Canadian Journal of Diabetes最新文献

{"title":"Investigating Beliefs Toward Physical Activity in Pregnancy Among Women With and Without Gestational Diabetes Mellitus","authors":"Sophie Pellerin BSc,&nbsp;Stéphanie Girard PhD,&nbsp;Pier-Olivier Caron PhD,&nbsp;Jean Lemoyne PhD,&nbsp;Laurence Simard MSc,&nbsp;Véronique Babineau MD,&nbsp;Jean-Patrice Baillargeon MD,&nbsp;S. John Weisnagel MD,&nbsp;Evelyne Rey MD,&nbsp;Stephanie-May Ruchat PhD","doi":"10.1016/j.jcjd.2026.03.007","DOIUrl":"10.1016/j.jcjd.2026.03.007","url":null,"abstract":"<div><h3>Objectives</h3><div>Physical activity (PA) is beneficial for pregnant women, including those who develop gestational diabetes mellitus (GDM). However, only a few are sufficiently active to reap health benefits. In this prospective cohort study we aimed to: 1) validate the Theory of Planned Behaviour (TPB) model for predicting moderate-to-vigorous PA (MVPA) among pregnant women; 2) examine whether the model varies by GDM status (with or without GDM); and 3) identify beliefs predicting intention toward MVPA and assess whether these beliefs differ by GDM status.</div></div><div><h3>Methods</h3><div>Women with and without GDM completed 2 questionnaires: the first assessed TPB constructs; the second, completed 2 to 4 weeks later, assessed MVPA behaviour. Structural equation modelling and multigroup analyses were conducted.</div></div><div><h3>Results</h3><div>The sample included 191 women without and 149 with GDM. The main results show that perceived behavioural control (PBC) was a significant moderator of the relationship between intention toward MVPA and the behaviour, the relationship being stronger when PBC was moderate to high. Some beliefs that indirectly predicted the intention toward MVPA varied between women with and without GDM. For example, in women with GDM, higher intention was found in those believing that MVPA would unlikely cause discomfort or pain related to pregnancy (β=0.289, p&lt;0.001), that their health professionals would approve MVPA practice (β=0.149, p=0.023), and that even if they lack time (β=0.282, p&lt;0.001) or are tired (β=0.185, p=0.008), they would practice MVPA.</div></div><div><h3>Conclusions</h3><div>Our results highlight the importance of pregnant women’s confidence in their ability to be active and of targeting specific beliefs when designing interventions promoting prenatal PA.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 5","pages":"Pages 318-328.e1"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Circulating Vitamin C Concentrations and Risk of Diabetes Mellitus: Dual Evidence From NHANES Database and Mendelian Randomization Analysis","authors":"Masashi Hasebe MD,&nbsp;Chen-Yang Su MSc","doi":"10.1016/j.jcjd.2025.06.005","DOIUrl":"10.1016/j.jcjd.2025.06.005","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 5","pages":"Pages 369-370"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Combination Therapy vs Stepwise Escalation in Newly Diagnosed Type 2 Diabetes: A Systematic Review and Meta-analysis of Multiple Clinical Outcomes","authors":"Naseem Eisa MD,&nbsp;Omar Barood MD","doi":"10.1016/j.jcjd.2026.02.002","DOIUrl":"10.1016/j.jcjd.2026.02.002","url":null,"abstract":"<div><div>Our aim in this study was to evaluate efficacy, durability, and safety of early combination therapy compared with stepwise escalation in newly diagnosed type 2 diabetes. We searched PubMed, Cochrane Central Register of Controlled Trials, and Embase through November 2025 for trials comparing early combination therapy with stepwise escalation in treatment-naive patients. Outcomes included A1C reduction, time to treatment failure, beta-cell function, hypoglycemia, weight change, cardiovascular risk markers, and hepatic outcomes. The random-effects meta-analysis used the inverse variance method. Eleven studies (24,364 participants) were included. Early combination therapy achieved greater glycated hemoglobin reduction vs stepwise escalation (mean difference −0.49%, 95% confidence interval −0.53 to −0.45, p&lt;0.001) and nearly doubled time to treatment failure (61.9 vs 36.1 months; hazard ratio 0.51, p&lt;0.0001). Beta-cell function was preserved for 3.5 years with early combination therapy, as compared with a progressive decline with stepwise therapy. Early combination therapy demonstrated a 7.5-fold lower incidence of hypoglycemia, favourable effects on weight (5.3-kg difference), reduced carotid atherosclerosis progression, improved blood pressure and lipid profiles, and reduced hepatic fat accumulation. Early combination therapy is superior to stepwise escalation in glycemic management, durability, beta-cell preservation, safety, and cardiovascular risk reduction, thereby supporting disease modification rather than merely symptomatic control.