Calcified Tissue International最新文献

{"title":"Geraniin Promotes Osteoblast Proliferation, Bone Formation, and Autophagy by Regulating the PI3K/Akt/mTOR Cascade to Improve Glucocorticoid-Induced Osteoporosis.","authors":"XueGang Liang, QianPeng Ma, LiJuan Wang, XianRui Xu, WenHui Jiang, Long Bao, Fei Liu","doi":"10.1007/s00223-025-01387-5","DOIUrl":"https://doi.org/10.1007/s00223-025-01387-5","url":null,"abstract":"<p><p>Geraniin is a plant natural product that has been testified to perfect osteoporosis (OP). However, Geraniin's impacts on osteoblast autophagy and its latent molecular mechanisms remain uncertain. In this study, Geraniin's impacts on autophagy in osteoblasts were figured out and its molecular mechanism was uncovered. We established in vivo and in vitro models of OP using glucocorticoids and administered Geraniin. The results manifested that Geraniin dose-dependently promoted the phosphorylation of PI3K/Akt/mTOR in OP rats and osteoblasts, increased the bone mineral density, bone surface area/bone volume, Trabecular number and trabecular bone thickness of rat femurs, enhanced alkaline phosphatase activity in OP rats and osteoblasts, elevated osteogenesis-linked proteins RUNX2, OSX and OCN, facilitated autophagosome formation in osteoblasts, elevated Beclin-1 and ACTG5 expression levels and LC3II/LC3I ratio and downregulated p62. However, these effects of Geraniin were attenuated by PI3K/Akt/mTOR inhibitors. All in all, the results of this study indicate Geraniin can perfect glucocorticoid-induced OP by motivating autophagy in osteoblasts through PI3K/Akt/mTOR cascade, which offers strong data support for the future development of Geraniin as a drug for OP cure.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"77"},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of a Body Shape Index with Bone Mineral Density and Osteoporosis Among U.S. Adults: Evidence from NHANES.","authors":"He-Gang Niu, Gao-Kai Hu, Tong Li, Zhao Guo, Yang Hu, Yu-Kang Gong, Gao-Qi Ye, De-Jin Chen, Ji-Long An, Wen-Shan Gao","doi":"10.1007/s00223-025-01386-6","DOIUrl":"https://doi.org/10.1007/s00223-025-01386-6","url":null,"abstract":"<p><p>Obesity significantly impacts bone health. The ABSI is an innovative metric for assessing obesity, offering greater accuracy than traditional measures such as body mass index and waist circumference in reflecting visceral fat accumulation. This study aims to investigate the relationship between ABSI and BMD as well as its association with osteoporosis among U.S. adults, utilizing data from the NHANES. This cross-sectional study analyzed data from adults aged 18 years and older, collected during the 2005-2006, 2013-2014, and 2017-2018 cycles of the NHANES. Multivariate linear regression models were used to evaluate the association between ABSI and BMD. Multivariate logistic regression models were applied to assess the relationship between ABSI and osteoporosis. Restricted cubic spline models were employed to evaluate potential nonlinear associations between ABSI and BMD as well as osteoporosis. Additionally, subgroup analyses and sensitivity analyses were conducted to ensure the robustness of the findings. A total of 5487 participants were included in the analysis, with a mean age of 47.04 years. ABSI was found to be negatively associated with BMD at the femoral neck, total femur, and lumbar spine. Participants in the highest ABSI quartile exhibited a significantly higher prevalence of osteoporosis compared to those in the lowest quartile (OR = 1.95; 95% CI 1.61-2.26). Nonlinear relationships were observed between ABSI and BMD at the femoral neck, total femur, lumbar spine, and osteoporosis, with inflection points at 8.84, 8.56, 9.23, and 8.14, respectively. Sensitivity analyses confirmed the robustness of these associations. Subgroup analyses revealed significant interactions between ABSI and BMD in smokers (P < 0.05). This study identifies a significant negative association between ABSI and BMD and a positive association with osteoporosis. The nonlinear relationship observed between ABSI and both BMD and osteoporosis underscores the importance of maintaining an optimal ABSI to promote bone health. These findings support the utility of ABSI as a valuable marker for early identification and prevention of osteoporosis, offering actionable insights for clinical and public health strategies. Future longitudinal research is warranted to validate these results and further elucidate the underlying mechanisms.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"76"},"PeriodicalIF":3.