Cell Transplantation最新文献

{"title":"The nude rat is capable of mounting a strong fibrotic response against cell-containing and cell-free subcutaneously implanted encapsulation devices.","authors":"Kelly M Pasowisty, Amy C Kelly, Trisha M Fabijanic, Leah V Steyn, Hannah A Hagen, Thomas Loudovaris, Robert C Johnson, Charles W Putnam, Klearchos K Papas","doi":"10.1177/09636897261424579","DOIUrl":"10.1177/09636897261424579","url":null,"abstract":"","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897261424579"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Kellgren-Lawrence grade on clinical outcomes following adipose-derived stem cell therapy for knee osteoarthritis: A propensity score-matched retrospective cohort study.","authors":"Naoki Nakano, Tomoyuki Matsumoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Kazunari Ishida, Rinako Osaka, Masaki Otsuji, Norimasa Nakamura, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda","doi":"10.1177/09636897251414212","DOIUrl":"10.1177/09636897251414212","url":null,"abstract":"<p><p>Knee osteoarthritis (OA) causes pain and disability, and autologous adipose-derived stem cell (ASC) therapy has emerged as a regenerative treatment option. This retrospective cohort study compared short-term outcomes of intra-articular ASC injections between patients with moderate (Kellgren-Lawrence [KL] 2/3) and severe (KL 4) OA. Among 242 treated patients, 98 in each group were analyzed after propensity score matching for age, sex, and body mass index. Pain (VAS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales were evaluated at baseline and 1, 3, and 6 months. Both groups showed significant improvements in pain and function, with KL 2/3 patients exhibiting greater gains in KOOS Total, Activities of Daily Living, Sports/Recreation, Quality of Life, and VAS pain compared with KL 4. KOOS pain and symptoms improved similarly in both groups. Analgesic effects increased over time, and no serious adverse events were observed. Mild transient swelling or discomfort occurred in about 5% to 6% of cases. ASC injections provided meaningful symptom relief and functional improvement, particularly in moderate OA, suggesting that preserved joint structure benefits therapeutic efficacy. In advanced OA, benefits were present but attenuated, indicating limited regenerative potential in end-stage disease.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897251414212"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12812197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress and application prospect of engineered small extracellular vesicles.","authors":"Haoyu Zhang, Jian Chen, Xijie Tang, Xiangzhong Liu, Zhanghua Li","doi":"10.1177/09636897251409473","DOIUrl":"10.1177/09636897251409473","url":null,"abstract":"<p><p>Extracellular vesicles (Evs) act as a natural intercellular message transmitter, Evs can carry proteins, ribonucleic acid (RNA) and other bioactive substances, and have rich biological regulatory functions. Because of its low immunogenicity and high biocompatibility, it has become a popular research object in drug delivery. These remarkable properties also create new opportunities for modern therapy. However, due to the complex preparation process, there are challenges in terms of targeting accuracy, load release controllability, and pharmacokinetic optimization, and many problems may be encountered in reality. Based on real-life biomedical experiments, this paper summarizes the methods and types of Evs loading drugs, membrane modification methods, and the use of biological materials to improve the release efficiency, so as to provide reference for future research on engineered Evs.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897251409473"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage nintedanib plus low-dose ruxolitinib therapy for bronchiolitis obliterans syndrome refractory to calcineurin inhibitors and glucocorticoids after allogeneic transplantation.","authors":"Ya Luo, Ying Wu, Qiu-Sha Huang, Xian-Ying Yin, Qian-Nan Shang, Yi-Han Yang, Ao-Ran Zhang, Tong Su, Xiao-Han Su, Su-Xuan Liu, Zheng-Li Xu, Jing Liu, Xiao-Dong Mo, Yu-Qian Sun, Yu Wang, Meng Lv","doi":"10.1177/09636897261438731","DOIUrl":"10.1177/09636897261438731","url":null,"abstract":"<p><p>Bronchiolitis obliterans syndrome (BOS) is a severe pulmonary complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with limited therapeutic options once refractory to standard immunosuppression. We conducted a pilot study from January 2018 to December 2024, enrolling consecutive patients with BOS