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 5","pages":"Pages 337-344"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Hypertension Treatment and Control in Canadians With Diabetes","authors":"Krishna Jaipal MBBS,&nbsp;Sanjana Bebu Punshi MBBS,&nbsp;Mehak Kumari Bansari MBBS","doi":"10.1016/j.jcjd.2025.06.004","DOIUrl":"10.1016/j.jcjd.2025.06.004","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Page 286"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eAlert_col_8_1-8x10_7-8.pdf","authors":"","doi":"10.1016/S1499-2671(26)00141-3","DOIUrl":"10.1016/S1499-2671(26)00141-3","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Page A4"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148559832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Patient Partner Engagement and Integration in Research: Recommendations From a Qualitative Study of Focus Groups With Patient Partners Living With Type 1 or Type 2 Diabetes","authors":"Isabella Herrington BSc,&nbsp;Rathini Sivasubramaniam MSc,&nbsp;Krystle Amog PhD(c),&nbsp;Julie Makarski MSc(c),&nbsp;Michelle Murray MAP,&nbsp;Aunima Bhuiya PhD(c),&nbsp;Alexa Gruber BSc,&nbsp;Pascual Delgado,&nbsp;Dana Greenberg,&nbsp;Rebecca Ganann PhD,&nbsp;Linxi Mytkolli MSc,&nbsp;Maman Joyce Dogba PhD,&nbsp;Holly O. Witteman PhD,&nbsp;Tracy McQuire MSc,&nbsp;Monika Kastner PhD","doi":"10.1016/j.jcjd.2025.12.002","DOIUrl":"10.1016/j.jcjd.2025.12.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Diabetes is a global health emergency, affecting more than 420 million people worldwide, but care gaps persist. Patient engagement (PE) in research may address these gaps, but meaningful engagement with representative populations of diverse race, language, and socioeconomic status is lacking. Power imbalances and tokenistic engagement are common. Our aim in this study was to understand what diverse patient partners (PPs) who live with diabetes need to participate in research and <em>how</em> to integrate and engage them meaningfully.</div></div><div><h3>Methods</h3><div>A purposive sampling strategy was used to recruit PPs from the Diabetes Action Canada (DAC) research network. A semistructured focus group guide was used to conduct focus group sessions. Sessions were audio-recorded and transcribed verbatim. Data analysis and synthesis involved Braun and Clarke’s reflexive thematic analysis to develop patterned meanings across the data set.</div></div><div><h3>Results</h3><div>Thirty-five PPs participated in 13 focus groups (9 English, 4 French). PPs had a mean age of 55 years, were living with type 2 (46%) or type 1 (37%) diabetes, identified as female/woman (77%), and resided in Ontario (47%) or Québec (40%); 34% identified as racialized. Themes were developed across 3 broad domains: 1) enablers; 2) opportunities for improvement (challenges and recommendations); and 3) diabetes-specific considerations, highlighting distinct challenges and enablers related to participants’ lived experiences with diabetes. We used these data to codesign research-stage–specific recommendations to optimize patient integration and engagement in research.</div></div><div><h3>Conclusions</h3><div>Our focus group study identified enablers and opportunities for improvement to integrate PP perspectives into the DAC research network more meaningfully.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Pages 195-216.e1"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Biological Sex on Physical Function After 16-Week Elastic-band Resistance Training Along With Diabetes Education in Older Men and Women With Type 2 Diabetes Mellitus and Frailty","authors":"Quinn R. Eberts BDKin,&nbsp;Amy M. Thomson MScKin,&nbsp;Logan E. Peskett BScKin,&nbsp;Isaac C. Cull MScKin,&nbsp;Danielle R. Bouchard PhD,&nbsp;Martin Sénéchal PhD","doi":"10.1016/j.jcjd.2026.02.005","DOIUrl":"10.1016/j.jcjd.2026.02.