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Two Different Non-invasive Advanced Glycation End Products and Osteoporosis in the Non-diabetic Population: A Cross-Sectional Study.","authors":"Yu-Yi Tian, Lu-Lu Xu, Ya-Qian Fu, Shan Zhou, Chun Yue, Li Hu, Yan-Yi Yang, Yu-Qi Lu, Zhi-Feng Sheng, Li-Hong Liu","doi":"10.1007/s00223-025-01384-8","DOIUrl":"https://doi.org/10.1007/s00223-025-01384-8","url":null,"abstract":"<p><p>Advanced glycation end products (AGEs) are associated with osteoporosis (OP) in the diabetic population. However, their relationship with OP in the non-diabetic population remains unclear. This study aimed to investigate cross-sectional associations of AGEs levels in the skin and lens with OP in the non-diabetic population. A retrospective analysis of clinical data of 652 participants was conducted. Bone mineral density (BMD) was quantified by dual-energy X-ray absorptiometry. Lens and skin AGEs were assessed by lens and skin autofluorescence (LAF and SAF). This study included 652 individuals, 280 males (42.9%) and 372 females (57.1%), with a mean age of (55.5 ± 6.9) years. The population with osteopenia exhibited significantly higher levels of SAF-AGEs than those with normal BMD, while the population with OP had significantly higher levels of both SAF- and LAF-AGEs. After adjusting for age and body mass index, LAF-AGEs were negatively correlated with BMD at the femoral neck and total hip. In contrast, SAF-AGEs were negatively correlated with BMD at the lumbar1-4 spine. Furthermore, multiple linear stepwise regression analysis demonstrated that LAF-AGEs were negatively associated with BMD at both the femoral neck and total hip. However, SAF-AGEs showed no association with BMD at any of the three measured sites. Additionally, after adjusting for other covariates, the logistic regression analysis emphasized that LAF-AGEs were associated with OP in the non-diabetic population, but SAF-AGEs do not. The results revealed a significant correlation between LAF-AGEs and OP in the non-diabetic population and their potential clinical utility warrants further validation. Therefore, we urge for larger longitudinal analyses and experimental research to validate and extend these cross-sectional findings.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"75"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grading Pseudo Fractures.","authors":"Sudhaker D Rao","doi":"10.1007/s00223-025-01383-9","DOIUrl":"https://doi.org/10.1007/s00223-025-01383-9","url":null,"abstract":"","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"74"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition Care for Young Persons with Rare Bone Mineral Conditions: A Consensus Recommendation from the ECTS Rare Bone Disease Action Group.","authors":"Corinna Grasemann, Joline Wernsmann, Natasha M Appelman-Dijkstra, Chloe Morgan, Tenna Toft Sylvest, Adalbert Raimann, Heide Siggelkow, Willem F Lems, Serap Turan, M Carola Zillikens, Lena Lande Wekre, Inês Alves, M Cohen Solal, Maria P Yavropoulou, Gavin Clunie","doi":"10.1007/s00223-025-01382-w","DOIUrl":"https://doi.org/10.1007/s00223-025-01382-w","url":null,"abstract":"<p><p>Transition care (TC) is crucial for young persons with rare bone and mineral conditions (RBMCs) as they move from pediatric to adult healthcare. Effective TC prevents care disruptions and supports medical and psychosocial needs. However, gaps in communication, a shortage of adult RBMC specialists, and challenges in navigating adult healthcare necessitate standardized care. This study aimed to develop consensus-based recommendations for TC in RBMCs, focusing on best practices for seamless transition and patient empowerment. A two-round Delphi survey (September 2023-April 2024) was conducted among European RBMC experts, including 3 pediatric and 8 adult clinicians and 3 patient representatives from the European Calcified Tissue Society (ECTS). The panel formulated and refined statements through literature review and iterative scoring. Statements reaching ≥ 70% consensus were retained. A total of 81 statements were finalized across seven domains: initiation and planning, TC requirements, patient empowerment, organization and communication, service infrastructure and funding, and clinical care. Consensus was achieved on 64 out of 81 statements, with strong agreement on general and RBMC-specific recommendations. Key priorities included structured coordination among healthcare providers and a patient-centered approach that fosters self-advocacy and self-management. This Delphi consensus provides a structured framework for TC in young persons with RBMCs, emphasizing multidisciplinary care and patient empowerment. Future studies should assess the feasibility and impact of these guidelines across diverse healthcare systems.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"73"},"PeriodicalIF":3.