defined by NIH criteria who failed glucocorticoids and calcineurin inhibitors for ≥4 weeks. Sixteen patients received salvage therapy with ruxolitinib 5 mg twice daily and nintedanib 150 mg twice daily (RN cohort) in continuous 28-day cycles for up to six cycles, while 37 contemporary patients served as controls. At baseline, NIH lung scores in the RN cohort were 18.8% NIH 1, 18.8% NIH 2, and 62.5% NIH 3. The median number of treatment cycles was 3.5 (range, 1-6). At 3 months, 11 patients (68.8%) achieved ≥10% improvement in %FEV1 from baseline (median = 26.5%, range = 15.6%-58.2%). By NIH lung response criteria, the overall response rate (ORR) was 62.5% (12.5% complete response, 50.0% partial response) in the RN cohort versus 13.5% (5.4% complete, 8.1% partial) in controls. Notably, hematologic toxicities were less frequent with RN therapy than in controls. These findings suggest that low-dose ruxolitinib combined with nintedanib is an effective and well-tolerated salvage regimen for BOS after allo-HSCT and warrant confirmation in a prospective phase II study.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897261438731"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging-based tracking of stem-cell responses for 3D bioprinting optimization.","authors":"Bohdan Karabinskyi, Svitlana Alkhimova, Olena Holembiovska","doi":"10.1177/09636897261445006","DOIUrl":"10.1177/09636897261445006","url":null,"abstract":"<p><p>This review examines how mechanical and chemical stimuli shape stem-cell behavior and how live-cell imaging combined with artificial intelligence can support the evaluation and optimization of 3D bioprinting workflows. Current evidence indicates that substrate stiffness, stretch, shear stress, compression, and soluble factors such as transforming growth factor beta (TGF-β), bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (FGF-2) influence viability, migration, morphology, and lineage commitment in biopolymeric constructs. Imaging modalities including phase-contrast, fluorescence, confocal, two-photon, and light-sheet microscopy enable dynamic observation of these responses, while computational pipelines for segmentation, tracking, and feature extraction improve scalability and reproducibility of analysis. Across the reviewed studies, image-derived readouts such as cell distribution, motility, adhesion patterns, and early morphological changes emerge as promising indicators of construct quality and maturation potential. At the same time, broader application remains limited by phototoxicity, imaging depth constraints, data-processing demands, incomplete standardization of metrics, and restricted model generalizability. Overall, imaging-based cell tracking integrated with AI-assisted analysis offers a practical framework for post-print evaluation and iterative optimization in 3D bioprinting, with potential to strengthen quality control, reproducibility, and biological interpretation in regenerative engineering.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897261445006"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the efficacy and survival of allogeneic hematopoietic stem cell transplantation and nontransplantation treatment in chronic active Epstein-Barr virus infection.","authors":"Xi Ming, Xiaoying Zhang, Jiaying Wu, Wanying Liu, Qi Zhang, Delian Zhou, Yicheng Zhang, Xiaojian Zhu, Yi Xiao","doi":"10.1177/09636897261443609","DOIUrl":"10.1177/09636897261443609","url":null,"abstract":"<p><p>This retrospective study evaluated 75 patients with chronic active Epstein-Barr virus infection (CAEBV) to compare the efficacy and survival outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) and programmed death-1 (PD-1) blockade therapy. Patients were classified into HSCT and non-HSCT groups. The primary endpoints were overall response rate (ORR), overall survival (OS), and event-free survival (EFS). HSCT significantly improved ORR, 3-year OS, and 3-year EFS compared to non-HSCT treatment. Subgroup analysis showed that PD-1 blockade achieved outcomes comparable to HSCT in a subset of patients; however, HSCT remained superior, overall, particularly in patients without hemophagocytic lymphohistiocytosis (HLH). The presence of HLH was identified as an independent risk factor for inferior survival. In conclusion, allogeneic HSCT remains the preferred curative strategy for CAEBV, whereas PD-1 blockade represents a promising alternative for carefully selected patients. Early recognition and management of HLH are crucial for improving prognosis.