Case Reports in Nephrology最新文献_第3页

Epitope Spreading: The Underlying Mechanism for Combined Membranous Lupus Nephritis and Anti-GBM Disease? 表位扩散:联合膜性狼疮性肾炎和抗gbm疾病的潜在机制?

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/3190042

Olusola Sogbein, Tina Kochar, Marjan Afrouzian

引用次数: 0

Disseminated Peritoneal Tuberculosis Initially Misdiagnosed as Nephrogenic Ascites. 弥散性腹膜结核最初误诊为肾源性腹水。

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/4240423

Lauren Crossman, Christopher Ronald Funk, Sheetal Kandiah, Reena Hemrajani

{"title":"Disseminated Peritoneal Tuberculosis Initially Misdiagnosed as Nephrogenic Ascites.","authors":"Lauren Crossman, Christopher Ronald Funk, Sheetal Kandiah, Reena Hemrajani","doi":"10.1155/2023/4240423","DOIUrl":"https://doi.org/10.1155/2023/4240423","url":null,"abstract":"A middle-aged immigrant male from a region with endemic tuberculosis who had a history of end-stage kidney disease presented to the emergency room for routine hemodialysis and abdominal swelling. He was admitted to the medicine service for suggested daily dialysis to improve his volume overload, which was attributed to nephrogenic ascites. He was found to have several findings concerning for systemic illness, including fevers, night sweats, hypercalcemia, lymphadenopathy, omental thickening, ascitic fluid with a serum ascites albumin gradient of less than 1.1 gm/dL, and exudative pleural effusions. Our suspicion for hematologic malignancy versus disseminated infection was high. During admission, there were many diagnostic challenges in obtaining histologic and bacteriologic confirmation of our leading suspected diagnosis, disseminated tuberculosis. Ultimately, tuberculosis infection was confirmed with histologic evidence of granulomatous inflammation of cervical lymph node and sputum culture positive for Mycobacterium tuberculosis. This case highlights the necessity for every patient presenting with new ascites to undergo diagnostic paracentesis. Nephrogenic ascites is a rare syndrome that is possible in volume overloaded states but is a diagnosis of exclusion that should be supported by an exudative serum ascites albumin gradient and no evidence of an alternate etiology.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9762495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Castleman's Disease during the Long-Term Course of Membranous Nephropathy. 膜性肾病长期病程中的Castleman病1例。

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/4926000

Shuhei Nakajima, Kei Nagai, Akiko Sakata, Joichi Usui, Kunihiro Yamagata, Atsushi Ueda

{"title":"A Case of Castleman's Disease during the Long-Term Course of Membranous Nephropathy.","authors":"Shuhei Nakajima, Kei Nagai, Akiko Sakata, Joichi Usui, Kunihiro Yamagata, Atsushi Ueda","doi":"10.1155/2023/4926000","DOIUrl":"https://doi.org/10.1155/2023/4926000","url":null,"abstract":"Concomitant with nephrotic syndrome and multicentric castleman's disease (MCD) has only been described in a limited number of small studies and case reports. Among those, none confirmed the renal pathology prior to the onset of MCD, and none of the cases had a history of nephrotic syndrome. A 76 year-old Japanese man visited a nephrologist because of incident nephrotic syndrome. He had previously experienced three episodes of nephrotic syndrome, the last one 13 years ago, and had been diagnosed with membranous nephropathy by renal biopsy. Apart from these previous episodes, he also suffered from systemic lymphadenopathy, anemia, elevated C-reactive protein, polyclonal hypergammopathy, and elevated interleukin (IL)-6. An inguinal lymph node biopsy revealed CD138-positive plasma cells in the interfollicular region. Based on these findings, MCD was diagnosed. Renal biopsy indicated primary membranous nephropathy with spike lesions and bubbling in the basement membranes and deposition of immunoglobulin (Ig) G, IgA, IgM, and phospholipase A2 receptor along the glomerular basement membrane. Corticosteroid monotherapy successfully reduced the edema, proteinuria, and IL-6, but hypoalbuminemia was not sufficiently improved due to castleman's disease and remission of the nephrotic syndrome was not achieved. Later, tocilizumab was administered for remission induction in another facility. To the best of our knowledge, this represents the first report of Castleman's disease with previously diagnosed membranous nephropathy. This case does not provide a causal mechanism for the pathophysiology, but it may be worth suggesting possible involvement of MCD as a trigger for recurrence of membranous nephropathy.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9099692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitubular Basement Membrane Antibody Disease Associated with Nivolumab Infusion and Concomitant Acute Pyelonephritis Leading to Acute Kidney Injury : a Case Report and Literature Review. 抗肾管基底膜抗体病与纳武单抗输注和合并急性肾盂肾炎导致急性肾损伤:1例报告和文献回顾

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/6681756

Ahmad Oussama Rifai, Kristin M Denig, Tiffany Caza, Shana M Webb, Sarah Rifai, Sarah Khan, Sally Dahan, Samaa Alamin

