Case Reports in Nephrology最新文献_第10页

Can Antinuclear Antibodies (ANA) be Monoclonal? 抗核抗体(ANA)可以单克隆吗?

Case Reports in Nephrology Pub Date : 2021-09-30 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7006466

Laura Biederman, Anjali A Satoskar, Mohankumar Doraiswamy, Samir Parikh, Brad Rovin, Brian Mussio, Galina Mikhalina, Sergey V Brodsky

{"title":"Can Antinuclear Antibodies (ANA) be Monoclonal?","authors":"Laura Biederman, Anjali A Satoskar, Mohankumar Doraiswamy, Samir Parikh, Brad Rovin, Brian Mussio, Galina Mikhalina, Sergey V Brodsky","doi":"10.1155/2021/7006466","DOIUrl":"https://doi.org/10.1155/2021/7006466","url":null,"abstract":"Background: Nuclear staining by immunofluorescence in a kidney biopsy is often seen in patients with positive antinuclear antibodies (ANA) in the serum. These ANA are usually polyclonal, but herein we report 9 cases with an unusual finding of monoclonal nuclear staining by immunofluorescence on kidney biopsy. Case Presentation. Nine cases with predominant stain for kappa or lambda light chain were identified by searching the renal pathology laboratory database for the past 10 years. All cases had positive stain for only kappa (six cases) or lambda (three cases) light chain in the nuclei. Eight out of nine cases had positive nuclear IgG stain, and one case had positive nuclear IgA stain. Among cases with positive nuclear IgG staining, six cases were positive for IgG1 subclass, one case was positive for IgG2 subclass, and one case was positive for IgG3 subclass. All patients with positive IgG nuclear stain, who had testing for ANA, had positive ANA. Patients with positive IgG1 subclass did not have monoclonal protein in the serum or urine, but the patient with positive IgG2 subclass and lambda light chain stain in the nuclei had IgG lambda monoclonal gammopathy.Conclusions: We identified a new unique pattern of nuclear stain by immunofluorescence in kidney biopsies that suggests the presence of monoclonal ANA. Workup for underlying monoclonal gammopathy is warranted in such patients.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"7006466"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39505844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycoplasma pneumoniae Infection Associated C3 Glomerulopathy Presenting as Severe Crescentic Glomerulonephritis. 肺炎支原体感染相关的C3肾小球病变表现为严重新月状肾小球肾炎。

Case Reports in Nephrology Pub Date : 2021-09-27 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6295543

Lalani De Silva, Dinesha Jayasinghe, Priyani Amarathunga

{"title":"Mycoplasma pneumoniae Infection Associated C3 Glomerulopathy Presenting as Severe Crescentic Glomerulonephritis.","authors":"Lalani De Silva, Dinesha Jayasinghe, Priyani Amarathunga","doi":"10.1155/2021/6295543","DOIUrl":"https://doi.org/10.1155/2021/6295543","url":null,"abstract":"C3 glomerulopathy (C3GP) is a group of diseases caused by a deregulated complement system, which encompasses both dense deposit disease and C3 glomerulonephritis. Renal manifestations of C3GP are primarily of proliferative glomerulonephritis, and only a few case reports of crescentic glomerulonephritis (CGN) in association with C3GP are available. Here is a case of an adult South-Asian female, who was diagnosed as seropositive acute Mycoplasma pneumoniae infection, with associated systemic manifestations, including immune-type extravascular haemolysis and nephrotic range proteinuria. Subsequent renal biopsy revealed CGN with disrupted Bowman's capsules and necrotizing lesions. Immunofluorescence showed coarse granular mesangial C3 deposits with negative IgM, IgG, IgA, and C1q. The immunomorphological phenotype raised two possibilities including C3GP and infection-related glomerulonephritis (IRGN). Persistent proteinuria with no evidence of resolution even after 6 months of follow-up favoured C3GP over IRGN. The patient proceeded to end-stage renal failure requiring renal replacement despite aggressive immunosuppression. This case illustrates the rare association of CGN with C3GP induced by Mycoplasma pneumoniae infection, highlighting the importance of correct diagnosis as well as timely identification of triggering factors in CGN on patient outcome.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"6295543"},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39516425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mutation in the SLC2A9 Gene: A New Family with Familial Renal Hypouricemia Type 2. SLC2A9基因突变：家族性2型肾性高尿酸血症的一个新家族。

