Central European Journal of Urology最新文献

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Evolving types of pudendal neuromodulation for lower urinary tract dysfunction. 用于治疗下尿路功能障碍的不断演变的阴部神经调控类型。
IF 1.2
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-01-06 DOI: 10.5173/ceju.2023.86
Stefano Parodi, Harry J Kendall, Carlo Terrone, John Pfa Heesakkers
{"title":"Evolving types of pudendal neuromodulation for lower urinary tract dysfunction.","authors":"Stefano Parodi, Harry J Kendall, Carlo Terrone, John Pfa Heesakkers","doi":"10.5173/ceju.2023.86","DOIUrl":"https://doi.org/10.5173/ceju.2023.86","url":null,"abstract":"<p><strong>Introduction: </strong>Sacral neuromodulation and posterior tibial nerve stimulation for lower urinary tract dysfunction (LUTD) and overactive bladder yield good and reliable results. However, neuromodulation research is continuously evolving because there is still need for more patient-friendly treatment options in the therapeutic management of LUTD. Pudendal neuromodulation (PNM) has been emerging as a promising alternative treatment option for the last few decades. The aim of this study is to review the current state of the art of PNM.</p><p><strong>Material and methods: </strong>A wide literature search was conducted in the field of PNM using Medline through the PubMed database and Elsevier using the Scopus database; a critical review of the results was then carried out. PNM has been studied in its various possible aspects: percutaneous PNM, transrectal/transvaginal PNM, and both percutaneous and transcutaneous dorsal genital nerve stimulation.</p><p><strong>Results: </strong>Each technique was found to result in promising improvements in different clinical outcomes, with some trials reporting even better results than sacral neuromodulation.</p><p><strong>Conclusions: </strong>As a result of a comparison between the various PNM techniques with both sacral neuromodulation and posterior tibial nerve stimulation, we think that PNM should be seen as seriously promising, and we believe it will expand the treatment options for overactive bladder. Even though several studies accordingly showed PNM to be safe and effective, a systematic review and meta-analysis were not feasible. PNM in its various techniques is a promising treatment for LUTD. Nevertheless, further research is needed to include it in treatment algorithms.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 1","pages":"82-88"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological characteristics of 214,063 hospital admissions to adult urological departments in Poland in 2022. 2022 年波兰成人泌尿科 214,063 例住院病人的流行病学特征。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-06-18 DOI: 10.5173/ceju.2024.55.R1
Gabriela Moczeniat, Mateusz Jankowski, Paweł Goryński, Mariusz Gujski
{"title":"Epidemiological characteristics of 214,063 hospital admissions to adult urological departments in Poland in 2022.","authors":"Gabriela Moczeniat, Mateusz Jankowski, Paweł Goryński, Mariusz Gujski","doi":"10.5173/ceju.2024.55.R1","DOIUrl":"10.5173/ceju.2024.55.R1","url":null,"abstract":"<p><strong>Introduction: </strong>Nationwide data on urological hospitalizations may improve the quality of care. This study aimed to evaluate the epidemiological characteristics of all registered hospital admissions to adult urological departments in Poland in 2022.</p><p><strong>Material and methods: </strong>This epidemiological retrospective analysis is based on the national registry on hospital admissions managed by the National Institute of Public Health - National Research Institute. All adult patients admitted to urological departments were included in the analysis.</p><p><strong>Results: </strong>In 2022, 214,063 hospital admissions were recorded in Polish urological departments, 72% of the patients were male. Emergency admissions accounted for 17.6% of these admissions. There were significant differences in hospitalization rate per 100,000 population between the administrative regions (voivodeships), with extreme values recorded in the Opolskie (411.5) and Podkarpackie (987.9) voivodeships. The major causes of admission were genitourinary diseases (ICD-10: N00-N99) at 59% and cancers (ICD-10: C00-C97; D00-D48) at 36%. In general, kidney and ureteral stones (19.9%), bladder cancer (15.2%), and prostate hyperplasia (10%) were the most common causes of hospital admissions. The highest hospitalization rate per 100,000 inhabitants was observed among adults aged 60-69 and 70-79 years. A quarter of hospitalizations were one-day hospitalizations, and the mean duration of hospitalization was 2.93 days for all hospitalizations, and when excluding one-day hospitalizations 3.89 days. Epidemiological characteristics of patients and duration of hospitalization differed by cause of admission.