Natasha J. Verhoeff HBHSc , Wajeeha Cheema HBSc , Sara Mojdehi BMSc , Hoda Gad BSc, MSc, PhD , Doug Mumford BASc(EE) , Mary Rose Waniss BSc , Andrej Orszag MD , Akshay Jain MD , Priya Bapat MD, PhD , Dalton Budhram BSc, MD , Abdulmohsen Bakhsh MBBS , Mohammad I. Abuabat MD , Leif Erik Lovblom MSc, PhD , Noah Ivers MD, PhD , Bruce A. Perkins MD, MPH
{"title":"Barriers to Diabetic Ketoacidosis Prevention in Adults With Type 1 Diabetes: Implications for Education and Implementation of New Monitoring Technologies","authors":"Natasha J. Verhoeff HBHSc , Wajeeha Cheema HBSc , Sara Mojdehi BMSc , Hoda Gad BSc, MSc, PhD , Doug Mumford BASc(EE) , Mary Rose Waniss BSc , Andrej Orszag MD , Akshay Jain MD , Priya Bapat MD, PhD , Dalton Budhram BSc, MD , Abdulmohsen Bakhsh MBBS , Mohammad I. Abuabat MD , Leif Erik Lovblom MSc, PhD , Noah Ivers MD, PhD , Bruce A. Perkins MD, MPH","doi":"10.1016/j.jcjd.2025.11.002","DOIUrl":"10.1016/j.jcjd.2025.11.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Diabetic ketoacidosis (DKA) is a major acute complication whose prevention depends on patient knowledge and self-management skills. In this study we aimed to identify the patient-level barriers to effective DKA prevention behaviours.</div></div><div><h3>Methods</h3><div>We conducted a qualitative study using a behavioural science lens and implementation science methods involving 3 independent, sequential focus groups. Informed by the Action, Actor, Context, Target, Time framework, 3 targeted behaviours were defined: testing ketone levels; acting upon ketone results; and seeking emergency medical care. Deductive coding was used to categorize barriers and enablers for each targeted behaviour using the Theoretical Domains Framework. This was followed by thematic analysis and then member checking of key findings.</div></div><div><h3>Results</h3><div>Twenty-two participants (9 with type 1 diabetes, 1 caregiver, 12 health-care providers) contributed to 1 of 3 focus groups. Key barriers to engaging in the target behaviours were 1) a lack of understanding of the clinical relevance of ketones; 2) inability to retain necessary steps for ketone testing and a lack of access to supplies; 3) mental health challenges, sense of identity, and resistance to change; and 4) negative experiences with and fear of stigma from the health-care system. Key enablers included 1) reminders from clinicians and technologies; and 2) community supports and accessible resources.</div></div><div><h3>Conclusions</h3><div>Acknowledgment of specific barriers is essential to designing future simplified DKA prevention educational tools and for implementation of continuous ketone monitoring. In a subsequent step we aim to co-create a simplified DKA prevention infographic that addresses these barriers for individuals living with diabetes.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 72-81.e2"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karla Freeman MSc , John Tamale MBChB, MMed, MCISc, CCFP(EM), FCFP , Edward Tamale MD , Jennifer Salerno MSc, PhD
{"title":"Evaluating Virtual Care for Adults with Type 2 Diabetes During the COVID-19 Pandemic: Results From a Pre–Post Retrospective Cohort Pilot Study in a Canadian Family Health Team","authors":"Karla Freeman MSc , John Tamale MBChB, MMed, MCISc, CCFP(EM), FCFP , Edward Tamale MD , Jennifer Salerno MSc, PhD","doi":"10.1016/j.jcjd.2025.12.010","DOIUrl":"10.1016/j.jcjd.2025.12.010","url":null,"abstract":"<div><h3>Objectives</h3><div>In this study we aimed to determine the feasibility of using electronic medical record (EMR) data to assess whether virtual care provided by a family health team (FHT) located in Ontario during the early COVID-19 pandemic impacted key diabetes indicators, and to identify whether content of diabetes-specific appointments was comparable to in-person care.</div></div><div><h3>Methods</h3><div>A retrospective pre–post cohort study was performed using patient-level EMR data from eligible FHT patients with type 2 diabetes. Feasibility outcomes were defined with prespecified success criteria. Scientific outcomes included 3 diabetes indicators: glycated hemoglobin (A1C), low-density lipoprotein (LDL), and blood pressure (BP). Indicator results from the prepandemic period (September 2019) and during-pandemic period (March 2020 to March 2021) were recorded and compared. Patient characteristics and content of diabetes-specific appointments were also collected.</div></div><div><h3>Results</h3><div>All feasibility outcomes met predefined criteria for success. No significant differences in A1C, LDL, or BP were identified between pre- and during-pandemic cohorts. Depression screening was performed significantly more frequently during the pandemic (73.85% vs 47.06%, p<0.001) at diabetes-specific appointments compared with the pre-pandemic period. No significant differences in frequency of screening for other complications (i.e. hypoglycemia, foot, eye) were found.