Case Reports in Obstetrics and Gynecology最新文献

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Primary Ovarian Choriocarcinoma: Rare Entity. 原发性卵巢绒毛膜癌:罕见病例。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4545375
Mequanent Tariku Adow, Shimelis Fantu Gebresilasie, Natnael Alemayehu Abebe
{"title":"Primary Ovarian Choriocarcinoma: Rare Entity.","authors":"Mequanent Tariku Adow,&nbsp;Shimelis Fantu Gebresilasie,&nbsp;Natnael Alemayehu Abebe","doi":"10.1155/2021/4545375","DOIUrl":"https://doi.org/10.1155/2021/4545375","url":null,"abstract":"<p><strong>Background: </strong>Primary pure ovarian choriocarcinoma is a rare aggressive tumor which can be nongestational arising from germ cells or gestational origin. Preoperative diagnosis of extrauterine choriocarcinoma is challenging due to nonspecific clinical presentation. <i>Case Presentation</i>. This article reports primary ovarian choriocarcinoma, likely gestational in a 25-year-old para 2 woman presenting with lower abdominal pain and swelling of two-week duration. Diagnosis was suspected by serum beta-human chorionic gonadotropin and confirmed histologically after surgery. Postoperatively, she was managed with multiple courses of chemotherapy using a bleomycin, etoposide, and cisplatin regimen, and the treatment was effective.</p><p><strong>Conclusion: </strong>In patients with adnexal mass presenting with nonspecific symptoms especially with high Doppler blood flow of the mass on ultrasound evaluation, serum beta-human chorionic gonadotropin determination is recommended before laparotomy. In setups where the genomic test is not available, histological and clinical effort to differentiate gestational versus nongestational choriocarcinoma is useful for specific management decision.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"4545375"},"PeriodicalIF":0.0,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Novel Use of Laryngoscope for Difficult Papanicolaou Smear Collection. 喉镜在困难的巴氏涂片采集中的新应用。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6986768
Sarah Boudova, Caitlin Thomas, John Wolfe, Jeanne M Schilder
{"title":"A Novel Use of Laryngoscope for Difficult Papanicolaou Smear Collection.","authors":"Sarah Boudova,&nbsp;Caitlin Thomas,&nbsp;John Wolfe,&nbsp;Jeanne M Schilder","doi":"10.1155/2021/6986768","DOIUrl":"https://doi.org/10.1155/2021/6986768","url":null,"abstract":"<p><p>The prevalence of cervical cancer has dropped significantly since introduction of the Papanicolaou (Pap) screen. The greatest risk factor for cervical cancer is inadequate screening. Altered pelvic anatomy can limit the ability to collect a Pap smear. In the presented case, a woman with a history of fibroids and bleeding presented for an exam under anesthesia. Traditional approaches for collecting a Pap smear failed. A GlideScope video laryngoscope was used to visualize the cervix, and a Pap smear was collected. The specimen was satisfactory, negative for intraepithelial lesion or malignancy, and HPV negative. A laryngoscope can be repurposed to visualize collection of a challenging Pap smear. Novel approaches for Pap smear collection and cervical cancer screening are needed and have the potential to save lives.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"6986768"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39482684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Omphalocele Secondary to Spontaneous Rupture of Allantoic Cyst in the Third Trimester of Pregnancy. 妊娠晚期尿囊囊肿自发性破裂继发于脐膨出。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-18 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6940685
Giuliana Orlandi, Paolo Toscano, Lavinia Di Meglio, Letizia Di Meglio, Aniello Di Meglio
{"title":"Omphalocele Secondary to Spontaneous Rupture of Allantoic Cyst in the Third Trimester of Pregnancy.","authors":"Giuliana Orlandi,&nbsp;Paolo Toscano,&nbsp;Lavinia Di Meglio,&nbsp;Letizia Di Meglio,&nbsp;Aniello Di Meglio","doi":"10.1155/2021/6940685","DOIUrl":"10.1155/2021/6940685","url":null,"abstract":"<p><strong>Objective: </strong>We report the first case in which the onset of omphalocele was after the spontaneous rupture of an allantoic cyst. We hypothesize a causal link between the spontaneous rupture of the cyst and the herniation of the viscera. <i>Case Presentation</i>. A 36-year-old woman was diagnosed with an allantoic cyst during the first trimester. The allantoic cyst underwent spontaneous rupture during the 32nd week of gestation, and an omphalocele developed secondary to the cyst's rupture. Two days after birth, the peritoneum covering intestinal loops broke spontaneously and the newborn underwent successful urgent surgery.</p><p><strong>Conclusions: </strong>This case may suggest that the relative benignity of the allantoid cysts may recommend a close ultrasound follow-up in order to identify the onset of any complications, as a late third trimester onset of omphalocele. Prenatal diagnosis of such complications may allow multidisciplinary management of the pregnancy with planned cesarean section, prenatal pediatric surgery consultation, and neonatal surgery.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"6940685"},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report of a Rare Nonpuerperal Uterine Inversion Managed with Uterosacral Ligament Hysteropexy. 子宫骶韧带子宫切除术治疗一例罕见的非产褥期子宫内翻。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-16 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4054924
