Case Reports in Nephrology最新文献_第10页

Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient. 以肾病综合征为表现的肺结核患者利福平相关继发性微小改变疾病

Case Reports in Nephrology Pub Date : 2021-04-14 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5546942

Satyanand Sathi, Anil Kumar Garg, Manoj Kumar Singh, Virendra Singh Saini, Devinder Vohra

{"title":"Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient.","authors":"Satyanand Sathi, Anil Kumar Garg, Manoj Kumar Singh, Virendra Singh Saini, Devinder Vohra","doi":"10.1155/2021/5546942","DOIUrl":"https://doi.org/10.1155/2021/5546942","url":null,"abstract":"Various extraglomerular disease processes have been associated with drug-induced secondary minimal change disease (MCD). In a majority of cases, preferably, a hypersensitivity reaction appears to be involved, and in some cases, there is direct toxic effect over glomerular capillaries. There are several reports to demonstrate that rifampicin has been associated with various nephrotoxic adverse effects, but rifampicin-induced secondary minimal change disease (MCD) is very rare. Here, we report the case of a young adult male who presented with nephrotic proteinuria with bland urine sediment after one month of initiation of rifampicin treatment for pulmonary tuberculosis. The patient had no proteinuria before the start of antituberculosis treatment. Renal biopsy showed nonproliferative glomerulopathy and immunofluorescence did not show significant glomerular immune deposits. Electron microscopy showed diffuse effacement of visceral epithelial cell foot processes and did not show any presence of glomerular immune complexes and thickening of glomerular basement membrane, promoting the diagnosis of minimal change nephrotic syndrome. The patient got complete remission after discontinuation of rifampicin.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"5546942"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38940995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy. 妊娠期新发抗肾小球基底膜病1例。

Case Reports in Nephrology Pub Date : 2021-03-17 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5539205

F A K Lodhi, T Akcan, J N Mojarrab, S Sajjad, R Blonsky

{"title":"A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy.","authors":"F A K Lodhi, T Akcan, J N Mojarrab, S Sajjad, R Blonsky","doi":"10.1155/2021/5539205","DOIUrl":"https://doi.org/10.1155/2021/5539205","url":null,"abstract":"Background. Acute kidney injury (AKI) requiring dialysis during pregnancy is uncommon. We present a case of a young female diagnosed with antiglomerular basement membrane (anti-GBM) disease during pregnancy. Case Presentation. A 23-year-old woman approximately 15 weeks pregnant experienced weakness, nausea, vomiting, and anorexia for one week and anuria for 48 hours. No known drug allergies and no significant social or family history for kidney or genitourinary disease were reported. Laboratory analysis revealed anemia, life-threatening hyperkalemia, AKI, and elevated antiglomerular basement membrane (GBM) antibodies. Renal biopsy revealed 100% cellular crescents, confirming the diagnosis. The patient was treated using plasmapheresis and methylprednisolone followed by oral steroids, azathioprine, and tacrolimus. At 24 weeks and 4 days of gestation, the patient had hypoxic respiratory failure as well as preterm premature rupture of membranes. Due to the development of infection and lack of renal recovery, immunosuppression was discontinued. At 28 weeks and 0 days of gestation, the patient developed uncontrollable hypertension requiring emergent delivery. Postpartum, her hypertension improved without signs of preeclampsia though still requires dialysis. Discussion. Pregnancy presents a unique challenge for providers treating patients with anti-GBM disease. Fetal safety should be considered and risks thoroughly discussed with the patient when choosing an immunosuppressive regimen for this condition.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"5539205"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25574130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients-A Report of 10 Cases. 针对 COVID-19 中的细胞因子风暴：使用三醋酸非对称纤维素进行在线血液滤过在维持性血液透析患者中的作用--10 个病例的报告。

Case Reports in Nephrology Pub Date : 2021-03-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5575928

José C De La Flor, Francisco Valga, Alexander Marschall, Tania Monzon, Cristina Albarracín, Elisa Ruiz, Miguel Rodeles

{"title":"Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients-A Report of 10 Cases.","authors":"José C De La Flor, Francisco Valga, Alexander Marschall, Tania Monzon, Cristina Albarracín, Elisa Ruiz, Miguel Rodeles","doi":"10.1155/2021/5575928","DOIUrl":"10.1155/2021/5575928","url":null,"abstract":"Early reports have suggested that maintenance hemodialysis (MHD) patients could be more susceptible to a severe course of COVID-19. Among the therapeutic approaches, the use of drugs that reduce the cytokine storm characteristic of this disease has been proposed. Some dialyzers, such as the new generation of asymmetric cellulose triacetate (ATA) membranes, could favor the effective elimination of medium-sized molecules and other inflammatory mediators. In this case series, we describe in depth the clinical, analytical, and radiological details, therapeutic aspects, and outcomes of the case series of 10 MHD patients of our dialysis unit, who tested positive for SARS-CoV-2 from 5 October to 30 November 2020. Furthermore, we evaluate the removal of hyperinflammatory parameters with the ATA membrane in postdilution online hemodiafiltration (OL-HDF) in these patients through a variety of biomarkers of systemic inflammation from the diagnosis until stripping. Biochemical blood analysis was carried out at baseline and at days 7 and 14 after diagnosis, respectively. 50% of the patients presented COVID-19 pneumonia and required hospital admission. Median hospitalization time was 21 days. A total of 4 patients developed severe pneumonia (3 of them died) and 1 patient developed moderate pneumonia. Patients who died (n = 3) were more likely to present bilateral pneumonia (100% vs 14.3%) at diagnosis and less reduction in interleukin 6 (IL-6) at day 14, as compared to those who survived. The use of the ATA membrane could be considered a therapeutic option, due to its immunomodulatory effect in MHD patients with SARS-CoV-2 infection, especially at the beginning of the disease, where the inflammatory component is predominant.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"5575928"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25501556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and Transplantation of a SARS-CoV-2 Seropositive Kidney Candidate. SARS-CoV-2血清阳性候选肾脏的评估和移植。

