Case Reports in Infectious Diseases最新文献

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A Case of Cowpox Presenting as Progressive Unilateral Facial Swelling and Fever Without Any Skin Lesions. 牛痘1例,表现为进行性单侧面部肿胀和发热,无任何皮肤损害。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-13 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/4441632
Oliver T R Toovey, Simon C Wooding, Amy Belfield, Jenna Furneaux, Nicola Eisenhauer, Tommy Rampling
{"title":"A Case of Cowpox Presenting as Progressive Unilateral Facial Swelling and Fever Without Any Skin Lesions.","authors":"Oliver T R Toovey, Simon C Wooding, Amy Belfield, Jenna Furneaux, Nicola Eisenhauer, Tommy Rampling","doi":"10.1155/crdi/4441632","DOIUrl":"10.1155/crdi/4441632","url":null,"abstract":"<p><strong>Introduction: </strong>Although a rare infection, sporadic human cases of cowpox do occur in endemic areas, often through contact with an infected cat. Cats are also incidental hosts but provide an important intermediary to the animal reservoir for cowpox, which in the United Kingdom (UK) includes bank and field voles.</p><p><strong>Case discussion: </strong>We present a case of cowpox in an immunocompetent 25-year-old male who developed a progressive unilateral facial swelling over the course of 10 days associated with pyrexia. He never developed any lesions, nor did he develop any necrotising lymphadenitis as has been described in previous such cases without visible lesions. He had been exposed to his cat at a time when the cat only displayed eye disease and had not been exposed during the phase of the cat's illness when it had cutaneous manifestations. Both patient and cat made a full recovery.</p><p><strong>Conclusion: </strong>Cases of cowpox in immunocompetent patients typically involve distinctive skin lesions at the site of the inoculation, but facial swelling with or without lymphadenitis can occur.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"4441632"},"PeriodicalIF":0.8,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Cervical Pyogenic Spondylodiscitis Caused by Streptococcus gallolyticus subsp. pasteurianus: A Case Report. 败胆链球菌亚种所致复发性颈椎病化脓性椎间盘炎。巴氏杆菌一例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-12 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/2798487
Takeshi Yamashita, Katsuyuki Yoshida, Michiko Matsuzawa Adachi, Takumi Otsuki, Takahiko Fukuchi
{"title":"Recurrent Cervical Pyogenic Spondylodiscitis Caused by Streptococcus gallolyticus subsp. pasteurianus: A Case Report.","authors":"Takeshi Yamashita, Katsuyuki Yoshida, Michiko Matsuzawa Adachi, Takumi Otsuki, Takahiko Fukuchi","doi":"10.1155/crdi/2798487","DOIUrl":"10.1155/crdi/2798487","url":null,"abstract":"<p><p>Pyogenic spondylodiscitis is a rare infection, with cervical spine involvement occurring in only 3%-10% of the cases. <i>Streptococcus gallolyticus</i> subsp. <i>pasteurianus</i>, a normal gut flora component, is a rare causative agent of spinal infections. Here, we report the case of an 88-year-old man with cervical pyogenic spondylodiscitis caused by this organism, complicated by a clinical relapse following a standard antibiotic course. The patient presented with fever and neck pain. Blood cultures revealed <i>Streptococcus gallolyticus</i> subsp. <i>pasteurianus</i>, and cervical magnetic resonance imaging (MRI) revealed spondylodiscitis at the C4-C6 levels. The patient was treated with a 90-day course of antibiotics (46 days intravenous and 44 days oral), leading to initial clinical and biochemical resolution. However, clinical relapse occurred on day 174, characterized by recurrent neck pain and elevated C-reactive protein levels despite no clear signs of active inflammation on repeat MRI. Extended oral antibiotic therapy was resumed and continued for 9 months, resulting in sustained remission without surgical intervention. To our knowledge, only isolated case reports of spinal infections caused by this subspecies have been published, and no prior case has described clinical recurrence. This case suggests that standard antibiotic durations may be insufficient in selected complex or relapsing spinal infections caused by <i>Streptococcus gallolyticus</i> subsp. <i>pasteurianus</i> and highlights the importance of individualized treatment duration and long-term surveillance.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2798487"},"PeriodicalIF":0.8,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breakthrough Pulmonary Nocardiosis Due to Nocardia cyriacigeorgica in a Lung Transplant Recipient in Brazil: A Case Report Highlighting Management Without Susceptibility Testing. 巴西肺移植受者因cyriacigeorgica诺卡菌引起的肺诺卡菌病的突破性进展:一个病例报告强调在没有药敏检测的情况下进行管理。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-12 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/2026205
