Cell Transplantation最新文献_第4页

Intra-Articular Injection of Human Bone Marrow-Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial. 膝关节骨性关节炎关节内注射人骨髓间充质干细胞：一项随机、双盲、对照试验。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 DOI: 10.1177/09636897241303275

Bong-Woo Lee, Jennifer Jooha Lee, Joon-Yong Jung, Ji Hyeon Ju

{"title":"Intra-Articular Injection of Human Bone Marrow-Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial.","authors":"Bong-Woo Lee, Jennifer Jooha Lee, Joon-Yong Jung, Ji Hyeon Ju","doi":"10.1177/09636897241303275","DOIUrl":"10.1177/09636897241303275","url":null,"abstract":"To assess the impact of a single intra-articular (IA) injection of bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with knee osteoarthritis (OA), a randomized, double-blind, placebo-controlled study was conducted. The study included 24 patients with knee OA who were randomly assigned to receive either a single IA injection of BM-MSCs or normal saline. Changes in the visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Injury and Osteoarthritis Outcome Score (KOOS) after IA injection were assessed at 3, 6, 9, and 12 months. Magnetic resonance imaging (MRI) with T2 mapping sequences was conducted for knee cartilage assessment at baseline and at 3 and 12 months. The MSC group showed between-group improvement in WOMAC (-5.0 ± 3.6 vs. -0.1 ± 5.5, P = 0.02) and KOOS (23.9 ± 18.3 vs. 7.2 ± 15.9, P = 0.028) scores at 9 months compared with the control group. The MSC group exhibited a less sharp increase in the mean T2 value of the medial compartment than the control group at 12 months, with no serious adverse events observed during follow-up. A single IA injection of allogeneic BM-MSCs provided satisfactory pain relief for patients with knee OA compared with the control group at 9 months. Quantitative T2 MRI mapping of the cartilage showed that IA BM-MSCs could have a preventive effect on OA progression for 12 months. Our findings suggest the potential of allogeneic BM-MSCs IA injection as a pain-relieving and disease-modifying treatment for patients with knee OA in the outpatient setting.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241303275"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Combination of Intravenous Immunoglobulin, Dexamethasone, and a High Dose of Mononuclear Cells Transfusion: An Effective Strategy for Decreasing Donor-Specific Antibodies During Haploidentical Hematopoietic Stem Cell Transplantation. 静脉注射免疫球蛋白、地塞米松和大剂量单核细胞输注：单倍体造血干细胞移植过程中降低供体特异性抗体的有效策略。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 DOI: 10.1177/09636897241303292

Xiaoping Li, Yu Li, Dingsong Zhang, Xiaozhuang Hu, Lin Liu, Zhongtao Yuan, Shiqi Li, Yancheng Dong, Yingnian Chen, Sanbin Wang

{"title":"The Combination of Intravenous Immunoglobulin, Dexamethasone, and a High Dose of Mononuclear Cells Transfusion: An Effective Strategy for Decreasing Donor-Specific Antibodies During Haploidentical Hematopoietic Stem Cell Transplantation.","authors":"Xiaoping Li, Yu Li, Dingsong Zhang, Xiaozhuang Hu, Lin Liu, Zhongtao Yuan, Shiqi Li, Yancheng Dong, Yingnian Chen, Sanbin Wang","doi":"10.1177/09636897241303292","DOIUrl":"10.1177/09636897241303292","url":null,"abstract":"Donor-specific antibodies (DSAs) are essential causes of graft rejection in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). DSAs are unavoidable for some patients who have no alternative donor. Effective interventions to reduce DSAs are still needed, and the cost of the current therapies is relatively high. In this study, we retrospectively analyzed the data of 11 DSA-positive patients who received haplo-HSCT at our center and evaluated the therapeutic efficacy of the combination of intravenous immunoglobulin (IVIG), dexamethasone and high dose of transfused mononuclear cells (MNCs) for DSA desensitization. The kinetics of DSAs at different times and the engraftment and transplantation outcomes were also observed. We found that all patients had successful donor-cell engraftment and that no patient developed poor graft function. The median engraftment times of neutrophils and platelets were 14 days (range, 11-24 days) and 13 days (range, 11-123 days), respectively. The DSA levels of all patients became negative or dropped under 2000 within 22 days after HSCT. A total of 36.4% of patients developed grade II-IV acute graft-versus-host disease (aGVHD), and 9.1% of patients died of severe gastrointestinal aGVHD. Of the 7 surviving patients, four were diagnosed with chronic GVHD. After a median follow-up of 28.9 months (2.0-52.1 months), four patients died: of relapse (two), aGVHD (one), and multiple-organ failure (one). The 2-year OS, DFS, and NRM were 63.6%, 45.4%, and 18.2%, respectively. Combination therapy with IVIG, dexamethasone, and a high dose of MNCs transfusion, a simple and efficient procedure, was safe and effective for DSA desensitization and peripheral blood stem cell (PBSC) engraftment.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241303292"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential of Neonatal Organ Donation in Central Sweden. 瑞典中部新生儿器官捐献的潜力。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 DOI: 10.1177/09636897241303269

