Feasibility of 100 kV Low-voltage Bone Mineral Density Measurement with Quantitative CT: Phantom and Clinical Research.

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yali Li, Dan Jin, Yan Zhang, Mengze Zhang, Zhen Qian, Chenyu Jiang, Ming Ni, Suwei Liu, Huishu Yuan
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Abstract

To investigate the feasibility and accuracy of 100 kV low-voltage quantitative CT (QCT) for bone mineral density (BMD) measurement using the European Spine Phantom and patients. The accuracy and precision of the BMD measurements were assessed using relative measurement error (RME%), coefficient of variation (CV%), root mean square standard deviation (RMS-SD), and root mean square CV (RMS-%CV). Linear regression and Bland‒Altman analyses were used to assess the agreement between 100 and 120 kV QCT-based BMD measurements. The diagnostic performance of 100 kV QCT for osteoporosis was evaluated using receiver operating characteristic curve analysis. For the ESP, the mean BMD values at 100 kV were slightly greater than those at 120 kV, mainly due to small inaccuracies remaining in the BMD calibration process. The RME% values for all vertebrae were -3.31 to 15.00% at 100 kV and -9.34 to 3.06% at 120 kV, falling within ± 10% at 120 kV but within 0‒15% at 100 kV. The CV% and RMS-%CV values decreased as the BMD increased with increasing tube voltage, while the RMS-SD exhibited a decreasing trend. For patients, linear regression and Bland‒Altman analyses revealed good agreement between 120 and 100 kV (R2 = 0.987, P < 0.001; mean error, -3.39 mg/cm3; 95% limits of agreement, -16.49 to 9.71 mg/cm3). The 100 kV QCT achieved high accuracy in diagnosing osteoporosis (AUC = 0.992, P < 0.001), with a sensitivity of 99.04% and a specificity of 94.28%. 100 kV low-voltage QCT demonstrated acceptable accuracy and good reproducibility for measuring BMD, opening the possibility of 100 kV low-voltage chest CT obtained for lung cancer screening for opportunistic osteoporosis screening.

100kv低压骨矿物质密度定量CT测量的可行性:幻影及临床研究。
目的:探讨100kv低压定量CT (QCT)测量骨矿物质密度(BMD)的可行性和准确性。采用相对测量误差(RME%)、变异系数(CV%)、均方根标准差(RMS- sd)和均方根CV (RMS-%CV)评价骨密度测量的准确性和精密度。使用线性回归和Bland-Altman分析来评估100和120 kV基于qct的BMD测量之间的一致性。采用受试者工作特征曲线分析评价100kv QCT对骨质疏松症的诊断价值。对于ESP, 100 kV的平均BMD值略大于120 kV,主要是由于BMD校准过程中存在较小的误差。所有椎骨的RME%值在100 kV时为-3.31 ~ 15.00%,在120 kV时为-9.34 ~ 3.06%,在120 kV时为±10%,在100 kV时为0 ~ 15%。CV%和RMS-%CV值随着管电压的增加而降低,而RMS- sd值呈下降趋势。对于患者,线性回归和Bland-Altman分析显示120和100 kV之间的一致性很好(R2 = 0.987, p3;95%一致限为-16.49 ~ 9.71 mg/cm3)。100 kV QCT对骨质疏松症的诊断准确率较高(AUC = 0.992, P
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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