Canadian Journal of Diabetes最新文献

{"title":"Response to: Critical Insights on Promoting Self-management in Adults With Type 2 Diabetes: Development and Validation of the Glucose Monitoring Impact Scale","authors":"Michael Vallis PhD, Lori Berard BScN, Emmanuel Cosson MD, Finn Boerlum Kristensen PhD, Fleur Levrat-Guillen PhD, Nicolas Naiditch PhD, Remi Rabasa-Lhoret MD, William Polonsky PhD","doi":"10.1016/j.jcjd.2025.02.005","DOIUrl":"10.1016/j.jcjd.2025.02.005","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 140-141"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Systemic Immune-Inflammation Index With Mortality Risk Among Adults in Diabetic Kidney Disease, NHANES 1999 to 2018","authors":"Yun She MS ,&nbsp;Xiangyun Guo MS ,&nbsp;Ying Tan PhD ,&nbsp;Qingqing Liu MS ,&nbsp;Lingling Zhu MS ,&nbsp;Xiqiao Zhou PhD ,&nbsp;Jiangyi Yu MS ,&nbsp;Qianhua Yan PhD","doi":"10.1016/j.jcjd.2025.01.003","DOIUrl":"10.1016/j.jcjd.2025.01.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Immune inflammation plays a crucial role in the pathogenesis of diabetic kidney disease (DKD), but an exact assessment of indicators remains undefined. In this study we address the link between systemic immune-inflammation index (SII) and mortality risk in DKD, and we explore the effect of sex disparities.</div></div><div><h3>Methods</h3><div>Data from patients with DKD from the National Health and Nutritional Examination Surveys (NHANES, 1999 to 2018) were studied and their causes of death were identified from NHANES-related files. A weighted Cox model was used to evaluate hazard ratios for all-cause, cardiovascular, and cardiocerebrovascular mortality, and these associations were visualized by smoothing curves.</div></div><div><h3>Results</h3><div>The average SII was 634.20 (10³/μL). There were 1,283 deaths recorded during 273,422 person-months (396 were cardiovascular related and 461 were cardiocerebrovascular related). Higher SIIs in the fifth quintile were significantly associated with increased mortality (p&lt;0.01). SII trends showed an increased risk of all-cause mortality of &gt;697.0 (10³/μL), cardiovascular risk of &gt;717.8 (10³/μL), and cardiocerebrovascular risk of &gt;650.0 (10³/μL). Mortality increased when SII reached 500 to 660 (10³/μL) in men and 700 to 760 (10³/μL) in women.</div></div><div><h3>Conclusions</h3><div>There was a significant association between higher SII and increased risk of all-cause, cardiovascular, and cardiocerebrovascular mortality in DKD patients. In addition, although men had lower SII, their mortality was higher than that of women.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 152-163.e1"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparing a New Generation of Providers in Canada: The Mental Health + Diabetes Training Program","authors":"Tricia S. Tang PhD, RPsych ,&nbsp;Jessica C. Kichler CDCES, PhD, CPsych ,&nbsp;Zosia R. Anders MSW, PSW ,&nbsp;Marie Raffray RN, CDE, MSN ,&nbsp;Tiffany R. Shepherd PhD, RPsych ,&nbsp;Brandy A. Wicklow MD, MSc(Epi), FRCPC ,&nbsp;Julia Bannister MEd, MSW, RSW, CDE ,&nbsp;Mona Gupta MD, CM, FRCPC, PhD ,&nbsp;Amanda M. Hailman MPH ,&nbsp;Gerri M. Klein RN, MSN, CDE ,&nbsp;Joanne Lewis RD, CDE ,&nbsp;Sarah E. Linklater PhD ,&nbsp;Sadinand D. Mankikar MSc, MS ,&nbsp;Caleb Pope BA ,&nbsp;Katie D. Ryan MA ,&nbsp;Remi Rabasa-Lhoret MD, PhD ,&nbsp;Christine Tourigny BA ,&nbsp;Michael Vallis PhD, RPsych","doi":"10.1016/j.jcjd.2025.02.007","DOIUrl":"10.1016/j.jcjd.2025.02.007","url":null,"abstract":"<div><div>Diabetes care in Canada is compromised by the lack of resources to adequately address the mental health challenges associated with both type 1 and type 2 diabetes. To address this gap Breakthrough T1D (formerly JDRF) Canada and Diabetes Canada developed a bilingual training program, and associated directory listing successful graduates, to educate and empower existing mental health providers to better provide services to those living with diabetes. This study reports on the development and initial outcomes of this virtual training program. Training involved 6 self-learning modules and a 3-hour interactive