</p><p><strong>Conclusions: </strong>Findings from this study provide precise epidemiological data on inpatient urological care in Poland. Physicians and policymakers may use this study to evaluate and improve inpatient urological care in Poland.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"538-546"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What kind of water should I advise my kidney stone patient to drink: the Dutch experience. 建议肾结石患者喝什么水:荷兰的经验。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI: 10.5173/ceju.2024.42.R1
Simone J M Stoots, Michaël M E L Henderickx, Guido M Kamphuis
{"title":"What kind of water should I advise my kidney stone patient to drink: the Dutch experience.","authors":"Simone J M Stoots, Michaël M E L Henderickx, Guido M Kamphuis","doi":"10.5173/ceju.2024.42.R1","DOIUrl":"10.5173/ceju.2024.42.R1","url":null,"abstract":"<p><strong>Introduction: </strong>To compare the mineral content of commercially available water (tap and bottled) in the Netherlands and to evaluate which type of water should be recommended for kidney stone patients.</p><p><strong>Material and methods: </strong>All Dutch water supply companies were contacted to request water analysis reports of tap water. Bottled still and sparkling water available in the 5 main supermarket chains in the Netherlands were also included. Information regarding the mineral composition of bottled waters was read from the manufacturers' ingredient label on the bottles. Data regarding sodium, potassium, bicarbonate, calcium, magnesium, and sulphate content were evaluated.</p><p><strong>Results: </strong>All Dutch water supply companies, consisting of 179 production locations, were included. Twenty-one bottled still waters and 25 bottled sparkling waters were included. There was a wide range of results for the evaluated minerals. Sodium levels were highest in tap water (134.0 mg/l), whereas potassium concentrations were highest in bottled water (18.0 mg/l). Bicarbonate, calcium, and sulphate concentrations were highest in bottled still water (432.0 mg/l, 240.0 mg/l, and 400.0 mg/l, respectively). Magnesium levels were highest in bottled sparkling water (51.4 mg/l).</p><p><strong>Conclusions: </strong>Commercially available water (bottled and tap) in the Netherlands is safe to use for KSD patients. However, specific bottled waters can be described as calcium and magnesium rich. Therefore, it remains important for KSD patients and their physicians to realise that the mineral composition of drinking water may vary, and its consumption might require alterations of their diet.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"494-506"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk-adapted scoring model to identify candidates benefiting from adjuvant chemotherapy after radical nephroureterectomy in nonmetastatic upper tract urothelial carcinoma with ≤pT2. 风险适应性评分模型,用于识别≤pT2的非转移性上尿路上皮癌根治性肾切除术后辅助化疗的受益者。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI: 10.5173/ceju.2024.45.R1
Sung Jun Sou, Won Ik Seo, Jae Il Chung, Hyun Seok Lee, Kweon Sik Min, Soo Jin Jung, Chan Ho Lee
{"title":"Risk-adapted scoring model to identify candidates benefiting from adjuvant chemotherapy after radical nephroureterectomy in nonmetastatic upper tract urothelial carcinoma with ≤pT2.","authors":"Sung Jun Sou, Won Ik Seo, Jae Il Chung, Hyun Seok Lee, Kweon Sik Min, Soo Jin Jung, Chan Ho Lee","doi":"10.5173/ceju.2024.45.R1","DOIUrl":"10.5173/ceju.2024.45.R1","url":null,"abstract":"<p><strong>Introduction: </strong>After radical nephroureterectomy (RNU), adjuvant chemotherapy (AC) is recommended in either muscle invasive or lymph node positive upper urinary tract urothelial carcinoma (UTUC). However, optimal patient selection remains to be studied. We propose a risk-adapted scoring model for selecting patients for AC in localised UTUC with ≤pT2.