Cell calcium最新文献

ROS and calcium signaling are critical determinant of skin pigmentation.

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-12-20 DOI: 10.1016/j.ceca.2024.102987

Kriti Ahuja, Sharon Raju, Sakshi Dahiya, Rajender K Motiani

{"title":"ROS and calcium signaling are critical determinant of skin pigmentation.","authors":"Kriti Ahuja, Sharon Raju, Sakshi Dahiya, Rajender K Motiani","doi":"10.1016/j.ceca.2024.102987","DOIUrl":"https://doi.org/10.1016/j.ceca.2024.102987","url":null,"abstract":"Pigmentation is a protective phenomenon that shields skin cells from UV-induced DNA damage. Perturbations in pigmentation pathways predispose to skin cancers and lead to pigmentary disorders. These ailments impart psychological trauma and severely affect the patients' quality of life. Emerging literature suggests that reactive oxygen species (ROS) and calcium (Ca2+) signaling modules regulate physiological pigmentation. Further, pigmentary disorders are associated with dysregulated ROS homeostasis and changes in Ca2+ dynamics. Here, we systemically review the literature that demonstrates key role of ROS and Ca2+ signaling in pigmentation and pigmentary disorders. Further, we discuss recent studies, which have revealed that organelle-specific Ca2+ transport mechanisms are critical determinant of pigmentation. Importantly, we deliberate upon the possibility of clinical management of pigmentary disorders by therapeutically targeting ROS generation and cellular Ca2+ handling toolkit. Finally, we highlight the key outstanding questions in the field that demand critical and timely attention. Although an important role of ROS and Ca2+ signaling in regulating skin pigmentation has emerged, the underlying molecular mechanisms remain poorly understood. In future, it would be vital to investigate in detail the signaling cascades that connect perturbed ROS homeostasis and Ca2+ signaling to human pigmentary disorders.","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"125 ","pages":"102987"},"PeriodicalIF":4.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress.

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-12-13 DOI: 10.1016/j.ceca.2024.102986

Leandro C Clementino, Andrew P Thomas, Emily M Rocha, Sabine Hilfiker

引用次数: 0

Regulation of SR and mitochondrial Ca²⁺ signaling by L-type Ca²⁺ channels and Na/Ca exchanger in hiPSC-CMs.

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-12-12 DOI: 10.1016/j.ceca.2024.102985

Xiao-Hua Zhang, Martin Morad

{"title":"Regulation of SR and mitochondrial Ca2+ signaling by L-type Ca2+ channels and Na/Ca exchanger in hiPSC-CMs.","authors":"Xiao-Hua Zhang, Martin Morad","doi":"10.1016/j.ceca.2024.102985","DOIUrl":"https://doi.org/10.1016/j.ceca.2024.102985","url":null,"abstract":"Rationale & methods: While signaling of cardiac SR by surface membrane proteins (ICa & INCX) is well studied, the regulation of mitochondrial Ca2+ by plasmalemmal proteins remains less explored. Here we have examined the signaling of mitochondria and SR by surface-membrane calcium-transporting proteins, using genetically engineered targeted fluorescent probes, mito-GCamP6 and R-CEPIA1er.Results: In voltage-clamped and TIRF-imaged cardiomyocytes, low Na+ induced SR Ca2+ release was suppressed by short pre-exposures to ∼100 nM FCCP, suggesting mitochondrial Ca2+ contribution to low Na+ triggered SR Ca2+release. Even though low Na+- or caffeine-triggered SR Ca2+ release activated global mitochondrial Ca2+ uptake, focal mitochondrial Ca2+ signals varied in kinetics and magnitude, showing uptake or release of calcium, depending on cellular location of mitochondria. In spontaneously pacing cells, sustained caffeine exposures depleted the SR Ca2+ content activating mitochondrial Ca2+ uptake followed by sustained mitochondrial pacing. Spontaneous hiPSCCMs pacing was strongly suppressed by L-type calcium channels blockers, but not by inhibiting SERCA2a by CPA.Conclusion: Spontaneous hiPSCCMs pacing is triggered by influx of calcium through L-type Ca2+ channel that gates the release of SR pools supplemented by NCX-mediated mitochondrial calcium contribution.","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"125 ","pages":"102985"},"PeriodicalIF":4.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology. 神经系统中的离子信号（除钙外）：生理学和病理生理学。

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-12-07 DOI: 10.1016/j.ceca.2024.102984

Verena Untiet, Chritsine R Rose, Maiken Nedergaard, Alexei Verkhratsky

引用次数: 0

All-optical mapping of Ca²⁺ transport and homeostasis in dendrites.