Case Reports in Nephrology Pub Date : 2021-09-23 DOI: 10.1155/2021/4751099

Christian Maalouli, Karin Dahan, Arnaud Devresse, Valentine Gillion

引用次数: 0

Acute Severe Hyponatremia following Hysteroscopic Procedure in a Young Patient: A Case Report and Review of the Literature. 年轻患者宫腔镜手术后急性严重低钠血症1例报告及文献复习。

Case Reports in Nephrology Pub Date : 2021-09-20 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7195660

Anwar S Atieh, Omar K Abu Shamma, Mohammad O Abdelhafez, Muath A Baniowda, Samia Abed, Basheer H Babaa, Abdurrahman Hamadah, Kamel A Gharaibeh

{"title":"Acute Severe Hyponatremia following Hysteroscopic Procedure in a Young Patient: A Case Report and Review of the Literature.","authors":"Anwar S Atieh, Omar K Abu Shamma, Mohammad O Abdelhafez, Muath A Baniowda, Samia Abed, Basheer H Babaa, Abdurrahman Hamadah, Kamel A Gharaibeh","doi":"10.1155/2021/7195660","DOIUrl":"https://doi.org/10.1155/2021/7195660","url":null,"abstract":"Background: Hysteroscopic surgery is a minimally invasive procedure used to diagnose and treat intrauterine pathologies. It requires distension of the uterine cavity for the adequate visualization of the operative field. Glycine (1.5%) is one of the most commonly used solutions because it is nonconductive and also has good optical properties. However, acute hyponatremia is a critical complication that can develop after the absorption of a sufficient amount of the irrigation medium. Case Presentation. We report a case of a 43-year-old female patient who developed acute symptomatic hyponatremia (104 mEq/L) and pulmonary edema secondary to hysteroscopic resection of leiomyoma and hastily approached with rapid sodium correction measures.Conclusion: Multiple strategies can be taken to reduce the risk of fluid absorption and subsequent hyponatremia. Moreover, attention should be paid to the treatment approach for patients with acute hyponatremia following hysteroscopic procedures; rapid correction of acute hyponatremia for such patients might be safe, although there is no consensus in the literature, and further trials are needed.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"7195660"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39474885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion. 快速肾小球-肾小管肾炎是致死性地奎特摄入的初始表现。

Case Reports in Nephrology Pub Date : 2021-09-11 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4723092

Daniel Guck, Reynaldo Hernandez, Steven Moore, Andry Van de Louw, Philippe Haouzi

{"title":"Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion.","authors":"Daniel Guck, Reynaldo Hernandez, Steven Moore, Andry Van de Louw, Philippe Haouzi","doi":"10.1155/2021/4723092","DOIUrl":"https://doi.org/10.1155/2021/4723092","url":null,"abstract":"Introduction: Diquat is an herbicide that can lead to rapid multiorgan system failure upon toxic ingestion. Although Diquat shares a similar chemical structure with paraquat, diquat is still readily available to the general population, and in contrast to paraquat, it is not regulated. We present a case of an intentional diquat poisoning which emphasizes the necessity of the early recognition due to atypical symptoms within the first 24 hours and certainly enhanced regulatory restrictions on this very toxic compound.Case: A 60-year-old male with a history of severe depression presented to the emergency department after intentional ingestion of a commercial herbicide containing diquat dibromide 2.30%. The earliest manifestations of this acute diquat intoxication comprised a glomerulonephritis and proximal tubular dysfunction. Progressive multiorgan system failure then developed with a significant delay (24-38 hours) including acute renal, liver failure, and then respiratory failure with refractory hypoxemia. Despite maximal supportive care, the end organ failure was lethal. Discussion. Diquat intoxication should be suspected in patient presenting an acute glomerulonephritis with coma. Diquat should undergo the same regulatory restrictions as paraquat-containing compounds.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"4723092"},"PeriodicalIF":0.0,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39440285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Rare Case of Xanthogranulomatous Pyelonephritis with Spontaneous Renocolic Fistula and IVC Thrombosis. 黄色肉芽肿性肾盂肾炎合并自发性肾结肠瘘及静脉血栓1例。

