{"title":"Fallopian tube cavernous haemangioma found during the caesarean section of a woman with a history of endometriosis: a case report and literature review","authors":"Konstantinos Malligiannis Ntalianis , Gladys Hulipas , Hemapriya Mohanraj , Christina Anastasia Resta , Anitha Nayar , Sahathevan Sathiyathasan","doi":"10.1016/j.crwh.2025.e00763","DOIUrl":"10.1016/j.crwh.2025.e00763","url":null,"abstract":"<div><div>This case report describes the management of fallopian tube cavernous haemangioma discovered at caesarean section, and provides insight to the literature on this extremely rare benign vascular tumor with regard to clinical recognition and management. A 39-year-old nulliparous woman with a history of endometriosis and adenomyosis underwent caesarean section at 42 weeks of gestation following in vitro fertilization conception. Intraoperatively, a brown-colored nodule measuring 1 × 1 cm was identified at the fimbrial end of the left fallopian tube. The lesion was excised and sent for histopathological examination. Microscopic analysis revealed dilated thin-walled vessels lined by flattened endothelial cells with focal fibrin thrombi, confirming the diagnosis of fallopian tube cavernous haemangioma. The patient remained asymptomatic throughout pregnancy and recovered well postoperatively. Fallopian tube haemangiomas are extremely rare benign vascular tumours. These lesions are typically asymptomatic and can be discovered incidentally during surgical procedures. Accurate intraoperative recognition is crucial, as misdiagnosis may lead to unnecessary extensive surgery with potential fertility implications, while failure to recognize malignancy could be life-threatening. To the authors' knowledge this represents the first reported case of fallopian tube cavernous haemangioma identified during pregnancy, highlighting the importance of careful histopathological evaluation of incidental adnexal findings.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00763"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Jore, Nneoma Edokobi, Ishani Deliwala, Marykate Potter, Meg Johnson, LucyBeth Nieves
{"title":"Fertility-sparing management of perivascular epithelioid cell tumors: A case report and literature review","authors":"Laura Jore, Nneoma Edokobi, Ishani Deliwala, Marykate Potter, Meg Johnson, LucyBeth Nieves","doi":"10.1016/j.crwh.2025.e00766","DOIUrl":"10.1016/j.crwh.2025.e00766","url":null,"abstract":"<div><div>Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms. Approximately 25 % occur in the female reproductive tract. The treatment strategy suggested in the literature is largely limited to hysterectomy, with little consideration of fertility-sparing approaches in reproductive-aged patients. This report concerns the use of a fertility-sparing approach in the management of a nulligravid woman who presented with abnormal uterine bleeding. She was diagnosed with a cervical perivascular epithelioid cell tumor based on biopsy and immunohistochemical analysis. Imaging confirmed a localized cervical mass and an endometrial lesion. The patient underwent hysteroscopic removal of the endometrial mass. Loop electrosurgical excision was utilized for the cervical tumor. Pathology demonstrated a benign cervical perivascular epithelioid cell tumor and an endometrial polyp. The patient remained disease-free with negative pelvic magnetic resonance imaging at three, six, and twelve months. This case highlights a novel use of loop electrosurgical excision to preserve fertility in those with gynecologic tumors, although ongoing surveillance is essential to ensure long-term safety.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00766"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Desmoid tumor in pregnancy complicated by deep vein thrombosis: A case report","authors":"Monchai Suntipap , Potsanop Kassayanan , Kasidis Nontaprom","doi":"10.1016/j.crwh.2025.e00754","DOIUrl":"10.1016/j.crwh.2025.e00754","url":null,"abstract":"<div><div>Desmoid tumor is a rare, locally aggressive soft-tissue neoplasm that primarily arises from the abdominal wall. Deep vein thrombosis is more common in pregnancy due to hypercoagulability. The coexistence of desmoid tumor and pregnancy complicated by deep vein thrombosis is extremely rare and poses unique diagnostic and therapeutic challenges.</div><div>A 29-year-old woman, gravida 2 para 1, with obesity, presented at 28 + 6 weeks of gestation for routine antenatal care. She had a history of left lower limb deep vein thrombosis and presented with progressive leg swelling. Ultrasonography revealed a 10.7 × 6.5 × 10.6 cm abdominal wall mass arising from the left rectus abdominis compressing the left external iliac vein consistent with chronic deep vein thrombosis. Because of financial constraints, warfarin was prescribed temporarily instead of low-molecular-weight heparin. At 38 + 5 weeks of gestation, elective cesarean delivery was performed with a modified surgical approach to avoid damage to the tumor. Resection was deferred due to the high risk of hemorrhage while on anticoagulation. A healthy female newborn was delivered. Postpartum biopsy confirmed desmoid-type fibromatosis with extension into adjacent muscles and iliac vessels. Radiotherapy was planned but delayed, again owing to financial constraints. Lifelong anticoagulation with warfarin and surveillance were planned for the patient.</div><div>The case highlights the importance of considering abdominal wall tumors as a potential cause of pregnancy-related deep vein thrombosis. It also demonstrates how financial considerations can shape clinical decisions and underscores the role of multidisciplinary planning in optimizing maternal and fetal outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00754"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonia Gayete-Lafuente , Umar Mian , Elizabeth Choong , David H. Barad , Norbert Gleicher
