Case Reports in Nephrology最新文献_第5页

Osteitis Fibrosa Cystica: An Unusual Cause of Left-Sided Chest Pain. 囊性纤维性骨炎：左侧胸痛的不寻常原因。

Case Reports in Nephrology Pub Date : 2026-01-08 eCollection Date: 2026-01-01 DOI: 10.1155/crin/3576066

Raahima Habib, Maha Anjum, Ayesha Mahmood, Nabiha Rizvi

{"title":"Osteitis Fibrosa Cystica: An Unusual Cause of Left-Sided Chest Pain.","authors":"Raahima Habib, Maha Anjum, Ayesha Mahmood, Nabiha Rizvi","doi":"10.1155/crin/3576066","DOIUrl":"10.1155/crin/3576066","url":null,"abstract":"We report a case of osteitis fibrosa cystica resulting from secondary hyperparathyroidism in a 21-year-old male patient with end-stage renal disease. The patient presented with persistent, moderate chest pain localized to the left fifth and sixth ribs for eight months. A chest X-ray revealed well-defined, expansile lytic lesions in these ribs. Prior testing showed elevated parathyroid hormone (PTH) levels for five years, along with decreased serum calcium and elevated phosphorus levels. Findings from ultrasound and SPECT scans were consistent with hyperparathyroidism. Repeat laboratory tests showed a PTH level of 939.8 pg/mL (normal: 10-69 pg/mL), calcium level of 8.3 mg/dL (normal: 8.4-10.2 mg/dL), and phosphorus level of 5.1 mg/dL (normal: 2.5-5.0 mg/dL). The patient declined surgical intervention and was managed conservatively with calcium and vitamin D supplementation. Within 4 weeks, symptoms resolved and calcium and phosphorus levels normalized, although PTH levels remained elevated. Osteitis fibrosa cystica can be challenging to diagnose due to its rarity, especially in developed countries, and its nonspecific clinical presentation. This case highlights the importance of considering this diagnosis and outlines an approach to management in resource-limited settings.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2026 ","pages":"3576066"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Glomerular Hypertrophy in Kidney Transplants Associated With Focal Segmental Glomerulosclerosis: Report of Three Cases. 肾移植伴局灶节段性肾小球硬化的适应性肾小球肥大：3例报告。

Case Reports in Nephrology Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.1155/crin/7613213

Autumn LaRocque, Ujwal Gautam, Nora Ewis, Richard Ugarte, Emily Daniel, John C Papadimitriou, Abdolreza Haririan, Cinthia B Drachenberg

{"title":"Adaptive Glomerular Hypertrophy in Kidney Transplants Associated With Focal Segmental Glomerulosclerosis: Report of Three Cases.","authors":"Autumn LaRocque, Ujwal Gautam, Nora Ewis, Richard Ugarte, Emily Daniel, John C Papadimitriou, Abdolreza Haririan, Cinthia B Drachenberg","doi":"10.1155/crin/7613213","DOIUrl":"10.1155/crin/7613213","url":null,"abstract":"Transplant kidneys face increased functional demands in comparison to physiological conditions, and glomerular hypertrophy (GH) appears to be a common compensatory mechanism. Adaptive GH could contribute to improved graft function, but a so-called \"maladaptive\" response may lead to shortened graft survival. We assessed in three patients the mean glomerular diameter in donor preimplantation wedge biopsies and in subsequent posttransplant biopsies and correlated the glomerular size with Banff scores and clinical course. Mean glomerular size increased from 192.09 ± 28.65, 188.98 ± 19.86, and 168.96 ± 18.5 in preimplantation biopsies to 279.43 ± 50.6 (p < 0.0001), 275.23 ± 68.17 (p < 0.0001), and 266.23 ± 40.5 (p < 0.00001) in the last biopsies, respectively. The proportion of enlarged glomeruli (> 200 µ) increased from 42.86%, 31%, and 5% in the donor biopsies to 93.3% (p0.008), 95.7% (p < 0.0001), and 95.1% (p < 0.00001) in the last biopsy, respectively. Although GH was initially associated with the achievement of good graft function, secondary FSGS and proteinuria developed at 3, 7, and > 17 years posttransplant, respectively. GH (glomerulomegaly) can be easily appreciated by light microscopy, but is not routinely recorded in transplant biopsy reports. Recognition and documentation of GH could help identify factors associated with the \"maladaptive\" phase of this adaptive response and find interventions that can potentially prolong graft survival.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2025 ","pages":"7613213"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calciphylaxis in the Upper GI Tract in an ESRD Patient: An Atypical Presentation and Review of Literature. ESRD患者上消化道的钙化反应：一个不典型的表现和文献回顾。