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897261443609"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor-specific immunomodulation is mediated by mechanisms beyond CD4⁺ regulatory T cells.","authors":"Makiko Kumagai-Braesch, Nils Ågren, Masaaki Watanabe, Bo-Göran Ericzon, Michael Uhlin, Ming Yao","doi":"10.1177/09636897261473440","DOIUrl":"10.1177/09636897261473440","url":null,"abstract":"<p><p>Donor-specific immunomodulatory cells (DSIMC) have successfully induced donor-specific tolerance in clinical living donor liver transplantation. These cells are generated from recipient peripheral blood mononuclear cells (PBMCs) stimulated with irradiated donor PBMC in the presence of costimulatory blockade, yielding a heterogeneous population of recipient-derived immune cells including T cells, B cells, and NK cells, in which CD4⁺ regulatory T cells (Tregs) are thought to play a central role. Here, we examined the cell populations and functions crucial for donor-specific immunomodulation within the DSIMC product. DSIMC were generated from PBMC of healthy volunteers using belatacept to achieve costimulatory blockade. Tregs were enriched by CD4⁺CD25⁺ magnetic-cell activated cell sorting (MACS) or CD25⁺CD127^-/low fluorescence-activated cell sorting (FACS). CD4⁺, CD8⁺, CD19⁺, and CD25⁺CD127^-/low fractions were also individually depleted from DSIMC. Immunomodulatory function of each resulting population was assessed by tritium-labelled thymidine incorporation in mixed lymphocyte cultures (MLC), and cytokine-producing capacity was evaluated by ELISA/ELISpot assays. Unsorted DSIMC exhibited donor-specific suppression at lower cell numbers than CD4⁺CD25⁺ enriched cells, while CD4⁺CD25^- T cells showed no immunosuppressive effect. Depletion of CD4⁺, CD8⁺, or CD19⁺ cells did not substantially impair immunomodulatory function. In contrast, depletion of the CD25⁺CD127^-/low fraction reduced inhibitory function and abolished donor specificity. Depletion of CD4⁺ or CD25⁺CD127^-/low reduced IFN-γ and IL-10 production in response to donor stimulation compared with unsorted DSIMC, implicating CD4⁺ Tregs as important contributors to cytokine production under allogeneic stimulation. Furthermore, Treg expansion following donor antigen restimulation was observed in unsorted DSIMC but not in CD4⁺CD25⁺-enriched cells, suggesting that Tregs can be induced from non-Treg CD4⁺ populations within the DSIMC. In conclusion, CD4⁺CD25⁺CD127^-/lowFoxP3⁺-associated cells appear to contribute to donor-specific immunomodulation; however, the enrichment of CD4⁺CD25⁺ T cell diminished DSIMC efficacy. Since the unsorted DSIMC showed stronger activity, we suggest that multiple cell populations may act together to mediate the DSIMC effect.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897261473440"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell benchmarking separates epidermal stratification from appendage programme maintenance in an air-liquid interface skin model.","authors":"Yanghonghong Fei, Vincent Chi Hang Lui, Paul David Blakeley, Kenneth Kak Yuen Wong","doi":"10.1177/09636897261503847","DOIUrl":"https://doi.org/10.1177/09636897261503847","url":null,"abstract":"<p><p>Full-thickness skin equivalents (FTS) reproduce epidermal stratification, yet rarely generate hair follicles or glands. Defining the cellular features associated with this limitation could inform the engineering of appendage-bearing skin. Here we profiled mouse induced pluripotent stem cell-derived early epithelial progenitors (EEPs) and EEP-derived FTS by single-cell RNA sequencing, using developing mouse skin as a reference. FTS established a stratified epidermis with basal cell enrichment, but was accompanied by a marked reduction in appendage-primed cells (1.17% versus 8.69% in EEPs). Developmental mapping showed that FTS cells mapping to the hair follicle trajectory concentrated at early positions, whereas EEPs spanned a later and broader correspondence. Compared with matched developing skin states, FTS epithelium exhibited stronger injury-response and reactive transcriptional programmes. This epithelial reactivity coincided with an inferred dermal-epithelial signalling network with weaker BMP and noncanonical WNT inputs, no epithelial Hedgehog communication, and biased FGF and extracellular matrix interactions. Together, these findings link limited appendage formation in FTS to reduced appendage priming, a reactive interfollicular epidermal state, and a remodelled dermal signalling environment that diverges from native developmental niches.