Caian L Vinhaes, M Gabriela Gallegos, Joana R Deheinzelin, Priscila Leon, Bruno B Andrade, Silvia Vidal Campos
{"title":"Breakthrough Pulmonary Nocardiosis Due to <i>Nocardia cyriacigeorgica</i> in a Lung Transplant Recipient in Brazil: A Case Report Highlighting Management Without Susceptibility Testing.","authors":"Caian L Vinhaes, M Gabriela Gallegos, Joana R Deheinzelin, Priscila Leon, Bruno B Andrade, Silvia Vidal Campos","doi":"10.1155/crdi/2026205","DOIUrl":"10.1155/crdi/2026205","url":null,"abstract":"<p><strong>Background: </strong><i>Nocardia</i> infection is an emerging concern in solid organ recipients due to prolonged immunosuppression.</p><p><strong>Case presentation: </strong>We report the case of a 45-year-old woman with a history of cystic fibrosis who underwent bilateral lung transplantation. Eight years posttransplant, she developed progressive respiratory symptoms. Imaging revealed cavitary nodular lesions, and <i>Nocardia cyriacigeorgica</i> was isolated from bronchoalveolar lavage and sputum cultures. Treatment with meropenem and trimethoprim-sulfamethoxazole led to clinical and radiological improvement.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic challenges of <i>Nocardia</i> infections, the importance of microbiological interpretation, and the potential for late-onset disease in transplant recipients despite prophylaxis. Awareness of <i>Nocardia</i> as an opportunistic pathogen is crucial for timely diagnosis and management. Our findings underscore the need for continued vigilance in solid organ transplant recipients, particularly in cases of persistent pulmonary infections and high immunosuppressive therapy.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2026205"},"PeriodicalIF":0.8,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Hydatid Cyst Rupture Associated With Albendazole Commencement: Case Report and Literature Review. 肺包虫囊肿破裂与阿苯达唑相关:病例报告和文献复习。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-08 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/8899087
Thomas Ledger, Abiny Vignarajan, Ross Harvey, Lawrence Yuen, Rogan Lee, Bernard Hudson, Mark W Douglas
{"title":"Pulmonary Hydatid Cyst Rupture Associated With Albendazole Commencement: Case Report and Literature Review.","authors":"Thomas Ledger, Abiny Vignarajan, Ross Harvey, Lawrence Yuen, Rogan Lee, Bernard Hudson, Mark W Douglas","doi":"10.1155/crdi/8899087","DOIUrl":"10.1155/crdi/8899087","url":null,"abstract":"<p><p>We report a 54-year-old immunocompetent female of Pakistani origin who presented with a 3 month history of abdominal fullness associated with hepatic and pulmonary cysts suggesting hydatid disease but negative <i>Echinococcus granulosus</i> serology. The hepatic cyst was resected, confirming hydatid disease, and perioperative albendazole was continued to treat the smaller pulmonary cyst. Three weeks after commencing albendazole, the patient developed acute chest pain due to rupture of the pulmonary cyst, with subsequent seroconversion for <i>Echinococcus granulosus</i>. A literature review identified four reports of ruptured pulmonary hydatid cysts during albendazole therapy, including a total of nine patients. Eight of 9 cases reported rupture of pulmonary cysts, all within 3 weeks of albendazole commencement, which was speculated to be due to decreased cuticular membrane pressures.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"8899087"},"PeriodicalIF":0.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupationally Acquired Polymicrobial Keratitis Caused by Acanthamoeba and Rare Enteric Bacteria Following Gastrointestinal Splash Exposure: A Case Report. 胃肠道飞溅暴露后由棘阿米巴和罕见肠道细菌引起的职业性多微生物角膜炎1例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-08 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/3791851