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Older adults living with type 2 diabetes mellitus (T2DM) and frailty have greater physical function impairment than those with either condition alone. Women have disproportionately worse outcomes, including reduced physical function, higher glycated hemoglobin (A1C), and greater frailty. However, little is known about sex effects on physical function after elastic-band training with diabetes education. In this study we aimed to determine how sex influences physical function after 16-week elastic-band resistance training combined with T2DM education in older adults living with T2DM and frailty.</div></div><div><h3>Methods</h3><div>Participants (n=182) included in the Band-Frail program were: 1) ≥65 years of age; 2) living with T2DM or with an A1C ≥6.5%; and 3) were at least pre-frail based on the Fried Frailty Scale. The intervention was a 16-week elastic-band resistance training twice per week and T2DM education once per week. The primary outcome was physical function (Short Physical Performance Battery: score 0 to 12), with secondary outcomes of A1C, and frailty score (1 to 5).</div></div><div><h3>Results</h3><div>Intention-to-treat assessment revealed significant changes for physical function (β=0.83, 95% confidence interval [CI] 0.28% to 1.37%; p=0.004), A1C (β=−0.28, 95% CI −0.53% to −0.03%; p=0.03), and frailty (β=−0.49, 95% CI −0.73% to −0.24%; p&lt;0.01). A significant time × sex interaction (β=0.70, 95% CI 0.07% to 1.33%; p=0.028) was observed for physical function, with women improving by 0.70 point more than men after completion of the 16-week intervention.</div></div><div><h3>Conclusions</h3><div>Biological sex impacts the change in physical function after a 16-week elastic-band resistance training program and T2DM education in older adults living with T2DM and frailty.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Pages 266-275.e1"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future Directions for Diabetic Foot Ulcer Interventions: A Scoping Review of Continuous Glucose Monitoring–based Telemedicine","authors":"Clara Bender PhD,&nbsp;Peter Vestergaard MD, PhD,&nbsp;Simon Lebech Cichosz PhD","doi":"10.1016/j.jcjd.2026.01.008","DOIUrl":"10.1016/j.jcjd.2026.01.008","url":null,"abstract":"<div><h3>Objectives</h3><div>Nonadherence to diabetes treatment leads to persistent hyperglycemia, a key driver of nonhealing diabetic foot ulcers (DFUs). Continuous glucose monitoring (CGM) and telemedicine have independently improved glycemic management, glycated hemoglobin levels, and time in range. In this study we review the various components of telemedicine and CGM to gain insight that could contribute to future directions for enhancing DFU interventions.</div></div><div><h3>Methods</h3><div>A scoping review was conducted through searches involving PubMed, Embase, CINAHL, and Scopus.</div></div><div><h3>Results</h3><div>Sixteen studies were included in this review. Overall, 3 main implication areas, the first one with subdivisions, were identified: 1) Components in a remote treatment package, subdivided by a) The telemedicine term, b) The specialized health-care professional, c) Monitoring health data, and d) Supervision and feedback on monitored data; 2) Improved glycemic management with remote treatment; and 3) Future directions for DFU interventions.</div></div><div><h3>Conclusions</h3><div>Selected components of telemedicine and CGM may be used in future DFU interventions, but they need to be tested in a future feasibility study.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Pages 276-283"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the Basal Insulin Treatment Preferences of People Living in Canada With Type 2 Diabetes When Glycemic Management and Cost Are Held Constant: A Discrete Choice Experiment","authors":"Pam Hallworth BSc,&nbsp;Sophi Tatlock MA,&nbsp;Sophie Wallace BSc,&nbsp;Elizabeth Tute MSc,&nbsp;Bethany Bell BSc,&nbsp;Godfrey Mau BScPHM,&nbsp;Elisabeth de Laguiche MSc","doi":"10.1016/j.jcjd.2026.01.006","DOIUrl":"10.1016/j.jcjd.2026.01.