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"35 ","pages":"9636897261503847"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149294875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation.","authors":"Christopher Orr, Jeannette Stratton, Mohamed El-Shahawy, Elena Forouhar, Alice Peng, Gagandeep Singh, Keiko Omori, Meirigeng Qi, Fouad Kandeel","doi":"10.1177/09636897241309412","DOIUrl":"10.1177/09636897241309412","url":null,"abstract":"<p><p>Herein, we characterized the percentage of tacrolimus to the combined sirolimus and tacrolimus trough levels (tacrolimus %) observed during islet transplant-associated immune suppression therapy with post-transplant skin cancer. Although trough levels of tacrolimus and sirolimus were not different (<i>P</i> = 0.79, 0.73, respectively), high tacrolimus % resulted in a 1.32-fold increase in skin cancer odds when adjusting for age, sex, body mass index (BMI), and use of mycopheonlate mofetil (MMF; <i>p</i> = 0.039). Skin cancer patients were likely to have been older but not differ significantly (mean difference 12 years, <i>P</i> = 0.056), but age was significantly associated with a 1.22-fold increase in adjusted skin cancer odds (<i>P</i> = 0.046). BMI was inversely associated with skin cancer, with an adjusted odds ratio (OR) of 0.40 (<i>P</i> = 0.022). High tacrolimus % (>35) resulted in a 4.6-fold increase in skin cancer frequency, whereas sirolimus above 75% of the combined therapy led to a 5.2-fold increase in islet graft dysfunction (IGD) events/year. By calculating the maximum safe exposure (MSE) to tacrolimus % according to patient age and BMI, we found that cumulative months spent above MSE was predictive of skin cancer (1.20-fold increase, <i>P</i> = 0.003). Individuals exceeding the MSE for 1 year were 9.2 times more likely to develop skin cancer (<i>P</i> = 0.008). Results suggest that strategies targeting immunosuppression ratios based on age and BMI may minimize cancer risk while improving graft survival and function.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241309412"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation.","authors":"Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel","doi":"10.1177/09636897241310989","DOIUrl":"10.1177/09636897241310989","url":null,"abstract":"<p><p>Although islet transplantation is effective in reducing severe hypoglycemia events and controlling blood glucose in patients with type 1 diabetes, maintaining islet graft function long-term is a significant challenge. Islets from multiple donors are often needed to achieve insulin independence, and even then, islet function can decline over time when metabolic demand exceeds islet mass/insulin secretory capacity. We previously developed a method that calculated the islet graft function index (GFI) and a patient's predicted insulin requirement (PIR) using mathematical nonlinear regression. Both PIR and GFI could be used by physicians as tools to monitor islet graft function and to guide supplementing the patient with exogenous insulin to prevent beta-cell exhaustion. This study investigates the factors relating to the islet preparation process, as well as donor and recipient characteristics, and assessed their associations with PIR and GFI after transplantation. The goal is to determine the most relevant factors that influence islet graft function after transplantation. We examined the effects of donor and recipient characteristics, and islet processing factors on posttransplanted PIR and GFI. The PIR and GFI at 3 months were calculated using patients' baseline insulin intake, posttransplant 2-h postprandial blood glucose, and glucagon-stimulated C-peptide. Thirteen transplants that resulted in progressive decline in patients' weekly averaged insulin intake over the initial weeks after transplant (assuming constant glucose level) with available 3-month PIR and GFI data were chosen for the investigation. Univariate analyses were performed to assess the effects of donor and recipient characteristics and islet processing factors on islet graft function as reflected by PIR and GFI. The PIR and GFI were treated as continuous response variables in separate linear regression models. Shorter digestion time of isolated donor islets were associated with lower PIR (<i>P</i> = 0.014) and a higher GFI (<i>P</i> = 0.027) after transplantation. Islet injury related to digestion enzyme exposure influenced islet function as estimated using PIR and GFI post-transplantation.</p>","PeriodicalId":9721,"journal":{"name":"Cell Transplantation","volume":"34 ","pages":"9636897241310989"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}