Case Reports in Obstetrics and Gynecology最新文献

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Ruptured Ovarian Ectopic Pregnancy Managed Laparoscopically With Subsequent Term Delivery After 2 years Follow-Up: A Case Report and Literature Review. 随访2年后腹腔镜治疗卵巢宫外孕破裂并足月分娩:1例报告及文献复习。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-09 eCollection Date: 2026-01-01 DOI: 10.1155/crog/8974058
Elizabeth Bajomo, Asma Aziz, Mona Sharma
{"title":"Ruptured Ovarian Ectopic Pregnancy Managed Laparoscopically With Subsequent Term Delivery After 2 years Follow-Up: A Case Report and Literature Review.","authors":"Elizabeth Bajomo, Asma Aziz, Mona Sharma","doi":"10.1155/crog/8974058","DOIUrl":"10.1155/crog/8974058","url":null,"abstract":"<p><strong>Background: </strong>An ovarian ectopic pregnancy (OEP) is a very rare form of ectopic pregnancy. Ectopic pregnancies are 2% of pregnancies, and OEP are 0.5%-3% of all ectopic pregnancies, with an even rarer risk of recurrence. Diagnosis is aided via ultrasound and surgical assessment, but confirmation is via histopathology.</p><p><strong>Case: </strong>We present a case of a woman in her late 20 s (Gravida 2, Para 1-previous normal vaginal delivery at term) with a planned pregnancy who had presented after a private scan to find a right-sided OEP and free fluid in her abdomen. She had only complained of mild lower abdominal cramping and no pervaginal bleeding. After evaluation, including pelvic ultrasound in our Early Pregnancy Assessment Unit (EPAU) that suspected a right OEP, she had a laparoscopic resection of the right ovarian ectopic tissue, and histopathology confirmed OEP. She recovered well and went home the next day. Serum BHCG returned to normal after repeated testing for 4 weeks, her periods returned to normal after 3 months, and she had a pelvic ultrasound scan 8 months later which showed normal ovaries. Two years later, she conceived naturally and delivered vaginally at term as a low-risk uncomplicated pregnancy.</p><p><strong>Conclusion: </strong>An OEP is very rare but can be effectively managed laparoscopically with very good outcomes and fertility preservation. Full-term delivery outcome observed in this case after 2-year follow-up.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"8974058"},"PeriodicalIF":0.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Maternal-Assisted Cesarean Using a Modified Australian Protocol. 使用改进的澳大利亚方案成功的产妇辅助剖宫产。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-09 eCollection Date: 2026-01-01 DOI: 10.1155/crog/7684108
Caroline Lamoutte, Adaeze Anamege, Lauren Silva, Joanne J Tanner, Natalie Elphinstone, Adam L Wendling, Adetola F Louis-Jacques
{"title":"Successful Maternal-Assisted Cesarean Using a Modified Australian Protocol.","authors":"Caroline Lamoutte, Adaeze Anamege, Lauren Silva, Joanne J Tanner, Natalie Elphinstone, Adam L Wendling, Adetola F Louis-Jacques","doi":"10.1155/crog/7684108","DOIUrl":"10.1155/crog/7684108","url":null,"abstract":"<p><strong>Background: </strong>Several delivery methods such as the natural, gentle, Charité, and family-centered cesareans have been introduced to labor and delivery units to help facilitate immediate skin-to-skin, earlier breastfeeding, and bonding, as well as increase patient satisfaction with the birthing experience. For patients who deliver by cesarean and desire further involvement in the delivery process, maternal-assisted cesarean (MAC) may be an option.</p><p><strong>Case presentation: </strong>This case details a MAC at 39 weeks gestational age (GA) for a 31-year-old female with a history of two unplanned cesareans. The first was due to arrest of dilation and nonreassuring fetal heart tracing, and the second followed a failed trial of labor. In this current case, the patient desired a controlled delivery she could actively participate in. Following multidisciplinary planning and simulation, the cesarean was performed with modifications to maintain sterility while allowing maternal participation. After delivery of the fetal head and shoulders, sterile drapes were lowered, and the patient, guided by the surgical team, assisted in delivering the newborn onto her chest. Both mother and newborn remained stable postoperatively.</p><p><strong>Conclusion: </strong>This emerging patient-centered cesarean enables active participation of the patient during delivery while maintaining surgical safety. Despite its rising popularity, studies are needed to evaluate its risks and benefits before wider adoption.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"7684108"},"PeriodicalIF":0.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herpes Simplex Virus 1 Encephalitis in First Trimester of Pregnancy: A Case Report. 妊娠早期单纯疱疹病毒1型脑炎1例报告