Case Reports in Nephrology Pub Date : 2021-09-07 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3604017

Daniele Sforza, Leandro Siragusa, Matteo Ciancio Manuelli, Linda De Luca, Bruno Sensi, Simona Grande, Renato Argirò, Marco Nezzo, Massimo Villa, Michele Grande

{"title":"A Rare Case of Xanthogranulomatous Pyelonephritis with Spontaneous Renocolic Fistula and IVC Thrombosis.","authors":"Daniele Sforza, Leandro Siragusa, Matteo Ciancio Manuelli, Linda De Luca, Bruno Sensi, Simona Grande, Renato Argirò, Marco Nezzo, Massimo Villa, Michele Grande","doi":"10.1155/2021/3604017","DOIUrl":"https://doi.org/10.1155/2021/3604017","url":null,"abstract":"Xanthogranulomatous pyelonephritis (XGPN) is a rare disorder affecting the kidney which can fistulise to the colon in exceptional cases. We herein report a case of XGPN with renocolic fistula and large vessel thrombosis presenting with sepsis and pulmonary embolism. Preoperative diagnosis and strategic planning resulted in successful management. A 64-year-old woman presented to the emergency department with abdominal pain and a septic condition, corroborated by venous thromboembolism. Workup diagnosed a left renal abscess with calicocolic fistula. Scintigraphy confirmed a nonfunctioning left kidney. The patient underwent inferior vena cava filter placement and staged surgery. The first, damage control procedure was a loop ileostomy. Ten days later, when the patient's conditions improved, she underwent left nephrectomy and left colectomy with primary anastomosis. Finally, a year later, the ileostomy was closed. At follow-up, the patient was well, with unremarkable renal function. Scrupulous diagnostics, multidisciplinary decision making, and staged intervention have been key to optimal outcome.","PeriodicalId":9604,"journal":{"name":"Case Reports in Nephrology","volume":"2021 ","pages":"3604017"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39424104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Patiromer in Delaying the Onset of Renal Replacement Therapy in Patients with Advanced Renal Failure. 帕替洛尔在延缓晚期肾衰竭患者开始接受肾脏替代疗法方面的作用

Case Reports in Nephrology Pub Date : 2021-09-07 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6987456

Nand K Wadhwa, Jason A Kline, Sreedhar R Adapa

引用次数: 0

Renal Tubular Acidosis in the Postpartum Period: A Case Report and Literature Review. 产后肾小管酸中毒1例报告及文献复习。

Case Reports in Nephrology Pub Date : 2021-09-07 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6693013

Carlos E Duran, Mayra Estacio, Fredy Lozano, Esteban Echeverri, Maria Juliana Riascos, Juan Guillermo Posada, Johanna Schweineberg

引用次数: 1

COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis. COVID-19和apol1高危基因型相关塌陷性肾小球肾炎

Case Reports in Nephrology Pub Date : 2021-08-04 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3737751

Sasmit Roy, Srikanth Kunaparaju, Narayana Murty Koduri, Vikram Sangani, Mytri Pokal, Venu Madhav Konala, Mamtha Balla, Sreedhar Adapa

引用次数: 6

Acute Kidney Injury Secondary to Rhabdomyolysis and COVID-19: A Case Report and Literature Review. 横纹肌溶解和 COVID-19 引起的急性肾损伤：病例报告和文献综述

Case Reports in Nephrology Pub Date : 2021-08-02 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5528461

Vishaka K Chetram, Akram I Ahmad, Saira Farid, Tanuj Sood

引用次数: 0