</p><p><strong>Material and methods: </strong>The model was based on 7 risk factors modified from the risk stratification system in the European Association of Urology guideline for localised UTUC. Each risk factor indicated one point; total scores were used to categorise patients as at low or high risk for disease recurrence. We applied our model to 135 patients with localised UTUC with ≤pT2, who underwent RNU without AC. Recurrence-free survival and cancer-specific survival were analysed based on risk group.</p><p><strong>Results: </strong>A risk score of ≥4 points indicated high risk (33/135 patients [24.4%]). The accuracy of predicting recurrence was 82.9% (95% confidence interval [CI]: 75.5-88.9%) with a negative predictive value of 93.1% (95% CI: 87.9-96.2%). Disease recurred in 51.5% of high-risk patients and 6.9% of low-risk patients. Multivariate analysis indicated that high-risk was independently associated with recurrence and cancer-specific death (hazard ratio [HR] = 10.20, 95% CI: 3.94-26.44%, HR = 8.72, 95% CI: 2.47-30.73%, all p <0.001, respectively).</p><p><strong>Conclusions: </strong>The risk-adapted scoring model might be an effective way for selecting patients who may benefit from AC after RNU in nonmetastatic UTUC with ≤pT2. These results should be validated in a larger, prospective study.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"389-397"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Summary of guidelines from the Polish Urological Association, Polish Society of Gynaecologists and Obstetricians, and Polish Society of Family Medicine on the diagnosis, therapy, and management of community-acquired lower urinary tract infections. 波兰泌尿外科协会、波兰妇产科医师协会和波兰家庭医学协会关于社区获得性下尿路感染的诊断、治疗和管理的指南摘要。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-10-29 DOI: 10.5173/ceju.2024.01.Guid
Kajetan Juszczak, Bartosz Dybowski, Michał Holecki, Waleria Hryniewicz, Hanna Klimek, Karolina Kłoda, Piotr Sieroszewski, Tomasz Drewa
{"title":"Summary of guidelines from the Polish Urological Association, Polish Society of Gynaecologists and Obstetricians, and Polish Society of Family Medicine on the diagnosis, therapy, and management of community-acquired lower urinary tract infections.","authors":"Kajetan Juszczak, Bartosz Dybowski, Michał Holecki, Waleria Hryniewicz, Hanna Klimek, Karolina Kłoda, Piotr Sieroszewski, Tomasz Drewa","doi":"10.5173/ceju.2024.01.Guid","DOIUrl":"10.5173/ceju.2024.01.Guid","url":null,"abstract":"<p><strong>Introduction: </strong>This publication provides a summary of national guidelines developed in response to the regional characteristics of aetiological factors, resistance patterns, and the availability of antibacterial drugs in Poland.</p><p><strong>Material and methods: </strong>After reviewing the epidemiological evidence, case-control studies, randomised control trials, and current international guidelines and statements, a Polish multidisciplinary group prepared the final recommendations. These recommendations cover diagnosis and management of community-acquired lower urinary tract infections in both genders, pregnant and breastfeeding women, recurrent lower urinary tract infections, and asymptomatic bacteriuria.</p><p><strong>Results: </strong>The regional choice of antimicrobial agents for first-line therapy of uncomplicated cystitis in women includes fosfomycin trometamol, pivmecillinam, furazidin (furagin), and nitroxoline. For men, co-trimoxazole or fluoroquinolone therapy is recommended. Pivmecillinam and fosfomycin are recommended for the treatment of pregnant and breastfeeding women. For continuous prophylaxis of recurrent urinary tract infections in women, the following antimicrobial agents can be used: fosfomycin trometamol, trimethoprim, furazidin (furagin), and cefaclor. The significance of behavioural management and the use of vaginal hormonal therapy, vaginal probiotics, and immunoprophylaxis is emphasised. Asymptomatic bacteriuria should be treated in pregnant women and in patients prior to surgical intervention in the urinary tract.</p><p><strong>Conclusions: </strong>New national guidelines based on locally available therapeutic resources should contribute to a more rational choice of therapy in patients with lower urinary tract infection and asymptomatic bacteriuria in Poland.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"520-527"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of manual hand pump irrigation on intrapelvic temperature during retrograde intrarenal surgery: a thermography-based in vitro study. 手泵冲洗对逆行肾内手术中盆腔内温度的影响:一项基于热成像的体外研究。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-05-10 DOI: 10.5173/ceju.2024.98
