Associations of Systemic Immune-Inﬂammation Index With Mortality Risk Among Adults in Diabetic Kidney Disease, NHANES 1999-2018.

Canadian journal of diabetes Pub Date : 2025-02-13 DOI:10.1016/j.jcjd.2025.01.003

Yun She, Xiangyun Guo, Ying Tan, Qingqing Liu, Lingling Zhu, Xiqiao Zhou, Jiangyi Yu, Qianhua Yan

{"title":"Associations of Systemic Immune-Inﬂammation Index With Mortality Risk Among Adults in Diabetic Kidney Disease, NHANES 1999-2018.","authors":"Yun She, Xiangyun Guo, Ying Tan, Qingqing Liu, Lingling Zhu, Xiqiao Zhou, Jiangyi Yu, Qianhua Yan","doi":"10.1016/j.jcjd.2025.01.003","DOIUrl":null,"url":null,"abstract":"Background: Immune-Inﬂammation plays a crucial role in the pathogenesis of diabetic kidney disease (DKD), but the exact assessment of indicators are undefined. Our paper examined the link between Systemic immune-inflammation index (SII) and mortality risk in DKD, and explore the effect of sex disparities on it.Methods: Data of DKD patients from the National Health and Nutritional Examination Surveys (NHANES) data (1999-2018) were studied and the causes of mortality were identified from NHANES-related files. A Weighted Cox model evaluated hazard ratios (HR) for all-cause, cardiovascular and cardio-cerebrovascular mortality, and these associations were visualized by smoothing curves.Results: The average level of SII was 634.20 (10ˆ3/uL). 1,283 deaths were recorded during 273,422 person-months, of which, 396 died form cardiovascular and 461 form cardio-cerebrovascular. Higher SII levels in the Q5 quintile were significantly associated with the increased mortality (P < 0.01). Trends in SII levels showed an increased risk of all-cause mortality at levels >697 (10ˆ3/uL), cardiovascular risk at levels >717.8 (10ˆ3/ uL), and cardio-cerebrovascular risk at levels >650.0 (10ˆ3/uL). In male, the mortality would increase with the SII levels of 500-660 (10ˆ3/ uL), while it was 700-760 (10ˆ3/uL) in female.Conclusions: A significant association between higher SII levels and increased risks of all-cause, cardiovascular and cardio-cerebrovascular mortality in DKD patients. In addition, though male have lower SII levels, their mortality was higher than that of female.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of diabetes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jcjd.2025.01.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Immune-Inﬂammation plays a crucial role in the pathogenesis of diabetic kidney disease (DKD), but the exact assessment of indicators are undefined. Our paper examined the link between Systemic immune-inflammation index (SII) and mortality risk in DKD, and explore the effect of sex disparities on it.

Methods: Data of DKD patients from the National Health and Nutritional Examination Surveys (NHANES) data (1999-2018) were studied and the causes of mortality were identified from NHANES-related files. A Weighted Cox model evaluated hazard ratios (HR) for all-cause, cardiovascular and cardio-cerebrovascular mortality, and these associations were visualized by smoothing curves.

Results: The average level of SII was 634.20 (10ˆ3/uL). 1,283 deaths were recorded during 273,422 person-months, of which, 396 died form cardiovascular and 461 form cardio-cerebrovascular. Higher SII levels in the Q5 quintile were significantly associated with the increased mortality (P < 0.01). Trends in SII levels showed an increased risk of all-cause mortality at levels >697 (10ˆ3/uL), cardiovascular risk at levels >717.8 (10ˆ3/ uL), and cardio-cerebrovascular risk at levels >650.0 (10ˆ3/uL). In male, the mortality would increase with the SII levels of 500-660 (10ˆ3/ uL), while it was 700-760 (10ˆ3/uL) in female.

Conclusions: A significant association between higher SII levels and increased risks of all-cause, cardiovascular and cardio-cerebrovascular mortality in DKD patients. In addition, though male have lower SII levels, their mortality was higher than that of female.

查看原文本刊更多论文

成人糖尿病肾病患者全身免疫炎症指数与死亡风险的关系，NHANES 1999-2018。

背景：免疫炎症在糖尿病肾病（DKD）的发病机制中起着至关重要的作用，但其确切的评价指标尚不明确。本文研究了DKD患者全身免疫炎症指数（SII）与死亡风险之间的关系，并探讨了性别差异对其的影响。方法：研究1999-2018年国家健康与营养检查调查（NHANES）数据中DKD患者的数据，并从NHANES相关文件中确定死亡原因。加权Cox模型评估全因死亡率、心血管死亡率和心脑血管死亡率的风险比（HR），并通过平滑曲线将这些关联可视化。结果：SII平均水平为634.20 （10 m3 /uL）。在273,422人月期间记录了1,283例死亡，其中396例死于心血管疾病，461例死于心脑血管疾病。Q5分位数SII水平越高，死亡率越高（P < 0.01）。SII水平的趋势显示，>水平为697（10³/uL）时全因死亡风险增加，>水平为717.8（10³/uL）时心血管风险增加，>水平为650.0（10³/uL）时心脑血管风险增加。男性SII值为500 ~ 660(10³/uL)，女性SII值为700 ~ 760(10³/uL)，死亡率呈上升趋势。结论：高SII水平与DKD患者全因、心血管和心脑血管死亡风险增加之间存在显著关联。此外，虽然男性的SII水平较低，但其死亡率高于女性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Canadian journal of diabetes

自引率

0.00%

发文量