Cancer Therapy & Oncology International Journal最新文献_第9页

Metastatic Spinal Cord Compression: A Prospective Observational Study at a Tertiary Care Center of North India 转移性脊髓压迫:印度北部三级保健中心的前瞻性观察研究

Cancer Therapy & Oncology International Journal Pub Date : 2019-07-15 DOI: 10.19080/ctoij.2019.14.555888

Pawan Kumar

{"title":"Metastatic Spinal Cord Compression: A Prospective Observational Study at a Tertiary Care Center of North India","authors":"Pawan Kumar","doi":"10.19080/ctoij.2019.14.555888","DOIUrl":"https://doi.org/10.19080/ctoij.2019.14.555888","url":null,"abstract":"Introduction: Metastatic spinal cord compression (MSCC) is a most commonly encountered emergency in oncology, that can lead to permanent paraplegia if left untreated or treatment delayed, so it is essential to diagnose early and treat aggressively to preserve or improve the patient’s quality of life. We analyzed the incident and the effect of common interventions on the outcome in these patients. Material and Methods: We prospectively evaluated 80 patients of MSCC without any intervention in the year 2017 and collected all relevant patient and disease characteristics. All patients received corticosteroids. Seven patients were operated, 59 patients treated by radiotherapy and 3 patients were treated by surgery followed by radiotherapy. Results: Most of the patients were in the age group of 40-70 years with male gender preponderance. Lung cancer was the most common incident (46.25%) malignancy followed by breast, myeloma and prostate cancer. Dorsal spine was the most common site of compression (50.5%) followed by lumbar spine (40.8%) and cervical spine (8.7%). 62 (77.5%) patients were presented with pain at affected site and 60 (75%) were presented with neurological motor deficit. 54 (87%) patients got relieved from pain and only 23(38%) patients had motor improvement after treatment. Conclusion: Patients presented 7-10 days after onset of neurological deficit were associated with poor outcome in neurological function, but radiotherapy proved an important modality for pain relief in MSCC and also beneficial in motor function preservation if instituted early. before predictive of response to treatment and overall outcome of motor functions.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80253605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apoptosis Caused by Natural Compounds in Cervical Cancer Cell Line 天然化合物对宫颈癌细胞凋亡的影响

Cancer Therapy & Oncology International Journal Pub Date : 2019-07-10 DOI: 10.19080/ctoij.2019.14.555886

A. kumar Jha

{"title":"Apoptosis Caused by Natural Compounds in Cervical Cancer Cell Line","authors":"A. kumar Jha","doi":"10.19080/ctoij.2019.14.555886","DOIUrl":"https://doi.org/10.19080/ctoij.2019.14.555886","url":null,"abstract":"Cancer is a type of disease that spreads due to uncontrolled of cell growth due to the collection of defects or variation in their DNA and with imminence to attack or distribute to other parts of the body. Cancer is specified as a wide group of several infections normally characterized by persistently uncontrolled and unnatural at usual cell yield, where cell proliferation comes via mitotic deregulations and thus contributes to overgrowth of cancerous cells. In the case of malignancy, these cells may transmigrate from one body parts to other in the form of tumors and metastasis in blood stream sand lymphatic system (Ochwang et al., 2015 and Srivatava et al., 2015). Various studies have demonstrated that the cancer danger at the level of particular organs is due to exposure to particular environmental chemicals, biological factors (as Human Papilloma virus, Helicobacter hepticus, HIV1, HBV) or physical factors (such as X-radiation, gamma radiation) (Zulkipli et al., 2015). Research proposes that most malignancies are caused by a dysfunction of multiple genes coding for macromolecules like as growth factors, growth factor receptors, anti-apoptotic proteins, transcription factors, and tumor suppressors, all of which establish the aim for disease treatment (Cogliano et al., 2011 and Vogelstein et al., 2004).","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83260384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Tolerance of Extended Field Radiation Therapy in Uterine Cervical Cancer Patients with Para-Aortic Lymph Node Metastasis 扩大野放疗在宫颈癌主动脉旁淋巴结转移患者中的疗效和耐受性

Cancer Therapy & Oncology International Journal Pub Date : 2019-07-08 DOI: 10.19080/ctoij.2019.14.555885