Krzysztof Balawender, Bartosz Dybowski
{"title":"Influence of manual hand pump irrigation on intrapelvic temperature during retrograde intrarenal surgery: a thermography-based in vitro study.","authors":"Krzysztof Balawender, Bartosz Dybowski","doi":"10.5173/ceju.2024.98","DOIUrl":"10.5173/ceju.2024.98","url":null,"abstract":"<p><strong>Introduction: </strong>Thermal injury to kidney tissue during holmium laser lithotripsy represents a significant complication. This issue is often unavoidable due to the variability of renal conditions and the absence of techniques for real-time intrarenal temperature monitoring. The objective of this research was to evaluate influence of manual hand pump irrigation on temperature of the fluid within a pelvicalyceal model during holmium laser lithotripsy.</p><p><strong>Material and methods: </strong>Laser lithotripsy of artificial stones was carried out in a 3D-printed model of the renal pelvicalyceal system. The irrigation system employed a continuous gravity approach (P = 60 cmH<sub>2</sub>O), augmented by manual pumping as required. A 9.2 Fr ureteroscope was inserted into the model via a ureteral access sheath (UAS), with sizes of either 10/12 Fr or 12/14 Fr.The power settings for the lithotripsy varied between 12 and 25 W. Temperature monitoring during the procedure was conducted using thermographic methods.</p><p><strong>Results: </strong>For all laser power settings, the temperatures recorded under gravity irrigation alone were significantly higher compared to those achieved when gravity was combined with a manual hand pump, regardless of the ureteral access sheath size. When using the hand pump system and a 12/14Fr UAS, the median temperatures in none of the laser settings exceeded 30°C. However, using a 10/12Fr UAS, the median temperatures did not exceed 35°C in any of the settings and were significantly lower compared to the use of the gravity flow system alone.</p><p><strong>Conclusions: </strong>The employment of gravity irrigation supplemented by a manually on-demand pump in retrograde intrarenal surgery is a critical component in mitigating the risk of significant temperature elevations, leading to thermal injury to the adjacent kidney tissues. Moreover, the interquartile ranges of temperatures indicating that gravity system enhanced by an on-demand pump irrigation not only reduce the median temperature but also promote a more consistent thermal environment.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"512-517"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of PARP inhibitors in prostate cancer. PARP抑制剂在前列腺癌中的作用。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-10-28 DOI: 10.5173/ceju.2024.72.R1
Julia Szczotka, Gabriela Szpila, Michał Hejduk, Ewa Mucha, Jolanta Rudel, Michał Kępiński, Julia Kaletka, Jakub Ryszawy, Piotr Zapala, Ichiro Tsuboi, Akihiro Matsukawa, Marcin Miszczyk, Tamas Fazekas, Fabio Zattoni, Piotr Bryniarski, Paweł Rajwa
{"title":"Role of PARP inhibitors in prostate cancer.","authors":"Julia Szczotka, Gabriela Szpila, Michał Hejduk, Ewa Mucha, Jolanta Rudel, Michał Kępiński, Julia Kaletka, Jakub Ryszawy, Piotr Zapala, Ichiro Tsuboi, Akihiro Matsukawa, Marcin Miszczyk, Tamas Fazekas, Fabio Zattoni, Piotr Bryniarski, Paweł Rajwa","doi":"10.5173/ceju.2024.72.R1","DOIUrl":"10.5173/ceju.2024.72.R1","url":null,"abstract":"<p><strong>Introduction: </strong>Olaparib, rucaparib, niraparib, and talazoparib are poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) targeted at recombination. To gain a comprehensive understanding of the mechanism of action of PARPi, scientists conducted research involving numerous studies that provided evidence regarding their efficacy and safety.</p><p><strong>Material and methods: </strong>A literature review was performed using the PubMed<sup>®</sup> and Google Scholar databases. Articles were reviewed and categorized based on the most crucial and current information regarding the pharmacological properties and use of PARPi in treating metastatic castration-resistant prostate cancer (mCRPC), while also indicating the future therapeutic direction toward which these pharmaceuticals are progressing. Data were extracted, analyzed and summarized.