Case Reports in Nephrology最新文献_第4页

A Case of Castleman's Disease during the Long-Term Course of Membranous Nephropathy. 膜性肾病长期病程中的Castleman病1例。

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/4926000

Shuhei Nakajima, Kei Nagai, Akiko Sakata, Joichi Usui, Kunihiro Yamagata, Atsushi Ueda

{"title":"A Case of Castleman's Disease during the Long-Term Course of Membranous Nephropathy.","authors":"Shuhei Nakajima, Kei Nagai, Akiko Sakata, Joichi Usui, Kunihiro Yamagata, Atsushi Ueda","doi":"10.1155/2023/4926000","DOIUrl":"https://doi.org/10.1155/2023/4926000","url":null,"abstract":"Concomitant with nephrotic syndrome and multicentric castleman's disease (MCD) has only been described in a limited number of small studies and case reports. Among those, none confirmed the renal pathology prior to the onset of MCD, and none of the cases had a history of nephrotic syndrome. A 76 year-old Japanese man visited a nephrologist because of incident nephrotic syndrome. He had previously experienced three episodes of nephrotic syndrome, the last one 13 years ago, and had been diagnosed with membranous nephropathy by renal biopsy. Apart from these previous episodes, he also suffered from systemic lymphadenopathy, anemia, elevated C-reactive protein, polyclonal hypergammopathy, and elevated interleukin (IL)-6. An inguinal lymph node biopsy revealed CD138-positive plasma cells in the interfollicular region. Based on these findings, MCD was diagnosed. Renal biopsy indicated primary membranous nephropathy with spike lesions and bubbling in the basement membranes and deposition of immunoglobulin (Ig) G, IgA, IgM, and phospholipase A2 receptor along the glomerular basement membrane. Corticosteroid monotherapy successfully reduced the edema, proteinuria, and IL-6, but hypoalbuminemia was not sufficiently improved due to castleman's disease and remission of the nephrotic syndrome was not achieved. Later, tocilizumab was administered for remission induction in another facility. To the best of our knowledge, this represents the first report of Castleman's disease with previously diagnosed membranous nephropathy. This case does not provide a causal mechanism for the pathophysiology, but it may be worth suggesting possible involvement of MCD as a trigger for recurrence of membranous nephropathy.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2023 ","pages":"4926000"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9099692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitubular Basement Membrane Antibody Disease Associated with Nivolumab Infusion and Concomitant Acute Pyelonephritis Leading to Acute Kidney Injury : a Case Report and Literature Review. 抗肾管基底膜抗体病与纳武单抗输注和合并急性肾盂肾炎导致急性肾损伤:1例报告和文献回顾

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/6681756

Ahmad Oussama Rifai, Kristin M Denig, Tiffany Caza, Shana M Webb, Sarah Rifai, Sarah Khan, Sally Dahan, Samaa Alamin

{"title":"Antitubular Basement Membrane Antibody Disease Associated with Nivolumab Infusion and Concomitant Acute Pyelonephritis Leading to Acute Kidney Injury : a Case Report and Literature Review.","authors":"Ahmad Oussama Rifai, Kristin M Denig, Tiffany Caza, Shana M Webb, Sarah Rifai, Sarah Khan, Sally Dahan, Samaa Alamin","doi":"10.1155/2023/6681756","DOIUrl":"https://doi.org/10.1155/2023/6681756","url":null,"abstract":"Antitubular basement membrane (anti-TBM) antibody disease is an extremely rare disorder. It may be idiopathic or secondary to exposure of the proximal tubular basement membrane, triggered by tubular injury due to acute pyelonephritis, acute allergic interstitial nephritis, or kidney allograft rejection. The histopathology of anti-TBM antibody disease is characterized by strong linear deposits of IgG with complement C3 along the proximal tubular cell basement membranes. The staining is restricted to proximal tubules. Currently, a kidney biopsy with these pathognomonic findings is the only diagnostic method. Serological testing and titers for anti-TBM antibodies are not clinically standardized. Our patient had pyelonephritis and possibly acute allergic interstitial nephritis as a result of nivolumab infusion. The kidney biopsy demonstrated dense interstitial infiltrates of neutrophil-rich interstitial inflammation, neutrophilic casts, and neutrophilic tubulitis consistent with acute pyelonephritis, as well as areas of mixed inflammation with lymphocytic tubulitis suggesting concurrent acute interstitial nephritis. The presence of linear IgG staining along proximal but not distal tubular basement membranes was diagnostic of anti-TBM antibody disease, favored to be due to both triggers. The patient was treated with discontinuation of nivolumab, intravenous antibiotics, and corticosteroids and was supported with hemodialysis. After 6 weeks, the patient's kidney function recovered enough to discontinue hemodialysis and had significant renal improvement.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2023 ","pages":"6681756"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANCA-Associated Vasculitis after Moderna COVID-19 Vaccination. 现代COVID-19疫苗接种后anca相关性血管炎

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/4906876

Shiko Gen, Takanori Iwai, Sayuri Ohnari, Kanako Nobe, Naofumi Ikeda

引用次数: 2

Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia. 派姆单抗诱导骨化三醇介导的高钙血症。

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/9160326

Tiffany T Oommen, Kelly Sun, Javier Barranco-Trabi, Jeffrey Berenberg, Myungjin Kim

引用次数: 1

A Case of Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome) in a Nonsurgical Patient with Plasma Cell Leukemia. 血浆细胞白血病非手术患者急性结肠假性梗阻(奥吉维综合征)1例。

Case Reports in Nephrology Pub Date : 2022-11-23 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6431248