Emil Bluhme, Ewa Henckel, Boubou Hallberg, Carl Jorns

{"title":"The Potential of Neonatal Organ Donation in Central Sweden.","authors":"Emil Bluhme, Ewa Henckel, Boubou Hallberg, Carl Jorns","doi":"10.1177/09636897241303269","DOIUrl":"10.1177/09636897241303269","url":null,"abstract":"Pediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal organ donation could potentially ameliorate the discrepancy but is currently not implemented in Sweden. This study aims to evaluate the potential of neonatal organ donation in central Sweden using a standardized protocol with organ specific criteria. Data on 2,061 neonates who deceased in central Sweden from 2006 to 2016 were collected; 308 neonates met criteria for possible donation. Medical records of all possible donors were reviewed, identifying 85 potential donors. Main cause of death was hypoxic ischemic encephalopathy 47% (n = 40). Median weight was 2,355 (IQR: 1,953) g, with 31% receiving inotropic support. Median creatinine of 72 (IQR: 67) µmol/l, urine production 3 (IQR: 2.2) ml/kg/h, ALT 0.51 (IQR: 1.5) µkat/l, and AST 1.7 (IQR: 3.1) µkat/l. Criteria for kidney donation was met in 39 potential neonatal, 29 for liver and 18 for heart, corresponding to a potential increase of 1.9, 1.4, and 0.9 donors PMP per year, respectively. In total, 16 neonates had a catastrophic neurological injury in combination with lack of brainstem reflexes, indicating plausibility of donation after brain death. Expanding organ donation into the neonatal period in Sweden could lead to an increase in organs available for transplant.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241303269"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective TCRαβ+ and CD45RA+ T-cell depletion of hematopoietic stem cell graft: An analysis on factors that affect depletion performance. 造血干细胞移植物选择性TCRαβ+和CD45RA+ t细胞耗竭：影响耗竭性能的因素分析。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 Epub Date: 2025-05-08 DOI: 10.1177/09636897251336965

Chieh Hwee Ang, Gina Gan, Ren How Ho, Kee Khiang Heng, Yeh Ching Linn

{"title":"Selective TCRαβ+ and CD45RA+ T-cell depletion of hematopoietic stem cell graft: An analysis on factors that affect depletion performance.","authors":"Chieh Hwee Ang, Gina Gan, Ren How Ho, Kee Khiang Heng, Yeh Ching Linn","doi":"10.1177/09636897251336965","DOIUrl":"https://doi.org/10.1177/09636897251336965","url":null,"abstract":"Selective depletion of TCRαβ+ and CD45RA+ subsets of apheresed hematopoietic progenitor cells, HPC(A), enables haploidentical hematopoietic stem cell transplant (haplo-HSCT) by circumventing risks of graft-versus-host disease. Here, we analyze our institution's large series of ex vivo T-cell depletion processes to review procedure performance and explore factors that affect depletion efficiency and graft composition. Over 6 years, 91 haploidentical donors underwent peripheral blood CD34+ stem cell mobilization with granulocyte-colony stimulating factor, with 12 (13%) receiving additional pre-emptive plerixafor. HPC(A) was split into two fractions for TCRαβ and CD45RA depletion with the CliniMACS PLUS device. TCRαβ depletion resulted in a median 4.3 (interquartile range, 4.1-4.5) log reduction, with CD34 recovery at 98% (94%-103%) and TCRγδ+ cell recovery at 89% (74%-98%). CD45RA depletion resulted in a median 4.8 (4.3-5.2) log reduction, with CD3+/CD45RO+ cell recovery at 41% (34%-47%) and CD34 recovery at 58% (51%-68%). TCRαβ depletion efficiency was maintained even when total nucleated cell counts exceeded the maximal specified number, provided the target fraction was within capacity of the depletion kit. Platelet contamination did not affect depletion efficacy or CD34 recovery. Age increases the proportion of CD45RO+ memory cells and TCRαβ subset in HPC(A), while plerixafor increases the latter. Although statistically significant correlation exists between pre-depletion cell composition and depletion performance for some cell subsets, the post-depletion product still met pre-specified threshold without being affected to a clinically relevant extent, over a wide range of input cell numbers. Such robustness of the depletion systems is critical for successful performance of haplo-HSCT.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897251336965"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of plasma sterilizer and conventional laminar flow room in allogeneic hematopoietic stem cell transplant recipients. 血浆消毒器与传统层流室在异基因造血干细胞移植受者中的比较。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 Epub Date: 2025-04-30 DOI: 10.1177/09636897251335722

