patients irrespective of prior response: a multicenter real-world study.","authors":"Shunsuke Watanabe, Yuichi Kitagawa, Asuka Uchiyama, Yuya Oishi, Hiroki Tanaka, Gaku Ishikawa, Shinya Watanabe, Eito Suzuki, Kyohei Watanabe, Yuto Matsushita, Hiromitsu Watanabe, Keita Tamura, Rikiya Matsumoto, Daisuke Motoyama, Masao Nagata, Teruo Inamoto","doi":"10.5173/ceju.2025.0315","DOIUrl":"10.5173/ceju.2025.0315","url":null,"abstract":"<p><strong>Introduction: </strong>Enfortumab vedotin (EV) is an antibody-drug conjugate (ADC) targeting nectin-4 and is widely used for patients with locally advanced or metastatic urothelial carcinoma (mUC) after prior systemic therapies. However, it remains unclear whether EV efficacy is influenced by responses to preceding platinum-based chemotherapy (PBC) or immune checkpoint inhibitors (ICI). This study evaluated the relationship between responses to prior therapy and EV outcomes in a real-world cohort.</p><p><strong>Material and methods: </strong>We retrospectively analyzed 60 patients with mUC who received EV between December 2021 and March 2024. All patients had previously undergone PBC and ICI. Based on responses to these therapies, patients were classified as responders (complete or partial response) or non-responders (stable or progressive disease). Primary endpoints were objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Multivariable Cox proportional hazards models were used to evaluate factors associated with survival outcomes.</p><p><strong>Results: </strong>The overall EV ORR was 41.7%. EV responders demonstrated significantly longer PFS and OS than non-responders. No significant differences in EV efficacy were observed between responders and non-responders to prior chemotherapy or ICI. Multivariable analyses confirmed that prior treatment response was not independently associated with PFS or OS.</p><p><strong>Conclusions: </strong>EV response was strongly associated with prolonged survival. Importantly, consistent antitumor activity was observed regardless of prior treatment efficacy, suggesting that even patients refractory to PBC or ICI may derive meaningful benefit. EV should be offered promptly even for patients with double-refractory mUC, as the presence of a prior non-response does not signify compromised efficacy.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 2","pages":"133-139"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency computed tomography in acute renal colic is essential for correct diagnosis and shortens time to treatment and stone-free status.","authors":"Maria Utter, Andreas Forsvall, Fredrik Altmark, Tomas Thiel, Christian Torbrand, Magnus Wagenius","doi":"10.5173/ceju.2025.0245","DOIUrl":"10.5173/ceju.2025.0245","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the clinical impact of implementing routine emergency computed tomography (eCT) for all patients presenting with suspected acute renal colic at the emergency department (ED).</p><p><strong>Material and methods: </strong>We did a retrospective observational study of all patients who underwent eCT for suspected acute renal colic at the ED in Helsingborg between May 9, 2023 and May 8, 2024 and compared with a 2019/2020 cohort not using routine eCT.</p><p><strong>Results: </strong>Of 66,540 ED visits during the study period, 1,566 patients underwent eCT for suspected acute renal colic; 1,261 were included in the analysis after exclusions. In 57% of patients, no symptomatic stone was identified; nevertheless, one fifth required hospital admission for alternative diagnoses. A radiologically proven stone explaining their symptoms was found in 43% of patients. Compared with the 2019/2020 cohort, the 2023/2024 cohort had more treatments (33% vs 21%), and significantly shorter time to both treatment (p = 0.01) and clinical closure (p <0.001). Stone size, location, type of treatment and number of visits to the ED were comparable between the two cohorts.</p><p><strong>Conclusions: </strong>Acute renal colic in its clinical presentation appeared to be less diagnostically reliable than previously assumed. The use of eCT ensured accurate diagnosis of urolithiasis, significantly shortened time to treatment, and to a stone-free patient as well as reduced the use of stents. We propose that eCT should be implemented as a routine procedure in the management of acute renal colic.