</p><p><strong>Results: </strong>PARP inhibitors like olaparib, rucaparib, niraparib, and talazoparib show promise in mCRPC, particularly for patients with specific genetic mutations (<i>BRCA1/2, ATM</i>). While they extend PFS and sometimes OS, side effects - especially anemia - are prevalent and impact treatment continuation.</p><p><strong>Conclusions: </strong>Despite PARPi already being recognized as the standard treatment for mCRPC, further research is crucial to optimize their efficacy and safety, particularly in the context of combination therapies and use in the early stages of the disease.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"424-435"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genitourinary microbiomes and prostate cancer: a systematic review and meta-analysis of tumorigeneses and cancer characteristics. 泌尿生殖系统微生物组和前列腺癌:肿瘤基因和癌症特征的系统回顾和荟萃分析。
IF 1.4
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-06-18 DOI: 10.5173/ceju.2024.80
Mehdi Kardoust Parizi, Akihiro Matsukawa, Arman Alimohammadi, Jakob Klemm, Ichiro Tsuboi, Tamás Fazekas, Ekaterina Laukhtina, Sever Chiujdea, Pierre I Karakiewicz, Shahrokh F Shariat
{"title":"Genitourinary microbiomes and prostate cancer: a systematic review and meta-analysis of tumorigeneses and cancer characteristics.","authors":"Mehdi Kardoust Parizi, Akihiro Matsukawa, Arman Alimohammadi, Jakob Klemm, Ichiro Tsuboi, Tamás Fazekas, Ekaterina Laukhtina, Sever Chiujdea, Pierre I Karakiewicz, Shahrokh F Shariat","doi":"10.5173/ceju.2024.80","DOIUrl":"10.5173/ceju.2024.80","url":null,"abstract":"<p><strong>Introduction: </strong>We assessed the association of genitourinary microbiomes with prostate cancer (PCa) tumorigeneses and cancer characteristics.</p><p><strong>Material and methods: </strong>A systematic search and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The primary endpoints were the association between relative abundance of genitourinary microbiomes and PCa compared to non-cancerous men/prostate specimen, high grade disease, and disease progression. The odds ratio (OR) was used as the summary statistic, and results were reported with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Seventeen studies, comprising 2,195 patients were eligible for review and meta-analysis. The specific microbiomes in urine, prostate tissue, and prostate (or seminal) secretions were significantly more abundant in patients with PCa compared to men in the control groups in individual studies. Certain bacterial phyla, genuses, and species were significantly associated with PCa aggressiveness and disease progression in individual studies. The relative abundance meta-analysis of five urine microbiomes revealed no statistically significant differences between PCa patients and control groups (pooled OR, 1.35; 95% CI: 0.70-2.59).</p><p><strong>Conclusions: </strong>Our systematic review indicates that specific genitourinary microbiomes are more abundant in PCa and have a potential to predict/prognosticate disease aggressiveness and clinical outcomes. Nevertheless, these findings should be interpreted with caution owing to the significant heterogeneity among studies in terms of microbiome analysis method, assessed sample's characteristics, and individual biological behavior of microbiomes for analysis. Further studies are needed to validate these observations and shed more light on the role of the microbiome across the development and natural history of PCa.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 3","pages":"447-455"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detrusor underactivity in symptomatic anterior pelvic organ prolapse. 有症状的前盆腔器官脱垂患者的逼尿肌活动不足。
IF 1.2
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI: 10.5173/ceju.2023.246
Emanuele Rubilotta, Marilena Gubbiotti, Achim Herms, Howard Goldman, Alessandro Antonelli, Matteo Balzarro
