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Cancer Biology & Medicine最新文献

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From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy. 从二分法到多样性：解读肿瘤相关巨噬细胞在癌症进展和治疗中的多方面作用。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-12-14 DOI: 10.20892/j.issn.2095-3941.2023.0370
Xiumei Wang, Jun Chen, Guangshuai Jia
{"title":"From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy.","authors":"Xiumei Wang, Jun Chen, Guangshuai Jia","doi":"10.20892/j.issn.2095-3941.2023.0370","DOIUrl":"10.20892/j.issn.2095-3941.2023.0370","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10884535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA methylation profiles in cancer: functions, therapy, and beyond. 癌症中的 DNA 甲基化图谱：功能、治疗及其他。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-12-07 DOI: 10.20892/j.issn.2095-3941.2023.0403
Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang, Rongxin Zhang
{"title":"DNA methylation profiles in cancer: functions, therapy, and beyond.","authors":"Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang, Rongxin Zhang","doi":"10.20892/j.issn.2095-3941.2023.0403","DOIUrl":"10.20892/j.issn.2095-3941.2023.0403","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10884540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer. 大规模功能缺失扰动揭示了乳腺癌的综合表观遗传调控网络。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-12-07 DOI: 10.20892/j.issn.2095-3941.2023.0276
Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang
{"title":"Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer.","authors":"Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang","doi":"10.20892/j.issn.2095-3941.2023.0276","DOIUrl":"10.20892/j.issn.2095-3941.2023.0276","url":null,"abstract":"<p><strong>Objective: </strong>Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression; however, the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain elusive. It is important to decipher the comprehensive epigenetic regulatory network in breast cancer cells to identify master epigenetic regulators and potential therapeutic targets.</p><p><strong>Methods: </strong>We employed high-throughput sequencing-based high-throughput screening (HTS<sup>2</sup>) to effectively detect changes in the expression of 2,986 genes following the knockdown of 400 epigenetic regulators. Then, bioinformatics analysis tools were used for the resulting gene expression signatures to investigate the epigenetic regulations in breast cancer.</p><p><strong>Results: </strong>Utilizing these gene expression signatures, we classified the epigenetic regulators into five distinct clusters, each characterized by specific functions. We discovered functional similarities between BAZ2B and SETMAR, as well as CLOCK and CBX3. Moreover, we observed that CLOCK functions in a manner opposite to that of HDAC8 in downstream gene regulation. Notably, we constructed an epigenetic regulatory network based on the gene expression signatures, which revealed 8 distinct modules and identified 10 master epigenetic regulators in breast cancer.</p><p><strong>Conclusions: </strong>Our work deciphered the extensive regulation among hundreds of epigenetic regulators. The identification of 10 master epigenetic regulators offers promising therapeutic targets for breast cancer treatment.</p>","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide drugs: a new direction in cancer immunotherapy. 多肽药物：癌症免疫疗法的新方向。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-12-07 DOI: 10.20892/j.issn.2095-3941.2023.0297
Xinghua Sui, Xiaoshuang Niu, Xiuman Zhou, Yanfeng Gao
{"title":"Peptide drugs: a new direction in cancer immunotherapy.","authors":"Xinghua Sui, Xiaoshuang Niu, Xiuman Zhou, Yanfeng Gao","doi":"10.20892/j.issn.2095-3941.2023.0297","DOIUrl":"10.20892/j.issn.2095-3941.2023.0297","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the value of molecular testing: current status and opportunities in colorectal cancer precision medicine. 提高分子检测的价值:结直肠癌精准医学的现状与机遇。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-11-30 DOI: 10.20892/j.issn.2095-3941.2023.0293
Haiyun Li, Linwei Guo, Chenchen Wang, Xin Hu, Ye Xu
{"title":"Improving the value of molecular testing: current status and opportunities in colorectal cancer precision medicine.","authors":"Haiyun Li, Linwei Guo, Chenchen Wang, Xin Hu, Ye Xu","doi":"10.20892/j.issn.2095-3941.2023.0293","DOIUrl":"10.20892/j.issn.2095-3941.2023.0293","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy. 深入了解b细胞相关的三级淋巴结构和肿瘤免疫治疗。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-11-30 DOI: 10.20892/j.issn.2095-3941.2023.0308
Jilong Yang, Jin Xu, Haotian Liu, Wanyi Xiao, Gengpu Zhang
