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Molecular Imaging of Steroid Receptors in Breast Cancer. 乳腺癌中类固醇受体的分子成像。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-05-01 DOI: 10.1097/PPO.0000000000000715
Quinton J Keigley, Amy M Fowler, Sophia R O'Brien, Farrokh Dehdashti
{"title":"Molecular Imaging of Steroid Receptors in Breast Cancer.","authors":"Quinton J Keigley, Amy M Fowler, Sophia R O'Brien, Farrokh Dehdashti","doi":"10.1097/PPO.0000000000000715","DOIUrl":"10.1097/PPO.0000000000000715","url":null,"abstract":"<p><strong>Abstract: </strong>Steroid receptors regulate gene expression for many important physiologic functions and pathologic processes. Receptors for estrogen, progesterone, and androgen have been extensively studied in breast cancer, and their expression provides prognostic information as well as targets for therapy. Noninvasive imaging utilizing positron emission tomography and radiolabeled ligands targeting these receptors can provide valuable insight into predicting treatment efficacy, staging whole-body disease burden, and identifying heterogeneity in receptor expression across different metastatic sites. This review provides an overview of steroid receptor imaging with a focus on breast cancer and radioligands for estrogen, progesterone, and androgen receptors.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 3","pages":"142-152"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A General Approach to Patients Presenting With Locally Advanced or Distant Metastatic Disease. 治疗局部晚期或远处转移性疾病患者的一般方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000704
James W Smithy, Paul B Chapman
{"title":"A General Approach to Patients Presenting With Locally Advanced or Distant Metastatic Disease.","authors":"James W Smithy, Paul B Chapman","doi":"10.1097/PPO.0000000000000704","DOIUrl":"10.1097/PPO.0000000000000704","url":null,"abstract":"<p><strong>Abstract: </strong>The widespread adoption of immune checkpoint inhibitors and small molecule inhibitors of the MAP kinase pathway has transformed the management of locally advanced and metastatic melanoma. Here, we provide a broad overview on the use of these agents in the first-line setting, incorporating a review of the clinical literature as well as the practice patterns of our respective melanoma groups. Throughout, we highlight areas of uncertainty that provide opportunities for future clinical investigation and additional improvement in outcomes for patients with melanoma.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"48-53"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigational Approaches for Treatment of Melanoma Patients Progressing After Standard of Care. 治疗标准疗法后病情进展的黑色素瘤患者的研究方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000702
Kylie A Fletcher, Douglas B Johnson
{"title":"Investigational Approaches for Treatment of Melanoma Patients Progressing After Standard of Care.","authors":"Kylie A Fletcher, Douglas B Johnson","doi":"10.1097/PPO.0000000000000702","DOIUrl":"10.1097/PPO.0000000000000702","url":null,"abstract":"<p><strong>Abstract: </strong>The advent of effective immunotherapy, specifically cytotoxic T-lymphocyte associated protein 4 and programmed cell death 1 inhibitors, as well as targeted therapy including BRAF/MEK inhibitors, has dramatically changed the prognosis for metastatic melanoma patients. Up to 50% of patients may experience long-term survival currently. Despite these advances in melanoma treatment, many patients still progress and die of their disease. As such, there are many studies aimed at providing new treatment options for this population. Therapies currently under investigation include, but are not limited to, novel immunotherapies, targeted therapies, tumor-infiltrating lymphocytes and other cellular therapies, oncolytic viral therapy and other injectables, and fecal microbiota transplant. In this review, we discuss the emerging treatment options for metastatic melanoma patients who have progressed on standard of care treatments.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"126-131"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Far We've Come. 我们走了多远
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000710
Mario Sznol, Jeffrey S Weber
{"title":"How Far We've Come.","authors":"Mario Sznol, Jeffrey S Weber","doi":"10.1097/PPO.0000000000000710","DOIUrl":"10.1097/PPO.0000000000000710","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"47"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local and Systemic Management Options for Melanoma Brain Metastases. 黑色素瘤脑转移的局部和全身治疗方案。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000711
Afsaneh Amouzegar, Hussein A Tawbi
{"title":"Local and Systemic Management Options for Melanoma Brain Metastases.","authors":"Afsaneh Amouzegar, Hussein A Tawbi","doi":"10.1097/PPO.0000000000000711","DOIUrl":"10.1097/PPO.0000000000000711","url":null,"abstract":"<p><strong>Abstract: </strong>Development of brain metastasis is one of the most serious complications of advanced melanoma, carrying a significant burden of morbidity and mortality. Although advances in local treatment modalities such as stereotactic radiosurgery and breakthrough systemic therapies including immunotherapy and targeted therapies have improved the outcomes of patients with metastatic melanoma, management of patients with melanoma brain metastases (MBMs) remains challenging. Notably, patients with MBMs have historically been excluded from clinical trials, limiting insights into their specific treatment responses. Encouragingly, a growing body of evidence shows the potential of systemic therapies to yield durable intracranial responses in these patients, highlighting the need for inclusion of patients with MBMs in future clinical trials. This is pivotal for expediting the advancement of novel therapies tailored to this distinct patient population. In this review, we will highlight the evolving landscape of MBM management, focusing on local and systemic treatment strategies.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"102-107"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Melanoma Treatment in Special Populations. 特殊人群的转移性黑色素瘤治疗。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000701
Madeline Miceli, Christina Boatwright, Janice M Mehnert