{"title":"Discordant phenotypic outcomes in monozygotic twins conceived via IVF: A case report involving Hirschsprung's disease, tricuspid and pulmonary atresia, and orofacial clefts without detectable genetic mutation","authors":"Sonia Gayete-Lafuente , Umar Mian , Elizabeth Choong , David H. Barad , Norbert Gleicher","doi":"10.1016/j.crwh.2025.e00752","DOIUrl":"10.1016/j.crwh.2025.e00752","url":null,"abstract":"<div><div>This report concerns the incidental finding of discordant congenital anomalies in twins diagnosed as monozygotic in a private, academically-affiliated fertility center in the United States. A 40-year-old woman conceived monozygotic dichorionic twins via in vitro fertilization (IVF). One twin presented with multiple congenital anomalies, including tricuspid and pulmonary atresia, cleft lip/palate, Hirschsprung's disease, facial skin tags, and a benign ocular tumor, while the other twin presented none of those abnormalities and appeared entirely healthy. Genetic testing, including amniocentesis and whole-exome sequencing, confirmed no identifiable mutations. This case emphasizes the potential role of postzygotic mosaicism, epigenetic dysregulation, and/or environmental disruption of neural crest-derived development, highlighting the complexity of embryologic development.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00752"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cerebral venous sinus thrombosis in the first trimester of pregnancy: A case report","authors":"Morolayo Ilori , Saachi Mittal , Mousa Eissa","doi":"10.1016/j.crwh.2025.e00759","DOIUrl":"10.1016/j.crwh.2025.e00759","url":null,"abstract":"<div><div>Cerebral venous sinus thrombosis (CVST) is a rare but potentially life-threatening cause of stroke, with increased incidence in pregnancy due to hypercoagulability, particularly during the third trimester and the postpartum period. First-trimester presentations are exceedingly rare. A 37-year-old woman, gravida 2, para 0, at 7 weeks of gestation, presented with severe, progressive headache, nausea, and vomiting. Her obstetric history was significant for intrauterine fetal demise (IUFD) at 22 weeks of gestation. Neurologic examination was nonfocal. Computed tomography venography (CTV), performed because magnetic resonance imaging (MRI) was contraindicated, demonstrated thrombosis of the left transverse and sigmoid sinuses extending into the left internal jugular vein. Therapeutic low-molecular-weight heparin resulted in clinical improvement. Evaluation during pregnancy was negative for acquired and inherited thrombophilias. The patient underwent an uncomplicated suction dilation and curettage and remained clinically stable on anticoagulation. This case illustrates the diagnostic challenges of CVST in early pregnancy and highlights CTV as a reliable alternative to MRI. Additionally, this case is notable for CVST presenting in the first trimester, a rare occurrence, with few cases reported in the literature. The combination of early pregnancy, prior IUFD without a known thrombophilia represents a unique risk factor constellation for CVST. Clinicians should maintain a high index of suspicion for CVST in patients presenting with severe, atypical headache in the first trimester, to enable timely diagnosis, anticoagulation, and optimized maternal outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00759"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Severe vulvar varicosities in pregnancy with the detailed sequential clinical course and management considerations: A case report","authors":"Yuka Nomura , Kiichiro Furuya , Koki Hayashi , Airi Kuruma , Saya Yamashita , Yangsil Chang , Kayoko Shikado , Hiroaki Tsubouchi , Kazuhide Ogita","doi":"10.1016/j.crwh.2025.e00764","DOIUrl":"10.1016/j.crwh.2025.e00764","url":null,"abstract":"<div><div>Vulvar varicosities occur in approximately 4 % of pregnant women and typically resolve within a few months postpartum without treatment. Careful intrapartum management is essential because of the risk of massive haemorrhage due to dilated veins. Only a few studies have documented detailed changes in vulvar varicosities during the antepartum, intrapartum, and postpartum periods. This report presents the case of a pregnant woman who developed large vulvar varicosities at approximately 20 weeks of gestation. The varicosities increased in size until 28 weeks of gestation and then remained stable until delivery. The patient underwent a successful vaginal delivery, with an estimated blood loss of 1070 mL. Postpartum haemorrhage due to uterine atony was confirmed, and uterine balloon tamponade was performed. Vulvar varicosities regressed rapidly after delivery and continued to diminish progressively over the postpartum period. Complete resolution had been achieved by 1 month postpartum. This report details the progression of vulvar varicosities during the antepartum, intrapartum, and postpartum periods, and highlights the need for appropriate delivery management to prevent complications.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00764"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fombeno Kueta Pascal , Johnny El Hanna , Abdelilah Arsalane , Justin Lewis Denakpo
