Lower Limb Bone Mineral Density Reduction is Closely Relative With Diabetic Peripheral Neuropathy in the Postmenopausal Women and Men Over 50 Years Old With T2DM: A cross-Sectional, Controlled Study.

Abstract

A cross-sectional, controlled study was designed to investigate the relationship between BMD at different sites and DPN in patients with type 2 diabetes mellitus (T2DM). Nerve conduction parameters and BMD of different sites were measured. Pearson's correlation analysis and receiver operating characteristic (ROC) analysis were performed to examine the relationship between BMD at different sites and DPN. The proportion of osteoporosis (OP) in the DPN group was higher compared to the non-DPN group (p < 0.05). The Z/T scores of femoral neck and hip joint BMD were lower in the DPN group (all p < 0.05). Sensory nerve amplitude, sensory nerve conduction velocity, and motor nerve amplitude were significantly lower in the osteoporosis group and positively correlated with the T scores of femoral neck and hip joint BMD in postmenopausal women and men over 50 years old with T2DM. ROC analysis revealed the following cutoff points for T2DM duration combined with femoral neck/hip joint BMD T scores to predict DPN in postmenopausal women and men over 50 years old with T2DM: (duration: 8 years, femoral neck T score: - 1.6; AUC = 0.64; 95% CI 0.60-0.68; sensitivity: 64.2%; specificity: 52.9%, p < 0.001) and (duration: 8 years, hip joint T score: - 1.6; AUC = 0.64; 95% CI 0.61-0.68; sensitivity: 60.8%; specificity: 56.0%, p < 0.001). A significant association was observed between reduced lower limb BMD and DPN in the postmenopausal women and men over 50 years old with T2DM.