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-08 eCollection Date: 2026-01-01 DOI: 10.1155/crog/8743269
Matej Furlan, Miha Lučovnik, Nina Grasselli Kmet
{"title":"Herpes Simplex Virus 1 Encephalitis in First Trimester of Pregnancy: A Case Report.","authors":"Matej Furlan, Miha Lučovnik, Nina Grasselli Kmet","doi":"10.1155/crog/8743269","DOIUrl":"10.1155/crog/8743269","url":null,"abstract":"<p><p>Encephalitis caused by herpes simplex virus 1 (HSV-1) has been described in pregnancy, but it's rare, with less than 20 cases being described in peer-reviewed literature. Physiologic changes in immune response during pregnancy influence the course of HSV-1 encephalitis (HSVE) and predispose pregnant women to severe complications. We present a case of herpetic encephalitis in a 12-weeks pregnant patient. In our patient neurologic condition deteriorated despite early diagnosis, appropriate antiviral and antiepileptic treatment, and suppurative neurocritical care, respectively. Disease progression stopped and the patient's condition improved after pregnancy termination. Improvement could be a consequence of multiple factors, including delayed therapeutic effect of antiviral treatment, the impact of intensive care management, seizure control, and the possibility of spontaneous recovery as part of the natural disease course, respectively. This case highlights the potential severity of HSV-1 in early pregnancy and underscores the importance of multidisciplinary management and individualized decision-making in complex clinical situations.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"8743269"},"PeriodicalIF":0.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fertility-Sparing Management of HPV-Associated FIGO IB1 Mucinous Cervical Adenocarcinoma With Signet-Ring Cell Features: A Case Report. 具有印戒细胞特征的hpv相关FIGO IB1宫颈粘液腺癌的保生育治疗:1例报告。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-08 eCollection Date: 2026-01-01 DOI: 10.1155/crog/8025579
Luiz Felipe Lessa Ortiz, Amanda Lino de Faria Lessa, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E Ribeiro, Henrique Cunha Vieira, Bárbara Bomfim Muniz Moraes, Roney César Signorini Filho, Giorgio Bogani
{"title":"Fertility-Sparing Management of HPV-Associated FIGO IB1 Mucinous Cervical Adenocarcinoma With Signet-Ring Cell Features: A Case Report.","authors":"Luiz Felipe Lessa Ortiz, Amanda Lino de Faria Lessa, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E Ribeiro, Henrique Cunha Vieira, Bárbara Bomfim Muniz Moraes, Roney César Signorini Filho, Giorgio Bogani","doi":"10.1155/crog/8025579","DOIUrl":"10.1155/crog/8025579","url":null,"abstract":"<p><strong>Background: </strong>Fertility-sparing surgery is an increasingly accepted option in carefully selected patients with early-stage cervical cancer. Radical vaginal trachelectomy combined with sentinel lymph node (SLN) mapping offers oncologic safety while preserving reproductive potential.</p><p><strong>Case: </strong>A 29-year-old nulliparous woman with FIGO stage IB1 poorly differentiated HPV-associated mucinous cervical adenocarcinoma with signet-ring cell features underwent radical vaginal trachelectomy and bilateral laparoscopic SLN mapping using indocyanine green (ICG). No nodal metastases were identified. Surgical margins were negative, and an abdominal cervical cerclage was placed. At 24 months of follow-up, the patient remains disease-free and is receiving counseling regarding assisted reproductive technologies.</p><p><strong>Conclusion: </strong>Fertility-preserving surgery may be safely performed in selected early-stage cervical cancer patients when combined with appropriate surgical staging and close follow-up. This case adds to the limited literature regarding the conservative management of high-grade mucinous adenocarcinomas with signet-ring cell morphology.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"8025579"},"PeriodicalIF":0.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Ectopic Pregnancies Following Bilateral Partial Salpingectomy: A Case Report. 双侧输卵管部分切除术后复发异位妊娠1例报告。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-07 eCollection Date: 2026-01-01 DOI: 10.1155/crog/6044663
