Cell calcium最新文献

Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024) 评论Li等人; T细胞表面的Ca2+瞬态可在数秒内触发整合素的快速激活。自然-通讯》（2024 年）。

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-11-09 DOI: 10.1016/j.ceca.2024.102968

Mohan Manjegowda, Bimal N. Desai

引用次数: 0

Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary 大鼠垂体中体生长抑素受体亚型的分布和钙信号功能

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-11-02 DOI: 10.1016/j.ceca.2024.102967

Sonja Sivcev , Stephanie Constantin , Kosara Smiljanic , Srdjan J. Sokanovic , Patrick A. Fletcher , Arthur S. Sherman , Hana Zemkova , Stanko S. Stojilkovic

{"title":"Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary","authors":"Sonja Sivcev , Stephanie Constantin , Kosara Smiljanic , Srdjan J. Sokanovic , Patrick A. Fletcher , Arthur S. Sherman , Hana Zemkova , Stanko S. Stojilkovic","doi":"10.1016/j.ceca.2024.102967","DOIUrl":"10.1016/j.ceca.2024.102967","url":null,"abstract":"<div><div>The somatostatin (SST) receptor family controls pituitary hormone secretion, but the distribution and specific roles of these receptors on the excitability and voltage-gated calcium signaling of hormone producing pituitary cells have not been fully characterized. Here we show that the rat pituitary gland expressed <em>Sstr1, Sstr2, Sstr3,</em> and <em>Sstr5</em> receptor genes in a cell type-specific manner: <em>Sstr1</em> and <em>Sstr2</em> in thyrotrophs, <em>Sstr3</em> in gonadotrophs and lactotrophs, <em>Sstr2, Sstr3</em>, and <em>Sstr5</em> in somatotrophs, and none in corticotrophs and melanotrophs. Most gonadotrophs and thyrotrophs spontaneously fired high-amplitude single action potentials, which were silenced by SST without affecting intracellular calcium concentrations. In contrast, lactotrophs and somatotrophs spontaneously fired low-amplitude plateau-bursting action potentials in conjunction with calcium transients, both of which were silenced by SST. Moreover, SST inhibited GPCR-induced voltage-gated calcium signaling and hormone secretion in all cell types expressing SST receptors, but the inhibition was more pronounced in somatotrophs. The pattern of inhibition of electrical activity and calcium signaling was consistent with both direct and indirect inhibition of voltage-gated calcium channels, the latter being driven by cell type-specific hyperpolarization. These results indicate that the action of SST in somatotrophs is enhanced by the expression of several types of SST receptors and their slow desensitization, that SST may play a role in the electrical resynchronization of gonadotrophs, thyrotrophs, and lactotrophs, and that the lack of SST receptors in corticotrophs and melanotrophs keeps them excitable and ready to responses to stress.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"124 ","pages":"Article 102967"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium signals as regulators of ferroptosis in cancer 钙信号是癌症中铁蛋白沉积的调节因子

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-29 DOI: 10.1016/j.ceca.2024.102966

Ioana Stejerean-Todoran , Christine S. Gibhardt , Ivan Bogeski

{"title":"Calcium signals as regulators of ferroptosis in cancer","authors":"Ioana Stejerean-Todoran , Christine S. Gibhardt , Ivan Bogeski","doi":"10.1016/j.ceca.2024.102966","DOIUrl":"10.1016/j.ceca.2024.102966","url":null,"abstract":"<div><div>The field of ferroptosis research has grown exponentially since this form of cell death was first identified over a decade ago. Ferroptosis, an iron- and ROS-dependent type of cell death, is controlled by various metabolic pathways, including but not limited to redox and calcium (Ca<sup>2+</sup>) homeostasis, iron fluxes, mitochondrial function and lipid metabolism. Importantly, therapy-resistant tumors are particularly susceptible to ferroptotic cell death, rendering ferroptosis a promising therapeutic strategy against numerous malignancies. Calcium signals are important regulators of both cancer progression and cell death, with recent studies indicating their involvement in ferroptosis. Cells undergoing ferroptosis are characterized by plasma membrane rupture and the formation of nanopores, which facilitate influx of ions such as Ca<sup>2+</sup> into the affected cells. Furthermore, mitochondrial Ca²⁺ levels have been implicated in directly influencing the cellular response to ferroptosis. Despite the remarkable progress made in the field, our understanding of the contribution of Ca<sup>2+</sup> signals to ferroptosis remains limited. Here, we summarize key connections between Ca²⁺ signaling and ferroptosis in cancer pathobiology and discuss their potential therapeutic significance.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"124 ","pages":"Article 102966"},"PeriodicalIF":4.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GPCR signalling: Yet another variant route in a highly complex road map GPCR 信号：高度复杂路线图中的另一条变异路线