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 1","pages":"42-48"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic impact of medication management by clinical pharmacists in a urology department.","authors":"Ulrich Warnke, Benjamin Ziehr","doi":"10.5173/ceju.2025.0229","DOIUrl":"10.5173/ceju.2025.0229","url":null,"abstract":"<p><strong>Introduction: </strong>The effectiveness of pharmaceutical care for urological inpatients has been shown, but this investigation aims to evaluate the economic benefit of clinical pharmacy services in a urology department. Return on investment (ROI) is to be determined.</p><p><strong>Material and methods: </strong>Medication management comprised pharmaceutical interventions (PIs) that were carried out by ward-based pharmacists following analysis of drug-related problems. Each pharmaceutical intervention was assigned a probability value indicating the likelihood of an adverse drug event (ADE) occurring without intervention. Assuming that each ADE results in a longer hospital stay, the average case costs for the urology department per day were used as the potential savings.</p><p><strong>Results: </strong>A total of 295 PIs were documented by the clinical pharmacists within 1,495 included patient days. The recorded acceptance rate by physicians was 77.97%. PIs prevented approximately 60 ADE and thus a potential extension of hospital stay of 132 days. Clinical pharmacy services resulted in avoided costs totaling €112,256, thus giving a ROI of 881%.</p><p><strong>Conclusions: </strong>The present investigation demonstrates the economic benefits of clinical pharmacy services for a surgical specialty, namely urology. PIs improve medication safety. Ward-based pharmacists have become a vital part of the urology care team.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 2","pages":"223-229"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic sutureless and clampless partial nephrectomy.","authors":"Antonio Cicione, Riccardo Lombardo, Antonio Franco, Antonio Pastore, Fabio Maria Valenzi, Yazan Al Salhi, Andrea Fuschi, Giorgia Tema, Antonio Nacchia, Andrea Tubaro, Cosimo De Nunzio","doi":"10.5173/ceju.2025.0283","DOIUrl":"https://doi.org/10.5173/ceju.2025.0283","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 2","pages":"209-210"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach to Peyronie's disease: Intralesional injection of lyophilized platelet-derived growth factors.","authors":"Islam Fathy Soliman Abdelrahman, Amr Abdel Raheem, Mahmoud Elbitar, Hossam Fahmy, Adham ZaaZaa, Ahmed Adel, Amr Gadalla, Mohamed Ahmed AbdElSalam","doi":"10.5173/ceju.2025.0197","DOIUrl":"10.5173/ceju.2025.0197","url":null,"abstract":"<p><strong>Introduction: </strong>Platelets store numerous growth factors that are released upon activation at sites of tissue injury. These factors support the wound healing process by enhancing chemotaxis, angiogenesis, cellular proliferation, extracellular matrix synthesis, and tissue remodeling.The aim of the study was to evaluate the therapeutic effect of intralesional lyophilized platelet-derived growth factors (PDGF) in men with Peyronie's disease (PD).</p><p><strong>Material and methods: </strong>This prospective study included 42 patients diagnosed with PD between June 2022 and October 2023; four were lost to follow-up. After providing informed consent, all participants underwent clinical evaluation, including medical history, physical examination, Sexual Health Inventory for Men (SHIM), Erection Hardness Score (EHS), Peyronie's Disease Questionnaire (PDQ), intracavernosal injection test, and penile duplex ultrasonography. Patients received six biweekly intralesional injections of lyophilized PDGF (one vial every two weeks over 12 weeks).</p><p><strong>Results: </strong>A significant reduction in penile curvature was observed, with the mean angle decreasing from 34.62 ±16.37° to 11.40 ±8.84° (mean reduction of 23.22°). Plaque size was also significantly reduced, from a mean of 2.70 ±0.87 cm to 1.43 ±0.44 cm. PDQ scores improved in all domains: Domain 1 by 9.18 points, Domain 2 by 14.74 points, and Domain 3 by 8.3 points. Additionally, erectile function improved, with no patients reporting an EHS grade of E1 or E2 after treatment.