</div></div><div><h3>Conclusions</h3><div>Results signal that virtual care delivery in the during-pandemic period was not associated with significant changes in diabetes indicators or reduced screening for complications; however, many patients did not have BP measurements recorded during the pandemic. Findings support evidence that virtual care may help maintain continuity of care for diabetes management when in-person appointments are not possible.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 97-105.e4"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Krogh Nygaard MScN, RN , Anne Sophie Mathiesen PhD, MPH, RN , Vibeke Zoffmann PhD, MScN, RN , Mette Juel Rothmann PhD, MSc (Health), RN
{"title":"The Experience of a Guided Self-determination Intervention on Diabetes Distress Among Adults With Type 2 Diabetes","authors":"Laura Krogh Nygaard MScN, RN , Anne Sophie Mathiesen PhD, MPH, RN , Vibeke Zoffmann PhD, MScN, RN , Mette Juel Rothmann PhD, MSc (Health), RN","doi":"10.1016/j.jcjd.2025.12.013","DOIUrl":"10.1016/j.jcjd.2025.12.013","url":null,"abstract":"<div><h3>Objectives</h3><div>Type 2 diabetes (T2D) can cause psychosocial difficulties, burdensome self-care, and stigmatization, which can lead to diabetes distress, reduced quality of life, and suboptimal diabetes management. Guided self-determination (GSD) has been identified as valuable in alleviating diabetes distress. In this study we explored the experience of a GSD intervention among people with T2D and aimed to understand the potential impact on diabetes distress.</div></div><div><h3>Methods</h3><div>A qualitative study was undertaken using semistructured interviews (n=10) and reflexive thematic analysis by Braun and Clarke. The study adhered to the Consolidated Criteria for Reporting Qualitative Studies checklist.</div></div><div><h3>Results</h3><div>Four themes were revealed: “Person-centred reflection creates self-insight,” becoming aware of how one deals with diabetes and finding renewed optimism; “Unburdening myself,” characterized by room and support for psychosocial aspects; “Making sense of diabetes: Creating meaning through reflection and dialogue,” reflecting on current difficulties while simultaneously making sense of diabetes; and “Barriers to changes: Between acceptance, effort, and everyday realities,” where readiness, motivation, and energy impacted possible changes.</div></div><div><h3>Conclusions</h3><div>GSD may improve the ability to alleviate stressors related to diabetes. However, some individuals experienced no changes. Readiness, motivation, and energy appear to be critical for the potential to change.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 106-114"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James W. Kim MBBCh, PgDip, MScCH (HPTE), CPC (HC) , Akshay B. Jain MD, FRCPC, FACE, CCD, ECNU, DABIM, DABOM , Atul Khullar MD, MSc, FRCPC, FAASM, DABPN
{"title":"Corrigendum to “Insomnia and Cardiometabolic Health: Bridging the Gap Between Sleep Deficit and Disease Prevention”","authors":"James W. Kim MBBCh, PgDip, MScCH (HPTE), CPC (HC) , Akshay B. Jain MD, FRCPC, FACE, CCD, ECNU, DABIM, DABOM , Atul Khullar MD, MSc, FRCPC, FAASM, DABPN","doi":"10.1016/j.jcjd.2026.01.002","DOIUrl":"10.1016/j.jcjd.2026.01.002","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Page 64"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole Prince MD, PhD , Zoe R. O’Neill MD , Mike Bleskie MPM , Jacob Sartor MSc , Juanita Wilzer BN , Annie Garon-Mailer MN , Heather Lochnan MD , Cathy J. Sun MD, MSc
{"title":"A Call for a Multidisciplinary Approach to Improving Treatment of In-hospital Nonsevere Hypoglycemia for People Living With Diabetes","authors":"Nicole Prince MD, PhD , Zoe R. O’Neill MD , Mike Bleskie MPM , Jacob Sartor MSc , Juanita Wilzer BN , Annie Garon-Mailer MN , Heather Lochnan MD , Cathy J. Sun MD, MSc","doi":"10.1016/j.jcjd.2025.10.179","DOIUrl":"10.1016/j.jcjd.2025.10.179","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 124-128"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of Second-line Diabetes Mellitus Medications and Adverse Events Among Older Adults After the Introduction of Glucagon-like Peptide-1 Receptor Agonists in Ontario, Canada: A Retrospective Cohort Study","authors":"Cherry Chu MSc , Dorsa Ghahramani MSc , Vasily Giannakeas PhD , Jeyani Jeyaparan MHSc , Onil Bhattacharyya MD, PhD , Tara Gomes PhD , Noah Ivers MD, PhD , Mina Tadrous PharmD, PhD","doi":"10.1016/j.jcjd.2025.12.009","DOIUrl":"10.1016/j.jcjd.2025.