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Local and Systemic Management Options for Melanoma Brain Metastases. 黑色素瘤脑转移的局部和全身治疗方案。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000711
Afsaneh Amouzegar, Hussein A Tawbi
{"title":"Local and Systemic Management Options for Melanoma Brain Metastases.","authors":"Afsaneh Amouzegar, Hussein A Tawbi","doi":"10.1097/PPO.0000000000000711","DOIUrl":"10.1097/PPO.0000000000000711","url":null,"abstract":"<p><strong>Abstract: </strong>Development of brain metastasis is one of the most serious complications of advanced melanoma, carrying a significant burden of morbidity and mortality. Although advances in local treatment modalities such as stereotactic radiosurgery and breakthrough systemic therapies including immunotherapy and targeted therapies have improved the outcomes of patients with metastatic melanoma, management of patients with melanoma brain metastases (MBMs) remains challenging. Notably, patients with MBMs have historically been excluded from clinical trials, limiting insights into their specific treatment responses. Encouragingly, a growing body of evidence shows the potential of systemic therapies to yield durable intracranial responses in these patients, highlighting the need for inclusion of patients with MBMs in future clinical trials. This is pivotal for expediting the advancement of novel therapies tailored to this distinct patient population. In this review, we will highlight the evolving landscape of MBM management, focusing on local and systemic treatment strategies.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"102-107"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Melanoma Treatment in Special Populations. 特殊人群的转移性黑色素瘤治疗。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000701
Madeline Miceli, Christina Boatwright, Janice M Mehnert
{"title":"Metastatic Melanoma Treatment in Special Populations.","authors":"Madeline Miceli, Christina Boatwright, Janice M Mehnert","doi":"10.1097/PPO.0000000000000701","DOIUrl":"10.1097/PPO.0000000000000701","url":null,"abstract":"<p><strong>Abstract: </strong>This review outlines the most up-to-date metastatic melanoma treatment recommendations and relevant risks for patients with solid organ transplants, patients with renal dysfunction, and patients with preexisting autoimmune conditions. These specific treatment populations were excluded from the original clinical trials, which studied immune checkpoint inhibitors and BRAF/MEK inhibitors in the advanced melanoma setting. We have synthesized the current body of literature, mainly case series and retrospective analyses, to reflect the evidence for the treatment of these special patient populations at present.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"71-78"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-Infiltrating Lymphocyte and Other Cell Therapies for Metastatic Melanoma. 治疗转移性黑色素瘤的肿瘤浸润淋巴细胞及其他细胞疗法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000705
Christy Los, Sebastian Klobuch, John B A G Haanen
{"title":"Tumor-Infiltrating Lymphocyte and Other Cell Therapies for Metastatic Melanoma.","authors":"Christy Los, Sebastian Klobuch, John B A G Haanen","doi":"10.1097/PPO.0000000000000705","DOIUrl":"10.1097/PPO.0000000000000705","url":null,"abstract":"<p><strong>Abstract: </strong>Major progress in prolonging survival of patients with advanced melanoma has been made in the past decade because of the development and approval of immune checkpoint inhibitor and targeted therapies. However, for nonresponding or relapsing patients, their prognosis is still dismal. Based on clinical trial data, treatment with adoptive cell therapies holds great promise. In patients with metastatic melanoma progressing on or nonresponsive to single-agent anti-programmed cell death 1, infusion of tumor-infiltrating lymphocytes can produce responses in up to half of patients, with durable complete responses in up to 20%. Genetic modification of peripheral blood T cells with T-cell receptors derived from tumor-specific T cells, or with chimeric antigen receptors, has the potential to further improve treatment outcomes in this refractory population. In this review, we will discuss the historical development, current status, and future perspectives of adoptive T-cell therapies in melanoma.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"113-119"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is There a Current Role for Combination Chemotherapy or High-Dose Interleukin 2 in Melanoma? 联合化疗或大剂量白细胞介素 2 目前在黑色素瘤中是否有作用？
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000703
Julie Fishman, Elizabeth I Buchbinder