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a Patient with Severe Osteogenesis Imperfecta Undergoing Laparoscopic Cholecystectomy.","authors":"Sarah Scott, Helen Jordan, Laura Gill, Andreas Luhmann, Jamie Abbott, Stuart H Ralston","doi":"10.1007/s00223-025-01375-9","DOIUrl":"10.1007/s00223-025-01375-9","url":null,"abstract":"<p><p>Individuals with severe osteogenesis imperfecta who require surgery often present a difficult management problem due to limb deformity and shortening, kyphoscoliosis, and deformity of the rib cage. All of these features may be associated with respiratory problems and impaired cardiovascular reserve. Surgical procedures and anaesthetic management represent a substantial challenge in these individuals. Here, we describe the clinical outcome of laparoscopic surgery to remove multiple gallstones in an individual with severe osteogenesis imperfecta. Meticulous pre-operative planning, combined with careful anaesthetic management resulted in a favourable outcome with a beneficial effect on quality of life. We provide a detailed account of the challenges faced and how these were surmounted in the hope that this may be of benefit to other clinicians faced with similar problems. Our experience demonstrates that laparoscopic surgery can be successfully performed in people with severe osteogenesis imperfecta with a favourable outcome.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"72"},"PeriodicalIF":3.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Markers of Inflammatory Status and Adiposity with Bone Phenotype at Age 60-64 Years: Findings from the MRC National Survey of Health and Development.","authors":"Ruth Durdin, Camille Pearse, Diana Kuh, Rachel Cooper, Elaine M Dennison, Cyrus Cooper, Kate A Ward","doi":"10.1007/s00223-025-01380-y","DOIUrl":"https://doi.org/10.1007/s00223-025-01380-y","url":null,"abstract":"<p><p>This study investigated associations between markers of inflammatory status and adiposity (interleukin-6 [IL-6], adiponectin and leptin) and measures of bone phenotype and fractures. The Medical Research Council (MRC) National Survey of Health and Development (NSHD) is a British birth cohort study. Participants (born during the same week in 1946) with complete data on DXA and pQCT parameters, markers of inflammatory status and adiposity, and potential confounders (498 men and 474 women) were included in cross-sectional analyses. At age 60-64 years, bone phenotype was assessed by DXA and pQCT. Fractures were self-reported at ages 60-64 and 68-70 years. Multiple linear regression was used to determine associations of IL-6, adiponectin and leptin with bone phenotype (adjusted for fat and lean mass and lifestyle confounders). Standard deviation (SD) differences in outcomes per SD increases in exposures were estimated. Higher IL-6 levels were associated with lower total volumetric bone mineral density (vBMD) (- 0.10[- 0.19, 0.00]) in men, and higher areal BMD (aBMD) at the spine (0.12[0.03, 0.22]) and whole body (0.11[0.01, 0.20]) in women. Higher levels of adiponectin were associated with lower aBMD and trabecular vBMD. In women, higher leptin levels were associated with higher cortical vBMD (0.11[0.02, 0.20]). Higher adiponectin was associated with moderately increased odds of having a fragility fracture during adulthood in women (OR 1.16 [95% CI 0.94, 1.43, p = 0.18]). Our results highlight non-mechanical associations between markers of inflammatory status and adiposity with BMD and, in women, fractures. Ensuring inflammaging is minimised may be important in healthy bone ageing.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"71"},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Variants and Bisphosphonates Treatment in Pregnancy and Lactation-Associated Osteoporosis (PLO): A Retrospective Study of 22 Chinese Patients.","authors":"Ziyao Fu, Xiaolin Ni, Sirui Han, Mei Li, Ou Wang, Xiaoping Xing, Yan Jiang, Weibo Xia","doi":"10.1007/s00223-025-01381-x","DOIUrl":"https://doi.org/10.1007/s00223-025-01381-x","url":null,"abstract":"<p><p>Pregnancy and lactation-associated osteoporosis (PLO) is a rare bone disorder with insufficient understanding on its pathogenesis and treatments. We retrospectively investigated 22 Chinese PLO patients diagnosed in our hospital. Whole exome sequencing was performed in 14 patients, and responses to bisphosphonates treatment were evaluated. The mean age of the patients was 30.8 ± 4.4 years. The mean number of vertebral fractures per patient was 4.0 ± 2.6. The bone mineral density (BMD) Z-scores were - 2.9 ± 0.9 at the lumbar spine (LS), - 1.7 ± 0.7 at the femoral neck, and - 1.8 ± 0.7 at the total hip. Trabecular bone score Z-score was - 2.2 ± 0.8. Genetic analysis identified relevant variants (RVs) in 11 of 14 patients, predominantly in LRP5, WNT1, and COL1A1/A2. Patients with RVs had significantly greater height loss (3.6 ± 2.1 cm vs. 0 cm, p = 0.028). All patients received bisphosphonate therapy, during which increases in BMD primarily at the LS were observed: 13.5 ± 8.8%, 17.8 ± 14.7%, 22.0 ± 17.0%, 27.0 ± 14.1% and 35.1 ± 18.5% at the 6-, 12-, 24-, 36-, and 48-month follow-ups. Patients with RVs demonstrated LS BMD percentage changes of 40.1 ± 22.1% (vs. no RVs group 26.2 ± 14.8%, p = 0.57) after 48-month follow-ups. In conclusion, our study highlights the significant clinical burden of PLO. Genetic RVs are prevalent in Chinese PLO patients. After bisphosphonate treatment, there is a significant increase in BMD, especially in LS. Patients with RVs have the potential of more robust therapeutic response.