{"title":"Marginal resection preferred over radical resection for a large abdominal wall desmoid tumor during pregnancy: A case report","authors":"Riku Watanabe , Hiroki Shinmura , Yasuyuki Yokoyama , Takashi Matsushima","doi":"10.1016/j.crwh.2025.e00701","DOIUrl":"10.1016/j.crwh.2025.e00701","url":null,"abstract":"<div><div>Desmoid tumors are locally aggressive soft-tissue tumors known for their lack of metastatic potential but high recurrence rate after resection. Few cases of desmoid tumors during pregnancy have been reported, making treatment decisions more challenging.</div><div>This report presents the case of a woman with an abdominal wall desmoid tumor resected at 17 weeks of gestation. The large mass (13.4 cm × 7.4 cm) was compressing the uterus, which necessitated surgical intervention. Marginal resection of the tumor was performed with microscopically positive margins. The patient's postoperative course was uneventful, and she had a normal vaginal delivery at 38 weeks. No recurrence of the tumor was observed at 24-month follow-up. This case represents the largest pregnancy-related abdominal desmoid tumor (22 cm × 12 cm) resected marginally during pregnancy. The procedure allowed for a vaginal delivery rather than a cesarean section.</div><div>Surgical management of desmoid tumors in pregnancy should aim to remove the tumor while preserving function and anatomical integrity. While this approach is feasible for smaller tumors, larger tumors, as in this case, may result in loss of function and anatomical structure. This raises the question of whether marginal resection should be considered when preservation of function and structure is not feasible with radical resection. This case reinforces the fundamental surgical principle that when clear surgical margins cannot be achieved without compromising function and structure, marginal resection should be considered.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00701"},"PeriodicalIF":0.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glanzmann's thrombasthenia in a twin pregnancy: A case report","authors":"Vicky X. Xu , Shaun P. Brennecke","doi":"10.1016/j.crwh.2025.e00697","DOIUrl":"10.1016/j.crwh.2025.e00697","url":null,"abstract":"<div><div>Glanzmann's thrombasthenia (GT) is a rare autosomal recessive bleeding disorder caused by deficient or defective integrin αIIbβ3 on platelets, leading to impaired platelet aggregation. Pregnancy in women with GT poses significant challenges due to the increased risk of bleeding antenatally, intrapartum, and postpartum, as well as potential complications for the neonate, such as neonatal alloimmune thrombocytopenia (NAIT). This case report details the contemporary, multidisciplinary management of a 35-year-old primigravid woman with a dichorionic, diamniotic twin pregnancy and GT which included an elective caesarean section under general anaesthesia performed at 36 + 5 weeks of gestation, with recombinant factor VIIa (NovoSeven) and tranexamic acid (TXA) treatment preoperatively and pre-emptive uterotonic administration intraoperatively to minimise haemorrhage. Postpartum management included a seven-week course of TXA. This case highlights the importance of a proactive, multidisciplinary care plan to optimize pregnancy outcomes in women with GT, with a focus on minimizing the risk of severe haemorrhage.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00697"},"PeriodicalIF":0.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaginocutaneous fistula caused by recurrent labial abscess: A case report","authors":"Komkrit Aimjirakul, Teerapan Seehanantawong, Apisith Saraluck","doi":"10.1016/j.crwh.2025.e00698","DOIUrl":"10.1016/j.crwh.2025.e00698","url":null,"abstract":"<div><div>Urogenital fistulas are characterized by communication tracts that connect two surfaces or distinct organ systems. A vaginocutaneous fistula is a rare type of urogenital fistula that is characterized by persistent perineal discharge. This case report describes a female patient who suffered from recurrent labial abscesses and a fistula that connected the lower vagina to the inner thigh. There were symptoms of persistent perineal discharge, and the patient had an offensive odor. The patient had a history of six recurrent right labial abscesses over a period of two years prior to the formation of two fistulous openings. The right medial aspect of the inner thigh, adjacent to the labia majora, was found to have a 0.7 cm opening, which was confirmed by magnetic resonance imaging. Intraoperatively, the fistulous tract was readily delineated using dye. Complete fistulectomy was performed. This report highlights an unusual presentation of a urogenital fistula, the diagnostic challenges, and the management strategies. It emphasizes the need for timely identification and intervention in such cases.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00698"},"PeriodicalIF":0.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards a greater understanding of uterine sarcomas","authors":"Raji Ganesan","doi":"10.1016/j.crwh.2025.e00683","DOIUrl":"10.1016/j.crwh.2025.e00683","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"45 ","pages":"Article e00683"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roland Csorba , Paul Buderath , Marc Ingenwerth , Sa'ed Almasarweh , Zeynep Atas Elfrink
