Cell calcium最新文献_第8页

Mitochondrial Ca2+ uniporter b (MCUb) regulates neuronal Ca2+ dynamics and resistance to ischemic stroke 线粒体Ca2+单转运蛋白b （MCUb）调节神经元Ca2+动力学和缺血性卒中的抵抗

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-06-01 Epub Date: 2025-02-27 DOI: 10.1016/j.ceca.2025.103013

Tam Nguyen , Zhihong Lin , Nirav Dhanesha , Rakesh B. Patel , Mallorie Lane , Grant C. Walters , Leonid P. Shutov , Stefan Strack , Anil K. Chauhan , Yuriy M. Usachev

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引用次数: 0

Crosstalk between calcium and reactive oxygen species signaling in cancer revisited 癌症中钙和活性氧信号之间的串扰

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.1016/j.ceca.2025.103014

Trayambak Pathak , J.Cory Benson , Priscilla W. Tang , Mohamed Trebak , Nadine Hempel

{"title":"Crosstalk between calcium and reactive oxygen species signaling in cancer revisited","authors":"Trayambak Pathak , J.Cory Benson , Priscilla W. Tang , Mohamed Trebak , Nadine Hempel","doi":"10.1016/j.ceca.2025.103014","DOIUrl":"10.1016/j.ceca.2025.103014","url":null,"abstract":"<div><div>The homeostasis of cellular reactive oxygen species (ROS) and calcium (Ca2+) are intricately linked. ROS signaling and Ca2+ signaling are reciprocally regulated within cellular microdomains and are crucial for transcription, metabolism and cell function. Tumor cells often highjack ROS and Ca2+ signaling mechanisms to ensure optimal cell survival and tumor progression. Expression and regulation of Ca2+ channels and transporters at the plasma membrane, endoplasmic reticulum, mitochondria and other endomembranes are often altered in tumor cells, and this includes their regulation by ROS and reactive nitrogen species (RNS). Likewise, alterations in cellular Ca2+ levels influence the generation and scavenging of oxidants and thus can alter the redox homeostasis of the cell. This interplay can be either beneficial or detrimental to the cell depending on the localization, duration and levels of ROS and Ca2+ signals. At one end of the spectrum, Ca2+ and ROS/RNS can function as signaling modules while at the other end, lethal surges in these species are associated with cell death. Here, we highlight the interplay between Ca2+ and ROS in cancer progression, emphasize the impact of redox regulation on Ca2+ transport mechanisms, and describe how Ca2+ signaling pathways, in turn, can regulate the cellular redox environment.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"127 ","pages":"Article 103014"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaling up neuronal Ca2+, signaling on ER ladders 放大神经元Ca2+，内质网梯子上的信号

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-05-01 Epub Date: 2025-04-01 DOI: 10.1016/j.ceca.2025.103016

Khaled Machaca

引用次数: 0

Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling 钙作为线粒体-核网络驱动的逆行信号的关键决定因素

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-05-01 Epub Date: 2025-04-08 DOI: 10.1016/j.ceca.2025.103017

Kriti Ahuja, Rajender K. Motiani

{"title":"Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling","authors":"Kriti Ahuja, Rajender K. Motiani","doi":"10.1016/j.ceca.2025.103017","DOIUrl":"10.1016/j.ceca.2025.103017","url":null,"abstract":"<div><div>Mitochondria are robust signaling organelle that regulate a variety of cellular functions. One of the key mechanisms that drive mitochondrial signaling is inter-organelle crosstalk. Mitochondria communicates with other organelles primarily via exchange of calcium (Ca2+), reactive oxygen species (ROS) and lipids across organelle membranes. Mitochondria has its own genome but a majority of mitochondrial proteins are encoded by nuclear genome. Therefore, several mitochondrial functions are controlled by nucleus via anterograde signaling. However, the role of mitochondria in driving expression of genes encoded by nuclear genome has recently gained attention. Recent studies from independent groups have demonstrated a critical role for mitochondrial Ca2+signaling in stimulating nuclear gene expression. These studies report that inhibition of mitochondrial Ca2+uptake through silencing of Mitochondrial Ca2+Uniporter (MCU) leads to Ca2+oscillations in the cytosol. The rise in cytosolic Ca2+ results in activation of Ca2+ sensitive transcription factors such as NFATs and NF-<math><mi>κ</mi></math>B. These transcription factors consequently induce expression of their target genes in the nuclear genome. It is important to highlight that these groups used different cell types and elegantly presented a phenomenon that is conserved across various systems. Notably, mitochondrial Ca2+ signaling mediated transcriptional regulation controls diverse cellular functions ranging from B-cell activation, melanogenesis and aging associated inflammation. Future studies on this signaling module would result in better understanding of this axis in human pathophysiology and could lead to development of novel therapeutic strategies.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"127 ","pages":"Article 103017"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing of the guards while steering a familiar course 在熟悉的路线上换岗