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"70"},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Serum Vitamin D with Sarcopenia in Patients with Chronic Liver Disease: A Population-Based Cross-Sectional Study.","authors":"Xinxing Tantai, Zhang Wen, Shuyue Tuo, Qiuju Ran, Chan Li, Yong Li, Jia Yuan, Jinhai Wang, Lu Li, Shejiao Dai","doi":"10.1007/s00223-025-01376-8","DOIUrl":"https://doi.org/10.1007/s00223-025-01376-8","url":null,"abstract":"<p><p>The association between vitamin D and sarcopenia in patients with chronic liver disease (CLD) has yet to be conclusively established, particularly in Western populations. We investigated the association between serum 25(OH)D levels and sarcopenia in adult CLD patients in the USA. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey III. Weighted logistic regression was used to determine the association between sarcopenia and serum 25(OH)D in participants with CLD. CLD was defined as chronic hepatitis B or C, non-alcoholic fatty liver disease, alcohol-related liver disease, and other liver diseases. A serum 25(OH)D level of less than 75 nmol/L was defined as vitamin D insufficiency. This study included 1402 participants with CLD. The serum 25(OH)D concentration was significantly lower in the sarcopenia group (45.3 nmol/l) compared to the non-sarcopenia group (50.6 nmol/l). The prevalence of vitamin D insufficiency was as high as 91.3% in participants with CLD, and the proportion of vitamin D insufficiency was higher in those with sarcopenia. In the full multivariate model, each 10-nmol/L increase in 25(OH)D concentration was significantly associated with a decreased risk of sarcopenia (OR 0.89; 95%CI 0.79-0.99). Conversely, participants with insufficient vitamin D levels had a significantly increased risk of sarcopenia (OR, 2.07; 95% CI 1.08-4.00). Subgroup analyses suggested a sex difference in the association between vitamin D levels and sarcopenia, with a significant association only observed in females. Restricted cubic spline curves indicated a linear inverse association between serum 25(OH)D concentration and risk of sarcopenia in all participants and in females. Low serum 25(OH)D levels were significantly associated with an increased risk of sarcopenia in individuals with CLD, with the observed gender differences in this association warranting further validation in future studies.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"69"},"PeriodicalIF":3.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Standardised Dataset for Natural History Studies in Fibrous Dysplasia/McCune-Albright Syndrome.","authors":"Ana Luisa Priego Zurita, Oana O Bulaicon, Jillian Bryce, Nerea Arrieta, Magdalena Caballero Campos, Mariya Cherenko, Gaby Doxiadis, Corinna Grasemann, M Kassim Javaid, Helen McDevitt, Stijn W van der Meeren, Diana Ovejero Crespo, Luisa de Sanctis, Lothar Seefried, Annemarie A Verrijn Stuart, Daniele Tessaris, Pieter Bas de Witte, Roland Chapurlat, S Faisal Ahmed, Natasha M Appelman-Dijkstra","doi":"10.1007/s00223-025-01379-5","DOIUrl":"https://doi.org/10.1007/s00223-025-01379-5","url":null,"abstract":"<p><p>Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare and complex condition caused by somatic variants in the GNAS gene that lead to a wide clinical spectrum. The diagnostic process and therapeutic pathway vary per centre and therefore international harmonisation of data collection should be pursued. To understand the diagnostic pathways and clinical outcomes of patients with FD/MAS reported on an electronic-reporting tool (e-REC) across European centres to guide the develop a condition-specific module within the European Registries for Rare Endocrine and Bone conditions. Centres that reported new cases on e-REC between October 2019 and May 2021 were approached to complete a survey in May 2021. Fifty-eight cases were included. Median age at presentation was 20 years (range, 0, 72). Of the 58 included cases, the presentation type was isolated craniofacial FD in 19 (33%), monostotic FD in 15 (26%), polyostotic FD in 10 (17%), and MAS in 13 (13%). Standardised questionnaires to assess pain and quality of life were used routinely in 21/58 patients (36%). The majority of patients had more than one healthcare provider, with great diversity in the specialty of the coordinating physician. A standardised dataset module for FD/MAS was developed through collaboration with the FD/MAS study group, incorporating expert consensus and clinical insights. Key variables were identified to capture essential diagnostic, clinical, and patient-reported outcomes. The diagnostic path for patients with FD/MAS across European expert centres is variable. The outcomes of this study allowed the building of the first international FD/MAS-specific data collection.</p>","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"116 1","pages":"68"},"PeriodicalIF":3.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}