Case Reports in Nephrology Pub Date : 2025-12-11 eCollection Date: 2025-01-01 DOI: 10.1155/crin/3967671

Pallavi D Shirsat, Kunal Sonavane, Leonardo Ramirez Botana, Bharat Sachdeva

{"title":"Calciphylaxis in the Upper GI Tract in an ESRD Patient: An Atypical Presentation and Review of Literature.","authors":"Pallavi D Shirsat, Kunal Sonavane, Leonardo Ramirez Botana, Bharat Sachdeva","doi":"10.1155/crin/3967671","DOIUrl":"10.1155/crin/3967671","url":null,"abstract":"Calciphylaxis, also referred to as calcific uremic arteriolopathy (CUA), is a rare and life-threatening condition characterized by vascular calcification, ischemic tissue injury, and high morbidity and mortality. It is predominantly observed in patients with end-stage renal disease (ESRD) who are undergoing dialysis and typically presents with painful cutaneous ulcers. We report an exceptional case of gastric mucosal CUA in a dialysis-dependent ESRD patient, presenting with severe upper gastrointestinal bleeding in the absence of preceding skin lesions. Histopathologic examination of gastric biopsies confirmed vascular calcification consistent with CUA. Despite medical intervention, the patient's course was complicated by poor treatment adherence and subsequent fatal outcome. This case underscores the importance of maintaining high index of suspicion for atypical, visceral presentations of CUA in high-risk ESRD patients. This case was previously presented as a poster at the National Kidney Foundation 2025 Spring Clinical Meeting. Trial Registration: ClinicalTrials.gov identifier: NCT02278692.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2025 ","pages":"3967671"},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradoxical Hyperkalemia in Bartter Syndrome: A Case Report of Severe Resistant Hyperkalemia Requiring Hemodialysis. Bartter综合征的矛盾高钾血症：需要血液透析的严重耐药高钾血症1例报告。

Case Reports in Nephrology Pub Date : 2025-12-11 eCollection Date: 2025-01-01 DOI: 10.1155/crin/2644098

Abhishek Vadher, Mehwish Zeb, Shayne Joseph, Sujata Kambhatla, Chadi Saad

{"title":"Paradoxical Hyperkalemia in Bartter Syndrome: A Case Report of Severe Resistant Hyperkalemia Requiring Hemodialysis.","authors":"Abhishek Vadher, Mehwish Zeb, Shayne Joseph, Sujata Kambhatla, Chadi Saad","doi":"10.1155/crin/2644098","DOIUrl":"10.1155/crin/2644098","url":null,"abstract":"(https://ce.mayo.edu/content/abstract-submission-mayo-clinic-nephrology-hypertension-and-kidney-transplantation-update-2). Bartter syndrome is characterized by severe hypokalemia due to renal tubular defects. A female in late 30s with Bartter syndrome Type IV presented with dizziness. She had been managing severe hypokalemia with intravenous potassium supplementation via an implanted port. She missed her scheduled potassium infusion and presented to the emergency department with a critically high potassium level of 8.2 mmol/L. Additionally, she was diagnosed with acute kidney injury, with a GFR of 39 mL/min down from 72 at her baseline. Her EKG showed QRS widening and tall T waves. Despite administration of multiple shifters, her potassium levels remained elevated. Urgent hemodialysis was initiated, temporarily reducing her potassium levels, but with a rebound to 9.1 mmol/L within hours. After three cycles of hemodialysis over 36 h, her potassium levels finally normalized to 4.7 mmol/L, and no further dialysis was required.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2025 ","pages":"2644098"},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrothorax as a Complication of Peritoneal Dialysis: A Case Report. 腹膜透析并发胸水1例。