Ting Wang, Yi Xia, Wei Hu, Boning Liu, Xiaohui Zhang, Wenxuan Huo, Jun Kong, Yaru Ma, Wenwen Xiao, Ce Shi, Qixin Du, Leqing Cao, Dong Han, Dongyue Yao, Hongyue Yin, Daoxing Deng, Jingyu Gao, Yashu Jia, Jiating Wang, Jing Liu, Xiaoshuang Han, Junxia Wang, Ling Ma, Yunjing Xia, Shanshan Hu, Yuanyuan Zhang, Fengmei Zheng, Xiaojun Huang, Xiaodong Mo

{"title":"Comparison of plasma sterilizer and conventional laminar flow room in allogeneic hematopoietic stem cell transplant recipients.","authors":"Ting Wang, Yi Xia, Wei Hu, Boning Liu, Xiaohui Zhang, Wenxuan Huo, Jun Kong, Yaru Ma, Wenwen Xiao, Ce Shi, Qixin Du, Leqing Cao, Dong Han, Dongyue Yao, Hongyue Yin, Daoxing Deng, Jingyu Gao, Yashu Jia, Jiating Wang, Jing Liu, Xiaoshuang Han, Junxia Wang, Ling Ma, Yunjing Xia, Shanshan Hu, Yuanyuan Zhang, Fengmei Zheng, Xiaojun Huang, Xiaodong Mo","doi":"10.1177/09636897251335722","DOIUrl":"https://doi.org/10.1177/09636897251335722","url":null,"abstract":"Patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) are typically placed in a laminar air flow room until hematopoietic reconstitution occurs. In this study, we compared the differences in clinical outcomes between patients receiving allo-HSCT in a conventional laminar flow room (n = 200) and those receiving allo-HSCT in a plasma sterilizer environment (n = 201). The overall infection rates (20.4% vs 25.5%, P = 0.224) and the sites of infection (sepsis, perianal infection, and catheter-related infection) were comparable between the two groups. Additionally, the engraftment times were comparable between the two groups in terms of time to allo-HSCT, leukocyte engraftment time, and platelet engraftment time. The 100-day posttransplantation clinical outcomes were also comparable between the two groups in terms of the probability of overall survival (98.5% vs 99.5%, P = 0.316), leukemia-free survival (96.5% vs 96.5%, P = 0.991), the cumulative incidence of relapse (2.0% vs 3.0%, P = 0.523), non-relapse mortality (1.5% vs 0.5%, P = 0.316) and acute graft-versus-host disease (23.4% vs 22.0%, P = 0.723). Thus, our results demonstrated that receiving allo-HSCT via a plasma sterilizer did not increase the risk of pre-engraftment infection, and the clinical outcomes of these patients were comparable to those of patients in a conventional laminar flow room.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897251335722"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing. 干细胞、人类胚胎和基因编辑研究指南建议。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 DOI: 10.1177/09636897241312793

Susanna R Var, Phoebe Strell, Anala Shetty, Alex Roman, Isaac H Clark, Andrew T Crane, Gary L Dunbar, Kyle Fink, Andrew W Grande, Ann M Parr, Julien Rossignol, Paul R Sanberg, Li-Ru Zhao, Layandysha V Zholudeva, Walter C Low

{"title":"Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing.","authors":"Susanna R Var, Phoebe Strell, Anala Shetty, Alex Roman, Isaac H Clark, Andrew T Crane, Gary L Dunbar, Kyle Fink, Andrew W Grande, Ann M Parr, Julien Rossignol, Paul R Sanberg, Li-Ru Zhao, Layandysha V Zholudeva, Walter C Low","doi":"10.1177/09636897241312793","DOIUrl":"10.1177/09636897241312793","url":null,"abstract":"Recent advances in biomedical technologies have extended the boundaries of previously established regulatory guidelines pertaining to stem cell research. These guidelines constrained the study of human pluripotent stem cells (hPSCs) and their derivatives from use under various conditions, including the introduction of hPSCs into the brains of host animals because of concerns of humanizing the brains of animal species. Other guidelines constrained the use of hPSCs in creating human-animal chimeras because of the potential contribution of human stem cells not only to the brain but also to the germline. Some regulatory guidelines forbid the growing of human embryos ex vivo beyond the stage of primitive streak development because of concerns regarding the creation of human forms of life ex vivo. At the subcellular level, there are guidelines regulating the transfer of mitochondria within human embryos. At the molecular level, there are guidelines regulating genome editing to prevent permanent genetic alterations in germline cells. These and other issues related to stem cells have been reviewed, and new research guidelines established by the International Society for Stem Cell Research (ISSCR) for its membership. Because many of the recommended changes by the ISSCR impact research being conducted by members of the American Society for Neural Therapy and Repair (ASNTR), the ASNTR established a task force to review relevant recommendations by the ISSCR to determine which new guidelines to adopt for research conducted by the ASNTR society membership. The final ASNTR recommendations are presented in this document.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241312793"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles. 间充质干细胞衍生的细胞外囊泡的研究进展。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 DOI: 10.1177/09636897241297623