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Basal insulin treatments have historically been administered once daily (OD) or twice daily (BD). Once weekly (OW) treatments are now available. In this study we aimed to quantify the relative importance of frequency of administration in basal insulin treatment preferences of Canadians living with type 2 diabetes (T2D) when glycemic management and cost are held constant, using a discrete choice experiment (DCE).</div></div><div><h3>Methods</h3><div>A targeted literature review and qualitative interviews informed the development of an attributes-and-levels grid. Pilot interviews assessed survey feasibility. Hierarchical Bayesian estimation was used to identify the relative importance of each attribute.</div></div><div><h3>Results</h3><div>The DCE survey was completed by 155 participants across 3 treatment experience categories: basal insulin naïve but injectable glucagon-like peptide-1 receptor agonist (GLP-1 RA) experienced (n=55); basal insulin experienced (n=53); and basal insulin and injectable GLP-1 RA naïve (n=47). Frequency of administration had a relative importance of 41% (confidence interval 38% to 45%), more than double any other attribute tested in this study. A preference for OW administration was observed relative to OD or BD. A reduction in the frequency of missing doses and taking doses at the prescribed time were considered the most positive impacts of OW administration.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the importance of frequency of administration in basal insulin treatment decisions when glycemic management and cost are held constant. Using prespecified conditions, participants indicated a preference for OW dosing, making trade-offs between treatment risks and convenience. Findings have implications for health-care decision-makers in ensuring patient preferences are considered in treatment decisions.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Pages 224-233.e4"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucocalyxin B Attenuates Diabetic Cardiomyopathy by Suppressing the NLRP3 Inflammasome and Restoring Gut Microbiota Homeostasis","authors":"Xinxin Zhang MD,&nbsp;Jingping Wu MD","doi":"10.1016/j.jcjd.2026.02.001","DOIUrl":"10.1016/j.jcjd.2026.02.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Glaucocalyxin B (GLB) has documented anti-inflammatory activity in several disease contexts; however, its role in diabetic cardiomyopathy (DCM)-associated inflammatory injury remains insufficiently defined. In this study we aimed to evaluate whether GLB alleviates myocardial inflammation and injury in DCM and to explore the underlying mechanisms.</div></div><div><h3>Methods</h3><div>We combined network pharmacology with experimental validation using a streptozotocin-induced diabetic rat model (8-week protocol) and high-glucose–challenged H9c2 rat cardiomyocytes. Oxidative stress–related indices (e.g. reactive oxygen species [ROS] and malondialdehyde [MDA]) and antioxidant capacity were assessed in vivo and in vitro. Gut microbiota composition was profiled by 16S rRNA sequencing. Activation of inflammatory signalling was evaluated with a focus on the nuclear factor-kappaB/NOD-like receptor pyrin domain–containing 3 (NFκB/NLRP3) axis.</div></div><div><h3>Results</h3><div>Network pharmacology suggested that GLB targets were enriched in pathways related to cardiomyocyte regulation and DCM-associated processes, including inflammation, apoptosis, and oxidative stress responses. In both diabetic rat myocardium and high-glucose–treated H9c2 cells, GLB reduced oxidative stress burden, as evidenced by decreased ROS and MDA levels and improved antioxidant-related readouts. In addition, GLB was associated with increased gut microbial richness and diversity in diabetic rats. Mechanistically, GLB treatment was accompanied by suppression of NFκB/NLRP3 pathway activation, consistent with attenuation of inflammatory injury.</div></div><div><h3>Conclusions</h3><div>These findings provide initial evidence that GLB mitigates oxidative stress and inflammatory damage in DCM. The cardioprotective effects of GLB appear to involve modulation of the NFκB/NLRP3 signalling pathway and partial restoration of gut microbial diversity, supporting GLB as a promising candidate for further investigation in DCM.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 4","pages":"Pages 234-249"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}