Case Reports in Nephrology Pub Date : 2025-11-30 eCollection Date: 2025-01-01 DOI: 10.1155/crin/4365717

Luca Piscitani, Paolo Sipari, Vittorio Di Michele, Lorenzo Ottavio Di Pietro, Vittorio Sirolli, Marilena Tunno

引用次数: 0

Successful Management of Relapsing Primary Focal Segmental Glomerulosclerosis With Tacrolimus and Mycophenolate Multitarget Therapy. 他克莫司联合霉酚酸酯多靶点治疗复发性原发性局灶节段性肾小球硬化的成功治疗。

Case Reports in Nephrology Pub Date : 2025-11-24 eCollection Date: 2025-01-01 DOI: 10.1155/crin/4805412

Frank Lee, Albert Yeam, Marrey Ruby Quizon, Wei Ling Lau

引用次数: 0

Pleomorphic Adenoma-Like Tumor in the Kidney: Case Report of a Rare Mixed Tumor. 肾脏多形性腺瘤样肿瘤：1例罕见混合性肿瘤报告。

Case Reports in Nephrology Pub Date : 2025-11-12 eCollection Date: 2025-01-01 DOI: 10.1155/crin/8959506

Eric Y Zhang, Haneen T Salah, Danice K Torman, Mukul K Divatia, Haijun Steve Zhou

{"title":"Pleomorphic Adenoma-Like Tumor in the Kidney: Case Report of a Rare Mixed Tumor.","authors":"Eric Y Zhang, Haneen T Salah, Danice K Torman, Mukul K Divatia, Haijun Steve Zhou","doi":"10.1155/crin/8959506","DOIUrl":"10.1155/crin/8959506","url":null,"abstract":"Background: Pleomorphic adenoma is the most common salivary gland tumor and is notably able to metastasize while displaying a benign-appearing morphological appearance, greatly resembling that of the primary tumor.Case report: Here, we report a case of a 66-year-old male who presented with a 7-month history of a left upper renal mass. Microscopic examination revealed characteristics typical of pleomorphic adenoma, including chondromyxoid stroma and benign ductal and tubular cells. Consequently, a diagnosis of benign mixed tumor resembling a metastasizing pleomorphic adenoma (MPA) to the kidney was made.Conclusions: We report a rare instance of a tumor resembling pleomorphic adenoma with metastasis to the kidney, the 13th reported case of kidney metastasis in the literature. This case is additionally the 2nd case with metastases to the kidney and no known primary salivary gland tumor. We believe that this entity is most consistent with the histopathological findings reported in our case, despite the lack of a patient history of primary salivary gland tumor. We subsequently compare patient outcomes across all known cases of benign MPA to the kidney or PA-like tumors in the kidney with patient outcomes described in a 2015 study that analyzed all cases of MPA in the literature.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2025 ","pages":"8959506"},"PeriodicalIF":0.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12629694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nocardia Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review. 肾移植受者诺卡菌感染表现为肌肉内脓肿：病例报告及文献复习。

Case Reports in Nephrology Pub Date : 2025-10-28 eCollection Date: 2025-01-01 DOI: 10.1155/crin/9102520