Bingyi Zheng, Xueting Wang, Meizhai Guo, Chi-Meng Tzeng

引用次数: 0

Macromolecular Crowding Supports the Generation of Basal Membrane-Rich Pericyte-Based Cell Sheets Useful for Cell Therapy of Diabetic Wounds. 大分子拥挤支持富基膜周细胞基细胞片的生成，有助于糖尿病伤口的细胞治疗。

IF 3.2 4区医学

Cell Transplantation Pub Date : 2025-01-01 Epub Date: 2025-03-12 DOI: 10.1177/09636897241309698

Andrea Rampin, Carlo Maria Ferdinando Caravaggi, Luigi Troisi, Gaia Spinetti

{"title":"Macromolecular Crowding Supports the Generation of Basal Membrane-Rich Pericyte-Based Cell Sheets Useful for Cell Therapy of Diabetic Wounds.","authors":"Andrea Rampin, Carlo Maria Ferdinando Caravaggi, Luigi Troisi, Gaia Spinetti","doi":"10.1177/09636897241309698","DOIUrl":"10.1177/09636897241309698","url":null,"abstract":"Diabetic foot ulcers (DFUs) are associated with a high risk of amputations and a 50% 5-year survival rate due at least in part to the limited angiogenic and wound healing capacity of patients with diabetes. Cell therapy via intramuscular injection of peripheral blood mononuclear cells showed encouraging but limited results. Such limitations may arise from the limited ability of therapeutic cells to adhere to the target tissue. The development of a methodology able to support the targeted delivery of viable angiogenic cells would improve cell therapy outcomes in DFU. Here, we optimized a protocol for the production of autologous extracellular matrix (ECM)-rich pericyte-based cell sheets for cell delivery. Pericytes were isolated from skeletal muscle biopsies of DFU patients and non-diabetic controls and characterized by flow cytometry and immunofluorescence. Human umbilical vein endothelial cells used for the optimization of collagen IV deposition showed a positive correlation with seeding density and a negative one with sub-culture passaging (P < 0.05). Macromolecular crowding significantly increased collagen IV deposition both in human umbilical vein endothelial cells and in patient-derived pericytes (P < 0.01) without affecting proliferation (P > 0.05). Finally, DFU patient-derived pericytes effectively deposited ECM supporting their use for autologous cell sheet production.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241309698"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASNTR 2024 Abstracts ASNTR 2024 摘要

IF 3.3 4区医学

Cell Transplantation Pub Date : 2024-05-23 DOI: 10.1177/09636897241250096

引用次数: 0

Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation 刺猬信号通路在多能间质干细胞分化中的作用

IF 3.3 4区医学

Cell Transplantation Pub Date : 2024-05-02 DOI: 10.1177/09636897241244943

Mengyu Wu, Junwei Mi, Guo-xin Qu, Shu Zhang, Yi Jian, Chu Gao, Qingli Cai, Jing Liu, Jianxin Jiang, Hong Huang

{"title":"Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation","authors":"Mengyu Wu, Junwei Mi, Guo-xin Qu, Shu Zhang, Yi Jian, Chu Gao, Qingli Cai, Jing Liu, Jianxin Jiang, Hong Huang","doi":"10.1177/09636897241244943","DOIUrl":"https://doi.org/10.1177/09636897241244943","url":null,"abstract":"Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application. MSCs originate from the mesoderm and can differentiate not only into osteoblasts, cartilage, adipocytes, and muscle cells but also into ectodermal and endodermal cell lineages across embryonic layers. To design cell therapy for replacement of damaged tissues, it is essential to understand the signaling pathways, which have a major impact on MSC differentiation, as this will help to integrate the signaling inputs to initiate a specific lineage. Hedgehog (Hh) signaling plays a vital role in the development of various tissues and organs in the embryo. As a morphogen, Hh not only regulates the survival and proliferation of tissue progenitor and stem populations but also is a critical moderator of MSC differentiation, involving tri-lineage and across embryonic layer differentiation of MSCs. This review summarizes the role of Hh signaling pathway in the differentiation of MSCs to mesodermal, endodermal, and ectodermal cells.","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"29 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0