session to consolidate knowledge. Over a 24-month period, 796 mental health providers (68.5% English-speaking, 31.5% French-speaking) enrolled in the training program. Over half of enrollees (56.3%) have completed the program to date (N=448) and 37% of completers (N=166) were approved for the Directory. The professions enrolled, spanning the country, included social workers (42.1%), psychologists (33.7%), psychotherapists (10.8%), counsellors (7.0%), mental health nurses (5.5%), and psychiatrists (0.6%). Satisfaction with the program was very high and training was considered very practical. The program is available at no cost on an ongoing basis, and follow-up research will evaluate the feasibility, acceptability, and potential health-related impact of training mental health providers in working with people with diabetes.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 205-212"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Training for People With Diabetes-related Foot Ulcers: A Systematic Review of Glycemia, Fitness, and Wound-healing Outcomes","authors":"Callum J. Baker PhD ,&nbsp;Vivienne Chuter PhD ,&nbsp;Magali Brousseau-Foley MD ,&nbsp;Danqing Min PhD ,&nbsp;Angela Searle ,&nbsp;Stephen M. Twigg PhD ,&nbsp;Nathan A. Johnson PhD","doi":"10.1016/j.jcjd.2025.02.002","DOIUrl":"10.1016/j.jcjd.2025.02.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Regular physical activity is a key, patient-centred therapy for people with diabetes to manage their glycemia. The International Working Group on the Diabetic Foot recommends optimization of glycemic management for people with/at risk of diabetes-related foot ulcer (DFU); however, people with DFU are commonly instructed by clinicians to avoid physical activity so as not to worsen the ulcer. The effects of exercise on glycemia, fitness, and wound healing in people with active DFU are not clear. In this study we examined the effects of regular exercise (training) on glycemia, cardiorespiratory fitness, muscular strength, metabolic health, and ulcer healing in adults with diabetes and an active foot ulcer.</div></div><div><h3>Methods</h3><div>Online databases and reference lists of included studies were searched from earliest records to December 2023. Studies involving adult populations with DFU and incorporating interventions of exercise training were included. Data were extracted independently by 2 reviewers.</div></div><div><h3>Results</h3><div>Of the 5,592 studies screened, 8 were included, with a total of 213 participants. Exercise interventions involved foot range-of-movement exercises and/or aerobic and/or resistance-type exercise. None of the studies reported on cardiorespiratory fitness or anthropometry and limited data were available for glycemic and muscular strength outcomes. Interpretation of data on safety, wound healing, and adherence to exercise were limited due to inconsistent reporting.</div></div><div><h3>Conclusions</h3><div>Despite some data that exercise may have a positive impact on wound healing, evidence regarding its benefits and safety is significantly lacking, despite metabolic (particularly glycemic) and fitness outcomes being core to the rationale for exercise therapy in diabetes. Given the importance of exercise in current management guidelines for diabetes, and the plausibility of positive health effects of exercise training for people with DFU, there is a need for research to move from foot-focussed to person-centred outcomes to better inform the implementation of exercise therapy for people with DFU.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 164-173.e1"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence and Common Forms of Maturity-onset Diabetes of the Young in Greenland","authors":"Anne Cathrine Baun Thuesen PhD ,&nbsp;Marie Balslev Backe PhD ,&nbsp;Genís Garcia-Erill PhD ,&nbsp;Mikkel Schubert PhD ,&nbsp;Kristian Ebbesen Hanghøj PhD ,&nbsp;Ida Moltke PhD ,&nbsp;Anders Albrechtsen PhD ,&nbsp;Niels Grarup DMSc ,&nbsp;Anette Prior Gjesing PhD ,&nbsp;Marit Eika Jørgensen PhD ,&nbsp;Torben Hansen PhD ,&nbsp;Michael Lynge Pedersen DMSc","doi":"10.1016/j.jcjd.2025.01.002","DOIUrl":"10.1016/j.jcjd.2025.01.