Ali Azadi, Alexandra Wolfe, Greg J Marchand
{"title":"Case Report of a Rare Nonpuerperal Uterine Inversion Managed with Uterosacral Ligament Hysteropexy.","authors":"Ali Azadi,&nbsp;Alexandra Wolfe,&nbsp;Greg J Marchand","doi":"10.1155/2021/4054924","DOIUrl":"https://doi.org/10.1155/2021/4054924","url":null,"abstract":"<p><p>Nonpuerperal uterine inversions are rare. Typically occurring in older women, they are most commonly due to transcervical mass expulsion. Diagnosis is often difficult because of vague symptomatology, presentation, and unknown course of the pathology. Surgical correction is often necessary in the presence of active bleeding or prolapse severity causing urinary retention. This case of nonpuerperal inversion presented to the emergency department with vaginal bleeding and mass protrusion. The examination was consistent with POPQ stage IV prolapse and uterine inversion secondary to cervical expulsion of multiple uterine fibroids. Because of full cervical dilation and concerns of ureteral injury with an extirpative procedure, vaginal myomectomy was performed with concomitant robotic uterosacral ligament hysteropexy. The operative procedure and postoperative course were uncomplicated, and discharge occurred on post-op day 1. She remained asymptomatic at the 6-month follow-up encounter. Though uterine preservation has been performed in cases of uterine inversion to maintain fertility, there are no reported cases of concomitant hysteropexy being completed for correction of POPQ stage IV prolapse simultaneously encountered. Additionally, the novel robotic approach has not been documented. This case illustrates the short-term success of robotic uterosacral hysteropexy as an additional option of care with potentially less morbidity when compared to hysterectomy for advanced stage uterine prolapse with nonpuerperal uterine inversion.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"4054924"},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39475407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Placenta Accreta Spectrum Disorder in a Patient with Six Previous Caesarean Deliveries: Step by Step Management. 6次剖宫产患者胎盘增生谱系障碍:分步处理。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/2105248
Calagna Gloria, Polito Salvatore, Labate Francesco, Guiglia Rosa Anna, De Maria Francesca, Bisso Chiara, Cucinella Gaspare, Calì Giuseppe
{"title":"Placenta Accreta Spectrum Disorder in a Patient with Six Previous Caesarean Deliveries: Step by Step Management.","authors":"Calagna Gloria,&nbsp;Polito Salvatore,&nbsp;Labate Francesco,&nbsp;Guiglia Rosa Anna,&nbsp;De Maria Francesca,&nbsp;Bisso Chiara,&nbsp;Cucinella Gaspare,&nbsp;Calì Giuseppe","doi":"10.1155/2021/2105248","DOIUrl":"https://doi.org/10.1155/2021/2105248","url":null,"abstract":"<p><p>The definition <i>placenta accreta spectrum disorders</i> (PAS) introduced by FIGO (International Federation of Gynaecology and Obstetrics) indicates an abnormal, pathological adherence or invasion of the placenta. The growing worldwide incidence of this pathological entity, and the possible serious correlated surgical risks, has caused a significant increase in attention among the scientific community. Previous caesarean delivery and presence of placenta previa are the main risk factors for the onset of PAS. Here, we present the intriguing case of a 39-year-old woman, at the 33rd week of gestation, with six previous caesarean sections and with a diagnosis of placenta previa accreta. At our referral center for PAS disorders, we successfully managed this difficult case with the help of a multidisciplinary skilled team.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"2105248"},"PeriodicalIF":0.0,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Uterocutaneous Fistula after a C-Section in a Patient with Second Trimester Fetal Demise and Chorioamnionitis. 妊娠中期胎儿死亡和绒毛膜羊膜炎患者剖腹产后子宫皮瘘。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-10 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3255188
Déborah Wernly, Valérie Besse, Daniela Huber
