Case Reports in Nephrology最新文献_第5页

A Case of Paediatric Anti-Glomerular Basement Membrane Disease Associated with Thrombotic Thrombocytopenic Purpura. 儿童抗肾小球基底膜病合并血栓性血小板减少性紫癜1例。

Case Reports in Nephrology Pub Date : 2022-08-27 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2676696

Joseph McAllister, Pradeep Nagisetty, Kay Tyerman

{"title":"A Case of Paediatric Anti-Glomerular Basement Membrane Disease Associated with Thrombotic Thrombocytopenic Purpura.","authors":"Joseph McAllister, Pradeep Nagisetty, Kay Tyerman","doi":"10.1155/2022/2676696","DOIUrl":"https://doi.org/10.1155/2022/2676696","url":null,"abstract":"Anti-GBM disease is a rare vasculitis that causes rapid progressive glomerulonephritis and pulmonary haemorrhage. It is usually an adult diagnosis with isolated paediatric cases reported. Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy mainly affecting adults that causes multiorgan ischaemia, microangiopathic haemolytic anaemia, and thrombocytopenia. We present the first paediatric case of concurrent anti-GBM disease and TTP. A 14-year-old boy presented with acute kidney failure and severe pulmonary haemorrhage due to anti-GBM disease, confirmed on auto-antibody testing. There was thrombocytopenia and moderately low ADAMTS13 activity suggestive of TTP. The renal prognosis was poor with a need for dialysis. He was severely unwell with pulmonary haemorrhages requiring the use of extracorporeal membrane oxygenation (ECMO). His disease was treated with corticosteroids, plasma exchange (PEX), rituximab, and cyclophosphamide, resulting in remission. Anti-GBM disease is rare in children but should be considered in those presenting with acute kidney injury, particularly where there has been exposure to pulmonary irritants. An aggressive presentation warrants aggressive treatment with methylprednisolone, PEX, and cyclophosphamide. Rituximab may benefit patients that have concurrent TTP. TTP may exacerbate pulmonary disease, but complete respiratory recovery is possible. Disease relapse is rare in the paediatric age group, and these patients are candidates for kidney transplantation.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"2676696"},"PeriodicalIF":0.0,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40352291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gadolinium-Induced Acute Graft Pancreatitis in a Simultaneous Pancreas-Kidney Transplant Recipient. 一名胰肾同时移植受者的钆诱发急性移植物胰腺炎

Case Reports in Nephrology Pub Date : 2022-08-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9533266

Chiang Sheng Lee, Rachel Yi Ping Tan, Nitesh N Rao

{"title":"Gadolinium-Induced Acute Graft Pancreatitis in a Simultaneous Pancreas-Kidney Transplant Recipient.","authors":"Chiang Sheng Lee, Rachel Yi Ping Tan, Nitesh N Rao","doi":"10.1155/2022/9533266","DOIUrl":"10.1155/2022/9533266","url":null,"abstract":"Gadolinium-induced acute pancreatitis is a rare phenomenon associated with the administration of gadolinium-based contrast agents. Only five cases of gadolinium-induced acute pancreatitis have been reported worldwide in patients with native pancreas and none with a pancreatic graft. We present a 32-year-old woman with prior history of simultaneous pancreas-kidney transplant who presented with generalized abdominal pain associated with systemic inflammatory response syndrome requiring admission to the intensive care unit. This occurred within 48 hours after having a magnetic resonance imaging (MRI) with gadolinium for investigation of subacute left optic atrophy. She was noted to have a marked rise in serum lipase, and the computed tomography findings were consistent with acute graft pancreatitis. Other causes of pancreatitis were ruled out, and she was managed conservatively with aggressive hydration, bowel rest, and analgesia with good recovery. This is the first reported case of gadolinium-induced acute graft pancreatitis occurring in a simultaneous pancreas-kidney transplant recipient. Clinicians should consider this rare differential diagnosis as a cause of graft pancreatitis in patients who have received gadolinium-based contrast agents.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"9533266"},"PeriodicalIF":0.0,"publicationDate":"2022-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ten Cases of Biopsy-Proven Acute Tubulointerstitial Nephritis: Report from a Single Center in a Rural Area from 2008 to 2021. 2008 - 2021年农村单一中心活检证实急性肾小管间质性肾炎10例报告

Case Reports in Nephrology Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6203803

