{"title":"Herpes Simplex Virus 1 Encephalitis in First Trimester of Pregnancy: A Case Report.","authors":"Matej Furlan, Miha Lučovnik, Nina Grasselli Kmet","doi":"10.1155/crog/8743269","DOIUrl":"https://doi.org/10.1155/crog/8743269","url":null,"abstract":"<p><p>Encephalitis caused by herpes simplex virus 1 (HSV-1) has been described in pregnancy, but it's rare, with less than 20 cases being described in peer-reviewed literature. Physiologic changes in immune response during pregnancy influence the course of HSV-1 encephalitis (HSVE) and predispose pregnant women to severe complications. We present a case of herpetic encephalitis in a 12-weeks pregnant patient. In our patient neurologic condition deteriorated despite early diagnosis, appropriate antiviral and antiepileptic treatment, and suppurative neurocritical care, respectively. Disease progression stopped and the patient's condition improved after pregnancy termination. Improvement could be a consequence of multiple factors, including delayed therapeutic effect of antiviral treatment, the impact of intensive care management, seizure control, and the possibility of spontaneous recovery as part of the natural disease course, respectively. This case highlights the potential severity of HSV-1 in early pregnancy and underscores the importance of multidisciplinary management and individualized decision-making in complex clinical situations.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"8743269"},"PeriodicalIF":0.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiz Felipe Lessa Ortiz, Amanda Lino de Faria Lessa, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E Ribeiro, Henrique Cunha Vieira, Bárbara Bomfim Muniz Moraes, Roney César Signorini Filho, Giorgio Bogani
{"title":"Fertility-Sparing Management of HPV-Associated FIGO IB1 Mucinous Cervical Adenocarcinoma With Signet-Ring Cell Features: A Case Report.","authors":"Luiz Felipe Lessa Ortiz, Amanda Lino de Faria Lessa, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E Ribeiro, Henrique Cunha Vieira, Bárbara Bomfim Muniz Moraes, Roney César Signorini Filho, Giorgio Bogani","doi":"10.1155/crog/8025579","DOIUrl":"https://doi.org/10.1155/crog/8025579","url":null,"abstract":"<p><strong>Background: </strong>Fertility-sparing surgery is an increasingly accepted option in carefully selected patients with early-stage cervical cancer. Radical vaginal trachelectomy combined with sentinel lymph node (SLN) mapping offers oncologic safety while preserving reproductive potential.</p><p><strong>Case: </strong>A 29-year-old nulliparous woman with FIGO stage IB1 poorly differentiated HPV-associated mucinous cervical adenocarcinoma with signet-ring cell features underwent radical vaginal trachelectomy and bilateral laparoscopic SLN mapping using indocyanine green (ICG). No nodal metastases were identified. Surgical margins were negative, and an abdominal cervical cerclage was placed. At 24 months of follow-up, the patient remains disease-free and is receiving counseling regarding assisted reproductive technologies.</p><p><strong>Conclusion: </strong>Fertility-preserving surgery may be safely performed in selected early-stage cervical cancer patients when combined with appropriate surgical staging and close follow-up. This case adds to the limited literature regarding the conservative management of high-grade mucinous adenocarcinomas with signet-ring cell morphology.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"8025579"},"PeriodicalIF":0.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Hill, Panagiotis Cherouveim, Shagun Tuli, Jay Holmes
{"title":"Recurrent Ectopic Pregnancies Following Bilateral Partial Salpingectomy: A Case Report.","authors":"Monica Hill, Panagiotis Cherouveim, Shagun Tuli, Jay Holmes","doi":"10.1155/crog/6044663","DOIUrl":"https://doi.org/10.1155/crog/6044663","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancies can be a life-threatening condition in early pregnancy. Risk factors include pelvic inflammatory disease, prior ectopic pregnancy, pelvic surgery, and anatomical variations. Although pregnancy after tubal sterilization is uncommon, recurrent ectopic pregnancy after bilateral partial salpingectomy is rare.</p><p><strong>Case: </strong>A 28-year-old G5P1031 African-American patient who underwent cesarean delivery with bilateral partial salpingectomy. Ten months later, she presented with a right ectopic pregnancy requiring laparoscopic salpingectomy. This was followed by a ruptured left ectopic pregnancy treated with salpingo-oophorectomy 7 months later.