{"title":"Uterocutaneous Fistula after a C-Section in a Patient with Second Trimester Fetal Demise and Chorioamnionitis.","authors":"Déborah Wernly,&nbsp;Valérie Besse,&nbsp;Daniela Huber","doi":"10.1155/2021/3255188","DOIUrl":"https://doi.org/10.1155/2021/3255188","url":null,"abstract":"<p><p>Uterocutaneous fistulae are very rare entities with only about 120 cases reported in the literature. They are mostly described after a C-section or other pelvic surgery. We hereby describe a uterocutaneous fistula in a 41-year-old patient 5 months after a C-section because of a chorioamnionitis and a 22-week fetal demise. One month after the C-section, she underwent a diagnostic hysteroscopy to exclude postoperative intrauterine adhesions. Afterwards, she complained of pelvic pain, persistent metrorrhagia, and significant weight loss during 2 months. She consulted the emergency unit several times, and lastly endometritis was diagnosed. She was treated with antibiotic therapy for 7 days, without significant clinical improvement. She presented at our institution 48 hours after a carbuncle had appeared in her right iliac fossa. A uterocutaneous fistula was diagnosed on the CT scan. The patient received IV antibiotic therapy and underwent a total hysterectomy with bilateral salpingectomy by laparotomy, as she did not want a conservative surgery. The clinical postoperative evolution was favorable. Symptoms of UCF can be very unspecific. To avoid medical wandering and improve the patient's care, UCF should be in the differential diagnostic of abdominal pain after a pelvic surgery. Moreover, in patients with previous C-section and infectious perioperative status, the risk of PID or pelvic abscess must be careful evaluated before intrauterine diagnostic or therapeutic procedures.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"3255188"},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39434601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hyperbaric Oxygen Therapy for Suburethral Vaginal Mucosal Necrosis after Interstitial Irradiation for Recurrent Cervical Cancer. 高压氧治疗复发性子宫颈癌间质照射后阴道黏膜坏死。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-09 eCollection Date: 2021-01-01 DOI: 10.1155/2021/1737975
Yoshihisa Arakaki, Yuko Shimoji, Tadaharu Nakasone, Yusuke Taira, Tomoko Nakamoto, Wataru Kudaka, Keiko Mekaru, Yoichi Aoki
{"title":"Hyperbaric Oxygen Therapy for Suburethral Vaginal Mucosal Necrosis after Interstitial Irradiation for Recurrent Cervical Cancer.","authors":"Yoshihisa Arakaki,&nbsp;Yuko Shimoji,&nbsp;Tadaharu Nakasone,&nbsp;Yusuke Taira,&nbsp;Tomoko Nakamoto,&nbsp;Wataru Kudaka,&nbsp;Keiko Mekaru,&nbsp;Yoichi Aoki","doi":"10.1155/2021/1737975","DOIUrl":"https://doi.org/10.1155/2021/1737975","url":null,"abstract":"<p><p>Patients with gynecological malignancies can develop radiation injuries, such as cystitis, proctitis, and soft tissue necrosis which have approved indications for hyperbaric oxygen therapy (HBOT). A 76-year-old Japanese woman with vaginal recurrence of cervical cancer was treated with the high-dose rate interstitial brachytherapy. Twenty-one months after the irradiation, she developed radiation necrosis on the external urethral opening. Two cycles of HBOT were performed. HBOT consisted of delivering 100% oxygen for 60 minutes at 2.4 atmospheres absolute. Pressure exposure was performed once daily, 5 days a week for 6 weeks. Eventually, the necrotic mucosa was completely replaced by the normal mucosa. No adverse effects were observed. We successfully treated a case of late adverse events of radiation therapy with HBOT. It was noninvasive and appears to be a useful treatment option which should be considered standard treatment practice.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"1737975"},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39432936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovarian Vein Thrombosis Complicated by Pulmonary Embolism after Cesarean Delivery in the Presence of a Large Fibroid: Case Report and Literature Review of Contributing Factors. 存在大肌瘤的剖宫产后卵巢静脉血栓形成并发肺栓塞:病例报告及相关因素的文献回顾
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6389713
Elie S Finianos, Stephanie F Yacoub, Mary F Chammas
