Apoptosis Caused by Natural Compounds in Cervical Cancer Cell Line

Abstract

Cancer is a type of disease that spreads due to uncontrolled of cell growth due to the collection of defects or variation in their DNA and with imminence to attack or distribute to other parts of the body. Cancer is specified as a wide group of several infections normally characterized by persistently uncontrolled and unnatural at usual cell yield, where cell proliferation comes via mitotic deregulations and thus contributes to overgrowth of cancerous cells. In the case of malignancy, these cells may transmigrate from one body parts to other in the form of tumors and metastasis in blood stream sand lymphatic system (Ochwang et al., 2015 and Srivatava et al., 2015). Various studies have demonstrated that the cancer danger at the level of particular organs is due to exposure to particular environmental chemicals, biological factors (as Human Papilloma virus, Helicobacter hepticus, HIV1, HBV) or physical factors (such as X-radiation, gamma radiation) (Zulkipli et al., 2015). Research proposes that most malignancies are caused by a dysfunction of multiple genes coding for macromolecules like as growth factors, growth factor receptors, anti-apoptotic proteins, transcription factors, and tumor suppressors, all of which establish the aim for disease treatment (Cogliano et al., 2011 and Vogelstein et al., 2004).