Case Reports in Pediatrics最新文献_第9页

Cytokine Storm Syndrome Responsive to IL-1 Inhibition in Trisomy 21. 细胞因子风暴综合征对 21 三体综合征 IL-1 抑制的反应。

IF 0.7

Case Reports in Pediatrics Pub Date : 2024-03-28 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9946401

Aimee Magnarelli, Julia Shalen, Maria J Gutierrez

{"title":"Cytokine Storm Syndrome Responsive to IL-1 Inhibition in Trisomy 21.","authors":"Aimee Magnarelli, Julia Shalen, Maria J Gutierrez","doi":"10.1155/2024/9946401","DOIUrl":"10.1155/2024/9946401","url":null,"abstract":"Background: Cytokine storm syndromes (CSS) are life-threatening systemic inflammatory disorders caused by immune system dysregulation. They can lead to organ failure and are triggered by various factors, including infections, malignancy, inborn errors of immunity, and autoimmune conditions. Trisomy 21 (TS21), also known as Down syndrome, is a genetic disorder associated with immune dysfunction, increased infection susceptibility, and inflammation. While TS21 has been linked to infectious-triggered hyperinflammation, its role as a primary cause of CSS has not been confirmed. Case Presentation. We present a case of a 16-year-old male with TS21 with fever, rash, joint pain, and abdominal symptoms. Extensive investigations ruled out infections, autoimmune conditions, malignancies, and inborn errors of immunity as triggers for a CSS. The patient's symptoms improved with treatment using IL-1 inhibition and corticosteroids.Conclusions: This case reinforces that TS21 is an immune dysregulation disorder and highlights the importance of considering CSS in TS21 patients, even when triggers are unclear. The positive response to IL-1 inhibition in this patient suggests that dysregulation of the IL-1 superfamily and the NLRP3 inflammasome may contribute to CSS in TS21. This finding raises the possibility of using IL-1 inhibition as a treatment approach for CSS in TS21 patients.","PeriodicalId":9623,"journal":{"name":"Case Reports in Pediatrics","volume":"2024 ","pages":"9946401"},"PeriodicalIF":0.7,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Too Much Salt to My Taste: An Entity to Think about in Neonatal Hypernatremia: A Case Report and Review of the Literature. 对我的口味来说，盐太多了：新生儿高钠血症的一个思考实体：病例报告和文献综述。

IF 0.9

Case Reports in Pediatrics Pub Date : 2024-03-08 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8838362

Marwa El Masri, Lidiya Samotiy-Hanna, Ramy Ghabril, Yolla Nassif, Dany Al Hamod

引用次数: 0

Digital Ischemia in an Extreme Preterm Infant Treated with Nitroglycerin Patch. 使用硝酸甘油贴片治疗极早产儿的数字缺血。

IF 0.9

Case Reports in Pediatrics Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2255756

Mansour Al Qurashi, Abdulaziz Al-Khotani, Farzeen Mohtisham, Eman AlRaddadi, Heba AlShaikh, Alqassem Y Hakami, Syed Sameer Aga

引用次数: 0

From Rarity to Recognition: Infantile Botulism and the Broad Spectrum of Differential Diagnoses. 从罕见到公认：婴儿肉毒中毒与广泛的鉴别诊断。

IF 0.9

Case Reports in Pediatrics Pub Date : 2024-02-26 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4647591

Matthew C Authement, Brandon M Jones, Robert J Kahoud, Elizabeth H Ristagno

引用次数: 0

Unmasking the Hidden Culprit: A Coma Mimicry in a Child Bitten by Cobra 揭开隐藏的罪魁祸首：被眼镜蛇咬伤儿童的昏迷模仿症

IF 0.9

Case Reports in Pediatrics Pub Date : 2024-01-09 DOI: 10.1155/2024/6630842

Aphirak Mekmangkonthong, Khanittha Khusiwilai, Sudathip Paticheep, Duangtip Tiacharoen

引用次数: 0

Successful Termination of Insulin Therapy in Transient Neonatal Diabetes Mellitus. 成功终止一过性新生儿糖尿病的胰岛素治疗。

IF 0.9

Case Reports in Pediatrics Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6667330