{"title":"Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy.","authors":"Jilong Yang, Jin Xu, Haotian Liu, Wanyi Xiao, Gengpu Zhang","doi":"10.20892/j.issn.2095-3941.2023.0308","DOIUrl":"10.20892/j.issn.2095-3941.2023.0308","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10884533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The outpost against cancer: universal cancer only markers. 对抗癌症的前哨:通用的癌症标记。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-11-28 DOI: 10.20892/j.issn.2095-3941.2023.0313
Chengchen Qian, Xiaolong Zou, Wei Li, Yinshan Li, Wenqiang Yu
{"title":"The outpost against cancer: universal cancer only markers.","authors":"Chengchen Qian, Xiaolong Zou, Wei Li, Yinshan Li, Wenqiang Yu","doi":"10.20892/j.issn.2095-3941.2023.0313","DOIUrl":"10.20892/j.issn.2095-3941.2023.0313","url":null,"abstract":"<p><p>Cancer is the leading cause of death worldwide. Early detection of cancer can lower the mortality of all types of cancer; however, effective early-detection biomarkers are lacking for most types of cancers. DNA methylation has always been a major target of interest because DNA methylation usually occurs before other detectable genetic changes. While investigating the common features of cancer using a novel guide positioning sequencing for DNA methylation, a series of universal cancer only markers (UCOMs) have emerged as strong candidates for effective and accurate early detection of cancer. While the clinical value of current cancer biomarkers is diminished by low sensitivity and/or low specificity, the unique characteristics of UCOMs ensure clinically meaningful results. Validation of the clinical potential of UCOMs in lung, cervical, endometrial, and urothelial cancers further supports the application of UCOMs in multiple cancer types and various clinical scenarios. In fact, the applications of UCOMs are currently under active investigation with further evaluation in the early detection of cancer, auxiliary diagnosis, treatment efficacy, and recurrence monitoring. The molecular mechanisms by which UCOMs detect cancers are the next important topics to be investigated. The application of UCOMs in real-world scenarios also requires implementation and refinement.</p>","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging trends in clinical cancer genomic research. 临床癌症基因组研究的新趋势。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-11-28 DOI: 10.20892/j.issn.2095-3941.2023.0383
Yingyan Yu
{"title":"Emerging trends in clinical cancer genomic research.","authors":"Yingyan Yu","doi":"10.20892/j.issn.2095-3941.2023.0383","DOIUrl":"10.20892/j.issn.2095-3941.2023.0383","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-arm trials for domestic oncology drug approvals in China. 中国国内肿瘤药物审批单臂试验。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-11-27 DOI: 10.20892/j.issn.2095-3941.2023.0360
Hong Zhang, Sen Liu, Chenghao Ge, Xiaozhen Liu, Yang Liu, Chen Yin, Yi Li, Jing An, Zhongtian Yan, Xiaoyuan Chen
{"title":"Single-arm trials for domestic oncology drug approvals in China.","authors":"Hong Zhang, Sen Liu, Chenghao Ge, Xiaozhen Liu, Yang Liu, Chen Yin, Yi Li, Jing An, Zhongtian Yan, Xiaoyuan Chen","doi":"10.20892/j.issn.2095-3941.2023.0360","DOIUrl":"10.20892/j.issn.2095-3941.2023.0360","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138447221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in oncolytic viruses modified with nanomaterials for intravenous application. 静脉应用纳米材料修饰溶瘤病毒的研究进展。
IF 5.5 2区 医学
Cancer Biology & Medicine Pub Date : 2023-11-24 DOI: 10.20892/j.issn.2095-3941.2023.0275
Liting Chen, Zhijun Ma, Chen Xu, Youbang Xie, Defang Ouyang, Shuhui Song, Xiao Zhao, Funan Liu
{"title":"Progress in oncolytic viruses modified with nanomaterials for intravenous application.","authors":"Liting Chen, Zhijun Ma, Chen Xu, Youbang Xie, Defang Ouyang, Shuhui Song, Xiao Zhao, Funan Liu","doi":"10.20892/j.issn.2095-3941.2023.0275","DOIUrl":"10.20892/j.issn.2095-3941.2023.0275","url":null,"abstract":"<p><p>In oncolytic virus (OV) therapy, a critical component of tumor immunotherapy, viruses selectively infect, replicate within, and eventually destroy tumor cells. Simultaneously, this therapy activates immune responses and mobilizes immune cells, thereby eliminating residual or distant cancer cells. However, because of OVs' high immunogenicity and immune clearance during circulation, their clinical applications are currently limited to intratumoral injections, and their use is severely restricted. In recent years, numerous studies have used nanomaterials to modify OVs to decrease virulence and increase safety for intravenous injection. The most commonly used nanomaterials for modifying OVs are liposomes, polymers, and albumin, because of their biosafety, practicability, and effectiveness. The aim of this review is to summarize progress in the use of these nanomaterials in preclinical experiments to modify OVs and to discuss the challenges encountered from basic research to clinical application.</p>","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138447220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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