{"title":"Ovarian pregnancy following fresh embryo transfer: A case report and literature review","authors":"Fombeno Kueta Pascal , Johnny El Hanna , Abdelilah Arsalane , Justin Lewis Denakpo","doi":"10.1016/j.crwh.2025.e00744","DOIUrl":"10.1016/j.crwh.2025.e00744","url":null,"abstract":"<div><div>Ovarian pregnancy is a rare and potentially life-threatening form of ectopic pregnancy, accounting for only 1.6 % to 2 % of all ectopic gestations. While its association with assisted reproductive technology is increasingly recognized, diagnosis remains challenging due to its nonspecific clinical and imaging features.</div><div>This report concerns the case of a 29-year-old primigravida who presented with mild pelvic pain and vaginal spotting following a fresh embryo transfer. Transvaginal ultrasound revealed an empty uterus and a right ovarian mass. The patient had a serum β-hCG level of 3952 IU/L. Diagnostic laparoscopy indicated the presence of an ectopic pregnancy within the right ovary. Histopathological analysis of the excised mass confirmed the diagnosis. The patient recovered uneventfully following surgical management.</div><div>Ovarian pregnancy following embryo transfer is an uncommon but serious complication of the use of assisted reproductive technology. Early diagnosis is crucial to prevent complications and preserve fertility.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"47 ","pages":"Article e00744"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathleen Mejia , Tara Ajith , Maria Memtsa , Emma Kirk
{"title":"Live normally sited pregnancy with concurrent residual tubal ectopic pregnancy: A case report","authors":"Kathleen Mejia , Tara Ajith , Maria Memtsa , Emma Kirk","doi":"10.1016/j.crwh.2025.e00739","DOIUrl":"10.1016/j.crwh.2025.e00739","url":null,"abstract":"<div><div>Expectant management of ectopic pregnancy employs regular monitoring of serum β-hCG levels until pregnancy testing is negative and the patient is asymptomatic. Although not routinely assessed in clinical practice, physical resolution of ectopic pregnancy can be determined via direct visualisation on transvaginal ultrasound. This report concerns the case of a woman in her late 20s who was managed expectantly for a right tubal ectopic pregnancy. Biochemical resolution was achieved 28 days from initial presentation. She was followed up with serial transvaginal ultrasound scans, as per unit protocol. During her follow-up, she conceived and transvaginal ultrasound scans showed a concurrent live normally sited pregnancy alongside the residual right tubal ectopic pregnancy. In view of this, she was followed up regularly until 13 + 0 weeks into her current pregnancy, when the residual ectopic pregnancy was no longer visualised.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"47 ","pages":"Article e00739"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laparoscopic management of a heterotopic cornual pregnancy following first-trimester miscarriage – A case report and literature review","authors":"Vishal Bahall , Reiaz Mohammed , Lance De Barry","doi":"10.1016/j.crwh.2025.e00745","DOIUrl":"10.1016/j.crwh.2025.e00745","url":null,"abstract":"<div><div>Heterotopic pregnancies, defined by the simultaneous occurrence of an intrauterine and ectopic pregnancy, present a rare but potentially life-threatening diagnostic and surgical challenge. Heterotopic pregnancy is rare in spontaneously conceived pregnancies; however, a dramatic rise in the incidence is observed in patients undergoing assisted reproductive technology procedures. Moreover, cornual localization comprises only a minority of ectopic cases yet bears the highest maternal mortality rate due to the risk of catastrophic hemorrhage.</div><div>This report presents the case of a 33-year-old woman with a confirmed first-trimester miscarriage who remained asymptomatic but demonstrated persistently elevated β-hCG levels. Transvaginal ultrasonography identified a right cornual ectopic pregnancy. Laparoscopic wedge resection was performed with the preservation of uterine anatomy.</div><div>This case illustrates a critical vulnerability in the follow-up of early pregnancy loss, where residual or ectopic trophoblastic tissue may be misattributed to a slowly resolving miscarriage. It reinforces the value of repeat imaging and surveillance of β-hCG when clinical resolution is incomplete. This report presents one of the first documented cases of asymptomatic, spontaneously conceived heterotopic cornual pregnancy managed laparoscopically in the Caribbean; it contributes to the evolving literature on heterotopic pregnancies in low-risk women and supports early surgical intervention to preserve reproductive potential.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"47 ","pages":"Article e00745"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obstetric and neonatal emergencies are still global health issues","authors":"Peter Chedraui , Faustino R. Pérez-López","doi":"10.1016/j.crwh.2025.e00705","DOIUrl":"10.1016/j.crwh.2025.e00705","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"47 ","pages":"Article e00705"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}