Case Reports in Nephrology Pub Date : 2021-03-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6613023

Maya C Graves, Sapna A Mehta, Bonnie E Lonze, Nicole M Ali

引用次数: 0

Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy. 纳武单抗治疗下的难治性急性间质性肾炎。

Case Reports in Nephrology Pub Date : 2021-03-01 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6640154

Antonio Faieta, Tavis Dancik

引用次数: 3

Listeria monocytogenes Peritonitis in a Patient Receiving Continuous Ambulatory Peritoneal Dialysis: A Case Report and Review of the Literature. 连续腹膜透析患者单核细胞增生李斯特菌腹膜炎1例报告及文献复习。

Case Reports in Nephrology Pub Date : 2021-01-28 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6681629

Ho-Kwan Sin, Au Cheuk, William Lee, Ka-Fai Yim, Clara Poon, Ivy Wong, Bosco Lam, Hon-Lok Tang, Samuel K Fung

引用次数: 1

Case Report on Anastomosing Haemangioma: An Unusual Vascular Tumor in Kidney. 吻合性血管瘤:一种罕见的肾脏血管肿瘤。

Case Reports in Nephrology Pub Date : 2021-01-07 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8847998

Chun-Hai Lo, Shui-Ying Cheng

引用次数: 4

Treatment of Severe Tumoral Calcinosis with Teriparatide in a Dialysis Patient after Total Parathyroidectomy. 特立帕肽治疗甲状旁腺全切除术后透析患者严重肿瘤钙质沉着症。

Case Reports in Nephrology Pub Date : 2021-01-06 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6695906

Ho-Kwan Sin, Ping-Nam Wong, Kin-Yee Lo, Man-Wai Lo, Shuk-Fan Chan, Kwok-Chi Lo, Yuk-Yi Wong, Lo-Yi Ho, Wing-Tung Kwok, Kai-Chun Chan, Andrew Kui-Man Wong, Siu-Ka Mak

{"title":"Treatment of Severe Tumoral Calcinosis with Teriparatide in a Dialysis Patient after Total Parathyroidectomy.","authors":"Ho-Kwan Sin, Ping-Nam Wong, Kin-Yee Lo, Man-Wai Lo, Shuk-Fan Chan, Kwok-Chi Lo, Yuk-Yi Wong, Lo-Yi Ho, Wing-Tung Kwok, Kai-Chun Chan, Andrew Kui-Man Wong, Siu-Ka Mak","doi":"10.1155/2021/6695906","DOIUrl":"https://doi.org/10.1155/2021/6695906","url":null,"abstract":"Tumoral calcinosis is a rare but debilitating condition that can affect dialysis patients. Optimal management is largely unknown. We report the clinical course, treatment, and outcome of a peritoneal dialysis (PD) patient who developed tumoral calcinosis refractory to conventional treatment but improved with teriparatide therapy. A 26-year-old lady on PD for 2 years presented to us with tumoral calcinosis involving bilateral hands. Response to surgical excision, parathyroidectomy, and conversion to hemodialysis failed to result in sustained remission, and tumoral calcinosis progressed. After total parathyroidectomy, the patient had transient but partial remission in which her calcinosis deposits remained but were asymptomatic without pain or clinical signs of inflammation. However, she later experienced a relapse with involvement of the left elbow, right shoulder, right hip, and right thigh. Tumoral calcinosis remained uncontrolled resulting in debilitation, likely attributable to poor calcium and phosphate control because of adynamic bone disease after parathyroidectomy despite treatment of superimposed tuberculosis and therapy with sodium thiosulphate and pamidronic acid. Clinical improvement was however evident after the use of teriparatide. Asymptomatic hypocalcemia occurred after teriparatide therapy but resolved after 2 months. In conclusion, teriparatide appears to be useful for treating tumoral calcinosis in the presence of adynamic bone disease. Hypocalcemia can occur in the initial months of therapy.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"6695906"},"PeriodicalIF":0.0,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38874208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Scleroderma Renal Crisis in a Case of Mixed Connective Tissue Disease Treated Successfully with Angiotensin-Converting Enzyme Inhibitors. 血管紧张素转换酶抑制剂成功治疗混合性结缔组织病硬皮病肾危重1例。

Case Reports in Nephrology Pub Date : 2021-01-06 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8862405

Jomana Madieh, Iman Khamayseh, Alaa Hrizat, Abdurrahman Hamadah, Kamel Gharaibeh

引用次数: 2

Highest Recorded Serum Creatinine 最高记录血清肌酐

Case Reports in Nephrology Pub Date : 2020-12-25 DOI: 10.1155/2021/6048919

Xinxiu Yang, Meng Gao, M. Miao, Cuihua Jiang, Dongjian Zhang, Zhiqi Yin, Y. Ni, Jing Chen, Jian Zhang

引用次数: 10