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI: 10.1016/j.ceca.2025.103002

Barbara A. Niemeyer , David I. Yule

引用次数: 0

Commentary to An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease (Zhao et al., EMBO Journal 2024) and A gain-of-function mutation in the Ca2+ channel ORAI1 causes Stormorken syndrome with tubular aggregates in mice (Pérez-Guàrdia et al., Cells 2024) Orai1功能获得性小管聚集性肌病小鼠模型显示了人类疾病的关键特征（Zhao等人，EMBO Journal 2024）和Ca2+通道Orai1的功能获得性突变导致小鼠具有小管聚集性Stormorken综合征（Pérez-Guàrdia等人，Cells 2024）。

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1016/j.ceca.2025.102998

Johann Böhm

引用次数: 0

Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries 神经血管耦合的惊人见解：电信号点燃脑毛细血管中的钙动力学。

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-03-01 Epub Date: 2025-02-01 DOI: 10.1016/j.ceca.2025.103001

Boris Lavanderos , Maria Paz Saldias , Scott Earley

引用次数: 0

You better keep an eye on your contacts 你最好看好你的隐形眼镜。

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-03-01 Epub Date: 2025-01-22 DOI: 10.1016/j.ceca.2025.102999

Tamas Balla, Gergo Gulyas

引用次数: 0

Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function 细胞内钙储存的快速定量揭示了膜微肽对SERCA功能的影响

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1016/j.ceca.2025.103000

Jacob D. Cunningham, Taylor A. Phillips, Jaroslava Seflova, Ellen E. Cho, Seth L. Robia

{"title":"Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function","authors":"Jacob D. Cunningham, Taylor A. Phillips, Jaroslava Seflova, Ellen E. Cho, Seth L. Robia","doi":"10.1016/j.ceca.2025.103000","DOIUrl":"10.1016/j.ceca.2025.103000","url":null,"abstract":"<div><div>To determine how regulation of the sarco(endo)plasmic reticulum calcium ATPase (SERCA) affects the Ca2+ content of the endoplasmic reticulum (ER), we developed a ratiometric ER-localized Ca2+ indicator to rapidly quantify Ca2+ stores and assess SERCA function in live cells. This assay enables screening of membrane micropeptides and small molecules that modulate SERCA and Na+/K+-ATPase activity and may facilitate development of therapies that target cellular Ca2+ handling. Of the micropeptides tested, phospholamban (PLB) had the greatest degree of inhibition of SERCA, as measured by a decrease in ER Ca2+ content compared to control. Sarcolipin (SLN), endoregulin (ELN), and another-regulin (ALN) also decreased ER Ca2+ content, though less potently than PLB. We also investigated micropeptides that have been shown to have a positive effect on ER Ca2+ uptake. Dwarf open reading frame (DWORF), a positive modulator of SERCA activity, and phospholemman (PLM), an inhibitor of the Na+/K+-ATPase, both increased ER Ca2+ content compared to control. A superinhibitory variant of PLM, R70C, further increased ER Ca2+ load compared to wild type PLM. Overall, our findings indicate that the inhibitory potency of micropeptides is governed by their relative binding affinities to SERCA. This allows for finely tuned modulation of Ca2+ handling in different tissues based on differential expressions of micropeptide species. Understanding the contribution of each micropeptide to SERCA regulation may reveal novel strategies for therapeutic intervention in conditions where calcium dysregulation plays a role, such as heart disease, vascular disease, or neurodegenerative disorders.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"126 ","pages":"Article 103000"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology 神经系统中的离子信号（除钙外）：生理学和病理生理学。

IF 4.3 2区生物学

Cell calcium Pub Date : 2025-01-01 Epub Date: 2024-12-07 DOI: 10.1016/j.ceca.2024.102984

Verena Untiet , Chritsine R. Rose , Maiken Nedergaard , Alexei Verkhratsky

引用次数: 0