Fatma Elnaggar, Heba AlSharif, Muhammad Haris Mazhar, Danya Aldahan, Halah Bin Helayel
{"title":"Occupationally Acquired Polymicrobial Keratitis Caused by Acanthamoeba and Rare Enteric Bacteria Following Gastrointestinal Splash Exposure: A Case Report.","authors":"Fatma Elnaggar, Heba AlSharif, Muhammad Haris Mazhar, Danya Aldahan, Halah Bin Helayel","doi":"10.1155/crdi/3791851","DOIUrl":"10.1155/crdi/3791851","url":null,"abstract":"<p><strong>Background: </strong>Polymicrobial keratitis is an uncommon but vision-threatening condition, particularly when it involves protozoal and bacterial pathogens. Healthcare workers may be at increased risk due to occupational exposure to hospital-associated microorganisms.</p><p><strong>Case presentation: </strong>We report a case of severe polymicrobial keratitis in a 40-year-old contact lens-wearing nurse who developed acute keratitis following inadvertent ocular exposure to nasogastric secretions while caring for a critically ill child. Contact lens culture and in vivo confocal microscopy identified <i>Acanthamoeba</i>, <i>Enterococcus faecalis</i>, <i>Staphylococcus capitis</i>, <i>and Pantoea</i> species. The patient developed progressive ring infiltrates, stromal haze, and endothelial dysfunction consistent with advanced infectious keratitis. Intensive antiamoebic and targeted antimicrobial therapy resulted in infection control but with significant corneal scarring requiring planned lamellar keratoplasty.</p><p><strong>Conclusion: </strong>This case represents a rare example of occupationally acquired polymicrobial keratitis involving Acanthamoeba and multiple healthcare-associated bacteria. It highlights the potential for gastrointestinal and hospital flora to cause severe ocular infection in contact lens users and underscores the need for heightened infection-control awareness among healthcare workers.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"3791851"},"PeriodicalIF":0.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lumbar Spine Mucormycosis Mimicking Pott's Spine: A Case Report. 腰椎毛霉菌病模拟波特病1例报告。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-08 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/1299422
Kanav Gupta, Kashif Qureshi, Sonal Gupta, Rakesh Dua, Shivanya Singh, Shaurya Darbari, Bipin Chaurasia, Kivanc Yangi
{"title":"Lumbar Spine Mucormycosis Mimicking Pott's Spine: A Case Report.","authors":"Kanav Gupta, Kashif Qureshi, Sonal Gupta, Rakesh Dua, Shivanya Singh, Shaurya Darbari, Bipin Chaurasia, Kivanc Yangi","doi":"10.1155/crdi/1299422","DOIUrl":"10.1155/crdi/1299422","url":null,"abstract":"<p><strong>Background: </strong>Spinal mucormycosis is an exceptionally rare form of invasive fungal infection, with fewer than 12 confirmed cases reported in the prior literature. Immunocompromised patients are disproportionately affected, and mortality exceeds 50% in this population. Chronic liver disease as a primary predisposing condition is underrepresented in the existing case series.</p><p><strong>Case presentation: </strong>A 54-year-old male with Child-Pugh Grade C chronic liver cirrhosis, diabetes mellitus, and hypothyroidism presented with progressive low back pain and bilateral lower limb weakness of one week duration. Lumbar MRI demonstrated L2-L3 spondylodiscitis with epidural abscess formation, initially attributed to Pott's spine, and antitubercular therapy (ATT) was initiated empirically. Rapid neurological deterioration prompted surgical re-evaluation. The patient underwent an L3 laminectomy with drainage of an L3-L4 anterior epidural abscess. Intraoperative microscopy revealed aseptate ribbon-like hyphae consistent with Mucorales species. Liposomal Amphotericin B (5 mg/kg/day), intravenous micafungin, and oral posaconazole were commenced. Antifungal therapy was complicated by progressive nephrotoxicity and hepatic decompensation requiring repeated dose modifications. The patient developed hepatic encephalopathy with sepsis and died on Postoperative day (POD) 12 from multiorgan failure.