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Population studies have identified common genetic variants contributing substantially to the burden of diabetes in Greenland. However, the handling of suspected monogenic diabetes in diabetes clinics in Greenland has not been described. In this study we aimed to describe the referral rate, prevalence, and genetic causes of clinically identified monogenic diabetes in Greenland.</div></div><div><h3>Methods</h3><div>All diabetes patients in Greenland referred for genetic testing due to suspected monogenic diabetes between 2014 and July 2022 were tallied. Targeted short-read sequencing and Sanger sequencing of probands and their family members were used to screen for potentially deleterious variants in the maturity-onset diabetes of the young (MODY) genes <em>GCK</em>, <em>HNF1A</em>, <em>HNF1B</em>, and <em>HNF4A</em>. Clinical data were extracted from the electronic medical records, and whole-genome sequencing was performed for families with potentially deleterious variants for genetic ancestry analysis.</div></div><div><h3>Results</h3><div>Between 2014 and July 2022, 58 probands were referred for genetic testing, equivalent to 0.1% of the population. Five variants were identified: <em>GCK</em> p.F133L, <em>GCK</em> p.D205E, <em>HNF1A</em> c.1108G&gt;T, <em>HNF1B</em> p.Q182∗, and <em>HNF4A</em> −178A&gt;G. These variants were found in 11 probands and 19 family members, equivalent to a population prevalence of monogenic diabetes of 0.05%. Local ancestry analysis revealed that all the variants were found exclusively in Inuit haplotypes, despite all individuals being admixed with both Inuit and European genetic ancestry.</div></div><div><h3>Conclusions</h3><div>The rate of referral and prevalence of monogenic diabetes is substantially higher in Greenland than in other populations, and both rare and more common population-specific variants of Inuit genetic ancestry contribute to this high prevalence.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 142-151.e2"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise and Glycemic Management in Females and Women With Diabetes: The Role of Sex and Gender Across the Lifespan","authors":"Tricia M. Peters MD, PhD ,&nbsp;Anne-Sophie Brazeau PhD ,&nbsp;Lia Bally MD, PhD ,&nbsp;Alexa Govette ,&nbsp;Elsa Heyman PhD ,&nbsp;Mary E. Jung PhD ,&nbsp;Céline I. Laesser MD ,&nbsp;Élodie Lespagnol PhD ,&nbsp;Jessica E. Logan BSc ,&nbsp;Zeinab Momeni PhD ,&nbsp;Tawnya Perry RN, CDE ,&nbsp;Meryem K. Talbo PhD, RD, MSc ,&nbsp;Anne Bonhoure MSc ,&nbsp;Jenna A.P. Sim MSc ,&nbsp;Jasmin von Zezschwitz BSc ,&nbsp;Dessi P. Zaharieva PhD, CDCES ,&nbsp;Jenna B. Gillen PhD ,&nbsp;Jane E. Yardley PhD","doi":"10.1016/j.jcjd.2025.02.001","DOIUrl":"10.1016/j.jcjd.2025.02.001","url":null,"abstract":"<div><div>The benefits of exercise and physical activity (PA) for people living with diabetes are clear. However, current exercise recommendations do not take into consideration the potential impact of female-specific hormonal changes across the lifespan on the glycemic response to exercise. Moreover, the impact of life phases on barriers to participation in exercise and PA for women compared to men with diabetes is not well described. In this narrative review we have synthesized the literature to date regarding the interaction of female sex hormone variations (menarche and the menstrual cycle, pregnancy, and the menopausal transition) with glycemic management in the context of exercise for females with type 1 and type 2 diabetes. We also evaluated PA behaviours and barriers to participation in exercise and PA among individuals with diabetes identifying as women. We observed a lack of evidence regarding the impact of female-specific hormonal changes on the glycemic response to exercise among females with diabetes, with a particular paucity of studies during pregnancy and postpartum and for the menopausal transition. In this study we demonstrate that additional research is required to understand the influence of exercise on glucose management for females with diabetes across the lifespan, with the aim to provide safe and effective exercise recommendations and to encourage equitable participation in exercise and PA for females and women with diabetes throughout life.