Monica Hill, Panagiotis Cherouveim, Shagun Tuli, Jay Holmes
{"title":"Recurrent Ectopic Pregnancies Following Bilateral Partial Salpingectomy: A Case Report.","authors":"Monica Hill, Panagiotis Cherouveim, Shagun Tuli, Jay Holmes","doi":"10.1155/crog/6044663","DOIUrl":"10.1155/crog/6044663","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancies can be a life-threatening condition in early pregnancy. Risk factors include pelvic inflammatory disease, prior ectopic pregnancy, pelvic surgery, and anatomical variations. Although pregnancy after tubal sterilization is uncommon, recurrent ectopic pregnancy after bilateral partial salpingectomy is rare.</p><p><strong>Case: </strong>A 28-year-old G5P1031 African-American patient who underwent cesarean delivery with bilateral partial salpingectomy. Ten months later, she presented with a right ectopic pregnancy requiring laparoscopic salpingectomy. This was followed by a ruptured left ectopic pregnancy treated with salpingo-oophorectomy 7 months later.</p><p><strong>Conclusion: </strong>This case highlights the rare but serious risk of recurrent ectopic pregnancy following partial salpingectomy. Residual tubal segments and young age may contribute to this. Clinicians should consider total salpingectomy when feasible to reduce recurrence and improve long-term outcomes.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"6044663"},"PeriodicalIF":0.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic Uterine Rupture at 20 Weeks of Gestation: A Case Report and Review of Literature. 妊娠20周无症状子宫破裂1例报告及文献复习。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-07 eCollection Date: 2026-01-01 DOI: 10.1155/crog/2515403
Marita Saliba, Barbara Jreij, Bachar Chebib
{"title":"Asymptomatic Uterine Rupture at 20 Weeks of Gestation: A Case Report and Review of Literature.","authors":"Marita Saliba, Barbara Jreij, Bachar Chebib","doi":"10.1155/crog/2515403","DOIUrl":"10.1155/crog/2515403","url":null,"abstract":"<p><strong>Introduction: </strong>Second-trimester ruptures are mainly associated with trauma, induced pregnancy terminations in scarred uterus, or complications. Risk of uterine rupture is specifically increased with the use of prostaglandin, notably Misoprostol, for the induction of labor in women with a history of cesarean section and uterine scar.</p><p><strong>Presentation of case: </strong>A 32-year-old female patient at 20 weeks and 3 days of gestation and intrauterine fetal demise (IUFD), with a history of C-sections, presented to our care initially for administration of Misoprostol for management of IUFD, and was sent home on Misoprostol due to slow response at the hospital. Two days later, the patient was diagnosed with uterine rupture on ultrasound during follow-up in the clinic. The patient, asymptomatic, was sent to the hospital for an emergency laparotomy.</p><p><strong>Conclusion: </strong>Second-trimester ruptures are a rare occurrence but are mainly seen in patients with induction of labor with prostaglandins in the case of IUFD or abortions. Our patient had a second-trimester rupture with no associated symptoms, which raises concern about diagnosing these ruptures before instability happens.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"2515403"},"PeriodicalIF":0.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrauterine Tampon Identified on CT as an Intrauterine Foreign Body Associated With Bilateral Leg Edema: A Case Report. 宫内棉条CT显示为宫内异物伴双侧腿水肿1例。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-07 eCollection Date: 2026-01-01 DOI: 10.1155/crog/1505612
Tadasu Nagaoka