</p><p><strong>Conclusion: </strong>This case represents the 12th documented instance of spinal mucormycosis and the first attributable to Child-Pugh Grade C liver disease. In tuberculosis-endemic settings, mucormycosis must be considered in the differential diagnosis of apparent Pott's spine in immunocompromised patients, particularly those with progressive neurological deterioration despite empirical ATT. Concurrent hepatic and renal impairment substantially constrains antifungal options and worsens prognosis. Multidisciplinary coordination and early tissue diagnosis are critical to the management of this rare, life-threatening condition.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"1299422"},"PeriodicalIF":0.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report of Rhodococcus erythropolis Contamination in Buruli Ulcer Lesions: Effects on Mycobacterium ulcerans Diagnosis. 布鲁里溃疡病变中红红球菌污染病例报告:对溃疡分枝杆菌诊断的影响。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-01 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/6627150
Francis Zeukeng, Jennifer Seyram Amedior, Evelyne Fegue Ndzodo, Solange E Kakou-Ngazoa, Stephen Mbigha Ghogomu, David N'golo Coulibaly, Wilfred Fon Mbacham, Jude Daiga Bigoga, Anthony Ablordey
{"title":"Case Report of <i>Rhodococcus erythropolis</i> Contamination in Buruli Ulcer Lesions: Effects on <i>Mycobacterium ulcerans</i> Diagnosis.","authors":"Francis Zeukeng, Jennifer Seyram Amedior, Evelyne Fegue Ndzodo, Solange E Kakou-Ngazoa, Stephen Mbigha Ghogomu, David N'golo Coulibaly, Wilfred Fon Mbacham, Jude Daiga Bigoga, Anthony Ablordey","doi":"10.1155/crdi/6627150","DOIUrl":"10.1155/crdi/6627150","url":null,"abstract":"<p><strong>Introduction: </strong>We describe cases of contamination of <i>Mycobacterium ulcerans</i> infections (Buruli ulcer) with <i>Rhodococcus erythropolis</i>, a bacterium of environmental origin that is rarely associated with human infection.</p><p><strong>Case presentation: </strong>The infectious pathogen of Buruli ulcer, <i>Mycobacterium ulcerans</i>, was detected and cultured in vitro from two lesion swabs taken from clinically described Buruli ulcer-like patients (4 and 34 years old). Infection by <i>M. ulcerans</i> was confirmed using the WHO-recommended IS2404/IPC-qPCR multiplex analysis of DNA extracts from patient samples, which were subsequently categorized as positive. PCR-positive samples were incubated in Löwenstein-Jensen (LJ) culture media, and colony phenotypes characteristic of <i>M. ulcerans</i> were observed 14 days postincubation. However, analysis of culture suspensions by qPCR revealed no <i>M. ulcerans</i> DNA, while Ziehl-Neelsen (ZN) staining showed phenotypes closely related to acid-fast bacilli (AFB) of <i>M. ulcerans</i>. Detected AFBs were not clustered after ZN staining. Further microbial identification and characterization by MALDI-TOF MS and Gram staining revealed the presence of <i>Rhodococcus erythropolis</i>. The identification was confirmed by whole-genome sequencing (WGS) to establish the genomic link between this originally called <i>Mycobacterium erythropolis</i> and <i>M. ulcerans</i>. Analysis of short reads from WGS confirmed the organism as <i>R. erythropolis</i>. When employing the <i>M. ulcerans</i> Agy99 reference chromosome, comparative analysis of whole-genome sequences revealed little genomic relatedness between the two organisms, with an average genome coverage of 5.72%.</p><p><strong>Conclusion: </strong>The study reports the first contamination cases of <i>M. ulcerans</i>-infected lesions with <i>R. erythropolis</i>. Although <i>R. erythropolis</i> did not interfere in the detection specificity of <i>M. ulcerans</i> by IS2404/IPC-qPCR, it completely inhibited <i>M. ulcerans</i> growth in recommended LJ culture media, complicating routine biological diagnosis by culture and microscopy. Hence, Buruli ulcer is likely to be underdiagnosed due to lesion contamination by <i>R. erythropolis</i> and difficulties in <i>M. ulcerans</i> identification in the routine clinical diagnosis procedure.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"6627150"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cephalic Tetanus Following Auricular Metallic Trauma in an Adult: A Rare Clinical Case Presentation. 成人耳穴金属外伤后的头性破伤风:一例罕见的临床病例。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-06-01 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/2576339
Sonia Taleb, Amel Ouyahia, Mounira Rais, Meriem Guechi