Kei Nagai, Tsuyoshi Tsukada, Akiko Sakata, Atsushi Ueda

{"title":"Ten Cases of Biopsy-Proven Acute Tubulointerstitial Nephritis: Report from a Single Center in a Rural Area from 2008 to 2021.","authors":"Kei Nagai, Tsuyoshi Tsukada, Akiko Sakata, Atsushi Ueda","doi":"10.1155/2022/6203803","DOIUrl":"https://doi.org/10.1155/2022/6203803","url":null,"abstract":"Acute tubulointerstitial nephritis (ATIN) can be caused by any number of factors, and it accounts for several percent of renal biopsy cases. In Japan, case reports exist, but there are few single-center series of ATIN cases. Case 1. A teenage male patient developed fever and cough on day X-61 and was found to have normal renal function and positive C-reactive protein (CRP) by his primary care physician. On day X-20, he presented with cough and nasal discharge in addition to low-grade fever, and his doctor noted renal dysfunction with serum creatinine of 2.12 mg/dL, negative urine occult blood, and positive urine glucose. Renal biopsy results showed diffuse interstitial nephritis with scarce glomerular involvement. There was no concurrent uveitis. Renal function normalized after 4 months of treatment with moderate-dose prednisolone. Cases 2-10. Of the 422 cases for which renal biopsies were performed at our institution from 2008 to 2021, acute tubulointerstitial nephritis was confirmed clinically and pathologically in 9 cases in addition to case 1, accounting for 2.4% of all biopsy cases. In the analysis of the 10 patients, the median age was 40 years old, eGFR at diagnosis was 19.4 (3.2-49.1) mL/min/1.73 m2, and 2 of them underwent hemodialysis, but both were weaned from dialysis, and the eGFR after treatment was 53.6 (20.8-110.0) mL/min/1.73 m2; all patients showed improvement (P < 0.001). Treatment consisted of steroids in 8 patients and no steroids in 2 patients, the latter being treated by discontinuation of the suspect drugs and treatment of infection; 7 of the 10 patients were examined for ocular uveitis, and uveitis was diagnosed in 5 patients. The causes and clinical course of ATIN are diverse, but it is treated according to individual judgment in addition to standard treatment, and it generally has a good renal prognosis.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"6203803"},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33442216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal Mucormycosis: Post-COVID-19 Infection Presenting as Unilateral Hydronephrosis in a Young Immunocompetent Male. 肾毛霉病:2019冠状病毒病感染后表现为单侧肾积水的年轻免疫功能正常的男性。

Case Reports in Nephrology Pub Date : 2022-07-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3488031

Rabin Nepali, Shreya Shrivastav, Dibya Singh Shah

引用次数: 2

A Case of Oxalate Nephropathy in a Known Diabetic Patient following Acute Alcoholic Pancreatitis. 已知糖尿病患者急性酒精性胰腺炎并发草酸肾病1例。

Case Reports in Nephrology Pub Date : 2022-07-19 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6284693

John Odhiambo, Hanika Patel, Anderson Mutuiri, Fazal Yakub, Ahmed Sokwala

引用次数: 0

A Patient with SIADH, Urinary Retention, Constipation, and Bell's Palsy following a Tick Bite. 一例被蜱虫叮咬后出现SIADH、尿潴留、便秘和贝尔氏麻痹的患者。

Case Reports in Nephrology Pub Date : 2022-07-11 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5937131

Mariana Leone, Anwar Iqbal, J R Hugo Bonatti, Samina Anwar, Catherine Feaga

{"title":"A Patient with SIADH, Urinary Retention, Constipation, and Bell's Palsy following a Tick Bite.","authors":"Mariana Leone, Anwar Iqbal, J R Hugo Bonatti, Samina Anwar, Catherine Feaga","doi":"10.1155/2022/5937131","DOIUrl":"https://doi.org/10.1155/2022/5937131","url":null,"abstract":"Introduction. Lyme disease is the most common vector borne disease in the USA caused by the bacterium Borrelia burgdorferi. If untreated, Lyme disease can cause a variety of secondary symptoms often difficult to interpret. Some of the rare manifestations of Lyme disease include SIADH-like syndrome, enteroparesis, and urinary retention. Case Report. A 69-year-old male presented with anorexia and constipation and was found to have hyponatremia. Several days after admission, Bell's palsy developed and he experienced urinary retention requiring catheterization. Lyme disease was confirmed on serology, and he recalled a rash on his elbow four weeks prior. Ceftriaxone was started and the patient improved; he had multiple bowel movements after receiving laxatives and the Foley catheter was removed; serum sodium normalized with fluid restriction. He was discharged home and was well with symptoms completely resolved at three-month follow-up. Discussion. There should be a high alert of atypical presentation of this common tick bite associated infection. Review of the literature revealed ten similar cases, but only three of these patients were reported to have a combination of SIADH, urinary retention, and enteroparesis.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"5937131"},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40524931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Iatrogenic Infective Endocarditis in Hemodialysis Patients: A Case Report and Review of the Literature. 血透患者的医源性感染性心内膜炎1例报告及文献复习。