</p><p><strong>Conclusion: </strong>This case highlights the rare but serious risk of recurrent ectopic pregnancy following partial salpingectomy. Residual tubal segments and young age may contribute to this. Clinicians should consider total salpingectomy when feasible to reduce recurrence and improve long-term outcomes.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"6044663"},"PeriodicalIF":0.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Asymptomatic Uterine Rupture at 20 Weeks of Gestation: A Case Report and Review of Literature.","authors":"Marita Saliba, Barbara Jreij, Bachar Chebib","doi":"10.1155/crog/2515403","DOIUrl":"https://doi.org/10.1155/crog/2515403","url":null,"abstract":"<p><strong>Introduction: </strong>Second-trimester ruptures are mainly associated with trauma, induced pregnancy terminations in scarred uterus, or complications. Risk of uterine rupture is specifically increased with the use of prostaglandin, notably Misoprostol, for the induction of labor in women with a history of cesarean section and uterine scar.</p><p><strong>Presentation of case: </strong>A 32-year-old female patient at 20 weeks and 3 days of gestation and intrauterine fetal demise (IUFD), with a history of C-sections, presented to our care initially for administration of Misoprostol for management of IUFD, and was sent home on Misoprostol due to slow response at the hospital. Two days later, the patient was diagnosed with uterine rupture on ultrasound during follow-up in the clinic. The patient, asymptomatic, was sent to the hospital for an emergency laparotomy.</p><p><strong>Conclusion: </strong>Second-trimester ruptures are a rare occurrence but are mainly seen in patients with induction of labor with prostaglandins in the case of IUFD or abortions. Our patient had a second-trimester rupture with no associated symptoms, which raises concern about diagnosing these ruptures before instability happens.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"2515403"},"PeriodicalIF":0.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intrauterine Tampon Identified on CT as an Intrauterine Foreign Body Associated With Bilateral Leg Edema: A Case Report.","authors":"Tadasu Nagaoka","doi":"10.1155/crog/1505612","DOIUrl":"https://doi.org/10.1155/crog/1505612","url":null,"abstract":"<p><strong>Background: </strong>Foreign bodies retained within the vaginal canal are relatively common in gynecological practice, particularly forgotten vaginal tampons, which are well known to cause localized pelvic infection and life-threatening toxic shock syndrome. However, the transcervical intrauterine migration and retention of a tampon is exceptionally rare, as the cervical canal typically acts as a robust mechanical barrier.</p><p><strong>Case presentation: </strong>I report the case of a 32-year-old multiparous woman presenting with lower abdominal pain and acute bilateral leg edema. Due to the presence of systemic edema, computed tomography (CT) was utilized as the primary imaging modality to rule out vascular emergencies. The CT scan revealed a hyperdense intrauterine foreign body, later confirmed via speculum examination to be a tampon.</p><p><strong>Conclusion: </strong>This case emphasizes the importance of considering retained foreign bodies in reproductive-aged women with unexplained pelvic symptoms and highlights the invaluable role of cross-sectional imaging in diagnosis when atypical systemic symptoms, such as venous compression resulting in edema, divert initial clinical suspicion. Adherence to the CARE guidelines for clinical case reporting was maintained throughout this manuscript.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"1505612"},"PeriodicalIF":0.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sigmoid Volvulus in a Pregnant Woman: A Rare Case Report of Intestinal Obstruction During Pregnancy That Requires Prompt Surgical Intervention.","authors":"Berat Krasniqi, Arben Haliti, Mentor Sopjani","doi":"10.1155/crog/7321070","DOIUrl":"https://doi.org/10.1155/crog/7321070","url":null,"abstract":"<p><strong>Background and aims: </strong>Sigmoid volvulus (SV) is a common cause of large-bowel obstruction in elderly patients but represents a rare and potentially life-threatening cause of intestinal obstruction during pregnancy. Physiological and anatomical changes in pregnancy may delay diagnosis, increasing maternal and fetal risks. This case report aims to highlight the diagnostic and therapeutic challenges of SV in pregnancy.