Meenu Gupta

{"title":"Efficacy and Tolerance of Extended Field Radiation Therapy in Uterine Cervical Cancer Patients with Para-Aortic Lymph Node Metastasis","authors":"Meenu Gupta","doi":"10.19080/ctoij.2019.14.555885","DOIUrl":"https://doi.org/10.19080/ctoij.2019.14.555885","url":null,"abstract":"Aim: To determine the response and toxicity of extended field radiation therapy and concurrent chemotherapy on uterine cervical cancer patients with para - aortic lymph node metastasis. Methods: Forty patients with cervical cancer with para -aortic lymphadenopathy metastasis were treated by photons on LINAC with extended field radiotherapy (46-50Gy/23-25#) along with weekly concurrent cisplatin (35mg/m2) followed by 3 sessions of weekly intracavitory brachytherapy (7Gy per session by HDR Ir-192) at our institution. The primary endpoint was to assess efficacy in terms of response to the treatment. The secondary endpoint was to assess tolerance of treatment in terms of toxicities (hematological and non-hematological). Results: Complete clinical response in pelvis and para-aortic disease were observed in 28(70%) and 27(67.5%) patients. Partial clinical response in pelvis and para-aortic disease were observed in 11(27.5%) and 12(30%) of patients. One patient did not respond to the treatment and had progression of disease. Anemia grade 1-2 was seen in 22(55%) patients. Neutropenia grade 1-2 was seen in 10(25%) of patients. Thrombocytopenia grade 1 was seen in only 2(5%) of patients. None of the patient had grade 4 hematological","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89498502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology & Management of Anemia in Cancer Patients: A Systematic Review Nanda 肿瘤患者贫血的病理生理及治疗:系统综述

Cancer Therapy & Oncology International Journal Pub Date : 2019-06-27 DOI: 10.19080/ctoij.2019.14.555884

Biplab Misra

引用次数: 0

Metal Complexes in Medicine: An Overview and Update from Drug Design Perspective 金属配合物在医学上的应用:从药物设计的角度综述与更新

Cancer Therapy & Oncology International Journal Pub Date : 2019-06-17 DOI: 10.19080/ctoij.2019.14.555883

Ravinderpal Kour Sodhi

引用次数: 38

Prophylactic Para-Aortic Nodal Irradiation in Carcinoma Cervix: To Do or Not to Do? 预防宫颈癌主动脉旁淋巴结放射治疗:该做还是不该做?

Cancer Therapy & Oncology International Journal Pub Date : 2019-06-13 DOI: 10.19080/ctoij.2019.14.555881

K. Sood

引用次数: 0

“A Rare Case Report: Carcinoma Esophagus in 12-year-old Girl with Unknown Etiology” 12岁女童食管癌1例罕见病例，病因不明

Cancer Therapy & Oncology International Journal Pub Date : 2019-06-13 DOI: 10.19080/ctoij.2019.14.555882

Pawan Kumar

引用次数: 2

Apocrine Breast Carcinoma Histopathological Characteristics 大汗腺乳腺癌的组织病理学特征

Cancer Therapy & Oncology International Journal Pub Date : 2019-06-11 DOI: 10.19080/CTOIJ.2019.14.555880

M. Budzik

{"title":"Apocrine Breast Carcinoma Histopathological Characteristics","authors":"M. Budzik","doi":"10.19080/CTOIJ.2019.14.555880","DOIUrl":"https://doi.org/10.19080/CTOIJ.2019.14.555880","url":null,"abstract":"Introduction: Apocrine carcinoma (AC) is a distinctive and rare type of malignancy, counted to 0.3-4% of all breast cancer cases. It does not have a particular clinical or radiological feature, although it is characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile. Material and Methods: Studied material came from biopsies, excisional biopsies and modified radical mastectomies. Examined samples were stained with standard methods including hematoxylin and eosin. To determine the immunohistochemical expression of ER, PR and HER2 receptors appropriate antibodies were used. Results: Among 1,222 patients with breast cancer only 5 of them were diagnosed with apocrine carcinoma (0.4%). All of them were above 50 years old (51-63, mean: 57). Tumor size varied from 1.4 cm to 3.8 cm with a mean size 2.4 cm, while mean size in all 1,222 studied cases counted for 1.9cm. 2 tumors were classified as high-grade (G3), 1 as G2 and 1 as G2. 4 out of 5 tumors did not affect lymph nodes (N0 stage), whereas 1 sample was classified as N2 with 9/19 affected nodes. This observation was consistent with the whole studied group, in which N0 stage made up the largest percentage. Discussion: Presented results suggest that AC is less frequent in premenopausal patients. AC tends to present as noninvasive without nodal involvement and its biological behavior is less aggressive. Due to the fact that AC is definitely rare type of breast cancer, modern medicine has still limited options to offer for its treatment. Further research needs to be conducted in order to develop target therapies for this carcinoma.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83754999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Some Trace Element Contents and Ratios in Prostatic Fluid as Ancillary Diagnostic Tools in Distinguishing Between the Benign Prostatic Hyperplasia and Prostate Cancer 前列腺液中微量元素含量及比值作为鉴别前列腺增生与前列腺癌的辅助诊断工具

Cancer Therapy & Oncology International Journal Pub Date : 2019-06-10 DOI: 10.19080/ctoij.2019.14.555879

V. Zaichick

引用次数: 1

Chemotherapeutic Management of Hemangiosarcoma in Canines – An Update 犬血管肉瘤的化疗治疗-最新进展

Cancer Therapy & Oncology International Journal Pub Date : 2019-05-30 DOI: 10.19080/ctoij.2019.14.555878

K. Sharun

引用次数: 1