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>Our aim in this study was to describe incident use of second-line diabetes medications and serious adverse events among older adults before and after the introduction of glucagon-like peptide-1 receptor agonists (GLP-1RAs).</div></div><div><h3>Methods</h3><div>We conducted a population-based cohort study from June 2011 to March 2023 using administrative data from Ontario, Canada. We identified individuals ≥66 years of age with a new prescription for a second-line diabetes medication and recent history of metformin use. We also calculated the number and proportion of individuals using medications monthly with hypoglycemia and gastrointestinal events, stratified by drug class. Joinpoint models were used to determine whether any significant changes aligned with the introduction of GLP-1RAs</div></div><div><h3>Results</h3><div>Metformin was initially the most dispensed diabetes drug (peak 105,245 individuals treated in 2016), but its use was overtaken by second-line medications in 2019. Among second-line drugs, dipeptidyl peptidase-4 (DPP-4) inhibitors were dominant (peak 77,477 individuals in 2020). Use of sodium-glucose cotransporter-2 (SGLT2) inhibitors surpassed DPP-4 inhibitor use in 2022. Adverse events of interest were rare; however, insulin had the highest percentage of individuals affected with hypoglycemia (average 0.13% per month), while more individuals using second-line medications were affected with gastrointestinal outcomes (average 0.23% for diverticular disease in those using GLP-1RAs). Joinpoint models did not reveal any breaks in trend during the time of GLP-1RA introduction.</div></div><div><h3>Conclusions</h3><div>Metformin was the most common drug class used, but the use of second-line medications, such as SGLT2 inhibitors, DPP-4 inhibitors, and GLP-1RAs, exceeded the number of individuals using metformin in recent years---a major shift from historic trends.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 88-96.e5"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chung-Chih Liao MD, PhD , Chun-I Lee MD, PhD , Jung-Miao Li MD, PhD
{"title":"Causal Relationship Between Multiple Modifiable Risk Factors and Gestational Diabetes Mellitus: A 2-Sample Mendelian Randomization Study","authors":"Chung-Chih Liao MD, PhD , Chun-I Lee MD, PhD , Jung-Miao Li MD, PhD","doi":"10.1016/j.jcjd.2025.10.178","DOIUrl":"10.1016/j.jcjd.2025.10.178","url":null,"abstract":"<div><h3>Objectives</h3><div>Gestational diabetes mellitus (GDM) is a significant metabolic disorder affecting pregnant women, leading to increased risks of adverse maternal and fetal outcomes. Effective management and preventive strategies are crucial to mitigate its short- and long-term complications. In this study we aim to elucidate the causal relationships between multiple modifiable risk factors and GDM using a 2-sample Mendelian randomization (MR) approach.</div></div><div><h3>Methods</h3><div>We analyzed 41 modifiable risk factors, categorized into metabolic and weight factors, dietary habits, smoking and alcohol behaviours, and physical activities. Genetic variants associated with these risk factors were identified from genome-wide association studies (GWAS). GDM data came from the largest GWAS on GDM, including 12,332 GDM cases and 131,109 Finnish ancestry controls from the FinnGen study. MR analysis was performed using inverse variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods.</div></div><div><h3>Results</h3><div>Preliminary screening identified 12 significant modifiable risk factors, with fasting glucose, fasting insulin, glycated hemoglobin (A1C) levels, triglycerides, body mass index (BMI), 2-hour glucose, and processed meat intake increasing GDM risk, whereas high-density lipoprotein (HDL) cholesterol, tea consumption, cheese intake, lamb/mutton intake, and dried fruit intake decreased the risk. After correction for multiple comparisons, fasting glucose, fasting insulin, A1C, triglycerides, BMI, and HDL cholesterol remained significant and consistent across various methods.</div></div><div><h3>Conclusions</h3><div>This comprehensive MR study provides strong evidence for the causal effects of various modifiable risk factors on GDM, highlighting the importance of lifestyle interventions targeting metabolic and dietary factors to prevent GDM and improve maternal and fetal outcomes.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 65-71.e3"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uyanga Ganbat MD, MSc, MPH , Altan-Ochir Byambaa BSc , Boris Feldman MD , Shane Arishenkoff MD , Graydon S. Meneilly MD , Jonathan Little PhD , Teresa Liu-Ambrose PT, PhD , Kenneth M. Madden MD, MSc