{"title":"Is There a Current Role for Combination Chemotherapy or High-Dose Interleukin 2 in Melanoma?","authors":"Julie Fishman, Elizabeth I Buchbinder","doi":"10.1097/PPO.0000000000000703","DOIUrl":"10.1097/PPO.0000000000000703","url":null,"abstract":"<p><strong>Abstract: </strong>Immune checkpoint inhibition and targeted therapies have revolutionized the treatment of melanoma. However, chemotherapy and interleukin 2 (IL-2) therapy may still have a role in the later-line treatment of patients who do not have durable responses to other treatments. Chemotherapy can work transiently in patients whose disease has progressed on immune checkpoint inhibitors and for whom there are no appropriate targeted therapy options. High-dose IL-2 therapy can still be effective for a very small number of patients following progression on other therapies. In addition, modified IL-2 agents and IL-2 in combination with tumor-infiltrating lymphocyte therapy may play a role in future treatments for melanoma.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"120-125"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melanoma-Modern Treatment for Metastatic Melanoma. 黑色素瘤--转移性黑色素瘤的现代治疗方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000707
Maya Dimitrova, Jeffrey Weber
{"title":"Melanoma-Modern Treatment for Metastatic Melanoma.","authors":"Maya Dimitrova, Jeffrey Weber","doi":"10.1097/PPO.0000000000000707","DOIUrl":"10.1097/PPO.0000000000000707","url":null,"abstract":"<p><strong>Abstract: </strong>Traditional chemotherapy has been ineffective in the treatment of metastatic melanoma. Until the use of checkpoint inhibitors, patients had very limited survival. Since the original US Food and Drug Administration approval of ipilimumab over a decade ago, the armamentarium of immunotherapeutic agents has expanded to include programmed cell death protein 1 and lymphocyte activation gene 3 antibodies, requiring a nuanced approach to the selection of frontline treatments, managing patients through recurrence and progression, and determining length of therapy. Herein, we review the existing evidence supporting current standard immunotherapy regimens and discuss the clinical decision-making involved in treating patients with metastatic melanoma with checkpoint inhibitors.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"79-83"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates in the Management of Uveal Melanoma. 葡萄膜黑色素瘤的最新治疗方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000708
Mali Barbi, Richard D Carvajal, Craig E Devoe
{"title":"Updates in the Management of Uveal Melanoma.","authors":"Mali Barbi, Richard D Carvajal, Craig E Devoe","doi":"10.1097/PPO.0000000000000708","DOIUrl":"10.1097/PPO.0000000000000708","url":null,"abstract":"<p><strong>Abstract: </strong>Uveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibitors and innovative liver-directed therapy, are also under investigation. Although recent progress has improved outcomes, ongoing research aims to address the unique challenges of UM and develop effective therapies, particularly for HLA-A*02:01-negative patients who represent a significant unmet medical need. This review comprehensively discusses the molecular characteristics of UM, risk stratification methods, and the current and future spectrum of regional and systemic therapeutic modalities.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"92-101"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Stage III Resectable Melanoma-Adjuvant and Neoadjuvant Approaches. III 期可切除黑色素瘤的治疗--辅助和新辅助方法。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000706
Ahmad A Tarhini, Ella Castellano, Islam Eljilany
{"title":"Treatment of Stage III Resectable Melanoma-Adjuvant and Neoadjuvant Approaches.","authors":"Ahmad A Tarhini, Ella Castellano, Islam Eljilany","doi":"10.1097/PPO.0000000000000706","DOIUrl":"10.1097/PPO.0000000000000706","url":null,"abstract":"<p><strong>Abstract: </strong>Patients with stage III resectable melanoma carry a high risk of melanoma recurrence that ranges from approximately 40% to 90% at 5 years following surgical management alone. Postoperative systemic adjuvant therapy targets residual micrometastatic disease that could be the source of future recurrence and death from melanoma. Randomized phase III adjuvant trials reported significant improvements in overall survival with high-dose interferon α in 2 of 3 studies (compared with observation and GMK ganglioside vaccine) and with anti-cytotoxic T-lymphocyte antigen 4 ipilimumab at 10 mg/kg compared with placebo and ipilimumab 3 mg/kg compared with high-dose interferon α. In the modern era, more recent phase III trials demonstrated significant recurrence-free survival improvements with anti-programmed cell death protein 1, pembrolizumab, and BRAF-MEK inhibitor combination dabrafenib-trametinib (for BRAF mutant melanoma) versus placebo. Furthermore, anti-programmed cell death protein 1, nivolumab and pembrolizumab have both been shown to significantly improve recurrence-free survival as compared with ipilimumab 10 mg/kg. For melanoma patients with clinically or radiologically detectable locoregionally advanced disease, emerging data support an important role for preoperative systemic neoadjuvant therapy. Importantly, a recent cooperative group trial (S1801) reported superior event-free survival rates with neoadjuvant versus adjuvant therapy. Collectively, current data from neoadjuvant immunotherapy and targeted therapy trials support a future change in clinical practice in favor of neoadjuvant therapy for eligible melanoma patients.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"54-70"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Is the Timing and Role of Targeted Therapy in Metastatic Melanoma? 转移性黑色素瘤靶向治疗的时机和作用是什么？