</p><p><strong>Methods: </strong>We report the case of a 32-year-old pregnant woman at 27 weeks and 4 days of gestation who presented with acute abdominal pain, nausea, and constipation. Clinical evaluation, laboratory testing, abdominal ultrasound, magnetic resonance imaging (MRI), and colonoscopy were used to establish the diagnosis.</p><p><strong>Results: </strong>SV was confirmed, and endoscopic detorsion was attempted twice as first-line management but was unsuccessful. Given persistent obstruction and symptom severity, surgical intervention was undertaken. The patient underwent sigmoid colon resection with colostomy (Hartmann procedure). Both maternal and fetal postoperative courses were favorable, and the pregnancy was successfully prolonged to term.</p><p><strong>Conclusion: </strong>Although rare, SV should be considered in pregnant women presenting with symptoms of intestinal obstruction. Early diagnosis, appropriate imaging, and a multidisciplinary approach are essential. Endoscopic detorsion remains the first-line treatment when feasible, while timely surgical management is essential in cases of failed decompression to optimize maternal and fetal outcomes.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"7321070"},"PeriodicalIF":0.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Vona, Anna Pitsillidi, Guenter Noé, Stefano Bettocchi
{"title":"Partially Expelled Necrotic Uterine Fibroid After Relugolix Combination Therapy: Case Report and Literature Overview on Adverse Effects of GnRH Antagonists.","authors":"Laura Vona, Anna Pitsillidi, Guenter Noé, Stefano Bettocchi","doi":"10.1155/crog/1926623","DOIUrl":"https://doi.org/10.1155/crog/1926623","url":null,"abstract":"<p><strong>Background and clinical significance: </strong>Relugolix combination therapy (Relugolix CT) has emerged as an effective oral medical treatment for symptomatic uterine fibroids, offering an alternative to surgical interventions. While generally well tolerated, reports of adverse events beyond the common side effects are limited.</p><p><strong>Case presentation: </strong>A 34-year-old nulliparous woman presented with abdominal pain and abnormal uterine bleeding. She had previously been diagnosed with a large FIGO Type 1-5 anterior wall fibroid and started on Relugolix CT as a bridge to surgery. At referral, speculum examination revealed a necrotic, malodorous, partially expelled mass protruding through the cervix. Surgical removal under spinal anaesthesia was performed, followed by resection of the intracavitary component. Histopathology confirmed leiomyoma with extensive necrosis. Postoperative imaging showed a residual fibroid, leading to discontinuation of Relugolix and initiation of leuprorelin acetate. The patient reported symptom resolution but was lost to follow-up after 3 months. This case highlights potential serious but under-recognized adverse effects associated with Relugolix CT, particularly in patients with large or intracavitary fibroids. Clinicians should maintain vigilance and ensure appropriate monitoring during treatment.</p><p><strong>Conclusion: </strong>Relugolix CT represents a promising option in uterine fibroid management, but individualized patient evaluation and awareness of possible complications are essential to optimize safety and outcomes. The potential of this therapeutic approach warrants further investigation through randomized clinical trials, while real-world patient data are equally crucial to strengthen the evidence base and support broader clinical applicability.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"1926623"},"PeriodicalIF":0.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiz Felipe Lessa Ortiz, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E Ribeiro, Caio Bosquê Hidalgo Ribeiro, Amanda Lino De Faria Lessa, Bárbara Bomfim Muniz Moraes, Henrique Cunha Vieira, Giorgio Bogani
{"title":"Fertility-Sparing Management of Grade 2 Endometrioid Endometrial Adenocarcinoma Without Progesterone Receptor Expression: A Case Report.","authors":"Luiz Felipe Lessa Ortiz, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E Ribeiro, Caio Bosquê Hidalgo Ribeiro, Amanda Lino De Faria Lessa, Bárbara Bomfim Muniz Moraes, Henrique Cunha Vieira, Giorgio Bogani","doi":"10.1155/crog/5582003","DOIUrl":"https://doi.org/10.1155/crog/5582003","url":null,"abstract":"<p><p>Managing G2 endometrioid endometrial adenocarcinoma without progesterone receptor (PR) expression presents significant challenges, particularly when considering fertility preservation. Grade 2 tumors fall into an area of uncertainty within fertility-sparing strategies, making treatment decisions complex and requiring careful individualization. This