Case Reports in Nephrology Pub Date : 2022-06-29 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8500299

Ali Oullaï, Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Yasmin Zouggari, Joëlle Nortier, Maria Do Carmo Filomena Mesquita

{"title":"Iatrogenic Infective Endocarditis in Hemodialysis Patients: A Case Report and Review of the Literature.","authors":"Ali Oullaï, Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Yasmin Zouggari, Joëlle Nortier, Maria Do Carmo Filomena Mesquita","doi":"10.1155/2022/8500299","DOIUrl":"https://doi.org/10.1155/2022/8500299","url":null,"abstract":"Foreign bodies such as implanted cardiac devices are susceptible to infections and may be involved in infective endocarditis. Exposure to pathogens, by frequent use of intravascular accesses for hemodialysis (i.e., catheters or fistulas), combined with high rates of degenerative heart valve diseases in hemodialysis patients, both favor the development of infective endocarditis in this population. The mitral and aortic valves are predominantly implicated in endocardial infections. The involvement of both mitral and tricuspid valves is rare in the general population but can occur in hemodialysis patients with implanted cardiac devices. Infective endocarditis is associated with high morbidity and mortality rates among hemodialysis patients, mostly because of the complications of septic emboli. Prevention, prophylaxis, and early diagnosis of endocarditis can be lifesaving in this fragile population. We report a case of right and left heart methicillin-sensitive Staphylococcus aureus endocarditis with cerebral septic emboli in an elderly hemodialysis patient carrier of an arteriovenous fistula and an ipsilateral nonleadless pacemaker.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"8500299"},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40508276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Crescentic Glomerulonephritis and Membranous Nephropathy: A Rare Overlap. 月牙状肾小球肾炎和膜性肾病:罕见的重叠。

Case Reports in Nephrology Pub Date : 2022-06-24 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8292458

Mohamedanwar Ghandour, Heba Osman, Samer Alkassis, Alix Charles, Kristina Zalewski, Jarrett Weinberger, Yahya Malik-Osman, Zeenat Y Bhat

{"title":"Crescentic Glomerulonephritis and Membranous Nephropathy: A Rare Overlap.","authors":"Mohamedanwar Ghandour, Heba Osman, Samer Alkassis, Alix Charles, Kristina Zalewski, Jarrett Weinberger, Yahya Malik-Osman, Zeenat Y Bhat","doi":"10.1155/2022/8292458","DOIUrl":"https://doi.org/10.1155/2022/8292458","url":null,"abstract":"Background: Membranous nephropathy (MN) is a disease that affects the basement membrane of the glomeruli of the kidney resulting in proteinuria. The concurrent incidence of vasculitic glomerulonephritis and MN in the same patient is unusual. Herein, we report a case with this unusual combination.Case: Our patient is a 53-year-old Hispanic male with a medical history of tobacco use, type 2 diabetes mellitus, and hypertension who presented with hematuria and was found to have nephrotic range proteinuria and renal impairment. Blood workup revealed positive ANCA serology, which led to a renal biopsy that showed crescentic vasculitis in addition to membranous nephropathy. The patient was started on intermittent hemodialysis (HD) and treated initially with intravenous (IV) pulse steroids; subsequently, oral prednisolone and IV cyclophosphamide were initiated. The patient remained HD dependent at the time of discharge with the resolution of hematuria. A follow-up with an outpatient nephrology clinic was arranged.Conclusion: Membranous nephropathy complicated by crescentic glomerulonephritis has a more aggressive clinical course and decline in renal function compared to MN alone which can lead to initiating renal replacement therapy. However, immunosuppressive drugs can result in significant improvement of renal function if started early enough.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"8292458"},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calciphylaxis: A Long Road to Cure with a Multidisciplinary and Multimodal Approach. 钙抑制:多学科、多模式治疗的漫漫长路。

Case Reports in Nephrology Pub Date : 2022-06-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3818980

Vasiliki Zoi, Dimitra Bacharaki, Aggeliki Sardeli, Minas Karagiannis, Sophia Lionaki