{"title":"Isolated abdominal wall metastasis 42 years after curative surgery for ovarian cancer: A case report","authors":"Roland Csorba , Paul Buderath , Marc Ingenwerth , Sa'ed Almasarweh , Zeynep Atas Elfrink","doi":"10.1016/j.crwh.2025.e00696","DOIUrl":"10.1016/j.crwh.2025.e00696","url":null,"abstract":"<div><div>Despite the rarity of abdominal or chest wall metastases in ovarian cancer patients, reports have described instances of isolated late recurrence at surgical incision sites. We report the case of an 85-year-old woman who present with a massive metastatic tumor on the right anterior abdominal wall 42 years after undergoing a total abdominal hysterectomy and bilateral salpingo-oophorectomy for primary ovarian cancer. The abdominal wall tumor was resected en bloc, and abdominal wall reconstruction was performed using a mesh. Histology revealed a low-grade serous carcinoma.</div><div>This report highlights the possibility of abdominal wall metastases after prolonged survival following the treatment of ovarian cancer. Surgical excision combined with mesh reconstruction represents an adequate treatment approach for such cases. Caution should be exercised during laparotomy to ensure complete removal of malignant tissue and to prevent parietal dissemination. Long-term follow-up is crucial for ovarian cancer patients, as late recurrences, although rare, can occur even decades after initial treatment.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"45 ","pages":"Article e00696"},"PeriodicalIF":0.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caroline L.P. Muntinga , Sophieke C.H.A. van der Steen , Edith M.G. van Esch , Sander Kelderman
{"title":"Transient bacteraemia secondary to imiquimod use as a treatment for cervical high-grade squamous intraepithelial lesions – A case report","authors":"Caroline L.P. Muntinga , Sophieke C.H.A. van der Steen , Edith M.G. van Esch , Sander Kelderman","doi":"10.1016/j.crwh.2025.e00694","DOIUrl":"10.1016/j.crwh.2025.e00694","url":null,"abstract":"<div><div>Imiquimod is an immunomodulating cream used in the treatment of cervical high-grade squamous intraepithelial lesions (cHSIL). Side-effects are common and mostly well tolerated, but can be severe. A woman using imiquimod for recurrent cHSIL presented with signs of a distributive shock nearly three weeks after the start of imiquimod treatment, for which she was admitted to a medium care unit. No infectious source was identified. The woman recovered well with conservative treatment. This case demonstrates the importance of monitoring patients for side-effects during imiquimod treatment. Side-effects, including the possibility of severe side-effects, should be discussed during patient counselling on therapy options for cHSIL treatment.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"45 ","pages":"Article e00694"},"PeriodicalIF":0.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rayan R. Salahaldin, Mais E. Abubaker, Ghada M. Abdalqader, Anas R. Tuqan, Basel A. Zaben, Iba Barghouthi
{"title":"Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review","authors":"Rayan R. Salahaldin, Mais E. Abubaker, Ghada M. Abdalqader, Anas R. Tuqan, Basel A. Zaben, Iba Barghouthi","doi":"10.1016/j.crwh.2025.e00693","DOIUrl":"10.1016/j.crwh.2025.e00693","url":null,"abstract":"<div><div>Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis is confirmed through histopathologic examination after curettage, and treatment typically involves stage-dependent chemotherapy. This case report concerns a 25-year-old woman with heavy postpartum bleeding, later diagnosed with choriocarcinoma. Despite initial single-agent chemotherapy, disease progression led to uterine perforation and hemoperitoneum, requiring emergency surgery. Following recovery, multi-agent chemotherapy resolved her symptoms. Choriocarcinoma's rarity and varied presentation make diagnosis challenging, with lung metastases common. Levels of b-hCG indicate treatment response, and prompt management combining chemotherapy, monitoring, and surgery is crucial for positive outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"45 ","pages":"Article e00693"},"PeriodicalIF":0.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143300885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lea C. George , Rebecca Gendelman , Anat Chemerinski , Pierre Lespinasse , Inessa A. Goldman , Sara Morelli
{"title":"Co-occurrence of a Mullerian anomaly and Kallmann syndrome: A case report","authors":"Lea C. George , Rebecca Gendelman , Anat Chemerinski , Pierre Lespinasse , Inessa A. Goldman , Sara Morelli","doi":"10.1016/j.crwh.2025.e00692","DOIUrl":"10.1016/j.crwh.2025.e00692","url":null,"abstract":"<div><div>The evaluation of primary amenorrhea requires a thoughtful assessment for hormonal, structural and/or genetic causes. Although most cases of primary amenorrhea are caused by a single pathology, rarely multiple pathologies may be uncovered. We present the case of a 33-year-old woman with a history of pubertal failure and primary amenorrhea due to Kallmann syndrome. She reported previous short-term use of hormone replacement therapy, with onset of severe pelvic pain and vaginal bleeding following its discontinuation. Her workup revealed concern for uterine didelphys with OHVIRA syndrome on MRI. Surgical exploration revealed a normal-appearing vagina and cervix communicating with the left uterine horn and fallopian tube, a separate, contralateral, obstructed, and engorged right uterine horn with cervix and obstructed vagina, and normal ovaries bilaterally. She underwent laparoscopic resection of the obstructed right hemiuterus with right salpingectomy. Estrogen replacement therapy was initiated postoperatively with cyclic progestins, and she experienced complete resolution of her pain. In the workup of primary amenorrhea, it is important to consider that more than one pathology may be present. A thorough endocrine, genetic, and anatomic evaluation is imperative prior to confirming the diagnosis and initiating treatment. Kallmann syndrome has rarely been reported with Mullerian anomalies; in this case it represents a scenario in which the induction of puberty and menses brought an obstructive anomaly to light. The possibility of co-occurring pathologies should always be considered to provide optimal care to the patient.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"45 ","pages":"Article e00692"},"PeriodicalIF":0.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}