{"title":"Intrauterine Tampon Identified on CT as an Intrauterine Foreign Body Associated With Bilateral Leg Edema: A Case Report.","authors":"Tadasu Nagaoka","doi":"10.1155/crog/1505612","DOIUrl":"10.1155/crog/1505612","url":null,"abstract":"<p><strong>Background: </strong>Foreign bodies retained within the vaginal canal are relatively common in gynecological practice, particularly forgotten vaginal tampons, which are well known to cause localized pelvic infection and life-threatening toxic shock syndrome. However, the transcervical intrauterine migration and retention of a tampon is exceptionally rare, as the cervical canal typically acts as a robust mechanical barrier.</p><p><strong>Case presentation: </strong>I report the case of a 32-year-old multiparous woman presenting with lower abdominal pain and acute bilateral leg edema. Due to the presence of systemic edema, computed tomography (CT) was utilized as the primary imaging modality to rule out vascular emergencies. The CT scan revealed a hyperdense intrauterine foreign body, later confirmed via speculum examination to be a tampon.</p><p><strong>Conclusion: </strong>This case emphasizes the importance of considering retained foreign bodies in reproductive-aged women with unexplained pelvic symptoms and highlights the invaluable role of cross-sectional imaging in diagnosis when atypical systemic symptoms, such as venous compression resulting in edema, divert initial clinical suspicion. Adherence to the CARE guidelines for clinical case reporting was maintained throughout this manuscript.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"1505612"},"PeriodicalIF":0.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sigmoid Volvulus in a Pregnant Woman: A Rare Case Report of Intestinal Obstruction During Pregnancy That Requires Prompt Surgical Intervention. 孕妇乙状结肠扭转:一例罕见的妊娠期肠梗阻,需要及时手术治疗。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-04-02 eCollection Date: 2026-01-01 DOI: 10.1155/crog/7321070
Berat Krasniqi, Arben Haliti, Mentor Sopjani
{"title":"Sigmoid Volvulus in a Pregnant Woman: A Rare Case Report of Intestinal Obstruction During Pregnancy That Requires Prompt Surgical Intervention.","authors":"Berat Krasniqi, Arben Haliti, Mentor Sopjani","doi":"10.1155/crog/7321070","DOIUrl":"10.1155/crog/7321070","url":null,"abstract":"<p><strong>Background and aims: </strong>Sigmoid volvulus (SV) is a common cause of large-bowel obstruction in elderly patients but represents a rare and potentially life-threatening cause of intestinal obstruction during pregnancy. Physiological and anatomical changes in pregnancy may delay diagnosis, increasing maternal and fetal risks. This case report aims to highlight the diagnostic and therapeutic challenges of SV in pregnancy.</p><p><strong>Methods: </strong>We report the case of a 32-year-old pregnant woman at 27 weeks and 4 days of gestation who presented with acute abdominal pain, nausea, and constipation. Clinical evaluation, laboratory testing, abdominal ultrasound, magnetic resonance imaging (MRI), and colonoscopy were used to establish the diagnosis.</p><p><strong>Results: </strong>SV was confirmed, and endoscopic detorsion was attempted twice as first-line management but was unsuccessful. Given persistent obstruction and symptom severity, surgical intervention was undertaken. The patient underwent sigmoid colon resection with colostomy (Hartmann procedure). Both maternal and fetal postoperative courses were favorable, and the pregnancy was successfully prolonged to term.</p><p><strong>Conclusion: </strong>Although rare, SV should be considered in pregnant women presenting with symptoms of intestinal obstruction. Early diagnosis, appropriate imaging, and a multidisciplinary approach are essential. Endoscopic detorsion remains the first-line treatment when feasible, while timely surgical management is essential in cases of failed decompression to optimize maternal and fetal outcomes.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"7321070"},"PeriodicalIF":0.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transvaginal Pezzer Catheter Drainage in Treatment-Resistant Deep Pelvic Abscess After Cesarean Section: Case Report. 经阴道导管引流治疗剖宫产术后难治性盆腔深脓肿1例。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-03-19 eCollection Date: 2026-01-01 DOI: 10.1155/crog/7875567
Bekir Kahveci, Eser Sefik Ozyurek