{"title":"Metastatic Melanoma Treatment in Special Populations.","authors":"Madeline Miceli, Christina Boatwright, Janice M Mehnert","doi":"10.1097/PPO.0000000000000701","DOIUrl":"10.1097/PPO.0000000000000701","url":null,"abstract":"<p><strong>Abstract: </strong>This review outlines the most up-to-date metastatic melanoma treatment recommendations and relevant risks for patients with solid organ transplants, patients with renal dysfunction, and patients with preexisting autoimmune conditions. These specific treatment populations were excluded from the original clinical trials, which studied immune checkpoint inhibitors and BRAF/MEK inhibitors in the advanced melanoma setting. We have synthesized the current body of literature, mainly case series and retrospective analyses, to reflect the evidence for the treatment of these special patient populations at present.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"71-78"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-Infiltrating Lymphocyte and Other Cell Therapies for Metastatic Melanoma. 治疗转移性黑色素瘤的肿瘤浸润淋巴细胞及其他细胞疗法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000705
Christy Los, Sebastian Klobuch, John B A G Haanen
{"title":"Tumor-Infiltrating Lymphocyte and Other Cell Therapies for Metastatic Melanoma.","authors":"Christy Los, Sebastian Klobuch, John B A G Haanen","doi":"10.1097/PPO.0000000000000705","DOIUrl":"10.1097/PPO.0000000000000705","url":null,"abstract":"<p><strong>Abstract: </strong>Major progress in prolonging survival of patients with advanced melanoma has been made in the past decade because of the development and approval of immune checkpoint inhibitor and targeted therapies. However, for nonresponding or relapsing patients, their prognosis is still dismal. Based on clinical trial data, treatment with adoptive cell therapies holds great promise. In patients with metastatic melanoma progressing on or nonresponsive to single-agent anti-programmed cell death 1, infusion of tumor-infiltrating lymphocytes can produce responses in up to half of patients, with durable complete responses in up to 20%. Genetic modification of peripheral blood T cells with T-cell receptors derived from tumor-specific T cells, or with chimeric antigen receptors, has the potential to further improve treatment outcomes in this refractory population. In this review, we will discuss the historical development, current status, and future perspectives of adoptive T-cell therapies in melanoma.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"113-119"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is There a Current Role for Combination Chemotherapy or High-Dose Interleukin 2 in Melanoma? 联合化疗或大剂量白细胞介素 2 目前在黑色素瘤中是否有作用？
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000703
Julie Fishman, Elizabeth I Buchbinder
{"title":"Is There a Current Role for Combination Chemotherapy or High-Dose Interleukin 2 in Melanoma?","authors":"Julie Fishman, Elizabeth I Buchbinder","doi":"10.1097/PPO.0000000000000703","DOIUrl":"10.1097/PPO.0000000000000703","url":null,"abstract":"<p><strong>Abstract: </strong>Immune checkpoint inhibition and targeted therapies have revolutionized the treatment of melanoma. However, chemotherapy and interleukin 2 (IL-2) therapy may still have a role in the later-line treatment of patients who do not have durable responses to other treatments. Chemotherapy can work transiently in patients whose disease has progressed on immune checkpoint inhibitors and for whom there are no appropriate targeted therapy options. High-dose IL-2 therapy can still be effective for a very small number of patients following progression on other therapies. In addition, modified IL-2 agents and IL-2 in combination with tumor-infiltrating lymphocyte therapy may play a role in future treatments for melanoma.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"120-125"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melanoma-Modern Treatment for Metastatic Melanoma. 黑色素瘤--转移性黑色素瘤的现代治疗方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000707
Maya Dimitrova, Jeffrey Weber
{"title":"Melanoma-Modern Treatment for Metastatic Melanoma.","authors":"Maya Dimitrova, Jeffrey Weber","doi":"10.1097/PPO.0000000000000707","DOIUrl":"10.1097/PPO.0000000000000707","url":null,"abstract":"<p><strong>Abstract: </strong>Traditional chemotherapy has been ineffective in the treatment of metastatic melanoma. Until the use of checkpoint inhibitors, patients had very limited survival. Since the original US Food and Drug Administration approval of ipilimumab over a decade ago, the armamentarium of immunotherapeutic agents has expanded to include programmed cell death protein 1 and lymphocyte activation gene 3 antibodies, requiring a nuanced approach to the selection of frontline treatments, managing patients through recurrence and progression, and determining length of therapy. Herein, we review the existing evidence supporting current standard immunotherapy regimens and discuss the clinical decision-making involved in treating patients with metastatic melanoma with checkpoint inhibitors.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"79-83"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates in the Management of Uveal Melanoma. 葡萄膜黑色素瘤的最新治疗方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000708
Mali Barbi, Richard D Carvajal, Craig E Devoe
{"title":"Updates in the Management of Uveal Melanoma.","authors":"Mali Barbi, Richard D Carvajal, Craig E Devoe","doi":"10.1097/PPO.0000000000000708","DOIUrl":"10.1097/PPO.0000000000000708","url":null,"abstract":"<p><strong>Abstract: </strong>Uveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibitors and innovative liver-directed therapy, are also under investigation. Although recent progress has improved outcomes, ongoing research aims to address the unique challenges of UM and develop effective therapies, particularly for HLA-A*02:01-negative patients who represent a significant unmet medical need. This review comprehensively discusses the molecular characteristics of UM, risk stratification methods, and the current and future spectrum of regional and systemic therapeutic modalities.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"92-101"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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