</p><p><strong>Conclusions: </strong>Intralesional injection of lyophilized PDGF appears to be a promising non-surgical option for improving curvature, plaque size, and sexual function in patients with Peyronie's disease. Further studies are recommended to validate these findings.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 1","pages":"59-65"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The geriatric trifecta in benign urological surgery: An EAU endourology perspective on defining surgical success in older adults.","authors":"Patrick Juliebø-Jones, Christian Beisland, Ewa Bres-Niewada, Eugenio Ventimiglia, Olivier Traxer, Arman Tsaturyan, Selcuk Guven, Bhaskar K Somani","doi":"10.5173/ceju.2025.0294","DOIUrl":"10.5173/ceju.2025.0294","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"79 1","pages":"49-51"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it possible to predict the response to therapy in enuretic children? The PiFe score.","authors":"Pietro Ferrara, Ignazio Cammisa, Margherita Zona, Alessandra Vinci, Roberto Sacco","doi":"10.5173/ceju.2025.0027","DOIUrl":"10.5173/ceju.2025.0027","url":null,"abstract":"<p><strong>Introduction: </strong>Nocturnal enuresis (NE) is defined as the involuntary passage of urine during sleep in children over the age of five. Although the precise mechanisms of NE are unclear, factors like delayed development, genetic influences, excessive nighttime urine production, disrupted sleep, and bladder dysfunction play a role. This study aims to evaluate the role of comorbidities in NE and develop a scoring system to predict treatment response, with clinical applications.</p><p><strong>Material and methods: </strong>We recruited 374 patients aged 5-18 years undergoing pharmacological treatment (single or combined) for NE. Demographic and clinical data were collected through parent interviews. Statistical analyses included descriptive statistics and categorical analysis using χ² tests, followed by logistic regression.</p><p><strong>Results: </strong>Statistical associations were found between recurrence and learning disorders (χ² = 4.862, p = 0.027), and between treatment response and learning disorders, encopresis, polythelia, language delay, and snoring. Logistic regression identified learning disorders (OR = 3.023), encopresis (OR = 2.156), polythelia (OR = 2.196), language delay (OR = 2.137), and snoring (OR = 1.560) as predictors of poor treatment response. We propose the PiFe score, a clinical tool to predict treatment outcomes in children with NE. This score integrates factors such as comorbidities, age, and symptom severity, helping to guide multidisciplinary interventions.</p><p><strong>Conclusions: </strong>This study emphasizes the importance of a holistic approach to managing NE. The PiFe score could be a useful tool for predicting treatment outcomes and guiding interventions. Further research is needed to validate and refine the scoring system.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"358-366"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional prehabilitation in patients undergoing radical cystectomy: A systematic review for practicing urologists.","authors":"Marcin Chlabicz, Tomasz Lemiesz, Michał Sobolewski","doi":"10.5173/ceju.2025.0067","DOIUrl":"10.5173/ceju.2025.0067","url":null,"abstract":"<p><strong>Introduction: </strong>Immunonutrition plays a major role in the prehabilitation of patients undergoing radical cystectomy for bladder cancer. The aim of this study was to familiarize practitioners familiarize current clinical research on the nutritional preconditioning of patients prior to surgery.</p><p><strong>Material and methods: </strong>A systematic literature review was conducted in PubMed database. Out of 25 records identified, 7 studies were included. Only 1 of these was a randomized controlled trial.</p><p><strong>Results: </strong>Immunonutrition has been associated with a reduction in postoperative complications and hospital length of stay, as well as improvements in postoperative bowel function. It may also contribute to modulating the inflammatory response.</p><p><strong>Conclusions: </strong>Nutritional prehabilitation may positively influence postoperative outcomes following radical cystectomy. However, further randomized controlled trials are necessary to provide more robust and reliable evidence in this field.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"284-288"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}