{"title":"Transvaginal Pezzer Catheter Drainage in Treatment-Resistant Deep Pelvic Abscess After Cesarean Section: Case Report.","authors":"Bekir Kahveci, Eser Sefik Ozyurek","doi":"10.1155/crog/7875567","DOIUrl":"10.1155/crog/7875567","url":null,"abstract":"<p><p>A pelvic abscess occurs as an infectious complication of surgical intervention or as a result of infectious processes. Pelvic abscesses may be treated with broad-spectrum antibiotics, which often fail, and surgical intervention is necessary. Surgical procedures include abscess drainage through laparotomy or laparoscopy. Alternative approaches include imaging-guided abscess drainage in conjunction with antibiotics through transabdominal, transrectal, transvaginal or transgluteal routes. In this case, a Pezzer catheter was successfully applied to a deep pelvic abscess that was drained via the transvaginal approach. Transvaginal drainage with a Pezzer catheter following surgical drainage may be considered an effective treatment option for recurrent postoperative midline deep pelvic abscesses. Although this type of catheter is preferred by general surgeons, the advantage of using it vaginally by gynecologists offers an effective treatment approach. Additionally, it has a multifenestrated portion, which reduces the possibility of blockage during drainage.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"7875567"},"PeriodicalIF":0.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13370794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partially Expelled Necrotic Uterine Fibroid After Relugolix Combination Therapy: Case Report and Literature Overview on Adverse Effects of GnRH Antagonists. 瑞路高利联合治疗部分排出坏死性子宫肌瘤:GnRH拮抗剂不良反应的病例报告及文献综述。
IF 0.8
Case Reports in Obstetrics and Gynecology Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1155/crog/1926623
Laura Vona, Anna Pitsillidi, Guenter Noé, Stefano Bettocchi
{"title":"Partially Expelled Necrotic Uterine Fibroid After Relugolix Combination Therapy: Case Report and Literature Overview on Adverse Effects of GnRH Antagonists.","authors":"Laura Vona, Anna Pitsillidi, Guenter Noé, Stefano Bettocchi","doi":"10.1155/crog/1926623","DOIUrl":"10.1155/crog/1926623","url":null,"abstract":"<p><strong>Background and clinical significance: </strong>Relugolix combination therapy (Relugolix CT) has emerged as an effective oral medical treatment for symptomatic uterine fibroids, offering an alternative to surgical interventions. While generally well tolerated, reports of adverse events beyond the common side effects are limited.</p><p><strong>Case presentation: </strong>A 34-year-old nulliparous woman presented with abdominal pain and abnormal uterine bleeding. She had previously been diagnosed with a large FIGO Type 1-5 anterior wall fibroid and started on Relugolix CT as a bridge to surgery. At referral, speculum examination revealed a necrotic, malodorous, partially expelled mass protruding through the cervix. Surgical removal under spinal anaesthesia was performed, followed by resection of the intracavitary component. Histopathology confirmed leiomyoma with extensive necrosis. Postoperative imaging showed a residual fibroid, leading to discontinuation of Relugolix and initiation of leuprorelin acetate. The patient reported symptom resolution but was lost to follow-up after 3 months. This case highlights potential serious but under-recognized adverse effects associated with Relugolix CT, particularly in patients with large or intracavitary fibroids. Clinicians should maintain vigilance and ensure appropriate monitoring during treatment.</p><p><strong>Conclusion: </strong>Relugolix CT represents a promising option in uterine fibroid management, but individualized patient evaluation and awareness of possible complications are essential to optimize safety and outcomes. The potential of this therapeutic approach warrants further investigation through randomized clinical trials, while real-world patient data are equally crucial to strengthen the evidence base and support broader clinical applicability.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"1926623"},"PeriodicalIF":0.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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