{"title":"Ovarian Vein Thrombosis Complicated by Pulmonary Embolism after Cesarean Delivery in the Presence of a Large Fibroid: Case Report and Literature Review of Contributing Factors.","authors":"Elie S Finianos,&nbsp;Stephanie F Yacoub,&nbsp;Mary F Chammas","doi":"10.1155/2021/6389713","DOIUrl":"https://doi.org/10.1155/2021/6389713","url":null,"abstract":"<p><p>Ovarian vein thrombophlebitis is rare and mostly occurs during the puerperal period and in higher rates after a cesarean delivery. The objective of this case report and literature review is to highlight the rare occurrence of an ovarian vein thrombosis in a 37-year-old woman postcesarean delivery in the setting of a large uterine fibroid who subsequently developed a pulmonary embolism. The patient presented with severe abdominal pain, fever, and chills. Imaging showed a right ovarian vein thrombosis. Following initiation of anticoagulation therapy, she developed dyspnea and testing showed a subsegmental pulmonary embolism. Further investigation showed that the patient had an undiagnosed thrombophilia thus meeting the classic Virchow triad. Complete clinical recovery was observed, and anticoagulation therapy was continued for 1 year. Our case highlights the importance of recognizing ovarian vein thrombosis because of the risk of fatal complications such as pulmonary embolus. The presence of large fibroids should raise our awareness for OVT in the setting of abdominal pain and fever. The absence of complications in previous pregnancies should not alter our clinical suspicion.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"6389713"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39432937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Benign Recurrent Intrahepatic Cholestasis in Pregnancy: Fetal Death at 36 Weeks of Gestation. 妊娠期良性复发性肝内胆汁淤积:妊娠36周胎儿死亡。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-06 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5086846
Mariam Ayyash, Nicolina Smith, Madhurima Keerthy, Ashina Singh, Majid Shaman
{"title":"Benign Recurrent Intrahepatic Cholestasis in Pregnancy: Fetal Death at 36 Weeks of Gestation.","authors":"Mariam Ayyash,&nbsp;Nicolina Smith,&nbsp;Madhurima Keerthy,&nbsp;Ashina Singh,&nbsp;Majid Shaman","doi":"10.1155/2021/5086846","DOIUrl":"https://doi.org/10.1155/2021/5086846","url":null,"abstract":"<p><strong>Introduction: </strong>Benign recurrent intrahepatic cholestasis is a rare hepatologic disorder characterized by recurrent, self-limited episodes of severe pruritus, jaundice, and elevated bile acids. While there are guidelines for the management of intrahepatic cholestasis of pregnancy, the literature regarding benign recurrent intrahepatic cholestasis and pregnancy is limited.</p><p><strong>Case: </strong>A 29-year-old G1P0 woman, with history of liver toxicity, had elevated total serum bile acid levels and liver enzymes documented at 8 weeks of gestation and throughout her pregnancy. She had a reactive nonstress test just 3 days prior to her induction. Fetal demise was noted when she presented at 36 weeks for her induction.</p><p><strong>Conclusion: </strong>We recommend that women with elevated total serum bile acid early in pregnancy due to a separate entity relative to intrahepatic cholestasis of pregnancy be managed in a more individualized approach.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"5086846"},"PeriodicalIF":0.0,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39424106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment of Homozygous Type II Antithrombin Heparin-Binding Site Deficiency in Pregnancy. 妊娠期纯合子II型抗凝血酶肝素结合位点缺乏的治疗。
Case Reports in Obstetrics and Gynecology Pub Date : 2021-09-03 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4393821
Hilde Fiskvik, Anne F Jacobsen, Nina Iversen, Carola E Henriksson, Eva-Marie Jacobsen
{"title":"Treatment of Homozygous Type II Antithrombin Heparin-Binding Site Deficiency in Pregnancy.","authors":"Hilde Fiskvik,&nbsp;Anne F Jacobsen,&nbsp;Nina Iversen,&nbsp;Carola E Henriksson,&nbsp;Eva-Marie Jacobsen","doi":"10.1155/2021/4393821","DOIUrl":"https://doi.org/10.1155/2021/4393821","url":null,"abstract":"<p><p>Pregnancy is associated with an increased risk of venous thromboembolism (VTE). Previous VTE and severe thrombophilia are important risk factors. Our case was a 36-year-old woman, gravida 6, para 0, with antithrombin (AT) deficiency caused by a homozygous mutation in the heparin-binding site (HBS). Her history included seven prior VTEs, three early and two late pregnancy losses. She was prophylactically treated with both human plasma-derived AT concentrate (hpATC) and low molecular weight heparin (LMWH), resulting in a successful 6<sup>th</sup> pregnancy and a healthy live born baby. There is limited evidence and guidance on the management of AT deficiency in pregnancy. Dosing and monitoring of anticoagulants, alone or together with hpATC, must be based on individual risk assessment. The severity of clinical manifestations varies with the type of AT deficiency. Characterization of the AT mutation may aid in the decision-making process and optimize pregnancy outcomes.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2021 ","pages":"4393821"},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39409220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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