{"title":"Antitubular Basement Membrane Antibody Disease Associated with Nivolumab Infusion and Concomitant Acute Pyelonephritis Leading to Acute Kidney Injury : a Case Report and Literature Review.","authors":"Ahmad Oussama Rifai, Kristin M Denig, Tiffany Caza, Shana M Webb, Sarah Rifai, Sarah Khan, Sally Dahan, Samaa Alamin","doi":"10.1155/2023/6681756","DOIUrl":"https://doi.org/10.1155/2023/6681756","url":null,"abstract":"Antitubular basement membrane (anti-TBM) antibody disease is an extremely rare disorder. It may be idiopathic or secondary to exposure of the proximal tubular basement membrane, triggered by tubular injury due to acute pyelonephritis, acute allergic interstitial nephritis, or kidney allograft rejection. The histopathology of anti-TBM antibody disease is characterized by strong linear deposits of IgG with complement C3 along the proximal tubular cell basement membranes. The staining is restricted to proximal tubules. Currently, a kidney biopsy with these pathognomonic findings is the only diagnostic method. Serological testing and titers for anti-TBM antibodies are not clinically standardized. Our patient had pyelonephritis and possibly acute allergic interstitial nephritis as a result of nivolumab infusion. The kidney biopsy demonstrated dense interstitial infiltrates of neutrophil-rich interstitial inflammation, neutrophilic casts, and neutrophilic tubulitis consistent with acute pyelonephritis, as well as areas of mixed inflammation with lymphocytic tubulitis suggesting concurrent acute interstitial nephritis. The presence of linear IgG staining along proximal but not distal tubular basement membranes was diagnostic of anti-TBM antibody disease, favored to be due to both triggers. The patient was treated with discontinuation of nivolumab, intravenous antibiotics, and corticosteroids and was supported with hemodialysis. After 6 weeks, the patient's kidney function recovered enough to discontinue hemodialysis and had significant renal improvement.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANCA-Associated Vasculitis after Moderna COVID-19 Vaccination. 现代COVID-19疫苗接种后anca相关性血管炎

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/4906876

Shiko Gen, Takanori Iwai, Sayuri Ohnari, Kanako Nobe, Naofumi Ikeda

引用次数: 2

Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia. 派姆单抗诱导骨化三醇介导的高钙血症。

Case Reports in Nephrology Pub Date : 2023-01-01 DOI: 10.1155/2023/9160326

Tiffany T Oommen, Kelly Sun, Javier Barranco-Trabi, Jeffrey Berenberg, Myungjin Kim

引用次数: 1

A Case of Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome) in a Nonsurgical Patient with Plasma Cell Leukemia. 血浆细胞白血病非手术患者急性结肠假性梗阻(奥吉维综合征)1例。

Case Reports in Nephrology Pub Date : 2022-11-23 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6431248

Akbar Hamid, Jacob Sabu, Omar Elhawary, Isha Puri, Moro Salifu, Man Oh, Mary Mallappallil

引用次数: 1

Disseminated Mycobacterium Tuberculosis and IgA Nephropathy. 弥散性结核分枝杆菌与IgA肾病。

Case Reports in Nephrology Pub Date : 2022-11-01 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3785713

Gordon Audley, Bianca Davidson, Erika Jones, Brendon Price, Brian Rayner, Nicola Wearne, Zibya Barday

引用次数: 0

An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature. 慢性淋巴细胞白血病继发单克隆免疫球蛋白沉积的增殖性肾小球肾炎轻链变异一例:1例报告及文献复习。

Case Reports in Nephrology Pub Date : 2022-10-19 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9207282

José C De La Flor, Jacqueline Apaza, Francisco Díaz, Edna Sandoval, Tania Linares, Alexander Marschall, Patricia Núñez, Andrea Cecilia Rivas-Nieto, Elisa Ruiz

{"title":"An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature.","authors":"José C De La Flor, Jacqueline Apaza, Francisco Díaz, Edna Sandoval, Tania Linares, Alexander Marschall, Patricia Núñez, Andrea Cecilia Rivas-Nieto, Elisa Ruiz","doi":"10.1155/2022/9207282","DOIUrl":"https://doi.org/10.1155/2022/9207282","url":null,"abstract":"We present the case of an 86-year-old Caucasian male with an 11-year history of low-grade chronic lymphocytic leukemia (CLL) presenting with nephrotic syndrome (NS). Renal biopsy findings showed a diffuse mesangial and endocapillary proliferative glomerulonephritis (GN) lesion with fine granular deposits, consistent with a rare morphologic variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID)-lambda light chain (LC) only. Monthly combination therapy of rituximab (500 mg/m2 on day 1), fludarabine (30 mg/m2 on days 1-3), and cyclophosphamide (750 mg/m2 on days 1-3) was administered. Five courses of this regimen resulted in hematological remission, as well as a partial renal response with a reduction in the spot urine protein-to-creatinine ratio (UPCR) of 815.3 mg/g (reduction > 50% proteinuria without improvement in kidney function). This condition is a rare morphological variant of PGNMID, poorly described in CLL patients. We review the literature and suggest that this case provides sheds light on the unknown pathophysiological mechanisms of monoclonal immunoglobulins (MIg)-mediated glomerular damage in CLL patients, and may be helpful for the investigation of a more effective treatment.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40656382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-Free and Concentrated Ascites Reinfusion Therapy during Hemodialysis for Intradialytic Hypotension and Intractable Ascites 无细胞和浓缩腹水回输治疗透析期间的低血压和顽固性腹水

Case Reports in Nephrology Pub Date : 2022-10-15 DOI: 10.1155/2022/7099227

Hideyuki Hayasaka, K. Ito, S. Ookawara, Masaya Kofuji, Takayuki Uchida, S. Kawamura, Ayumi Gomyo, Haruhisa Miyazawa, Yuichiro Ueda, Keiji Hirai, S. Kimura, N. Momose, S. Kako, Yoshiyuki Morishita

引用次数: 0