{"title":"Association Between Sex-specific Handgrip Strength and Plasma Glycated Hemoglobin Levels Among Older Adults: A Cross-sectional Study","authors":"Uyanga Ganbat MD, MSc, MPH , Altan-Ochir Byambaa BSc , Boris Feldman MD , Shane Arishenkoff MD , Graydon S. Meneilly MD , Jonathan Little PhD , Teresa Liu-Ambrose PT, PhD , Kenneth M. Madden MD, MSc","doi":"10.1016/j.jcjd.2025.12.003","DOIUrl":"10.1016/j.jcjd.2025.12.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Adults with diabetes have 37% to 109% higher odds of sarcopenia than normoglycemic individuals. Handgrip strength (HGS) is a key marker of sarcopenia, yet its association with glycated hemoglobin (A1C), a measure of long-term glycemia, remains unclear.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of 121 outpatients ≥65 years of age (80 women, 41 men). HGS was measured 3 times per hand using a calibrated dynamometer and the mean was recorded. Low HGS was defined using cutoffs of the European Working Group on Sarcopenia in Older People. Fasting A1C, analyzed in an accredited laboratory, was categorized as normal (<5.7%), prediabetes (5.7% to 6.4%), and diabetes (≥6.5%). Correlations between A1C and anthropometric/functional measures were evaluated, and multivariate linear regression identified A1C predictors.</div></div><div><h3>Results</h3><div>The mean HGS was 26 kg in women and 39 kg in men; 11 participants (9.5%) had low HGS. Prediabetes prevalence was 49% in women and 41% in men. A1C correlated inversely with HGS in men (r=−0.47, p=0.002), but not in women (r=−0.16, p=0.14). Trend analysis showed decreasing grip strength and gait speed across A1C categories in men (p<sub>trend</sub>=0.0015 and 0.012, respectively), but not in women. Post hoc power analysis showed that the smaller correlation between HGS and A1C in women had low statistical power, suggesting that the nonsignificant result may be due to insufficient power rather than a true absence of association.</div></div><div><h3>Conclusions</h3><div>Lower HGS was associated with higher A1C in older men. The nonsignificant results in women are likely attributable to low statistical power.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 82-87.e2"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa Oxlad BA, BA(Hons), MPsych(Clin & Health), PhD , Lorraine Smith BPsychSc(Hons) , Tyla McNamara , Ashley Young , Ella Borrowdale , Alexia S. Pena FRACP, PhD
{"title":"Psychosocial Experiences of Adolescents With Type 2 Diabetes: A Systematic Review and Meta-synthesis","authors":"Melissa Oxlad BA, BA(Hons), MPsych(Clin & Health), PhD , Lorraine Smith BPsychSc(Hons) , Tyla McNamara , Ashley Young , Ella Borrowdale , Alexia S. Pena FRACP, PhD","doi":"10.1016/j.jcjd.2025.09.004","DOIUrl":"10.1016/j.jcjd.2025.09.004","url":null,"abstract":"<div><div>Globally, the prevalence of type 2 diabetes (T2D) among adolescents is increasing. Although T2D is known to bring physical health challenges, less is known about adolescents’ psychosocial experiences of T2D. We aimed to identify and synthesize existing qualitative research about adolescents’ psychosocial experiences of T2D to inform health-care recommendations. Guided by Preferred Reporting Items for Systematic reviews and Meta-Analyses and Joanna Briggs Institute guidelines, we conducted a systematic review and meta-synthesis using a meta-aggregative approach. We searched 5 electronic databases to identify qualitative or mixed-methods primary studies examining adolescents’ psychosocial experiences of T2D, published in English, in a peer-reviewed journal from database inception to August 2024. Eight studies were included, with findings aggregated into 2 synthesized findings related to the diagnosis of T2D and living with T2D. At diagnosis, adolescents had limited knowledge of T2D, often obtained via observing family members with T2D, and desired further education. Adolescents also described a range of negative emotions, some of which influenced disclosure of their diagnosis. In living with T2D, adolescents contended with psychosocial challenges, with some viewing T2D as a burden and others as an opportunity for positive self-care and lifestyle changes. Adolescents described challenges with health behaviour changes and medical management. Social support was noted to be important. Adolescents with T2D have limited knowledge about the condition and desire greater education. They experience a range of emotions and challenges with T2D management and benefit from support. Based on our findings, we propose recommendations that may optimize adolescents’ physical, psychological, and social well-being.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"50 2","pages":"Pages 115-123.e11"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}