Akbar Hamid, Jacob Sabu, Omar Elhawary, Isha Puri, Moro Salifu, Man Oh, Mary Mallappallil

引用次数: 1

Disseminated Mycobacterium Tuberculosis and IgA Nephropathy. 弥散性结核分枝杆菌与IgA肾病。

Case Reports in Nephrology Pub Date : 2022-11-01 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3785713

Gordon Audley, Bianca Davidson, Erika Jones, Brendon Price, Brian Rayner, Nicola Wearne, Zibya Barday

引用次数: 0

An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature. 慢性淋巴细胞白血病继发单克隆免疫球蛋白沉积的增殖性肾小球肾炎轻链变异一例:1例报告及文献复习。

Case Reports in Nephrology Pub Date : 2022-10-19 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9207282

José C De La Flor, Jacqueline Apaza, Francisco Díaz, Edna Sandoval, Tania Linares, Alexander Marschall, Patricia Núñez, Andrea Cecilia Rivas-Nieto, Elisa Ruiz

{"title":"An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature.","authors":"José C De La Flor, Jacqueline Apaza, Francisco Díaz, Edna Sandoval, Tania Linares, Alexander Marschall, Patricia Núñez, Andrea Cecilia Rivas-Nieto, Elisa Ruiz","doi":"10.1155/2022/9207282","DOIUrl":"https://doi.org/10.1155/2022/9207282","url":null,"abstract":"We present the case of an 86-year-old Caucasian male with an 11-year history of low-grade chronic lymphocytic leukemia (CLL) presenting with nephrotic syndrome (NS). Renal biopsy findings showed a diffuse mesangial and endocapillary proliferative glomerulonephritis (GN) lesion with fine granular deposits, consistent with a rare morphologic variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID)-lambda light chain (LC) only. Monthly combination therapy of rituximab (500 mg/m2 on day 1), fludarabine (30 mg/m2 on days 1-3), and cyclophosphamide (750 mg/m2 on days 1-3) was administered. Five courses of this regimen resulted in hematological remission, as well as a partial renal response with a reduction in the spot urine protein-to-creatinine ratio (UPCR) of 815.3 mg/g (reduction > 50% proteinuria without improvement in kidney function). This condition is a rare morphological variant of PGNMID, poorly described in CLL patients. We review the literature and suggest that this case provides sheds light on the unknown pathophysiological mechanisms of monoclonal immunoglobulins (MIg)-mediated glomerular damage in CLL patients, and may be helpful for the investigation of a more effective treatment.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"9207282"},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40656382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-Free and Concentrated Ascites Reinfusion Therapy during Hemodialysis for Intradialytic Hypotension and Intractable Ascites 无细胞和浓缩腹水回输治疗透析期间的低血压和顽固性腹水

Case Reports in Nephrology Pub Date : 2022-10-15 DOI: 10.1155/2022/7099227

Hideyuki Hayasaka, K. Ito, S. Ookawara, Masaya Kofuji, Takayuki Uchida, S. Kawamura, Ayumi Gomyo, Haruhisa Miyazawa, Yuichiro Ueda, Keiji Hirai, S. Kimura, N. Momose, S. Kako, Yoshiyuki Morishita

引用次数: 0

Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization. 朗格汉斯细胞组织细胞增多症在住院期间表现为急性严重高钠血症。

Case Reports in Nephrology Pub Date : 2022-10-14 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6120644

Kullaya Takkavatakarn, Hansamon Poparn, Pisut Katavetin

引用次数: 0

Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma. 恶性间皮瘤并发肾病综合征和冷球蛋白血症1例。

Case Reports in Nephrology Pub Date : 2022-09-28 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8677293

Kei Nagai, Hiroaki Tachi, Kohei Inoue, Atsushi Ueda

{"title":"Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma.","authors":"Kei Nagai, Hiroaki Tachi, Kohei Inoue, Atsushi Ueda","doi":"10.1155/2022/8677293","DOIUrl":"https://doi.org/10.1155/2022/8677293","url":null,"abstract":"Malignant pleural mesothelioma is rarely associated with nephrotic syndrome. Cryoglobulinemia is found in various pathological statuses, such as hepatitis C virus infection but rarely in malignant neoplasms. We recently encountered a patient with malignant mesothelioma coincident with nephrotic syndrome and cryoglobulinemia in the course of chemotherapy. A 60-year-old man employed as a building painter was diagnosed with malignant mesothelioma by lung biopsy two years earlier and was started on chemotherapy. Nivolumab seemed effective in controlling mesothelioma, but skin immune-related adverse events occurred during the course of treatment. After discontinuation of nivolumab and administration of gemcitabine as an alternative therapy, the patient was referred to a nephrologist because of the subsequent development of edema, renal injury, and proteinuria. Following the investigation, he was diagnosed with nephrotic syndrome and cryoglobulinemia with C4-dominant cold activation. However, a percutaneous renal biopsy could not be performed due to persistent severe cough induced by pleural involvement. The patient died a little over three years after the pathological diagnosis of pleural mesothelioma. Our case had three key features nephrotic syndrome was possibly associated with malignant mesothelioma; cryoglobulinemia occurred in malignant mesothelioma; and concomitant nephrotic syndrome and cryoglobulinemia occurred after chemotherapy. Unfortunately, our rare case lacks a basis in renal pathology or evidence of links between the pathogenesis of malignant mesothelioma, cryoglobulinemia, and nephrotic syndrome. This case does not provide a causal mechanism, but may be worth adding to the case list as one of the rare renal involvement in a patient with malignant mesothelioma.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":" ","pages":"8677293"},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33497086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1