Risa Sakai, Nobuyuki Kikuchi, Daisuke Nishi, Haruko Horiguchi

{"title":"Successful Termination of Insulin Therapy in Transient Neonatal Diabetes Mellitus.","authors":"Risa Sakai, Nobuyuki Kikuchi, Daisuke Nishi, Haruko Horiguchi","doi":"10.1155/2023/6667330","DOIUrl":"10.1155/2023/6667330","url":null,"abstract":"A sensor-augmented pump (SAP) therapy is used to treat neonatal diabetes mellitus (NDM). We treated a case for which SAP therapy was successful and prevented hypoglycemia. The patient was a baby boy who was small for his gestational age. He had hyperglycemia at 4 days of age, and a diagnosis of NDM had previously been made at another hospital. A continuous intravenous insulin infusion was initiated. At 29 days of age, the patient was transferred to our hospital for further treatment. SAP therapy was initiated at 39 days, which was successful and prevented hypoglycemia. Gradually, blood glucose levels improved. The insulin infusion was stopped to determine if any potential pump issues arose prior to discharge; the patient's blood glucose level did not increase. The decision was therefore made to discharge the patient from the hospital at 58 days of age with discontinued insulin. After discharge, genetic analysis showed hypomethylation on one of the alleles within 6q24, leading to a diagnosis of 6q24-related diabetes mellitus. Although almost all 6q24-related NDM cases are transient, no evidence exists for the appropriate timing of insulin discontinuation. Retrospective continuous glucose monitoring (CGM) analysis showed improved standard deviation (SD) values as well as improved blood glucose variability. This experience suggested SD values of CGM may be used as an index for tapering and discontinuing insulin in SAP therapy. However, future collaborative studies at other centers that focus on SD values as a guide for insulin discontinuation in SAP are required.","PeriodicalId":9623,"journal":{"name":"Case Reports in Pediatrics","volume":"2023 ","pages":"6667330"},"PeriodicalIF":0.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Cheilitis Associated with Oseltamivir after Influenzae A Infection 甲型流感嗜血杆菌感染后与奥司他韦相关的急性扁桃体炎

IF 0.9

Case Reports in Pediatrics Pub Date : 2023-12-06 DOI: 10.1155/2023/8618245

Koji Yokoyama, Mitsukazu Mamada

引用次数: 0

Chronic Morel-Lavallée Lesion in a Pediatric Patient: An Underrecognized Sequela after Trauma. 儿科患者的慢性morel - lavallsamae病变:创伤后未被充分认识的后遗症。

IF 0.7

Case Reports in Pediatrics Pub Date : 2023-11-21 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6662079

Anthony O Kamson, Bradley Lazzari, Joshua Murphy

引用次数: 0

Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes. 生长激素治疗胎龄小身材矮小的2型糖尿病。

IF 0.9

Case Reports in Pediatrics Pub Date : 2023-11-15 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9912817

Naohiro Nomura, Yuko Tanabe, Miki Minami, Junji Takaya, Kazunari Kaneko

{"title":"Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes.","authors":"Naohiro Nomura, Yuko Tanabe, Miki Minami, Junji Takaya, Kazunari Kaneko","doi":"10.1155/2023/9912817","DOIUrl":"https://doi.org/10.1155/2023/9912817","url":null,"abstract":"Growth Hormone therapy has been shown to induce transient insulin resistance in children, and there is concern regarding the diabetogenic potential of GH therapy in children born small for gestational age (SGA). In this case, female patient born SGA with a weight of 2,750 g (-1.73 standard deviation (SD)) and length of 45.5 cm (-2.6 SD). The patient's father and paternal grandfather were diagnosed with type 2 diabetes mellitus. At 3 years of age, the patient presented with short stature; height and weight were 85 cm (-2.5 SD) and 13 kg (-0.19 SD), respectively. She was placed on GH therapy. At 11 years of age, her fasting blood glucose and hemoglobin A1c levels were 116 mg/dL and 7.4%, respectively. Blood test results were negative for anti-glutamic acid decarboxylase and anti-islet antigen-2 antibodies. The patient discontinued GH therapy and started diet therapy and oral metformin (500 mg/day) administration. Five months later, the hemoglobin A1c level was 5.3% and glycemic control further improved. To our knowledge, family history may be an important risk factor for GH-induced diabetes. So, the GH dosage for patients born SGA with family history of diabetes should be adjusted so as not to be too excessive, and long-term follow-up studies will be required to evaluate fully the effects of GH therapy for them.","PeriodicalId":9623,"journal":{"name":"Case Reports in Pediatrics","volume":"2023 ","pages":"9912817"},"PeriodicalIF":0.9,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital Hepatic Fibrosis in a 2-Year-Old Child Presenting with Fever of Unknown Origin. 2岁儿童先天性肝纤维化伴不明原因发热。

IF 0.9

Case Reports in Pediatrics Pub Date : 2023-11-01 eCollection Date: 2023-01-01 DOI: 10.1155/2023/4497784

Michael P Penfold, Wentiirim B Annankra, Nathan C Hull, Margarita Corredor

引用次数: 0