{"title":"Cephalic Tetanus Following Auricular Metallic Trauma in an Adult: A Rare Clinical Case Presentation.","authors":"Sonia Taleb, Amel Ouyahia, Mounira Rais, Meriem Guechi","doi":"10.1155/crdi/2576339","DOIUrl":"10.1155/crdi/2576339","url":null,"abstract":"<p><strong>Introduction: </strong>Cephalic tetanus of otitic origin is a well-documented clinical entity. It is characterized by trismus associated with damage to one or more cranial nerves. Although rare, this form poses a real diagnostic challenge because of its often atypical clinical picture, which justifies rapid and appropriate treatment to limit morbidity and mortality.</p><p><strong>Case presentation: </strong>We report the case of a 31-year-old patient, working as a welder and whose tetanus vaccination status was not up to date with recommended booster doses, who developed purulent otitis following auricular trauma caused by a metallic projectile, which was not treated. The course was marked by the appearance of cephalic tetanus, manifested by trismus associated with the involvement of the third cranial nerve (ptosis). Management includes the administration of antitetanus serum, a first dose of tetanus vaccine, and a prescription of metronidazole. The outcome was favorable.</p><p><strong>Conclusion: </strong>This case highlights the importance of tetanus vaccination, which remains the cornerstone of prevention and underscores the need for increased community awareness and appropriate training for health professionals. Cephalic tetanus, a rare complication of auricular trauma, requires prompt management to prevent serious sequelae and ensure favorable outcomes.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"2576339"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking Balamuthia mandrillaris Through PCR in a Case of Multifocal Brain Lesions. 用PCR揭示多灶性脑病变中的山魈。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/4411823
Moamen Al Zoubi, Garry Jean-Louis, Kelly Sylvain, Cara Moll, Alison Schwartz VanEperen, Ammar Nasrallah, Amanda Carlson, Julie Duval, Norah Grady Letendre
{"title":"Unmasking <i>Balamuthia mandrillaris</i> Through PCR in a Case of Multifocal Brain Lesions.","authors":"Moamen Al Zoubi, Garry Jean-Louis, Kelly Sylvain, Cara Moll, Alison Schwartz VanEperen, Ammar Nasrallah, Amanda Carlson, Julie Duval, Norah Grady Letendre","doi":"10.1155/crdi/4411823","DOIUrl":"10.1155/crdi/4411823","url":null,"abstract":"<p><p><i>Balamuthia mandrillaris</i> is a rare free-living amoeba that causes granulomatous amoebic encephalitis (GAE), a frequently fatal central nervous system infection. Diagnosis is often delayed because of nonspecific clinical presentation and radiographic findings. We describe a 70-year-old man with recent soil exposure in rural Mexico who developed progressive neurologic decline and multifocal enhancing brain lesions initially concerning for malignancy. Extensive infectious, oncologic, and autoimmune evaluations were unrevealing. Brain biopsy demonstrated dense granulomatous inflammation without identifiable organisms on routine stains. Definitive diagnosis was established via 18S rRNA PCR testing of brain tissue and subsequently confirmed by the Centers for Disease Control and Prevention. A multidrug regimen including miltefosine and investigational nitroxoline was initiated but was complicated by renal and hepatic toxicity. Despite transient radiologic improvement, the patient experienced progressive disease and ultimately died. This case underscores the diagnostic difficulty of Balamuthia encephalitis and highlights the essential role of molecular diagnostics in identifying rare pathogens when conventional testing is inconclusive.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2026 ","pages":"4411823"},"PeriodicalIF":0.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burrata and the Bean: A Rare Case of Lactobacillus casei Endocarditis Complicated by Rapidly Progressive Glomerulonephritis. Burrata和Bean:一例罕见的干酪乳杆菌心内膜炎并发快速进展的肾小球肾炎。
IF 0.8
Case Reports in Infectious Diseases Pub Date : 2026-05-28 eCollection Date: 2026-01-01 DOI: 10.1155/crdi/7709602
Jason Chavez, Joseph Borick, Fernando Pedraza Taborda, Paola Lichtenberger
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