case report describes a 41-year-old patient who, despite PR and PE negativity, responded to conservative management with hysteroscopic resection, a levonorgestrel-releasing intrauterine device, metformin, and later megestrol, achieving complete histological remission in 15 months. The difficulty in managing G2 tumors lies in their variable behavior, necessitating a multidisciplinary approach, strict monitoring, and adaptability based on treatment response. This case underscores that, although fertility preservation in PR-negative G2 tumors remains challenging, it is feasible in highly selected cases. The evolving literature suggests that alternative strategies, such as immune modulation and aromatase inhibitors, may further expand options. Individualized management remains crucial, balancing oncological safety with reproductive goals through continuous reassessment and engagement with emerging therapeutic evidence.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"5582003"},"PeriodicalIF":0.8,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Qiang Wei, Qiu-Yang Wang, Tian Li, You-Bin Hu
{"title":"DICER1 Syndrome With Embryonal Rhabdomyosarcoma of the Uterine Cervix and Retroperitoneal Metastasis: A Case Report and Literature Review.","authors":"Xiao-Qiang Wei, Qiu-Yang Wang, Tian Li, You-Bin Hu","doi":"10.1155/crog/9718758","DOIUrl":"https://doi.org/10.1155/crog/9718758","url":null,"abstract":"<p><strong>Background: </strong>DICER1 syndrome is a rare autosomal dominant genetic disorder and presents a variety of manifestations.</p><p><strong>Case: </strong>A 15-year-old adolescent presented cervical embryonal rhabdomyosarcoma, retroperitoneal tumor and multinodular goiter. Genetic analysis demonstrated a mutation in Exon 25 of DICER1 gene, a mutation in Intron 19 of NF1 gene, and a mutation in Exon 7 of TP53 gene. The patient received surgical treatment and six courses of combination chemotherapy. After 7 months of initial diagnosis, the patient occurred a pleural and mediastinal metastasis and eventually died of respiratory failure.</p><p><strong>Conclusion: </strong>Multiple gene mutations, in addition to DICER1 gene mutation, may influence the behavior and prognosis of DICER1 syndrome. We detail the necessity of instituting personalized, multidisciplinary monitoring plans, including regular clinical evaluations and targeted imaging of high-risk organs, to enable early detection and intervention.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"9718758"},"PeriodicalIF":0.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hidden in the Scar: A Rare Case of Vulvar Endometriosis Mimicking Bartholin's Cyst at an Episiotomy Site.","authors":"Swati Kumari, Anna Zaradna, Valmiki Vijay Seeraj","doi":"10.1155/crog/7202665","DOIUrl":"https://doi.org/10.1155/crog/7202665","url":null,"abstract":"<p><strong>Background: </strong>Vulvar endometriosis is an exceptionally rare manifestation of extrapelvic endometriosis, particularly when located at the site of a prior episiotomy. Often misdiagnosed as more common vulvar pathologies, these lesions may present with cyclical pain and swelling, mimicking Bartholin's gland cysts or infected epidermal inclusion cysts.</p><p><strong>Case: </strong>We report the case of a 25-year-old gravida 3 para 2 woman with long-standing dysmenorrhea, dyspareunia, and a right vulvar mass that fluctuated with her menstrual cycle. Initially presumed to be a Bartholin's cyst, the lesion failed to respond to antibiotics and sitz baths. MRI revealed a complex vaginal wall cyst without classic signs of pelvic endometriosis. Examination under anesthesia and aspiration of chocolate-colored fluid raised suspicion for an endometriotic lesion. Surgical excision confirmed endometrial glands and stroma with hemosiderin-laden macrophages-consistent with vulvar endometriosis at the site of a right mediolateral episiotomy scar. Postoperative recovery was uneventful, and the patient experienced complete resolution of symptoms.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic challenge of vulvar endometriosis in women with prior perineal trauma. Clinicians should maintain a high index of suspicion for endometriosis in cyclical vulvar masses-especially when located along episiotomy scars and unresponsive to conventional treatment. Early recognition and surgical excision can be curative and significantly improve quality of life.</p>","PeriodicalId":9610,"journal":{"name":"Case Reports in Obstetrics and Gynecology","volume":"2026 ","pages":"7202665"},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}