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000712
Matthew J Hadfield, Ryan J Sullivan
{"title":"What Is the Timing and Role of Targeted Therapy in Metastatic Melanoma?","authors":"Matthew J Hadfield, Ryan J Sullivan","doi":"10.1097/PPO.0000000000000712","DOIUrl":"10.1097/PPO.0000000000000712","url":null,"abstract":"<p><strong>Abstract: </strong>Melanoma is the most lethal cutaneous malignancy worldwide. The last 15 years have ushered in several regulatory approvals that have dramatically altered the landscape of treatment options for patients with melanoma. Many patients with melanoma harbor activating mutations in the BRAF proto-oncogene, a key component of the mitogen-activated protein kinase (MAPK) intracellular signaling pathway. Therapies targeting BRAF have led to remarkable improvements in both response rates and survival in patients with metastatic disease. In parallel with these developments in MAPK-targeted therapy has been the clinical development of immune checkpoint inhibitors, which also have improved response rates and survival in patients with metastatic disease including randomized trials compared with MAPK-targeted therapy in patients with advanced, BRAF-mutant melanoma. Immune checkpoint inhibitors have become the preferred first-line standard-of-care treatment for patients with newly diagnosed metastatic disease in patients irrespective of BRAF mutational status. Given these developments, it is now less clear how to optimize the use of MAPK-targeted therapy regarding treatment setting and in sequence with immune checkpoint inhibitor.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"84-91"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Role and Status for Intratumoral Injection Therapies in Metastatic Melanoma. 转移性黑色素瘤瘤内注射疗法的作用和现状
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-03-01 DOI: 10.1097/PPO.0000000000000709
Alexandra M Haugh, Adil I Daud
{"title":"Current Role and Status for Intratumoral Injection Therapies in Metastatic Melanoma.","authors":"Alexandra M Haugh, Adil I Daud","doi":"10.1097/PPO.0000000000000709","DOIUrl":"10.1097/PPO.0000000000000709","url":null,"abstract":"<p><strong>Abstract: </strong>Intratumoral therapies represent a unique avenue for drug development in melanoma as patients often have accessible lesions that are particularly amenable to these approaches. In addition, a majority of intratumoral therapies have focused on stimulating antitumor immune responses, making them a particularly attractive option for use in melanoma. In this review, we describe applications for talimogene laherparepvec, a US Food and Drug Administration-approved intratumoral therapy in melanoma, as well as several classes of intratumoral therapies in development including novel oncolytic viruses, mRNA-based intratumoral injections, and cytokines and other signaling molecules.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 2","pages":"108-112"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telehealth and Outcomes in Patients With Cancer: Data and Innovation. 远程医疗与癌症患者的治疗效果：数据与创新。
IF 2.2 4区 医学
Cancer journal Pub Date : 2024-01-01 DOI: 10.1097/PPO.0000000000000697
Michael J Grant, Ann C Chiang
{"title":"Telehealth and Outcomes in Patients With Cancer: Data and Innovation.","authors":"Michael J Grant, Ann C Chiang","doi":"10.1097/PPO.0000000000000697","DOIUrl":"10.1097/PPO.0000000000000697","url":null,"abstract":"<p><strong>Abstract: </strong>Despite that telehealth has been crucial to the delivery of oncology care during the COVID-19 pandemic, the impact of this care delivery mechanism on outcomes in cancer care has not been rigorously studied relative standard in-person care for patients with cancer. Patient-centered outcomes such as quality of life, patient satisfaction, and symptoms are important outcomes that have been the primary focus of many of the existing studies in this space, yet only a select few have evaluated overall survival and other objective efficacy endpoints. Studies have alluded to positive effects of telehealth on mitigating financial toxicity and enhancing cost-effective care delivery in oncology. Telehealth carries much potential for advancing care for patients with cancer, but future study should focus on additional efficacy endpoints, implementation, and ways to reduce disparities.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 1","pages":"16-21"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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