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 194-204"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Square Peg in a Round Hole: Social Experiences of Living With Diabetes in Canada in 2024","authors":"Michael Vallis PhD, RPsych ,&nbsp;J.J. Bresolin MA ,&nbsp;Kim Fletcher PhD ,&nbsp;Elizabeth Holmes-Truscott PhD ,&nbsp;Jane Speight PhD ,&nbsp;Laura Syron MA","doi":"10.1016/j.jcjd.2025.03.001","DOIUrl":"10.1016/j.jcjd.2025.03.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Diabetes self-management often occurs in social contexts, around others without diabetes. International consensus identifies the pervasive presence of social stigma toward those with diabetes, negatively impacting health, well-being, and social and professional lives. In this study, we aimed to identify the social experiences of Canadian adults living with type 1 diabetes (T1D) or type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>An online survey was completed by 1,799 adults with diabetes (T1D: n=786; T2D: n=1,013). The survey assessed diabetes stigma, emotional well-being, diabetes distress, quality of life, and health-care experiences. Analyses involved descriptives of stigma experiences and associations with other measures.</div></div><div><h3>Results</h3><div>Experiencing blame and judgment for having diabetes was common. For T1D, 73% of respondents reported people making unfair assumptions about their capabilities, and 69% reported being judged for what they eat. For T2D, 41% reported being stigmatized as having a “lifestyle disease,” and 31% reported being judged for their food choices. Being treated differently due to diabetes was common: 54% with T1D reported being rejected, and 22% with T2D reported being treated as sick. Many respondents with T1D were concerned about managing diabetes in public (44.2%) and many with T2D were embarrassed about having diabetes (27.4%). Greater stigmatization was associated with lower general emotional well-being, greater diabetes distress, and greater negative impact on quality of life.</div></div><div><h3>Conclusions</h3><div>Adults with T1D or T2D commonly experience stigmatization, negatively impacting well-being and quality of life. These data support changing the conversation about diabetes in ways that will lead to greater respect, empathy, and support for all people living with diabetes in Canada.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 183-193"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Insights on Promoting Self-management in Adults With Type 2 Diabetes: Development and Validation of the Glucose Monitoring Impact Scale","authors":"Saad Khan MBBS,&nbsp;Fatima Naveed MBBS,&nbsp;Ayesha Khan MBBS,&nbsp;Rizwan Ahmad MBBS,&nbsp;Faraz Arshad MBBS","doi":"10.1016/j.jcjd.2024.12.007","DOIUrl":"10.1016/j.jcjd.2024.12.007","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Page 139"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Hyperemesis Syndrome Can Mimic Diabetic Gastroparesis in Cannabis Users With Type 1 Diabetes","authors":"Kagan E. Karakus MD,&nbsp;Halis K. Akturk MD","doi":"10.1016/j.jcjd.2025.02.004","DOIUrl":"10.1016/j.jcjd.2025.02.004","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 218-219"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Diabetes Laboratory Testing in Alberta Before and During the COVID-19 Pandemic","authors":"Jamie L. Benham MD, PhD, FRCPC ,&nbsp;Nikki Stephenson PhD ,&nbsp;Amy Metcalfe PhD ,&nbsp;Lois E. Donovan MD, FRCPC ,&nbsp;Denice S. Feig MD, MSc, FRCPC ,&nbsp;Christy Pylylpjuk MD, MSC, FRCPC ,&nbsp;Chelsea Ruth MD, MSC, FRCPC ,&nbsp;Howard Berger MD ,&nbsp;Sarah M. Sigurdson BSc ,&nbsp;Baiju R. Shah MD, PhD ,&nbsp;Jennifer M. Yamamoto MD, MSc, FRCPC","doi":"10.1016/j.jcjd.2025.02.008","DOIUrl":"10.1016/j.jcjd.2025.02.008","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"49 3","pages":"Pages 213-217.e1"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}