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-24 DOI: 10.1016/j.ceca.2024.102965

Alexander Demby, Manuela Zaccolo

引用次数: 0

Does a transmembrane sodium gradient control membrane potential in mammalian mitochondria? 跨膜钠梯度是否能控制哺乳动物线粒体的膜电位？

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-23 DOI: 10.1016/j.ceca.2024.102962

David G. Nicholls

引用次数: 0

Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues 钙和氯不同步：信号在斯约格伦唾液腺问题中的作用。

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-21 DOI: 10.1016/j.ceca.2024.102964

Felipe Tribiños, Marcelo A. Catalan

引用次数: 0

Corrigendum to “Loss-of-function W4645R mutation in the RyR2-caffeine binding site: implications for synchrony and arrhythmogenesis” [Cell Calcium 123 (2024) 102925] RyR2-咖啡因结合位点的功能缺失W4645R突变：对同步性和心律失常发生的影响》[Cell Calcium 123 (2024) 102925]的更正。

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-20 DOI: 10.1016/j.ceca.2024.102960

José-Carlos Fernández-Morales , Noemi Toth , Pinar Bayram , Taylor Rienzo , Martin Morad

引用次数: 0

ER stress as a sentinel mechanism for ER Ca2+ homeostasis ER应激是ER Ca2+平衡的哨兵机制。

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-18 DOI: 10.1016/j.ceca.2024.102961

Tadashi Makio, Junsheng Chen, Thomas Simmen

{"title":"ER stress as a sentinel mechanism for ER Ca2+ homeostasis","authors":"Tadashi Makio, Junsheng Chen, Thomas Simmen","doi":"10.1016/j.ceca.2024.102961","DOIUrl":"10.1016/j.ceca.2024.102961","url":null,"abstract":"<div><div>Endoplasmic reticulum (ER) stress is triggered upon the interference with oxidative protein folding that aims to produce fully folded, disulfide-bonded and glycosylated proteins, which are then competent to exit the ER. Many of the enzymes catalyzing this process require the binding of Ca<sup>2+</sup> ions, including the chaperones BiP/GRP78, calnexin and calreticulin. The induction of ER stress with a variety of drugs interferes with chaperone Ca<sup>2+</sup> binding, increases cytosolic Ca<sup>2+</sup>through the opening of ER Ca<sup>2+</sup> channels, and activates store-operated Ca<sup>2+</sup> entry (SOCE). Posttranslational modifications (PTMs) of the ER Ca<sup>2+</sup> handling proteins through ER stress-dependent phosphorylation or oxidation control these mechanisms, as demonstrated in the case of the sarco/endoplasmic reticulum ATPase (SERCA), inositol 1,4,5 trisphosphate receptors (IP<sub>3</sub>Rs) or stromal interaction molecule 1 (STIM1). Their aim is to restore ER Ca<sup>2+</sup> homeostasis but also to increase Ca<sup>2+</sup> transfer from the ER to mitochondria during ER stress. This latter function boosts ER bioenergetics, but also triggers apoptosis if ER Ca<sup>2+</sup> signaling persists. ER Ca<sup>2+</sup> toolkit oxidative modifications upon ER stress can occur within the ER lumen or in the adjacent cytosol. Enzymes involved in this redox control include ER oxidoreductin 1 (ERO1) or the thioredoxin-family protein disulfide isomerases (PDI) and ERp57. A tight, but adaptive connection between ER Ca<sup>2+</sup> content, ER stress and mitochondrial readouts allows for the proper functioning of many tissues, including skeletal muscle, the liver, and the pancreas, where ER stress either maintains or compromises their function, depending on its extent and context. Upon mutation of key regulators of ER Ca<sup>2+</sup> signaling, diseases such as muscular defects (e.g., from mutated selenoprotein N, SEPN1/SELENON), or diabetes (e.g., from mutated PERK) are the result.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"124 ","pages":"Article 102961"},"PeriodicalIF":4.3,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process 脱粘体上的 IP3 受体-KRAP 复合物：凋亡过程中的新角色

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-18 DOI: 10.1016/j.ceca.2024.102963

Jan B. Parys

引用次数: 0

MICU1 and MICU2, two peas in a pod or entirely different fruits? MICU1 和 MICU2 是一个豆荚里的两颗豆子，还是完全不同的果实？

IF 4.3 2区生物学

Cell calcium Pub Date : 2024-10-08 DOI: 10.1016/j.ceca.2024.102959

Jiuzhou Huo, Jeffery D. Molkentin

引用次数: 0