Ghia Spangenberg, Syme Aftab, Rajiv Juneja, David L Gordon, Jordan Y Z Li

{"title":"Nocardia Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review.","authors":"Ghia Spangenberg, Syme Aftab, Rajiv Juneja, David L Gordon, Jordan Y Z Li","doi":"10.1155/crin/9102520","DOIUrl":"10.1155/crin/9102520","url":null,"abstract":"Background: Nocardia is a gram-positive bacterium capable of causing both local and systemic infections, typically in immunocompromised patients. The most common clinical presentation is pulmonary infection. Muscle abscess due to Nocardia infection without disseminated nocardiosis is rare.Case report: In this report, we describe the case of a 67-year-old male kidney transplant recipient who developed a swelling of the right biceps muscle. CT imaging showed an intramuscular abscess, which was subsequently surgically drained. The drained fluid grew Nocardia pseudobrasiliensis, which was resistant to imipenem but susceptible to trimethoprim/sulfamethoxazole (TMP-SMX), ciprofloxacin and linezolid. The patient was initially treated with TMP-SMX and ciprofloxacin. Treatment was changed to 6 months of ciprofloxacin and azithromycin due to intolerance to TMP-SMX which resulted in a good clinical response and no recurrence for 3 years. We also review all previously reported N. pseudobrasiliensis infections and cases of nocardiosis presenting as intramuscular infections.Conclusion: Given its prevalence amongst immunocompromised patients, Nocardiosis requires consideration in the differential diagnosis for the cause of atypical infections in transplant recipients. The antimicrobial susceptibilities of Nocardia are variable depending on species. Of key note, carbapenem resistance has been recently described in N. pseudobrasiliensis. This development should be considered when initiating antimicrobial therapy to ensure good patient response to treatment.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2025 ","pages":"9102520"},"PeriodicalIF":0.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12585877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brevibacterium casei: A Rare Cause of Peritoneal Dialysis-Associated Peritonitis. 干酪短杆菌：腹膜透析相关性腹膜炎的罕见病因。

Case Reports in Nephrology Pub Date : 2025-10-15 eCollection Date: 2025-01-01 DOI: 10.1155/crin/3942963

Veerle Wijtvliet, Katrien Leyssens, Marleen Vanden Driessche, Veerle Matheeussen, Andrea Bertels

引用次数: 0

Treatment of ANCA-Associated Glomerulonephritis Complicated by Bacteremia and Vertebral Osteomyelitis: A Challenging Medical Situation. anca相关性肾小球肾炎合并菌血症和椎体骨髓炎的治疗：一个具有挑战性的医学状况。

Case Reports in Nephrology Pub Date : 2025-10-15 eCollection Date: 2025-01-01 DOI: 10.1155/crin/4392221

Bahjat Azrieh, Abdullah Thayyil, Mohamed Fawzi Mudarres, Nada Youssef, Naga Sumanth Gopireddy, Douglas Somers, Melissa Swee

{"title":"Treatment of ANCA-Associated Glomerulonephritis Complicated by Bacteremia and Vertebral Osteomyelitis: A Challenging Medical Situation.","authors":"Bahjat Azrieh, Abdullah Thayyil, Mohamed Fawzi Mudarres, Nada Youssef, Naga Sumanth Gopireddy, Douglas Somers, Melissa Swee","doi":"10.1155/crin/4392221","DOIUrl":"10.1155/crin/4392221","url":null,"abstract":"Although the prognosis for patients with ANCA-associated vasculitis (AAV) has improved with modern immunosuppressive drugs, treatment-related complications continue to contribute significantly to morbidity and mortality. Infections, in particular, pose a major risk. Older age, high disease activity at diagnosis, and use of potent immunosuppressants are the most important prognostic factors. Older age is independently associated with mortality, severe renal failure, pulmonary hemorrhage, and relapse. This case highlights the challenge of balancing effective immunosuppression with the associated increased risk of infection. A 77-year-old male treated for MPO-ANCA-positive crescentic glomerulonephritis developed severe complications, including bacteremia, osteomyelitis, and disseminated herpes zoster, ultimately resulting in septic shock. Emerging therapies such as avacopan and predictive tools such as the Death in ANCA Glomerulonephritis-Estimating the Risk (DANGER) score may help clinicians better navigate these complex scenarios by guiding treatment intensity and minimizing risks.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2025 ","pages":"4392221"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12543596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0