{"title":"Detrusor underactivity in symptomatic anterior pelvic organ prolapse.","authors":"Emanuele Rubilotta, Marilena Gubbiotti, Achim Herms, Howard Goldman, Alessandro Antonelli, Matteo Balzarro","doi":"10.5173/ceju.2023.246","DOIUrl":"https://doi.org/10.5173/ceju.2023.246","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to assess the detrusor underactivity (DUA) prevalence of females with symptomatic anterior pelvic organ prolapse (POP) and to evaluate the relationship between DUA and POP stage.</p><p><strong>Material and methods: </strong>This was a prospective study recruiting women with symptomatic anterior POP. Patients with symptomatic stage 2-4 POP quantification system (POP-Q) who underwent urodynamics (UD) between January 2018 and April 2021 were included.</p><p><strong>Results: </strong>Data on 330 women (mean age 63.7 ±18.4 years old) with anterior vaginal wall defect were enrolled. Concomitant apical defect (uterine/vaginal vault) requiring surgical correction was diagnosed in 38 women (11.5%). DUA was found in 166 females (50.3%). In DUA women, POP-Q stage 2 was found in 45.2%, stage 3 in 50.9% and stage 4 in 76.5%. Only stage POP-Q stage 4 showed a statistically significant difference between DUA and non-DUA females (p 0.006).</p><p><strong>Conclusions: </strong>In women with symptomatic POP, regardless of the POP-Q stage, the chance of DUA occurrence was high. DUA was diagnosed in approximately half of the women undergoing UD for symptomatic POP, and it was three-fold higher in cases of POP-Q stage 4. Due to the high incidence of DUA in POP-Q 4 stage, it may be advantageous to identify and treat prolapse before they progress to stage 4.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 1","pages":"77-81"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heavy as a rock or light as dust: a comparison between the perceived workload for extracorporeal shockwave lithotripsy, ureterorenoscopy and percutaneous nephrolithotomy. 重如磐石还是轻如尘埃:体外冲击波碎石术、输尿管镜检查和经皮肾镜碎石术的工作量比较。
IF 1.2
Central European Journal of Urology Pub Date : 2024-01-01 Epub Date: 2024-01-26 DOI: 10.5173/ceju.2023.214
Michaël Mel Henderickx, Nora Hendriks, A Carolien Bouma-Houwert, Joyce Baard, Guido M Kamphuis, Hugo W Schuil, Harrie P Beerlage, D Martijn de Bruin
{"title":"Heavy as a rock or light as dust: a comparison between the perceived workload for extracorporeal shockwave lithotripsy, ureterorenoscopy and percutaneous nephrolithotomy.","authors":"Michaël Mel Henderickx, Nora Hendriks, A Carolien Bouma-Houwert, Joyce Baard, Guido M Kamphuis, Hugo W Schuil, Harrie P Beerlage, D Martijn de Bruin","doi":"10.5173/ceju.2023.214","DOIUrl":"https://doi.org/10.5173/ceju.2023.214","url":null,"abstract":"<p><strong>Introduction: </strong>There are three common treatment options for kidney stones: extracorporeal shockwave lithotripsy (ESWL), ureterorenoscopy (URS) and percutaneous nephrolithotomy (PNL). The choice of treatment is based on stone- and patient-related characteristics. However, some stones are eligible for several approaches and the decision is made based on patient and urologist's preferences. This study evaluates which approach has the highest workload.</p><p><strong>Material and methods: </strong>Between March and August 2022, five members of the Amsterdam Endourology Research Group collected data from 22 ESWL, 31 URS and 22 PNL procedures. After each procedure, the SURG-TLX questionnaire was completed by the surgeon to evaluate workload. Six dimensions were scored for each procedure, including: mental demands, physical demands, temporal demands, task complexity, situational stress, and distractions. The total workload, and the median for each dimension, was calculated and compared for the three treatments.</p><p><strong>Results: </strong>ESWL scored significantly lower than URS for mental demands, physical demands, temporal demands, situational stress, distraction and total workload. However, task complexity did not differ significantly between the two techniques. Compared with PNL, ESWL scored significantly lower for all dimensions. Finally, PNL received significantly higher scores for mental demands, physical demands, temporal demands, situational stress, distractions and total workload than URS. Only task complexity showed no significant difference between both groups.</p><p><strong>Conclusions: </strong>Urologists perceive the highest workload during PNL, followed by URS and finally ESWL. A follow-up study is needed to identify stressors that increase perceived workload with the purpose to address these variables and as final objective to improve urologists' workload, patient safety and treatment outcomes.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"77 1","pages":"129-135"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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