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-12-05 DOI: 10.1016/j.ceca.2024.102983

Rebecca Frank Hayward, Adam E Cohen

{"title":"All-optical mapping of Ca2+ transport and homeostasis in dendrites.","authors":"Rebecca Frank Hayward, Adam E Cohen","doi":"10.1016/j.ceca.2024.102983","DOIUrl":"https://doi.org/10.1016/j.ceca.2024.102983","url":null,"abstract":"Calcium mediates many important signals in dendrites. However, the basic transport properties of calcium in dendrites have been difficult to measure: how far and how fast does a local influx of calcium propagate? We developed an all-optical system for simultaneous targeted Ca2+ import and Ca2+ concentration mapping. We co-expressed a blue light-activated calcium selective channelrhodopsin, CapChR2, with a far-red calcium sensor, FR-GECO1c, in cultured rat hippocampal neurons, and used patterned optogenetic stimulation to introduce calcium into cells with user-defined patterns of space and time. We determined a mean steady-state length constant for Ca2+ transport ϕ ∼ 5.8 μm, a half-life for return to baseline t1/2 ∼ 1.7 s, and an effective diffusion coefficient D ∼ 20 μm2/s, though there were substantial differences in Ca2+ dynamics between proximal and distal dendrites. At high Ca2+ concentration, distal dendrites showed nonlinear activation of Ca2+ efflux, which we pharmacologically ascribed to the NCX1 antiporter. Genetically encoded tools for all-optical mapping of Ca2+ transport and handling provide a powerful capability for studying this important messenger.","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"125 ","pages":"102983"},"PeriodicalIF":4.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles for TRPV4 in disease: A discussion of possible mechanisms

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-12-01 DOI: 10.1016/j.ceca.2024.102972

Ana M. Hernández-Vega , Refugio García-Villegas , Tamara Rosenbaum

{"title":"Roles for TRPV4 in disease: A discussion of possible mechanisms","authors":"Ana M. Hernández-Vega , Refugio García-Villegas , Tamara Rosenbaum","doi":"10.1016/j.ceca.2024.102972","DOIUrl":"10.1016/j.ceca.2024.102972","url":null,"abstract":"<div><div>The transient receptor potential vanilloid 4 (TRPV4) ion channel is a ubiquitously expressed Ca2+-permeable ion channel that controls intracellular calcium ([Ca2+]i) homeostasis in various types of cells. The physiological roles for TRPV4 are tissue specific and the mechanisms behind this specificity remain mostly unclarified. It is noteworthy that mutations in the TRPV4 channel have been associated to a broad spectrum of congenital diseases, with most of these mutations mainly resulting in gain-of-function. Mutations have been identified in human patients showing a variety of phenotypes and symptoms, mostly related to skeletal and neuromuscular disorders. Since TRPV4 is so widely expressed throughout the body, it comes as no surprise that the literature is growing in evidence linking this protein to malfunction in systems other than the skeletal and neuromuscular. In this review, we summarize the expression patterns of TRPV4 in several tissues and highlight findings of recent studies that address critical structural and functional features of this channel, particularly focusing on its interactions and signaling pathways related to Ca2+ entry. Moreover, we discuss the roles of TRPV4 mutations in some diseases and pinpoint some of the mechanisms underlying pathological states where TRPV4’s malfunction is prominent.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"124 ","pages":"Article 102972"},"PeriodicalIF":4.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STIMulating IRE1: How store-operated Ca²⁺ entry intersects with ER proteostasis.

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-11-29 DOI: 10.1016/j.ceca.2024.102980

Maria Livia Sassano, Robbe Van Gorp, Geert Bultynck, Patrizia Agostinis

引用次数: 0

PIP2 primes IP3 receptor activity: It takes at least three IP3s to open! PIP2 激发了 IP3 受体的活性：至少需要三个 IP3 才能打开！

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-11-20 DOI: 10.1016/j.ceca.2024.102970

Vikas Arige, David I. Yule

引用次数: 0

NAADP signaling: Master manipulation NAADP 信号：主控操作

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-11-17 DOI: 10.1016/j.ceca.2024.102969

Qianru Mu , Jade L. Harris , David I. Yule , James T. Slama , Jonathan S. Marchant , Sandip Patel

引用次数: 0

Electrogenic and non-electrogenic ion antiporters participate in controling membrane potential 电性和非电性离子反转运体参与控制膜电位。

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-11-16 DOI: 10.1016/j.ceca.2024.102971

Pablo Hernansanz-Agustín , Carmen Morales-Vidal , Enrique Calvo , Paolo Natale , Yolanda Martí-Mateos , Sara Natalia Jaroszewicz , José Luis Cabrera-Alarcón , Rebeca Acín-Pérez , Iván López-Montero , Jesús Vázquez , José Antonio Enríquez

引用次数: 0