{"title":"Calciphylaxis: A Long Road to Cure with a Multidisciplinary and Multimodal Approach.","authors":"Vasiliki Zoi, Dimitra Bacharaki, Aggeliki Sardeli, Minas Karagiannis, Sophia Lionaki","doi":"10.1155/2022/3818980","DOIUrl":"https://doi.org/10.1155/2022/3818980","url":null,"abstract":"Calciphylaxis is a rare yet potentially fatal condition, resulting from ectopic calcification of the small arterioles of the dermis with resulting necrotic lesions infection, sepsis, and death. In hemodialysis patients, its prevalence ranges between 1 and 4%, while mortality amounts to 30-80%. We present in here a 45-year-old female on chronic dialysis with morbid obesity, who was admitted for painful nodules in the lower abdomen and necrotic lesions at the lower extremities. Severe uremia and uncontrolled secondary hyperparathyroidism were the main characteristics in this patient, and thus, a clinical diagnosis of calciphylaxis was made. Treatment modalities included wound care plus antibiotics and analgesics, daily hemodialysis, and strategies targeting calcification with sodium thiosulfate, cinacalcet, and non-calcium-containing binders. A crucial factor for overcoming the infection-lesion vicious circle is thorough and daily care of the lesions. Nursing attention was focused on the motivation of her self-care, for the prevention of institutionalization and the psychological support of the patient and her family. The most intriguing feature was the fact that she experienced several exacerbations during the follow-up time. During the final relapse, she was prescribed hyperbaric oxygen sessions that actually put the disease under control thereafter. The good outcome for this patient was probably related to the combination of close follow-up along with a multidisciplinary approach.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"3818980"},"PeriodicalIF":0.0,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40025742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

ANCA-Negative Vasculitis in Eosinophilic Granulomatosis with Polyangiitis Complicated with Membranous Nephropathy: A Case Report and Brief Literature Review 嗜酸性肉芽肿病合并多血管炎并发膜性肾病的anca阴性血管炎1例报告及简要文献复习

Case Reports in Nephrology Pub Date : 2022-05-06 DOI: 10.1155/2022/8110940

Eri Kasama, Jun Ino, Fumika Iemura, S. Kumon, Mio Kodama, Keitaro Sato, Hitoshi Eizumi, K. Nitta, J. Hoshino

{"title":"ANCA-Negative Vasculitis in Eosinophilic Granulomatosis with Polyangiitis Complicated with Membranous Nephropathy: A Case Report and Brief Literature Review","authors":"Eri Kasama, Jun Ino, Fumika Iemura, S. Kumon, Mio Kodama, Keitaro Sato, Hitoshi Eizumi, K. Nitta, J. Hoshino","doi":"10.1155/2022/8110940","DOIUrl":"https://doi.org/10.1155/2022/8110940","url":null,"abstract":"Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA) typically occurs in anti-neutrophil cytoplasmic autoantibody (ANCA)-positive cases presenting with rapidly progressive renal insufficiency and urinary abnormalities induced by primarily necrotizing crescentic glomerulonephritis (NCGN). Recently, ANCA-negative EGPA has also been reported to manifest with renal involvement, such as NCGN or non-NCGN, including membranous nephropathy (MN). Herein, we report a 70-year-old female who presented with purpura on the lower legs, upper limb numbness, renal dysfunction (eGFR, 20.5 ml/min/1.73 m2), and eosinophilia (eosinophils, 37,570/μl). MPO-and PR3-ANCA were negative, and urinalysis revealed urine protein (0.63 g/day) but without red blood cells in the urine sediment. Thus, she was diagnosed with ANCA-negative EGPA with rapidly progressive renal dysfunction. A renal biopsy revealed vasculitis in the interlobular arteries without NCGN, with the vasculitis being complicated by MN. Micrograph findings on fluorescence immunostaining contained both primary and secondary characteristics of MN (dominance of IgG subclass 4 more than subclass 1 vs. negativity of PLA2R and THSD7A). After treatment with prednisolone, her eosinophil counts normalized, and renal dysfunction improved. Furthermore, urine protein did not increase above 1.0 g/day during the clinical course. This is a rare case of ANCA-negative EGPA presenting with acute renal dysfunction without NCGN and subclinical MN with unknown etiology. It is important to recognize that EGPA pathology varies widely throughout the disease course, and the clinical course of subclinical MN should be carefully assessed in further follow-ups.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80301145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1